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Conserved domains on  [gi|380805869|gb|AFE74810|]
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ankyrin repeat and KH domain-containing protein 1 isoform 1, partial [Macaca mulatta]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12790921)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
240-558 6.20e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 184.77  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  240 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 319
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  320 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA 399
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  400 AREGHEEMVALLLAQGANINAQTEETQetaltlaccggfsevadflikagadielgcsTPLMEASQEGHLELVKYLLASG 479
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGE-------------------------------TPLHLAAENGHLEIVKLLLEAG 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869  480 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 558
Cdd:COG0666   210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-357 1.35e-48

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 175.14  E-value: 1.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   76 IGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 155
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  156 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDiTPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 235
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  236 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHsNEFKESALTLACYKGHLDMVRFLLEA 315
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK-DNDGKTALDLAAENGNLEIVKLLLEA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 380805869  316 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 357
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
990-1283 3.53e-48

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 173.99  E-value: 3.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  990 ELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANK 1069
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1070 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTAL 1149
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-DNDGNTPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1150 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFC 1229
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNA--KDNDGKTALDLAAENGNLEIV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 380805869 1230 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1283
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-611 2.39e-13

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 2.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   526 LMKAARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHgADPTHRLkDGSTMLIEAAKGGHTNVV 605
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77


                   ....*.
gi 380805869   606 SYLLDY 611
Cdd:pfam12796   78 KLLLEK 83
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
700-786 3.09e-04

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  700 VEETEGKLNELGQRISAIEKaqlksleliqgeplNKDKIEELKKNREEQVQKKKKILKELQKVERQLqmKTQQQFTKEYL 779
Cdd:PRK03918  233 LEELKEEIEELEKELESLEG--------------SKRKLEEKIRELEERIEELKKEIEELEEKVKEL--KELKEKAEEYI 296


                  ....*..
gi 380805869  780 ETKGQKD 786
Cdd:PRK03918  297 KLSEFYE 303
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
240-558 6.20e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 184.77  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  240 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 319
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  320 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA 399
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  400 AREGHEEMVALLLAQGANINAQTEETQetaltlaccggfsevadflikagadielgcsTPLMEASQEGHLELVKYLLASG 479
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGE-------------------------------TPLHLAAENGHLEIVKLLLEAG 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869  480 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 558
Cdd:COG0666   210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-357 1.35e-48

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 175.14  E-value: 1.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   76 IGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 155
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  156 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDiTPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 235
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  236 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHsNEFKESALTLACYKGHLDMVRFLLEA 315
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK-DNDGKTALDLAAENGNLEIVKLLLEA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 380805869  316 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 357
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
990-1283 3.53e-48

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 173.99  E-value: 3.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  990 ELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANK 1069
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1070 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTAL 1149
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-DNDGNTPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1150 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFC 1229
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNA--KDNDGKTALDLAAENGNLEIV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 380805869 1230 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1283
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 132-452 6.12e-26

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 113.20  E-value: 6.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  132 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC--LACSAG-YYELAQVLLAMHANVedrgNKGDI---TPLMA-ASSGG 204
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEkVKDIVRLLLEAGADV----NAPERcgfTPLHLyLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  205 YLDIVKLLLLHDADVNSQSATGNTALtYACAGGF---VDIVKVLLNEGANIEDHNENGHTPL---MEAASAgHVEVARVL 278
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGFninPKVIRLLLRKGADVNALDLYGMTPLavlLKSRNA-NVELLRLL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  279 LDHGAGI-----------NTHSNEFKESAltlacykghlDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE--VARLL 345
Cdd:PHA03095  174 IDAGADVyavddrfrsllHHHLQSFKPRA----------RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  346 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA----- 420
Cdd:PHA03095  244 LIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETvaatl 323

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 380805869  421 ----QTEETQETALTLACcggfseVADFLIKAGADI 452
Cdd:PHA03095  324 ntasVAGGDIPSDATRLC------VAKVVLRGAFSL 353
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1045-1333 7.33e-26

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 112.07  E-value: 7.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1045 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV-----NIIKILLNAGAEINSrtGSKLGISPLMLAA 1119
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNA--PDNNGITPLLYAI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1120 MN--GHVPAVKLLLDMGSDINAqietnrntaltlacfqgraevvsllldrkanvehRAKTGLTPLMEAASGGYA--EVGR 1195
Cdd:PHA03100  115 SKksNSYSIVEYLLDNGANVNI----------------------------------KNSDGENLLHLYLESNKIdlKILK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1196 VLLDKGADVNAppvpssrdtaltiaADKghykfCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1275
Cdd:PHA03100  161 LLIDKGVDINA--------------KNR-----VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLV 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869 1276 DNRKITPLMSAFRKGHVkvvqYLVKEVNQFPSDIECM---------RYIATITDKELLKKCHQCVET 1333
Cdd:PHA03100  222 NKYGDTPLHIAILNNNK----EIFKLLLNNGPSIKTIietllyfkdKDLNTITKIKMLKKSIMYMFL 284
Ank_2 pfam12796
Ankyrin repeats (3 copies);
197-287 1.80e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 95.95  E-value: 1.80e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   197 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANieDHNENGHTPLMEAASAGHVEVAR 276
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|.
gi 380805869   277 VLLDHGAGINT 287
Cdd:pfam12796   79 LLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1115-1206 3.44e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 3.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1115 LMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTALTLACFQGRAEVVSLLLDrKANVEHRAKtGLTPLMEAASGGYAEVG 1194
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 380805869  1195 RVLLDKGADVNA 1206
Cdd:pfam12796   78 KLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
130-222 1.22e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   130 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA-MHANVEDRGNkgdiTPLMAASSGGYLDI 208
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGR----TALHYAARSGHLEI 76

                           90
                   ....*....|....
gi 380805869   209 VKLLLLHDADVNSQ 222
Cdd:pfam12796   77 VKLLLEKGADINVK 90
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 138-334 1.04e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 81.19  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  138 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 217
Cdd:PHA02875   47 DSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  218 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 297
Cdd:PHA02875  127 DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 380805869  298 TLACYKGHLDMVRFLLEAGADQEHKT---DEMHTALMEAC 334
Cdd:PHA02875  207 CYAIENNKIDIVRLFIKRGADCNIMFmieGEECTILDMIC 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-611 2.39e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 2.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   526 LMKAARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHgADPTHRLkDGSTMLIEAAKGGHTNVV 605
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77


                   ....*.
gi 380805869   606 SYLLDY 611
Cdd:pfam12796   78 KLLLEK 83
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 261-433 2.31e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 68.12  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  261 TPLMEAASAGHVEVARVLLdhgagINTHSNEFK-----ESALTLACYKGHLDMVRFLLEAGAD--QEHKTDEMH---TAL 330
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLL-----KCPSCDLFQrgalgETALHVAALYDNLEAAVVLMEAAPElvNEPMTSDLYqgeTAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  331 MEACMDGHVEVARLLLDSGAQVNMP--ADSF------------ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 396
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVVSPraTGTFfrpgpknliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 380805869  397 ----MEAAREGHEEMVALLLAQGANINAQTEETQE-----TALTLA 433
Cdd:cd22192   174 hilvLQPNKTFACQMYDLILSYDKEDDLQPLDLVPnnqglTPFKLA 219
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1078-1267 2.24e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.49  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1078 TPLSLAASGGYVNIIKILL-NAGAEINSRtGSkLGISPLMLAAMNGHVPAVKLLLD---------MGSDINAQietnrNT 1147
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLkCPSCDLFQR-GA-LGETALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQG-----ET 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1148 ALTLACFQGRAEVVSLLLDRKANVE---------HRAKTGLT-----PLMEAASGGYAEVGRVLLDKGADVNAppvpssR 1213
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRA------Q 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869 1214 D----TALTIAADKGHYKF-CE---LLIHRGAHID------VRNKKGNTPLWLASNGGHFDVVQLLVQ 1267
Cdd:cd22192   166 DslgnTVLHILVLQPNKTFaCQmydLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 526-648 5.48e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  526 LMKAARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 605
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 380805869  606 SYLLDY------------PNNVLSVPTT-DVSQLTPPSQDQSQVPRVPMHTLAMVV 648
Cdd:PTZ00322  165 QLLSRHsqchfelganakPDSFTGKPPSlEDSPISSHHPDFSAVPQPMMGSLIVIM 220
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 233-386 5.28e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.85  E-value: 5.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   233 ACAGGFVDIVKVLLNEGA--NIEDHNENGHTPLMEAASAG-HVEVARVLLDHGAGINThsnefkESALTLACYKGHLDMV 309
Cdd:TIGR00870   24 AAERGDLASVYRDLEEPKklNINCPDRLGRSALFVAAIENeNLELTELLLNLSCRGAV------GDTLLHAISLEYVDAV 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   310 ----RFLLEAGADQ-------EHKTDEM---HTALMEACMDGHVEVARLLLDSGAQVNMPA-----------DSF---ES 361
Cdd:TIGR00870   98 eailLHLLAAFRKSgplelanDQYTSEFtpgITALHLAAHRQNYEIVKLLLERGASVPARAcgdffvksqgvDSFyhgES 177

                          170       180
                   ....*....|....*....|....*
gi 380805869   362 PLTLAACGGHVELAALLIERGANLE 386
Cdd:TIGR00870  178 PLNAAACLGSPSIVALLSEDPADIL 202
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 130-285 1.86e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  130 LAEACSDGDVNAVRKLLdEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAmhaNVEDRGN--------KGDiTPLMA 199
Cdd:cd22192    21 LLLAAKENDVQAIKKLL-KCPSCDLFQRgaLGETALHVAALYDNLEAAVVLME---AAPELVNepmtsdlyQGE-TALHI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  200 ASSGGYLDIVKLLLLHDADVNSQSATGntalTYacaggFVDIVKVLLNEGanieDHnenghtPLMEAASAGHVEVARVLL 279
Cdd:cd22192    96 AVVNQNLNLVRELIARGADVVSPRATG----TF-----FRPGPKNLIYYG----EH------PLSFAACVGNEEIVRLLI 156


                  ....*.
gi 380805869  280 DHGAGI 285
Cdd:cd22192   157 EHGADI 162
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 391-420 2.46e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 2.46e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 380805869    391 EGYTPLMEAAREGHEEMVALLLAQGANINA 420
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1111-1139 1.17e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.17e-04
                            10        20
                    ....*....|....*....|....*....
gi 380805869   1111 GISPLMLAAMNGHVPAVKLLLDMGSDINA 1139
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
700-786 3.09e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  700 VEETEGKLNELGQRISAIEKaqlksleliqgeplNKDKIEELKKNREEQVQKKKKILKELQKVERQLqmKTQQQFTKEYL 779
Cdd:PRK03918  233 LEELKEEIEELEKELESLEG--------------SKRKLEEKIRELEERIEELKKEIEELEEKVKEL--KELKEKAEEYI 296


                  ....*..
gi 380805869  780 ETKGQKD 786
Cdd:PRK03918  297 KLSEFYE 303
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 980-1168 7.68e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 7.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   980 LTLACAGGHEELVSVLIARDAKIEHRDKkgftpLILAATAGHVGVVE----ILLDKGGDI--------EAQSERTKD-TP 1046
Cdd:TIGR00870   57 FVAAIENENLELTELLLNLSCRGAVGDT-----LLHAISLEYVDAVEaillHLLAAFRKSgplelandQYTSEFTPGiTA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1047 LSLACSGGRQEVVDLLLARGAN------------KEHRNVSDYT--PLSLAASGGYVNIIKILLNAGAEInsRTGSKLGI 1112
Cdd:TIGR00870  132 LHLAAHRQNYEIVKLLLERGASvparacgdffvkSQGVDSFYHGesPLNAAACLGSPSIVALLSEDPADI--LTADSLGN 209

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  1113 SPLMLAAMNGHVPAV---------KLLLDMG--SDINAQIE--TNRN--TALTLACFQGRAEVVSLLLDRK 1168
Cdd:TIGR00870  210 TLLHLLVMENEFKAEyeelscqmyNFALSLLdkLRDSKELEviLNHQglTPLKLAAKEGRIVLFRLKLAIK 280
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-220 5.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 5.04e-03
                            10        20
                    ....*....|....*....|....*.
gi 380805869    195 TPLMAASSGGYLDIVKLLLLHDADVN 220
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADIN 29
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 715-785 7.38e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 40.10  E-value: 7.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  715 SAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLqmktqQQFTKEYLETKGQK 785
Cdd:COG4026   114 NAIIRAGLKSLQNIPEYNELREELLELKEKIDEIAKEKEKLTKENEELESEL-----EELREEYKKLREEN 179
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
240-558 6.20e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 184.77  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  240 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 319
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  320 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA 399
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  400 AREGHEEMVALLLAQGANINAQTEETQetaltlaccggfsevadflikagadielgcsTPLMEASQEGHLELVKYLLASG 479
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGE-------------------------------TPLHLAAENGHLEIVKLLLEAG 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869  480 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 558
Cdd:COG0666   210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
306-615 2.27e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.23  E-value: 2.27e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  306 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL 385
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  386 EEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQetaltlaccggfsevadflikagadielgcsTPLMEASQ 465
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-------------------------------TPLHLAAY 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  466 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 545
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  546 ANVNrATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 615
Cdd:COG0666   210 ADVN-AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
206-493 1.24e-49

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 178.22  E-value: 1.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  206 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 285
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  286 NThSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 365
Cdd:COG0666    81 NA-KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  366 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEEtQETALTLACCGGFSEVADFL 445
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIVKLL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 380805869  446 IKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 493
Cdd:COG0666   239 LEAGADLNAKDkdgLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-357 1.35e-48

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 175.14  E-value: 1.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   76 IGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 155
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  156 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDiTPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 235
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  236 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHsNEFKESALTLACYKGHLDMVRFLLEA 315
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK-DNDGKTALDLAAENGNLEIVKLLLEA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 380805869  316 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 357
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
990-1283 3.53e-48

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 173.99  E-value: 3.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  990 ELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANK 1069
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1070 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTAL 1149
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-DNDGNTPL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1150 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFC 1229
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNA--KDNDGKTALDLAAENGNLEIV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 380805869 1230 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1283
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1027-1301 1.09e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 169.75  E-value: 1.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1027 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1106
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1107 gsKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIEtNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1186
Cdd:COG0666    85 --DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1187 SGGYAEVGRVLLDKGADVNAPPvpSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1266
Cdd:COG0666   162 ANGNLEIVKLLLEAGADVNARD--NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 380805869 1267 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1301
Cdd:COG0666   240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
966-1250 2.74e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 168.59  E-value: 2.74e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  966 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERtKDT 1045
Cdd:COG0666    11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1046 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTgsKLGISPLMLAAMNGHVP 1125
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD--NDGNTPLHLAAANGNLE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1126 AVKLLLDMGSDINAQIEtNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1205
Cdd:COG0666   168 IVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 380805869 1206 APpvPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1250
Cdd:COG0666   247 AK--DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1057-1300 2.30e-43

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.12  E-value: 2.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1057 EVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1136
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALA--DALGALLLLAAALAGDLLVALLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1137 INAQIEtNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPvpSSRDTA 1216
Cdd:COG0666    80 INAKDD-GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD--NDGNTP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1217 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQ 1296
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236


                  ....
gi 380805869 1297 YLVK 1300
Cdd:COG0666   237 LLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-330 1.69e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.73  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   65 ARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRK 144
Cdd:COG0666    26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  145 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDiTPLMAASSGGYLDIVKLLLLHDADVNSQSA 224
Cdd:COG0666   106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDN 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  225 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINtHSNEFKESALTLACYKG 304
Cdd:COG0666   185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN-AKDKDGLTALLLAAAAG 263

                         250       260
                  ....*....|....*....|....*.
gi 380805869  305 HLDMVRFLLEAGADQEHKTDEMHTAL 330
Cdd:COG0666   264 AALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1091-1300 3.08e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1091 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIEtNRNTALTLACFQGRAEVVSLLLDRKAN 1170
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADA-LGALLLLAAALAGDLLVALLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1171 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1250
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA--RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 380805869 1251 WLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1300
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
PHA03095 PHA03095
ankyrin-like protein; Provisional
 132-452 6.12e-26

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 113.20  E-value: 6.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  132 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC--LACSAG-YYELAQVLLAMHANVedrgNKGDI---TPLMA-ASSGG 204
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEkVKDIVRLLLEAGADV----NAPERcgfTPLHLyLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  205 YLDIVKLLLLHDADVNSQSATGNTALtYACAGGF---VDIVKVLLNEGANIEDHNENGHTPL---MEAASAgHVEVARVL 278
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGFninPKVIRLLLRKGADVNALDLYGMTPLavlLKSRNA-NVELLRLL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  279 LDHGAGI-----------NTHSNEFKESAltlacykghlDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE--VARLL 345
Cdd:PHA03095  174 IDAGADVyavddrfrsllHHHLQSFKPRA----------RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  346 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA----- 420
Cdd:PHA03095  244 LIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETvaatl 323

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 380805869  421 ----QTEETQETALTLACcggfseVADFLIKAGADI 452
Cdd:PHA03095  324 ntasVAGGDIPSDATRLC------VAKVVLRGAFSL 353
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1045-1333 7.33e-26

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 112.07  E-value: 7.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1045 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV-----NIIKILLNAGAEINSrtGSKLGISPLMLAA 1119
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNA--PDNNGITPLLYAI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1120 MN--GHVPAVKLLLDMGSDINAqietnrntaltlacfqgraevvsllldrkanvehRAKTGLTPLMEAASGGYA--EVGR 1195
Cdd:PHA03100  115 SKksNSYSIVEYLLDNGANVNI----------------------------------KNSDGENLLHLYLESNKIdlKILK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1196 VLLDKGADVNAppvpssrdtaltiaADKghykfCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1275
Cdd:PHA03100  161 LLIDKGVDINA--------------KNR-----VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLV 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869 1276 DNRKITPLMSAFRKGHVkvvqYLVKEVNQFPSDIECM---------RYIATITDKELLKKCHQCVET 1333
Cdd:PHA03100  222 NKYGDTPLHIAILNNNK----EIFKLLLNNGPSIKTIietllyfkdKDLNTITKIKMLKKSIMYMFL 284
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 339-517 7.11e-25

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 109.37  E-value: 7.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  339 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHV-----ELAALLIERGANLEEVNDEGYTPLMEAARE--GHEEMVALL 411
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  412 LAQGANINAQTEeTQETALTLA--CCGGFSEVADFLIKAGADI----------ELGC---------STPLMEASQEGHLE 470
Cdd:PHA03100  128 LDNGANVNIKNS-DGENLLHLYleSNKIDLKILKLLIDKGVDInaknrvnyllSYGVpinikdvygFTPLHYAVYNNNPE 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 380805869  471 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 517
Cdd:PHA03100  207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA03095 PHA03095
ankyrin-like protein; Provisional
 990-1295 9.01e-25

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 109.73  E-value: 9.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  990 ELVSVLIARDAKIEHRDKKGFTPL-ILAATAGHVG--VVEILLDKGGDIEAQsERTKDTPL-SLACSGGRQEVVDLLLAR 1065
Cdd:PHA03095   28 EEVRRLLAAGADVNFRGEYGKTPLhLYLHYSSEKVkdIVRLLLEAGADVNAP-ERCGFTPLhLYLYNATTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1066 GANKEHRNVSDYTPLSLAASGGYVN--IIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPA--VKLLLDMGSDINAqI 1141
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNAL--DLYGMTPLAVLLKSRNANVelLRLLIDAGADVYA-V 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1142 ETNRNTALTLAC--FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV--LLDKGADVNAppvpssrdtal 1217
Cdd:PHA03095  184 DDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINA----------- 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1218 tiaadkghykfcellihrgahidvRNKKGNTPLWLAS---NGGHFDvvqLLVQAGADVDAADNRKITPLMSAFRKGHVKV 1294
Cdd:PHA03095  253 ------------------------RNRYGQTPLHYAAvfnNPRACR---RLIALGADINAVSSDGNTPLSLMVRNNNGRA 305


                  .
gi 380805869 1295 V 1295
Cdd:PHA03095  306 V 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
197-287 1.80e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 95.95  E-value: 1.80e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   197 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANieDHNENGHTPLMEAASAGHVEVAR 276
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|.
gi 380805869   277 VLLDHGAGINT 287
Cdd:pfam12796   79 LLLEKGADINV 89
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 118-515 6.61e-23

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 105.53  E-value: 6.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  118 NSHNAGQVDTRSLAEACSDGDV--NAVRKLLDEGRSVNEHTEEGESLLclacsagyyelAQVLLAMHANVedrgNKGDI- 194
Cdd:PHA02876  113 NKHKLDEACIHILKEAISGNDIhyDKINESIEYMKLIKERIQQDELLI-----------AEMLLEGGADV----NAKDIy 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  195 --TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIedhNENGHTpLMEAASAGHV 272
Cdd:PHA02876  178 ciTPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI---NKNDLS-LLKAIRNEDL 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  273 EVARVLLDHGAGINThSNEFKESALTLACYKGHLD-MVRFLLEAGADQEHKTDEMHTALMEACMDGH-VEVARLLLDSGA 350
Cdd:PHA02876  254 ETSLLLYDAGFSVNS-IDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGA 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  351 QVNMPADSFESPLTLAAC-GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQeTA 429
Cdd:PHA02876  333 DVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TA 411

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  430 LTLACCGG--FSEVADfLIKAGADIELG---CSTPLMEASQEG-HLELVKYLLASGANVHATTATGDTALTYACenGHTD 503
Cdd:PHA02876  412 LHFALCGTnpYMSVKT-LIDRGANVNSKnkdLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHG 488

                         410
                  ....*....|..
gi 380805869  504 VADVLLQAGADL 515
Cdd:PHA02876  489 IVNILLHYGAEL 500
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 181-420 8.87e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 8.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  181 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV-----DIVKVLLNEGANIEDH 255
Cdd:PHA03100   23 MEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  256 NENGHTPLMEAASA--GHVEVARVLLDHGAGINTHSNEFKES-ALTLACYKGHLDMVRFLLEAGADQEHKTDemhtalme 332
Cdd:PHA03100  103 DNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLlHLYLESNKIDLKILKLLIDKGVDINAKNR-------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  333 acmdghVEvarLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 412
Cdd:PHA03100  175 ------VN---YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245


                  ....*...
gi 380805869  413 AQGANINA 420
Cdd:PHA03100  246 NNGPSIKT 253
PHA03095 PHA03095
ankyrin-like protein; Provisional
 288-596 5.71e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 101.25  E-value: 5.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  288 HSNEFKESAL---TLACYKGHLDMVRFLLEAGADQEHK----TDEMHTALMEACMDGhVEVARLLLDSGAQVNMPADSFE 360
Cdd:PHA03095    6 SVDIIMEAALydyLLNASNVTVEEVRRLLAAGADVNFRgeygKTPLHLYLHYSSEKV-KDIVRLLLEAGADVNAPERCGF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  361 SPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAAR--EGHEEMVALLLAQGANINAQTeetqetaltlacCGG 437
Cdd:PHA03095   85 TPLHLYLYNATTLdVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALD------------LYG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  438 FSEVADFLIKAGADIELgcstplmeasqeghlelVKYLLASGANVHATTATGDTALTYACENGHTDVADV--LLQAGADL 515
Cdd:PHA03095  153 MTPLAVLLKSRNANVEL-----------------LRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRARIVreLIRAGCDP 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  516 EHESEGGRTPLMKAArAGHLCT---VQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 592
Cdd:PHA03095  216 AATDMLGNTPLHSMA-TGSSCKrslVLPLLIAGISIN-ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTP 293


                  ....
gi 380805869  593 LIEA 596
Cdd:PHA03095  294 LSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
460-550 1.09e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.56  E-value: 1.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   460 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQaGADLEHESEgGRTPLMKAARAGHLCTVQ 539
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|.
gi 380805869   540 FLISKGANVNR 550
Cdd:pfam12796   79 LLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
230-322 4.29e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 4.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   230 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHgagINTHSNEFKESALTLACYKGHLDMV 309
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|...
gi 380805869   310 RFLLEAGADQEHK 322
Cdd:pfam12796   78 KLLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1005-1241 1.13e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 96.66  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1005 RDKKGFTPLILAATAGHVGVVEILLDKGGDIeAQSERTKDTPLSLACSGGR-----QEVVDLLLARGANKEHRNVSDYTP 1079
Cdd:PHA03100   31 SYKKPVLPLYLAKEARNIDVVKILLDNGADI-NSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1080 LSLAASG--GYVNIIKILLNAGAEINSRTgsKLGISPLMLAAMNGHV--PAVKLLLDMGSDINAqieTNRntaltlacfq 1155
Cdd:PHA03100  110 LLYAISKksNSYSIVEYLLDNGANVNIKN--SDGENLLHLYLESNKIdlKILKLLIDKGVDINA---KNR---------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1156 graevVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCELLIHR 1235
Cdd:PHA03100  175 -----VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNL--VNKYGDTPLHIAILNNNKEIFKLLLNN 247


                  ....*.
gi 380805869 1236 GAHIDV 1241
Cdd:PHA03100  248 GPSIKT 253
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 241-611 3.06e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 97.06  E-value: 3.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  241 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEfKESALTLACYKGHLDMVRFLLeagaDQE 320
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD-DLSVLECAVDSKNIDTIKAII----DNR 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  321 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV-ELAALLIERGANLEEVNDEGYTPLMEA 399
Cdd:PHA02876  235 SNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLM 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  400 AREGHE-EMVALLLAQGANINAqteetqetaltlaccggfsevADFLIkagadielgcSTPLMEASQ-EGHLELVKYLLA 477
Cdd:PHA02876  315 AKNGYDtENIRTLIMLGADVNA---------------------ADRLY----------ITPLHQASTlDRNKDIVITLLE 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  478 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH-LCTVQFLISKGANVNraTANND 556
Cdd:PHA02876  364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGANVN--SKNKD 441

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  557 -HTVVSLACAGG-HLAVVELLLAHGADPTH-RLKDGSTMLIEAakgGHTNVVSYLLDY 611
Cdd:PHA02876  442 lSTPLHYACKKNcKLDVIEMLLDNGADVNAiNIQNQYPLLIAL---EYHGIVNILLHY 496
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 142-355 3.35e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 95.12  E-value: 3.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  142 VRKLLDEGRSVNEHTEEGESLLCLACSAGYY-----ELAQVLLAMHANVEDRGNKGdITPLMAASSG--GYLDIVKLLLL 214
Cdd:PHA03100   51 VKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNG-ITPLLYAISKksNSYSIVEYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  215 HDADVNSQSATGNTALTYACAGGFVD--IVKVLLNEGAN----------------IEDHNENGHTPLMEAASAGHVEVAR 276
Cdd:PHA03100  130 NGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDinaknrvnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVK 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  277 VLLDHGAGINThSNEFKESALTLACYKGHLDMVRFLLEAGADQEH--------KTDEMHTALMEAcMDGHVEVARLLLDS 348
Cdd:PHA03100  210 YLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTiietllyfKDKDLNTITKIK-MLKKSIMYMFLLDP 287


                  ....*..
gi 380805869  349 GAQVNMP 355
Cdd:PHA03100  288 GFYKNRK 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
330-421 3.44e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 3.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   330 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANleEVNDEGYTPLMEAAREGHEEMVA 409
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|..
gi 380805869   410 LLLAQGANINAQ 421
Cdd:pfam12796   79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1115-1206 3.44e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 3.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1115 LMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTALTLACFQGRAEVVSLLLDrKANVEHRAKtGLTPLMEAASGGYAEVG 1194
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 380805869  1195 RVLLDKGADVNA 1206
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 228-526 1.03e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 93.87  E-value: 1.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  228 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGagINThsnefkeSALTLACYKGhlD 307
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG--VDT-------SILPIPCIEK--D 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  308 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 387
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  388 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQteetqetaltlaCCGGFsevadflikagadielgcsTPLMEASQeg 467
Cdd:PHA02874  186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNK------------CKNGF-------------------TPLHNAII-- 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380805869  468 HLELVKYLLASGANVHATTATGDTALTYA----CEnghTDVADVLLQAGADLEHESEGGRTPL 526
Cdd:PHA02874  233 HNRSAIELLINNASINDQDIDGSTPLHHAinppCD---IDIIDILLYHKADISIKDNKGENPI 292
Ank_2 pfam12796
Ankyrin repeats (3 copies);
263-353 2.65e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 2.65e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   263 LMEAASAGHVEVARVLLDHGAGINTHsNEFKESALTLACYKGHLDMVRFLLEaGADQEHKTDEMhTALMEACMDGHVEVA 342
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIV 77

                           90
                   ....*....|.
gi 380805869   343 RLLLDSGAQVN 353
Cdd:pfam12796   78 KLLLEKGADIN 88
PHA03095 PHA03095
ankyrin-like protein; Provisional
 198-509 6.86e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.62  E-value: 6.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  198 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY--ACAGGFV-DIVKVLLNEGANIEDHNENGHTPLMeaasaghvev 274
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLylHYSSEKVkDIVRLLLEAGADVNAPERCGFTPLH---------- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  275 arvlldhgaginthsnefkesalTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALmEACMDG---HVEVARLLLDSGAQ 351
Cdd:PHA03095   89 -----------------------LYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRKGAD 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  352 VNmpaDSFESPLTLAAC-----GGHVELAALLIERGANLEEVNDEGYTPL---MEAAREgHEEMVALLLAQGANINAqTE 423
Cdd:PHA03095  145 VN---ALDLYGMTPLAVllksrNANVELLRLLIDAGADVYAVDDRFRSLLhhhLQSFKP-RARIVRELIRAGCDPAA-TD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  424 ETQETALTLACCGGF---SEVADFLIkAGADIE----LGcSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 496
Cdd:PHA03095  220 MLGNTPLHSMATGSSckrSLVLPLLI-AGISINarnrYG-QTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297

                         330
                  ....*....|...
gi 380805869  497 CENGHTDVADVLL 509
Cdd:PHA03095  298 VRNNNGRAVRAAL 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1080-1174 1.25e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.09  E-value: 1.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1080 LSLAASGGYVNIIKILLNAGAEINSRTgsKLGISPLMLAAMNGHVPAVKLLLDMgsdINAQIETNRNTALTLACFQGRAE 1159
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQD--KNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*
gi 380805869  1160 VVSLLLDRKANVEHR 1174
Cdd:pfam12796   76 IVKLLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 264-577 4.33e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 88.93  E-value: 4.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  264 MEAASAGHVEVARVLLDHGAGINtHSNEFKESALTLACYKGH---LDMVRFLLEAGADQEHKTDEMHTAL-MEACMDGHV 339
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  340 EVARLLLDSGAQVNMPADSFESPLTLAACGG--HVELAALLIERGANLEEVNDEGYTPLMeaaregheemvALLLAQGAN 417
Cdd:PHA03095   98 DVIKLLIKAGADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLA-----------VLLKSRNAN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  418 InaqteetqetaltlaccggfsEVADFLIKAGADI---ELGCSTPLmeasqEGHLE-------LVKYLLASGANVHATTA 487
Cdd:PHA03095  167 V---------------------ELLRLLIDAGADVyavDDRFRSLL-----HHHLQsfkprarIVRELIRAGCDPAATDM 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  488 TGDTALTYA---CENGHTDVADvLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDhTVVSLAC 564
Cdd:PHA03095  221 LGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN-TPLSLMV 298

                         330
                  ....*....|...
gi 380805869  565 AGGHLAVVELLLA 577
Cdd:PHA03095  299 RNNNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1047-1140 6.59e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 6.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1047 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNaGAEINSRTGsklGISPLMLAAMNGHVPA 1126
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN---GRTALHYAARSGHLEI 76

                           90
                   ....*....|....
gi 380805869  1127 VKLLLDMGSDINAQ 1140
Cdd:pfam12796   77 VKLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
396-485 8.82e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 8.82e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   396 LMEAAREGHEEMVALLLAQGANINAQTEETQeTALTLACCGGFSEVADFLI-KAGADIELGCSTPLMEASQEGHLELVKY 474
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGR-TALHLAAKNGHLEIVKLLLeHADVNLKDNGRTALHYAARSGHLEIVKL 79

                           90
                   ....*....|.
gi 380805869   475 LLASGANVHAT 485
Cdd:pfam12796   80 LLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
363-454 1.28e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.00  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   363 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQgANINAQTEetQETALTLACCGGFSEVA 442
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN--GRTALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 380805869   443 DFLIKAGADIEL 454
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 978-1287 2.41e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.81  E-value: 2.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  978 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQsertkDTPLSLACSGGRQE 1057
Cdd:PHA02876  180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKN-----DLSLLKAIRNEDLE 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1058 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVN-IIKILLNAGAEINSRTGSklGISPLMLAAMNGH-VPAVKLLLDMGS 1135
Cdd:PHA02876  255 TSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIK--GETPLYLMAKNGYdTENIRTLIMLGA 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1136 DINAQiETNRNTALTLACFQGR-AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRD 1214
Cdd:PHA02876  333 DVNAA-DRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA--LSQKIG 409

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380805869 1215 TALTIA-ADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA-SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAF 1287
Cdd:PHA02876  410 TALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYAcKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL 484
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1024-1338 4.87e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 4.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1024 VVEILLDKGGDIEAQSERTKdTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEin 1103
Cdd:PHA02874   17 IEKIIKNKGNCINISVDETT-TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVD-- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1104 srtgsklgISPLMLAAMNGHVpaVKLLLDMGSDINAQiETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1183
Cdd:PHA02874   94 --------TSILPIPCIEKDM--IKTILDCGIDVNIK-DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1184 EAASGGYAEVGRVLLDKGADVNAPpvPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA---------- 1253
Cdd:PHA02874  163 IAIKHNFFDIIKLLLEKGAYANVK--DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAiihnrsaiel 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1254 -----------SNGG---HF--------DVVQLLVQAGADVDAADNRKITPLMSAFRK-GHVKVVQ------YLVKEVNQ 1304
Cdd:PHA02874  241 linnasindqdIDGStplHHainppcdiDIIDILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKdiianaVLIKEADK 320

                         330       340       350
                  ....*....|....*....|....*....|....
gi 380805869 1305 FPsDIECMRYIATITDKELLKKCHQCVETIVKAK 1338
Cdd:PHA02874  321 LK-DSDFLEHIEIKDNKEFSDFIKECNEEIEDMK 353
Ank_2 pfam12796
Ankyrin repeats (3 copies);
130-222 1.22e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   130 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA-MHANVEDRGNkgdiTPLMAASSGGYLDI 208
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGR----TALHYAARSGHLEI 76

                           90
                   ....*....|....
gi 380805869   209 VKLLLLHDADVNSQ 222
Cdd:pfam12796   77 VKLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1024-1287 2.67e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 84.34  E-value: 2.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1024 VVEILLDKGGDIEAQSERTKdTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1103
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCI-TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1104 SRTGSklgispLMLAAMNGHVPAVKLLLDMGSDINAqIETNRNTALTLAC-FQGRAEVVSLLLDRKANVEHRAKTGLTPL 1182
Cdd:PHA02876  239 KNDLS------LLKAIRNEDLETSLLLYDAGFSVNS-IDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1183 MEAASGGY-AEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFD 1260
Cdd:PHA02876  312 YLMAKNGYdTENIRTLIMLGADVNA--ADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVV 389

                         250       260
                  ....*....|....*....|....*..
gi 380805869 1261 VVQLLVQAGADVDAADNRKITPLMSAF 1287
Cdd:PHA02876  390 IINTLLDYGADIEALSQKIGTALHFAL 416
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 990-1143 3.77e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.41  E-value: 3.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  990 ELVSVLIARDAKIEHRDKKGFTPLILAATA--GHVGVVEILLDKGGDIEAQSERTKdTPLSLACSGGRQEV--------- 1058
Cdd:PHA03100   87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGE-NLLHLYLESNKIDLkilkllidk 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1059 ---------VDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTgsKLGISPLMLAAMNGHVPAVKL 1129
Cdd:PHA03100  166 gvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN--KYGDTPLHIAILNNNKEIFKL 243

                         170
                  ....*....|....
gi 380805869 1130 LLDMGSDINAQIET 1143
Cdd:PHA03100  244 LLNNGPSIKTIIET 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1182-1276 3.93e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 3.93e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1182 LMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCELLIhrgAHIDVRNK-KGNTPLWLASNGGHFD 1260
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANL--QDKNGRTALHLAAKNGHLEIVKLLL---EHADVNLKdNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 380805869  1261 VVQLLVQAGADVDAAD 1276
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1217-1300 4.17e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 4.17e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1217 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQaGADVDAADNRKiTPLMSAFRKGHVKVVQ 1296
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78


                   ....
gi 380805869  1297 YLVK 1300
Cdd:pfam12796   79 LLLE 82
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 204-454 4.39e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 82.35  E-value: 4.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  204 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAnIEDHNENG-HTPLMEAASAGHVEVARVLLDHG 282
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDiESELHDAVEEGDVKAVEELLDLG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  283 AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 362
Cdd:PHA02875   92 KFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  363 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQETALTLA-----CCG 436
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNIMFMIEGEECTILDmicnmCTN 251

                         250
                  ....*....|....*...
gi 380805869  437 GFSEVADFLIkagADIEL 454
Cdd:PHA02875  252 LESEAIDALI---ADIAI 266
PHA03095 PHA03095
ankyrin-like protein; Provisional
 406-619 4.48e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 82.77  E-value: 4.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  406 EMVALLLAQGANINaQTEETQETALT--LAC-CGGFSEVADFLIKAGADI---ELGCSTPL---MEASQEghLELVKYLL 476
Cdd:PHA03095   28 EEVRRLLAAGADVN-FRGEYGKTPLHlyLHYsSEKVKDIVRLLLEAGADVnapERCGFTPLhlyLYNATT--LDVIKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  477 ASGANVHATTATGDTAL-TYAC-ENGHTDVADVLLQAGADLEHESEGGRTPL---MKAARAgHLCTVQFLISKGANV--- 548
Cdd:PHA03095  105 KAGADVNAKDKVGRTPLhVYLSgFNINPKVIRLLLRKGADVNALDLYGMTPLavlLKSRNA-NVELLRLLIDAGADVyav 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  549 --NRATANNDHTVVSLACAgghlAVVELLLAHGADPTHRLKDGSTMLIEAAKGG---HTNVVSYLL-----DYPNNVLSV 618
Cdd:PHA03095  184 ddRFRSLLHHHLQSFKPRA----RIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLIagisiNARNRYGQT 259


                  .
gi 380805869  619 P 619
Cdd:PHA03095  260 P 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1149-1243 4.82e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1149 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKgADVNappVPSSRDTALTIAADKGHYKF 1228
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN---LKDNGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 380805869  1229 CELLIHRGAHIDVRN 1243
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 229-451 4.85e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 82.35  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  229 ALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFkESALTLACYKGHLDM 308
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGDVKA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  309 VRFLLEAG--ADQEHKTDEMhTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 386
Cdd:PHA02875   84 VEELLDLGkfADDVFYKDGM-TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380805869  387 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 451
Cdd:PHA02875  163 IEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 991-1204 7.54e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 82.80  E-value: 7.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  991 LVSVLIARDAKIEHRDKKGFTPLILAATAGH-VGVVEILLDKGGDIEAqSERTKDTPLSLACSGGR-QEVVDLLLARGAN 1068
Cdd:PHA02876  289 LVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNA-ADRLYITPLHQASTLDRnKDIVITLLELGAN 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1069 KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTgSKLGISplMLAAMNGHVP--AVKLLLDMGSDINAQiETNRN 1146
Cdd:PHA02876  368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALS-QKIGTA--LHFALCGTNPymSVKTLIDRGANVNSK-NKDLS 443

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869 1147 TALTLACFQG-RAEVVSLLLDRKANVEHRAKTGLTPLMEAAsgGYAEVGRVLLDKGADV 1204
Cdd:PHA02876  444 TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 978-1170 9.84e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 81.19  E-value: 9.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  978 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1057
Cdd:PHA02875   37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLD 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1058 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGskLGISPLMLAAMNGHVPAVKLLLDMGSDI 1137
Cdd:PHA02875  117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC--CGCTPLIIAMAKGDIAICKMLLDSGANI 194

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 380805869 1138 NAqieTNRNTALTLACF---QGRAEVVSLLLDRKAN 1170
Cdd:PHA02875  195 DY---FGKNGCVAALCYaieNNKIDIVRLFIKRGAD 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1157-1300 1.04e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.61  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1157 RAEVVSLLLDRKANVEHR---AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPpvPSSRDTALtiaadkgHYKFC---- 1229
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRgeyGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAP--ERCGFTPL-------HLYLYnatt 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1230 ----ELLIHRGAHIDVRNKKGNTPL--WLASNGGHFDVVQLLVQAGADVDAADNRKITPLmSAFRKGH---VKVVQYLVK 1300
Cdd:PHA03095   97 ldviKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRnanVELLRLLID 175
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 138-334 1.04e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 81.19  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  138 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 217
Cdd:PHA02875   47 DSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  218 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 297
Cdd:PHA02875  127 DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 380805869  298 TLACYKGHLDMVRFLLEAGADQEHKT---DEMHTALMEAC 334
Cdd:PHA02875  207 CYAIENNKIDIVRLFIKRGADCNIMFmieGEECTILDMIC 246
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 370-628 1.45e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 80.78  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  370 GHVELAALLIERGANLEEVN-DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTlACCGGFSEVADFLIKA 448
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISvDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLT-AIKIGAHDIIKLLIDN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  449 GADIELgCSTPLMEAsqeghlELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 528
Cdd:PHA02874   91 GVDTSI-LPIPCIEK------DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  529 AARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTnVVSYL 608
Cdd:PHA02874  164 AIKHNFFDIIKLLLEKGAYAN-VKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELL 241

                         250       260
                  ....*....|....*....|
gi 380805869  609 LdypnNVLSVPTTDVSQLTP 628
Cdd:PHA02874  242 I----NNASINDQDIDGSTP 257
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 184-365 1.55e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 82.22  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  184 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 263
Cdd:PLN03192  516 NGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  264 MEAASAGHVEVARVLLDHGAGINTHSNefkESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 343
Cdd:PLN03192  596 WNAISAKHHKIFRILYHFASISDPHAA---GDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVR 672

                         170       180
                  ....*....|....*....|...
gi 380805869  344 LLLDSGAQVN-MPADSFESPLTL 365
Cdd:PLN03192  673 LLIMNGADVDkANTDDDFSPTEL 695
Ank_2 pfam12796
Ankyrin repeats (3 copies);
980-1073 1.78e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   980 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKgGDIEAQSErtKDTPLSLACSGGRQEVV 1059
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN--GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 380805869  1060 DLLLARGANKEHRN 1073
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 329-581 9.34e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 78.11  E-value: 9.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  329 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAnLEEVNDEGY-TPLMEAAREGHEEM 407
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDIeSELHDAVEEGDVKA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  408 VALLLAQGANINaqteetqetaltlaccggfsevaDFLIKAGadielgcSTPLMEASQEGHLELVKYLLASGANVHATTA 487
Cdd:PHA02875   84 VEELLDLGKFAD-----------------------DVFYKDG-------MTPLHLATILKKLDIMKLLIARGADPDIPNT 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  488 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGG 567
Cdd:PHA02875  134 DKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENN 213

                         250
                  ....*....|....
gi 380805869  568 HLAVVELLLAHGAD 581
Cdd:PHA02875  214 KIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1045-1237 1.00e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 78.11  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1045 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSrTGSKLGISPLMLAAMNGHV 1124
Cdd:PHA02875   37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADD-VFYKDGMTPLHLATILKKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1125 PAVKLLLDMGSDINAQiETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1204
Cdd:PHA02875  116 DIMKLLIARGADPDIP-NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 380805869 1205 N----APPVpssrdTALTIAADKGHYKFCELLIHRGA 1237
Cdd:PHA02875  195 DyfgkNGCV-----AALCYAIENNKIDIVRLFIKRGA 226
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1050-1271 2.79e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 76.57  E-value: 2.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1050 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGsklGI-SPLMLAAMNGHVPAVK 1128
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIeSELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1129 LLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1208
Cdd:PHA02875   86 ELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIED 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 380805869 1209 VPSSrdTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN-TPLWLASNGGHFDVVQLLVQAGAD 1271
Cdd:PHA02875  166 CCGC--TPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 971-1315 2.83e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 77.23  E-value: 2.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  971 HTESNHDTALTLACAGGHE-------ELVSVLIARDAKIEHRDKKGFTPL-ILAATAGHVGVVEILLDKGGDIEAQSERT 1042
Cdd:PHA02878   25 HTENYSTSASLIPFIPLHQavearnlDVVKSLLTRGHNVNQPDHRDLTPLhIICKEPNKLGMKEMIRSINKCSVFYTLVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1043 kdtpLSLACSGGRQEVVDLLLARGANKEHrnVSDYTPLSLAASGGYVN--IIKILLNAGAEINSRTGSKLGiSPLMLAAM 1120
Cdd:PHA02878  105 ----IKDAFNNRNVEIFKIILTNRYKNIQ--TIDLVYIDKKSKDDIIEaeITKLLLSYGADINMKDRHKGN-TALHYATE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1121 NGHVPAVKLLLDMGSDINAQIETNrNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMeaASGGYA---EVGRVL 1197
Cdd:PHA02878  178 NKDQRLTELLLSYGANVNIPDKTN-NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH--ISVGYCkdyDILKLL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1198 LDKGADVNAppvpssRDTALTIAAdkghykfcellihrgAHIDVRNKkgntplwlasngghfDVVQLLVQAGADVDAADN 1277
Cdd:PHA02878  255 LEHGVDVNA------KSYILGLTA---------------LHSSIKSE---------------RKLKLLLEYGADINSLNS 298

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 380805869 1278 RKITPLMSAfrkghvkVVQYLVKEV-NQFPSDIECMRYI 1315
Cdd:PHA02878  299 YKLTPLSSA-------VKQYLCINIgRILISNICLLKRI 330
PHA03095 PHA03095
ankyrin-like protein; Provisional
 967-1209 1.00e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 75.45  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  967 DIDAhTESNHDTAL-TLACAGGHEELVSVLIARDAKIEHRDKKGFTPL--ILAATAGHVGVVEILLDKGGDIEAQSERTK 1043
Cdd:PHA03095   75 DVNA-PERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGM 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1044 dTPLS--------------LACSGG-----------------------RQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1086
Cdd:PHA03095  154 -TPLAvllksrnanvellrLLIDAGadvyavddrfrsllhhhlqsfkpRARIVRELIRAGCDPAATDMLGNTPLHSMATG 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1087 GYVNIIKI--LLNAGAEINSRtgSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNrNTALTLACFQGRAEVVSLL 1164
Cdd:PHA03095  233 SSCKRSLVlpLLIAGISINAR--NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDG-NTPLSLMVRNNNGRAVRAA 309

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 380805869 1165 LDRKANVEHRAKTgLTPLMEAASGGYAEVGR-----VLLDKGADVNAPPV 1209
Cdd:PHA03095  310 LAKNPSAETVAAT-LNTASVAGGDIPSDATRlcvakVVLRGAFSLLPEPI 358
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 324-598 1.11e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  324 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAnleevnDEGYTPLMEAareg 403
Cdd:PHA02874   33 DETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGV------DTSILPIPCI---- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  404 HEEMVALLLAQGANINAQTEETQeTALTLACCGGFSEVADFLIKAGADIEL----GCsTPLMEASQEGHLELVKYLLASG 479
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIeddnGC-YPIHIAIKHNFFDIIKLLLEKG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  480 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHlCTVQFLISKgANVNRATANND--- 556
Cdd:PHA02874  181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINN-ASINDQDIDGStpl 258

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 380805869  557 HTVVSLACAgghLAVVELLLAHGADPTHRLKDGSTMLIEAAK 598
Cdd:PHA02874  259 HHAINPPCD---IDIIDILLYHKADISIKDNKGENPIDTAFK 297
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1058-1312 2.03e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 2.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1058 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSklGISPLMLAAMNGHVPAVKLLLDMGSDI 1137
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD--DLSVLECAVDSKNIDTIKAIIDNRSNI 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1138 NAQ----IETNRNTALtlacfqgraEVVSLLLDRKANVEHRAKTGLTPLMEAASG-GYAEVGRVLLDKGADVNAPPVPSs 1212
Cdd:PHA02876  238 NKNdlslLKAIRNEDL---------ETSLLLYDAGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKG- 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1213 rDTALTIAADKGH-YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF-DVVQLLVQAGADVDAADNRKITPLMSAFRKG 1290
Cdd:PHA02876  308 -ETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRN 386

                         250       260
                  ....*....|....*....|..
gi 380805869 1291 HVKVVQYLVkevnQFPSDIECM 1312
Cdd:PHA02876  387 NVVIINTLL----DYGADIEAL 404
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-611 2.39e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 2.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   526 LMKAARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHgADPTHRLkDGSTMLIEAAKGGHTNVV 605
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77


                   ....*.
gi 380805869   606 SYLLDY 611
Cdd:pfam12796   78 KLLLEK 83
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 239-531 5.68e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.99  E-value: 5.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  239 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLdhgAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 318
Cdd:PHA02878   50 LDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---RSINKCSVFYTLVAIKDAFNNRNVEIFKIILTNRYK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  319 QEHKTDEMHtaLMEACMDGHVE--VARLLLDSGAQVNM-PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 395
Cdd:PHA02878  127 NIQTIDLVY--IDKKSKDDIIEaeITKLLLSYGADINMkDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  396 LMEAAREGHEEMVALLLAQGANINAQTEetqetaltlacCGgfsevadflikagadielgcSTPL-MEASQEGHLELVKY 474
Cdd:PHA02878  205 LHHAVKHYNKPIVHILLENGASTDARDK-----------CG--------------------NTPLhISVGYCKDYDILKL 253

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  475 LLASGANVHA-TTATGDTALTYACENghTDVADVLLQAGADLEHESEGGRTPLMKAAR 531
Cdd:PHA02878  254 LLEHGVDVNAkSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVK 309
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 196-452 8.49e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.61  E-value: 8.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  196 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEgaNIEDHNENGHTPLMEAASAGHVEVA 275
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS--INKCSVFYTLVAIKDAFNNRNVEIF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  276 RVLLdhgagINTHSNEfKESALTLACYKGHLD-----MVRFLLEAGADQEHKT-DEMHTALMEACMDGHVEVARLLLDSG 349
Cdd:PHA02878  118 KIIL-----TNRYKNI-QTIDLVYIDKKSKDDiieaeITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYG 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  350 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL-MEAAREGHEEMVALLLAQGANINAQTEETQET 428
Cdd:PHA02878  192 ANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGLT 271

                         250       260
                  ....*....|....*....|....
gi 380805869  429 ALTLACCGgfSEVADFLIKAGADI 452
Cdd:PHA02878  272 ALHSSIKS--ERKLKLLLEYGADI 293
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1083-1300 8.67e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 8.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1083 AASGGYVNIIKILLNAGaeINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRnTALTLACFQGRAEVVS 1162
Cdd:PHA02875    9 AILFGELDIARRLLDIG--INPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE-SELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1163 LLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADvnaPPVPSS-RDTALTIAADKGHYKFCELLIHRGAHID 1240
Cdd:PHA02875   86 ELLDLGKFADDVFyKDGMTPLHLATILKKLDIMKLLIARGAD---PDIPNTdKFSPLHLAVMMGDIKGIELLIDHKACLD 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869 1241 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK-ITPLMSAFRKGHVKVVQYLVK 1300
Cdd:PHA02875  163 IEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIK 223
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 128-318 1.81e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.45  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  128 RSLAEACSDGDVNAVRKLLdegrsVNEHTEEGESLLCLACSAGY-----YELAQVLLAMHANVEDRGNKGDITPLMAASS 202
Cdd:PHA02878  103 VAIKDAFNNRNVEIFKIIL-----TNRYKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINMKDRHKGNTALHYATE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  203 GGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL-MEAASAGHVEVARVLLDH 281
Cdd:PHA02878  178 NKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLhISVGYCKDYDILKLLLEH 257

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 380805869  282 GAGINTHSNEFKESALTLACYKGhlDMVRFLLEAGAD 318
Cdd:PHA02878  258 GVDVNAKSYILGLTALHSSIKSE--RKLKLLLEYGAD 292
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 341-548 1.99e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.15  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  341 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIna 420
Cdd:PHA02874   17 IEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT-- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  421 qteetqeTALTLACCGgfSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 497
Cdd:PHA02874   95 -------SILPIPCIE--KDMIKTILDCGIDVNIkdaELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 380805869  498 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 548
Cdd:PHA02874  166 KHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHI 216
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 339-519 4.53e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 71.05  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  339 VEVARLLLDSGAQVNMPADSFeSPLTLAACGGHVELAALLieRGANLEEVND-EGYTPLMEAAREGHEEMVALLLAQGAN 417
Cdd:PLN03192  507 LNVGDLLGDNGGEHDDPNMAS-NLLTVASTGNAALLEELL--KAKLDPDIGDsKGRTPLHIAASKGYEDCVLVLLKHACN 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  418 INAQtEETQETALTLACCGGFSEVADFLIK--------AGADIelgcstpLMEASQEGHLELVKYLLASGANVHATTATG 489
Cdd:PLN03192  584 VHIR-DANGNTALWNAISAKHHKIFRILYHfasisdphAAGDL-------LCTAAKRNDLTAMKELLKQGLNVDSEDHQG 655

                         170       180       190
                  ....*....|....*....|....*....|
gi 380805869  490 DTALTYACENGHTDVADVLLQAGADLEHES 519
Cdd:PLN03192  656 ATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1144-1300 1.16e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.48  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1144 NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA--DVNAPPVPSSrdtaLTIAA 1221
Cdd:PHA02875    1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIESE----LHDAV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1222 DKGHYKFCELLIHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1300
Cdd:PHA02875   77 EEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 378-615 1.21e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  378 LIERGANLEEVNDEGY----TPLMEAAREGHEEMVALLLAQGANINaQTEETQETALTLACCGGFS-----EVADFLIKA 448
Cdd:PHA03100   17 NIKYIIMEDDLNDYSYkkpvLPLYLAKEARNIDVVKILLDNGADIN-SSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  449 GADIELG---CSTPLMEASQE--GHLELVKYLLASGANVHATTATGDTALTYACENGHTDvadvllqagadleheseggr 523
Cdd:PHA03100   96 GANVNAPdnnGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKID-------------------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  524 tplmkaaraghLCTVQFLISKGANVNRATanndhtvvslacagghlaVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTN 603
Cdd:PHA03100  156 -----------LKILKLLIDKGVDINAKN------------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPE 206

                         250
                  ....*....|..
gi 380805869  604 VVSYLLDYPNNV 615
Cdd:PHA03100  207 FVKYLLDLGANP 218
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 261-433 2.31e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 68.12  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  261 TPLMEAASAGHVEVARVLLdhgagINTHSNEFK-----ESALTLACYKGHLDMVRFLLEAGAD--QEHKTDEMH---TAL 330
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLL-----KCPSCDLFQrgalgETALHVAALYDNLEAAVVLMEAAPElvNEPMTSDLYqgeTAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  331 MEACMDGHVEVARLLLDSGAQVNMP--ADSF------------ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 396
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVVSPraTGTFfrpgpknliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 380805869  397 ----MEAAREGHEEMVALLLAQGANINAQTEETQE-----TALTLA 433
Cdd:cd22192   174 hilvLQPNKTFACQMYDLILSYDKEDDLQPLDLVPnnqglTPFKLA 219
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 457-593 2.93e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 68.12  E-value: 2.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  457 STPLMEASQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE---SE--GGRTPLMKAA 530
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtSDlyQGETALHIAV 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869  531 RAGHLCTVQFLISKGANVN--RATAN------------NDHTVVSLACAgGHLAVVELLLAHGADPTHRLKDGSTML 593
Cdd:cd22192    98 VNQNLNLVRELIARGADVVspRATGTffrpgpknliyyGEHPLSFAACV-GNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 130-366 2.99e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 2.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  130 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG-----------------YYELAQVLLAMH---------- 182
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPnklgmkemirsinkcsvFYTLVAIKDAFNnrnveifkii 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  183 -ANVEDRGNKGDITPLMAASSGGYLD--IVKLLLLHDADVNSQSA-TGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 258
Cdd:PHA02878  121 lTNRYKNIQTIDLVYIDKKSKDDIIEaeITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  259 GHTPLMEAASAGHVEVARVLLDHGAGINtHSNEFKESALTLAC-YKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMD 336
Cdd:PHA02878  201 NNSPLHHAVKHYNKPIVHILLENGASTD-ARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKS 279

                         250       260       270
                  ....*....|....*....|....*....|
gi 380805869  337 GhvEVARLLLDSGAQVNMPADSFESPLTLA 366
Cdd:PHA02878  280 E--RKLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
456-509 9.68e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 58.44  E-value: 9.68e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   456 CSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 509
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 440-746 1.22e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  440 EVADFLIK-AGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 518
Cdd:PLN03192  508 NVGDLLGDnGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  519 SEGGRTPLMKAARAGHLCTVQFLiskganVNRATANNDHT---VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 595
Cdd:PLN03192  588 DANGNTALWNAISAKHHKIFRIL------YHFASISDPHAagdLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  596 AAKGGHTNVVSYLLDYPNNVLSVPTTDvsQLTPPSQDQSQVPRVPMHTLAMV--VPPQEPDRTSQEnspallGGQKGTSK 673
Cdd:PLN03192  662 AMAEDHVDMVRLLIMNGADVDKANTDD--DFSPTELRELLQKRELGHSITIVdsVPADEPDLGRDG------GSRPGRLQ 733

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380805869  674 QKSSSLQVADQDLLPSFHPYQPLECIVEETeGKLNELgqrisaieKAQLKSLELIQGEPLNKDKIEELKKNRE 746
Cdd:PLN03192  734 GTSSDNQCRPRVSIYKGHPLLRNERCCNEA-GKLINL--------PPSLEELKAIAGEKLGFDARKAMVTNEE 797
Ank_2 pfam12796
Ankyrin repeats (3 copies);
971-1038 1.50e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 1.50e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869   971 HTESNHDTALTLACAGGHEELVSVLIARdAKIEHRDkKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1038
Cdd:pfam12796   25 LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVK 90
PHA02798 PHA02798
ankyrin-like protein; Provisional
 206-423 1.53e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 65.24  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  206 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGH---VEVARVLL 279
Cdd:PHA02798   89 LDIVKILIENGADINKKNSDGETPLYCLLSNGYInnlEILLFMIENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  280 DHGAGINTHSNEFKESalTLACY------KGHLDMVRFLLEAG-----ADQEHKTDemhtaLMEACMDghvevarLLLDS 348
Cdd:PHA02798  169 EKGVDINTHNNKEKYD--TLHCYfkynidRIDADILKLFVDNGfiinkENKSHKKK-----FMEYLNS-------LLYDN 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380805869  349 GaqvNMPADSFEspltlaacgghvelaalLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 423
Cdd:PHA02798  235 K---RFKKNILD-----------------FIFSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITE 289
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 127-290 2.09e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  127 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-------------------------AM 181
Cdd:PHA02874   36 TTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdngvdtsilpipciekdmiktildcGI 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  182 HANVEDRGNKgdiTPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 261
Cdd:PHA02874  116 DVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGES 192

                         170       180
                  ....*....|....*....|....*....
gi 380805869  262 PLMEAASAGHVEVARVLLDHGAGINTHSN 290
Cdd:PHA02874  193 PLHNAAEYGDYACIKLLIDHGNHIMNKCK 221
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 137-258 5.13e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.53  E-value: 5.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  137 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL--AQVLL--AMHANVEDR--------------GNKGDiTPLM 198
Cdd:PHA03100  119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIdkGVDINAKNRvnyllsygvpinikDVYGF-TPLH 197

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  199 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 258
Cdd:PHA03100  198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
562-613 8.43e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 8.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869   562 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 613
Cdd:pfam12796    3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1113-1276 1.08e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 62.96  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1113 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRnTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1192
Cdd:PLN03192  527 SNLLTVASTGNAALLEELLKAKLDPDIGDSKGR-TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1193 VGRVLLDKGADVNappvPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1272
Cdd:PLN03192  606 IFRILYHFASISD----PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681


                  ....
gi 380805869 1273 DAAD 1276
Cdd:PLN03192  682 DKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
259-313 1.60e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 1.60e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 380805869   259 GHTPLMEAASAGHVEVARVLLDHGAGINtHSNEFKESALTLACYKGHLDMVRFLL 313
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADIN-AVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1246-1299 2.03e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.03e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869  1246 GNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1299
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
195-246 2.05e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.05e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869   195 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 246
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 125-266 2.53e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 2.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  125 VDTRSLAEACSDGDVnaVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDItPLMAASSGG 204
Cdd:PHA02874   92 VDTSILPIPCIEKDM--IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCY-PIHIAIKHN 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 380805869  205 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 266
Cdd:PHA02874  169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1250-1304 7.14e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 7.14e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 380805869  1250 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1304
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV 55
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1082-1184 8.11e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1082 LAASGGYVNIiKILLNAGAEINSRTGSklGISPLMLAAMNGHVPAVKLLLDMGSDINAqIETNRNTALTLACFQGRAEVV 1161
Cdd:PTZ00322   89 LAASGDAVGA-RILLTGGADPNCRDYD--GRTPLHIACANGHVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVV 164

                          90       100       110
                  ....*....|....*....|....*....|
gi 380805869 1162 SLLL-------DRKANVEHRAKTGLTPLME 1184
Cdd:PTZ00322  165 QLLSrhsqchfELGANAKPDSFTGKPPSLE 194
Ank_4 pfam13637
Ankyrin repeats (many copies);
489-542 8.47e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.66  E-value: 8.47e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   489 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 542
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1213-1266 8.80e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.66  E-value: 8.80e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869  1213 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1266
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
361-412 1.11e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 1.11e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869   361 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 412
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 205-510 1.31e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 58.98  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  205 YLDIVKLLLLHDADVNSQSaTGNTALTYACAGGFV--DIVKVLLNEGANIedhNENGH--TPL------MEAASAGHVEV 274
Cdd:PHA02989   15 DKNALEFLLRTGFDVNEEY-RGNSILLLYLKRKDVkiKIVKLLIDNGADV---NYKGYieTPLcavlrnREITSNKIKKI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  275 ARVLLDHGAGINTHSneFKESAlTLAC--YKGH---LDMVRFLLEAGADQEHKTDE-----MHTALmEACMDgHVEVARL 344
Cdd:PHA02989   91 VKLLLKFGADINLKT--FNGVS-PIVCfiYNSNinnCDMLRFLLSKGINVNDVKNSrgynlLHMYL-ESFSV-KKDVIKI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  345 LLDSGAQVNMPADSFE-SPLTL----AACGGHVELAALLIERGANLEEvNDEGYTPLMEAAREGHEEMValllaqganin 419
Cdd:PHA02989  166 LLSFGVNLFEKTSLYGlTPMNIylrnDIDVISIKVIKYLIKKGVNIET-NNNGSESVLESFLDNNKILS----------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  420 aqteeTQETaltlaccggfsEVADFL---IKAGADIELGCsTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 496
Cdd:PHA02989  234 -----KKEF-----------KVLNFIlkyIKINKKDKKGF-NPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYA 296

                         330
                  ....*....|....
gi 380805869  497 CENGHTDVADVLLQ 510
Cdd:PHA02989  297 IKHGNIDMLNRILQ 310
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1134-1299 1.55e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.50  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1134 GSDINAQIETNRNTALTLacfqGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSsr 1213
Cdd:PLN03192  518 GEHDDPNMASNLLTVAST----GNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANG-- 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1214 DTALTIAADKGHYKFCELLIHRgAHIDVRNKKGNTpLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1293
Cdd:PLN03192  592 NTALWNAISAKHHKIFRILYHF-ASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVD 669


                  ....*.
gi 380805869 1294 VVQYLV 1299
Cdd:PLN03192  670 MVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
558-609 2.19e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 2.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869   558 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 609
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1078-1267 2.24e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.49  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1078 TPLSLAASGGYVNIIKILL-NAGAEINSRtGSkLGISPLMLAAMNGHVPAVKLLLD---------MGSDINAQietnrNT 1147
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLkCPSCDLFQR-GA-LGETALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQG-----ET 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1148 ALTLACFQGRAEVVSLLLDRKANVE---------HRAKTGLT-----PLMEAASGGYAEVGRVLLDKGADVNAppvpssR 1213
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRA------Q 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869 1214 D----TALTIAADKGHYKF-CE---LLIHRGAHID------VRNKKGNTPLWLASNGGHFDVVQLLVQ 1267
Cdd:cd22192   166 DslgnTVLHILVLQPNKTFaCQmydLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
Ank_4 pfam13637
Ankyrin repeats (many copies);
326-379 2.80e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 2.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   326 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 379
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1113-1300 2.92e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.10  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1113 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT-----GLTPLMEAAS 1187
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyqGETALHIAVV 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1188 GGYAEVGRVLLDKGADVNAPPV------PSSR------DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLwlasn 1255
Cdd:cd22192    99 NQNLNLVRELIARGADVVSPRAtgtffrPGPKnliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL----- 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 380805869 1256 ggHFDVVQ------------LLVQAGADVDAA-----DNRKITPLMSAFRKGHVKVVQYLVK 1300
Cdd:cd22192   174 --HILVLQpnktfacqmydlILSYDKEDDLQPldlvpNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 262-582 4.46e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.20  E-value: 4.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  262 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKeSALTLACYKGHLDMVRFLLEAgaDQEHKTDEMHTALMEACMDGHVEV 341
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDL-TPLHIICKEPNKLGMKEMIRS--INKCSVFYTLVAIKDAFNNRNVEI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  342 ARLLLdsgaqvnmpADSFESpltlaacgghvelaalliERGANLEEVNDEGYTPLMEAaregheEMVALLLAQGANINAQ 421
Cdd:PHA02878  117 FKIIL---------TNRYKN------------------IQTIDLVYIDKKSKDDIIEA------EITKLLLSYGADINMK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  422 TEETQetaltlaccggfsevadflikagadielgcSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 501
Cdd:PHA02878  164 DRHKG------------------------------NTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYN 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  502 TDVADVLLQAGADLEHESEGGRTPL-MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHlaVVELLLAHGA 580
Cdd:PHA02878  214 KPIVHILLENGASTDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSER--KLKLLLEYGA 291


                  ..
gi 380805869  581 DP 582
Cdd:PHA02878  292 DI 293
Ank_4 pfam13637
Ankyrin repeats (many copies);
226-279 5.18e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 5.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   226 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 967-1137 9.32e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.61  E-value: 9.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  967 DIDAhTESNHDTALTLACA-GGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTkDT 1045
Cdd:PHA02876  333 DVNA-ADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKI-GT 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1046 PLSLACSGGRQEV-VDLLLARGANKEHRNVSDYTPLSLAASGG-YVNIIKILLNAGAEINSrtgskLGIS---PLMLAAm 1120
Cdd:PHA02876  411 ALHFALCGTNPYMsVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNA-----INIQnqyPLLIAL- 484

                         170
                  ....*....|....*..
gi 380805869 1121 nGHVPAVKLLLDMGSDI 1137
Cdd:PHA02876  485 -EYHGIVNILLHYGAEL 500
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 114-299 1.37e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  114 MKAENS--HNAGQVDTRSLAEAcSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 191
Cdd:PLN03192  512 LLGDNGgeHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  192 GDiTPLMAASSGGYLDIVKlLLLHDADVNSQSATGNTaLTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH 271
Cdd:PLN03192  591 GN-TALWNAISAKHHKIFR-ILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDH 667

                         170       180
                  ....*....|....*....|....*....
gi 380805869  272 VEVARVLLDHGAGInTHSNEFKE-SALTL 299
Cdd:PLN03192  668 VDMVRLLIMNGADV-DKANTDDDfSPTEL 695
Ank_4 pfam13637
Ankyrin repeats (many copies);
295-346 1.76e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 1.76e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869   295 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 346
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1057-1295 1.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 55.52  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1057 EVVDLLLARGANKEHRNVSDyTPL------SLAASGGYVNIIKILLNAGAEINSRTGSklGISPLMLAAMNGHVPAV--- 1127
Cdd:PHA02989   51 KIVKLLIDNGADVNYKGYIE-TPLcavlrnREITSNKIKKIVKLLLKFGADINLKTFN--GVSPIVCFIYNSNINNCdml 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1128 KLLLDMGSDINAQIETNRNTAL--TLACFQGRAEVVSLLLDRKANV-EHRAKTGLTP----LMEAASGGYAEVGRVLLDK 1200
Cdd:PHA02989  128 RFLLSKGINVNDVKNSRGYNLLhmYLESFSVKKDVIKILLSFGVNLfEKTSLYGLTPmniyLRNDIDVISIKVIKYLIKK 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1201 GADVNAPPVPSSRDTALTIAADKGHYKFC-ELL--IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1277
Cdd:PHA02989  208 GVNIETNNNGSESVLESFLDNNKILSKKEfKVLnfILKYIKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSK 287

                         250
                  ....*....|....*...
gi 380805869 1278 RKITPLMSAFRKGHVKVV 1295
Cdd:PHA02989  288 DGDTVLTYAIKHGNIDML 305
Ank_4 pfam13637
Ankyrin repeats (many copies);
392-446 2.13e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 2.13e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 380805869   392 GYTPLMEAAREGHEEMVALLLAQGANINAQTEEtQETALTLACCGGFSEVADFLI 446
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGN-GETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
976-1029 3.27e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 3.27e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   976 HDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL 1029
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1113-1165 3.50e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 3.50e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869  1113 SPLMLAAMNGHVPAVKLLLDMGSDINAQIEtNRNTALTLACFQGRAEVVSLLL 1165
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 985-1063 4.66e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 4.66e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869  985 AGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAqSERTKDTPLSLACSGGRQEVVDLLL 1063
Cdd:PTZ00322   91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLS 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 526-648 5.48e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  526 LMKAARAGHLCTVQFLISKGANVNrATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 605
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 380805869  606 SYLLDY------------PNNVLSVPTT-DVSQLTPPSQDQSQVPRVPMHTLAMVV 648
Cdd:PTZ00322  165 QLLSRHsqchfelganakPDSFTGKPPSlEDSPISSHHPDFSAVPQPMMGSLIVIM 220
Ank_4 pfam13637
Ankyrin repeats (many copies);
522-576 9.62e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 9.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 380805869   522 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDhTVVSLACAGGHLAVVELLL 576
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1077-1131 1.60e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 1.60e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 380805869  1077 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSklGISPLMLAAMNGHVPAVKLLL 1131
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGN--GETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 967-1155 1.88e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  967 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKggdieaqsertkdtp 1046
Cdd:PHA02878  159 DINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN--------------- 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1047 lslacsggrqevvdlllarGANKEHRNVSDYTPLSLAAsgGYV---NIIKILLNAGAEINSRTgSKLGISPLMLAAMNGH 1123
Cdd:PHA02878  224 -------------------GASTDARDKCGNTPLHISV--GYCkdyDILKLLLEHGVDVNAKS-YILGLTALHSSIKSER 281

                         170       180       190
                  ....*....|....*....|....*....|..
gi 380805869 1124 VpaVKLLLDMGSDINAqIETNRNTALTLACFQ 1155
Cdd:PHA02878  282 K--LKLLLEYGADINS-LNSYKLTPLSSAVKQ 310
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 978-1097 2.18e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  978 TALTLACAGGHEELVSVLIARDAKIE---------HRDKK-----GFTPLILAATAGHVGVVEILLDKGGDIEAQsERTK 1043
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQ-DSLG 169

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869 1044 DTPL---------SLACsggrqEVVDLLLARGANK-----EH-RNVSDYTPLSLAASGGYVNIIKILLN 1097
Cdd:cd22192   170 NTVLhilvlqpnkTFAC-----QMYDLILSYDKEDdlqplDLvPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1182-1265 2.79e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1182 LMEAASGGYAEVGRVLLDKGADvnappvPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1257
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGAD------PNCRDydgrTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159


                  ....*...
gi 380805869 1258 HFDVVQLL 1265
Cdd:PTZ00322  160 FREVVQLL 167
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 460-611 3.18e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  460 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 539
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 380805869  540 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 611
Cdd:PHA02875   86 ELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1165-1300 3.18e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1165 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCE---LLIHRGAHIDV 1241
Cdd:PHA03095    1 DEEDESVDIIMEAALYDYLLNASNVTVEEVRRLLAAGADVNF--RGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380805869 1242 RNKKGNTPLWL-ASNGGHFDVVQLLVQAGADVDAADNRKITPL---MSAFRKgHVKVVQYLVK 1300
Cdd:PHA03095   79 PERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhvyLSGFNI-NPKVIRLLLR 140
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 362-611 3.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  362 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPL----MEAAREGHEEMVAlllaqgaNINAQTEETQETALTLACCGG 437
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiicKEPNKLGMKEMIR-------SINKCSVFYTLVAIKDAFNNR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  438 FSEVADFLI----KAGADIELgcsTPLMEASQEGHLE--LVKYLLASGANVHATTA-TGDTALTYACENGHTDVADVLLQ 510
Cdd:PHA02878  113 NVEIFKIILtnryKNIQTIDL---VYIDKKSKDDIIEaeITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  511 AGADLEHESEGGRTPLMKAARAghlctvqfliskganvnratANNDhtvvslacagghlaVVELLLAHGADPTHRLKDGS 590
Cdd:PHA02878  190 YGANVNIPDKTNNSPLHHAVKH--------------------YNKP--------------IVHILLENGASTDARDKCGN 235

                         250       260
                  ....*....|....*....|.
gi 380805869  591 TMLieaakggHTNvVSYLLDY 611
Cdd:PHA02878  236 TPL-------HIS-VGYCKDY 248
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 138-413 3.71e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 51.28  E-value: 3.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  138 DVNAVRKLLDEGRSVNEhTEEGESLLCLACSAGYY--ELAQVLLAMHANVEDRGNKGdiTPLMAA------SSGGYLDIV 209
Cdd:PHA02989   15 DKNALEFLLRTGFDVNE-EYRGNSILLLYLKRKDVkiKIVKLLIDNGADVNYKGYIE--TPLCAVlrnreiTSNKIKKIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  210 KLLLLHDADVNSQSATGNTALT---YACAGGFVDIVKVLLNEGANIED-HNENGHTPL---MEAASAgHVEVARVLLDHG 282
Cdd:PHA02989   92 KLLLKFGADINLKTFNGVSPIVcfiYNSNINNCDMLRFLLSKGINVNDvKNSRGYNLLhmyLESFSV-KKDVIKILLSFG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  283 AGINTHSNEFKESALTLacYKGH------LDMVRFLLEAGADQEhKTDEMHTALMEACMDGH-------VEVARLLLdSG 349
Cdd:PHA02989  171 VNLFEKTSLYGLTPMNI--YLRNdidvisIKVIKYLIKKGVNIE-TNNNGSESVLESFLDNNkilskkeFKVLNFIL-KY 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 380805869  350 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 413
Cdd:PHA02989  247 IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRILQ 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
 495-628 3.82e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.18  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  495 YACENGHTDVADV--LLQAGADLEHESEGGRTPL-MKAARAGHLCT--VQFLISKGANVNRATANNDHTVVSLACAGGHL 569
Cdd:PHA03095   18 YLLNASNVTVEEVrrLLAAGADVNFRGEYGKTPLhLYLHYSSEKVKdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  570 AVVELLLAHGADPTHRLKDGSTMLIEAAKGG--HTNVVSYLLdypNNVLSVPTTDVSQLTP 628
Cdd:PHA03095   98 DVIKLLIKAGADVNAKDKVGRTPLHVYLSGFniNPKVIRLLL---RKGADVNALDLYGMTP 155
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 967-1151 3.93e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.41  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  967 DIDAHTESNHDTALTLACAGGHEELVSVliARDAKIEhrDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQsERTKDTP 1046
Cdd:PLN03192  520 HDDPNMASNLLTVASTGNAALLEELLKA--KLDPDIG--DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR-DANGNTA 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1047 LSLACSGGRQEVVDLLLARGANKEHRNVSDYtpLSLAASGGYVNIIKILLNAGAEINSRtgSKLGISPLMLAAMNGHVPA 1126
Cdd:PLN03192  595 LWNAISAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRNDLTAMKELLKQGLNVDSE--DHQGATALQVAMAEDHVDM 670

                         170       180
                  ....*....|....*....|....*
gi 380805869 1127 VKLLLDMGSDINAQIETNRNTALTL 1151
Cdd:PLN03192  671 VRLLIMNGADVDKANTDDDFSPTEL 695
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1231-1298 4.17e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 4.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869 1231 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1298
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 233-386 5.28e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.85  E-value: 5.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   233 ACAGGFVDIVKVLLNEGA--NIEDHNENGHTPLMEAASAG-HVEVARVLLDHGAGINThsnefkESALTLACYKGHLDMV 309
Cdd:TIGR00870   24 AAERGDLASVYRDLEEPKklNINCPDRLGRSALFVAAIENeNLELTELLLNLSCRGAV------GDTLLHAISLEYVDAV 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   310 ----RFLLEAGADQ-------EHKTDEM---HTALMEACMDGHVEVARLLLDSGAQVNMPA-----------DSF---ES 361
Cdd:TIGR00870   98 eailLHLLAAFRKSgplelanDQYTSEFtpgITALHLAAHRQNYEIVKLLLERGASVPARAcgdffvksqgvDSFyhgES 177

                          170       180
                   ....*....|....*....|....*
gi 380805869   362 PLTLAACGGHVELAALLIERGANLE 386
Cdd:TIGR00870  178 PLNAAACLGSPSIVALLSEDPADIL 202
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 263-367 6.06e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  263 LMEAASAGHVEVARVLLDHGAgiNTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 341
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGA--DPNCRDYDGRTpLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 380805869  342 ARLLL-----DSGAQVNMPADSF--------ESPLTLAA 367
Cdd:PTZ00322  164 VQLLSrhsqcHFELGANAKPDSFtgkppsleDSPISSHH 202
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 143-381 6.59e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.85  E-value: 6.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   143 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL----AMHANVEDRGNKGDItpLMAASSGGYLDIVKLLLLHDAD 218
Cdd:TIGR00870    1 RGPLDIVPAEESPLSDEEKAFLPAAERGDLASVYRDLeepkKLNINCPDRLGRSAL--FVAAIENENLELTELLLNLSCR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   219 VnsqsATGNTALtYACAGGFVDIVKVLLN-------EGANIEDHNEN-------GHTPLMEAASAGHVEVARVLLDHGAG 284
Cdd:TIGR00870   79 G----AVGDTLL-HAISLEYVDAVEAILLhllaafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGAS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   285 INT--HSNEFKESALT---------LACYK--GHLDMVRFLLEAGADQEhKTDEM-----HTALMEA------------C 334
Cdd:TIGR00870  154 VPAraCGDFFVKSQGVdsfyhgespLNAAAclGSPSIVALLSEDPADIL-TADSLgntllHLLVMENefkaeyeelscqM 232

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 380805869   335 MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 381
Cdd:TIGR00870  233 YNFALSLLDKLRDSKELEVILNHQGLTPLKLAAKEGRIVLFRLKLAI 279
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1245-1277 6.62e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 6.62e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 380805869  1245 KGNTPLWLAS-NGGHFDVVQLLVQAGADVDAADN 1277
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 315-412 7.38e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  315 AGADQEHKTDE------MHTALMEAC---MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL 385
Cdd:PTZ00322   62 ATPDHNLTTEEvidpvvAHMLTVELCqlaASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADP 141

                          90       100
                  ....*....|....*....|....*..
gi 380805869  386 EEVNDEGYTPLMEAAREGHEEMVALLL 412
Cdd:PTZ00322  142 TLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_5 pfam13857
Ankyrin repeats (many copies);
187-233 7.42e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 7.42e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 380805869   187 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYA 233
Cdd:pfam13857   10 NRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 209-292 7.57e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 7.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  209 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL-----DHGA 283
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqcHFEL 177


                  ....*....
gi 380805869  284 GINTHSNEF 292
Cdd:PTZ00322  178 GANAKPDSF 186
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1024-1206 8.36e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 8.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1024 VVEILLDKGGDieaQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1103
Cdd:PLN03192  509 VGDLLGDNGGE---HDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVH 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1104 SRTGSklGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNrntALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1183
Cdd:PLN03192  586 IRDAN--GNTALWNAISAKHHKIFRILYHFASISDPHAAGD---LLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQ 660

                         170       180
                  ....*....|....*....|...
gi 380805869 1184 EAASGGYAEVGRVLLDKGADVNA 1206
Cdd:PLN03192  661 VAMAEDHVDMVRLLIMNGADVDK 683
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 391-423 1.24e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.43  E-value: 1.24e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 380805869   391 EGYTPLMEAA-REGHEEMVALLLAQGANINAQTE 423
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
1045-1096 1.28e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.28e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 380805869  1045 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1096
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 309-378 1.56e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 1.56e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  309 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 378
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 130-285 1.86e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  130 LAEACSDGDVNAVRKLLdEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAmhaNVEDRGN--------KGDiTPLMA 199
Cdd:cd22192    21 LLLAAKENDVQAIKKLL-KCPSCDLFQRgaLGETALHVAALYDNLEAAVVLME---AAPELVNepmtsdlyQGE-TALHI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  200 ASSGGYLDIVKLLLLHDADVNSQSATGntalTYacaggFVDIVKVLLNEGanieDHnenghtPLMEAASAGHVEVARVLL 279
Cdd:cd22192    96 AVVNQNLNLVRELIARGADVVSPRATG----TF-----FRPGPKNLIYYG----EH------PLSFAACVGNEEIVRLLI 156


                  ....*.
gi 380805869  280 DHGAGI 285
Cdd:cd22192   157 EHGADI 162
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 472-554 1.91e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  472 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 551
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177


                  ...
gi 380805869  552 TAN 554
Cdd:PTZ00322  178 GAN 180
Ank_5 pfam13857
Ankyrin repeats (many copies);
278-330 1.94e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 1.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869   278 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 330
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
1178-1233 2.22e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 2.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 380805869  1178 GLTPLMEAASGGYAEVGRVLLDKGADVNAppVPSSRDTALTIAADKGHYKFCELLI 1233
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINA--VDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1111-1139 2.37e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 42.24  E-value: 2.37e-05
                           10        20
                   ....*....|....*....|....*....
gi 380805869  1111 GISPLMLAAMNGHVPAVKLLLDMGSDINA 1139
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 391-420 2.46e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 2.46e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 380805869    391 EGYTPLMEAAREGHEEMVALLLAQGANINA 420
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 258-286 2.58e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 2.58e-05
                            10        20
                    ....*....|....*....|....*....
gi 380805869    258 NGHTPLMEAASAGHVEVARVLLDHGAGIN 286
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1111-1267 5.48e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.57  E-value: 5.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1111 GISPLMLAAMN---GHVPAVKLLLDMGSD-------INAQIETNR---NTALTLACFQGRAEVVSLLLDRKANVEHRA-- 1175
Cdd:cd21882    26 GKTCLHKAALNlndGVNEAIMLLLEAAPDsgnpkelVNAPCTDEFyqgQTALHIAIENRNLNLVRLLVENGADVSARAtg 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1176 ----KTGLT-------PLMEAASGGYAEVGRVLLDKGADvnaPPVPSSRDT-------ALTIAADK--GHYKFC----EL 1231
Cdd:cd21882   106 rffrKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQ---PAALEAQDSlgntvlhALVLQADNtpENSAFVcqmyNL 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 380805869 1232 LIHRGAHID-------VRNKKGNTPLWLASNGGHFDVVQLLVQ 1267
Cdd:cd21882   183 LLSYGAHLDptqqleeIPNHQGLTPLKLAAVEGKIVMFQHILQ 225
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1119-1208 6.47e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 6.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1119 AMNGHVPAVKLLLDMGSDINAQiETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1198
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168

                          90
                  ....*....|....*
gi 380805869 1199 -----DKGADVNAPP 1208
Cdd:PTZ00322  169 rhsqcHFELGANAKP 183
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1015-1119 7.61e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1015 LAATAGHVGVvEILLDKGGDIEAQsERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1094
Cdd:PTZ00322   89 LAASGDAVGA-RILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 380805869 1095 LL---------NAGAEINSRTG--SKLGISPLMLAA 1119
Cdd:PTZ00322  167 LSrhsqchfelGANAKPDSFTGkpPSLEDSPISSHH 202
PHA02798 PHA02798
ankyrin-like protein; Provisional
 239-499 8.01e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.75  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  239 VDIVKVLLNEGANIEDHNENGHTPLMEAASaghvevarvlldhgaginthsnEFKEsaltlacYKGHLDMVRFLLEAGAD 318
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCTILS----------------------NIKD-------YKHMLDIVKILIENGAD 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  319 QEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNM-PADSFESPLTLAACGGHV--ELAALLIERGANLEEVND-E 391
Cdd:PHA02798  102 INKKNSDGETPLYCLLSNGYInnlEILLFMIENGADTTLlDKDGFTMLQVYLQSNHHIdiEIIKLLLEKGVDINTHNNkE 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  392 GYTPLMEAAREGHE----EMVALLLAQGANINAQTEETQETALT-----LACCGGF-SEVADFLIKAgADI----ELGCs 457
Cdd:PHA02798  182 KYDTLHCYFKYNIDridaDILKLFVDNGFIINKENKSHKKKFMEylnslLYDNKRFkKNILDFIFSY-IDInqvdELGF- 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 380805869  458 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 499
Cdd:PHA02798  260 NPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTAFEN 301
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 391-420 8.56e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.70  E-value: 8.56e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 380805869   391 EGYTPLMEAAREGHEEMVALLLAQGANINA 420
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 127-226 9.74e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  127 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE--DRGNKgdiTPLMAASSGG 204
Cdd:PTZ00322   83 TVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTllDKDGK---TPLELAEENG 159

                          90       100
                  ....*....|....*....|..
gi 380805869  205 YLDIVKLLLLHDADVNSQSATG 226
Cdd:PTZ00322  160 FREVVQLLSRHSQCHFELGANA 181
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1024-1255 1.09e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1024 VVEILLDKGGDIEAQsERTKDTPLSLACSGGRQ-----EVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN---IIKIL 1095
Cdd:PHA02798   53 IVKLFINLGANVNGL-DNEYSTPLCTILSNIKDykhmlDIVKILIENGADINKKNSDGETPLYCLLSNGYINnleILLFM 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1096 LNAGAEINSRtgSKLGISPLMLAAMNGH---VPAVKLLLDMGSDINaqIETNRNTALTLACFQGR------AEVVSLLLD 1166
Cdd:PHA02798  132 IENGADTTLL--DKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDIN--THNNKEKYDTLHCYFKYnidridADILKLFVD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1167 -----RKANVEHRAKtgLTPLMEAASGGYAEVGRVLLD---KGADVNAPPVPSSrdTALTIAADKGHYKFCELLIHRGAH 1238
Cdd:PHA02798  208 ngfiiNKENKSHKKK--FMEYLNSLLYDNKRFKKNILDfifSYIDINQVDELGF--NPLYYSVSHNNRKIFEYLLQLGGD 283

                         250
                  ....*....|....*..
gi 380805869 1239 IDVRNKKGNTPLWLASN 1255
Cdd:PHA02798  284 INIITELGNTCLFTAFE 300
Ank_5 pfam13857
Ankyrin repeats (many copies);
997-1050 1.13e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869   997 ARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKdTPLSLA 1050
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL-TALDLA 56
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 240-412 1.16e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 46.68  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  240 DIVKVLLNegANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN----------THSNE---FKESALTLACYKGHL 306
Cdd:cd22194   124 GILDRFIN--AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNahakgvffnpKYKHEgfyFGETPLALAACTNQP 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  307 DMVRFLLEAGADQEHKTDEMHTALMEACmdghVEVARlllDSGAQVNMPADSFESPLTlaACGGHvelaalliergaNLE 386
Cdd:cd22194   202 EIVQLLMEKESTDITSQDSRGNTVLHAL----VTVAE---DSKTQNDFVKRMYDMILL--KSENK------------NLE 260

                         170       180
                  ....*....|....*....|....*..
gi 380805869  387 EV-NDEGYTPLMEAAREGHEEMVALLL 412
Cdd:cd22194   261 TIrNNEGLTPLQLAAKMGKAEILKYIL 287
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1111-1139 1.17e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.17e-04
                            10        20
                    ....*....|....*....|....*....
gi 380805869   1111 GISPLMLAAMNGHVPAVKLLLDMGSDINA 1139
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 238-335 1.70e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 45.36  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  238 FVDIVKVLLNEGANIE---DHNENGHT-PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 313
Cdd:PHA02884   45 YTDIIDAILKLGADPEapfPLSENSKTnPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILL 124

                          90       100
                  ....*....|....*....|..
gi 380805869  314 EAGADQEHKTDEMHTALMEACM 335
Cdd:PHA02884  125 SYGADINIQTNDMVTPIELALM 146
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 258-287 1.91e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.93  E-value: 1.91e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 380805869   258 NGHTPLMEAASAGHVEVARVLLDHGAGINT 287
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
378-433 2.12e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 2.12e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869   378 LIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETqETALTLA 433
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG-LTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 226-254 2.15e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.15e-04
                            10        20
                    ....*....|....*....|....*....
gi 380805869    226 GNTALTYACAGGFVDIVKVLLNEGANIED 254
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 522-549 2.39e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.39e-04
                            10        20
                    ....*....|....*....|....*...
gi 380805869    522 GRTPLMKAARAGHLCTVQFLISKGANVN 549
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1245-1274 2.62e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.62e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 380805869   1245 KGNTPLWLASNGGHFDVVQLLVQAGADVDA 1274
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
211-263 2.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 2.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869   211 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 263
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 258-286 2.76e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 2.76e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 380805869   258 NGHTPLMEAA-SAGHVEVARVLLDHGAGIN 286
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
700-786 3.09e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  700 VEETEGKLNELGQRISAIEKaqlksleliqgeplNKDKIEELKKNREEQVQKKKKILKELQKVERQLqmKTQQQFTKEYL 779
Cdd:PRK03918  233 LEELKEEIEELEKELESLEG--------------SKRKLEEKIRELEERIEELKKEIEELEEKVKEL--KELKEKAEEYI 296


                  ....*..
gi 380805869  780 ETKGQKD 786
Cdd:PRK03918  297 KLSEFYE 303
Ank_4 pfam13637
Ankyrin repeats (many copies);
161-213 3.13e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 3.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869   161 SLLCLACSAGYYELAQVLLAMHANVEDRgNKGDITPLMAASSGGYLDIVKLLL 213
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAV-DGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 399-525 3.23e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  399 AAREGHEEMVAlllaqGANINAQTEETQETA----LTLACC----GGFSEVADFLIKAGAD---IELGCSTPLMEASQEG 467
Cdd:PTZ00322   52 EALEATENKDA-----TPDHNLTTEEVIDPVvahmLTVELCqlaaSGDAVGARILLTGGADpncRDYDGRTPLHIACANG 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  468 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLqaGADLEHESEGGRTP 525
Cdd:PTZ00322  127 HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS--RHSQCHFELGANAK 182
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 206-320 3.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 43.65  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  206 LDIVKLLLLHDADVNSQSATGNTAL--TYACAGGFV--DIVKVLLNEGANIEDHNENGHTPL---MEAASAgHVEVARVL 278
Cdd:PHA02859   66 VEILKFLIENGADVNFKTRDNNLSAlhHYLSFNKNVepEILKILIDSGSSITEEDEDGKNLLhmyMCNFNV-RINVIKLL 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 380805869  279 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 320
Cdd:PHA02859  145 IDSGVSFLNKDFDNNNILYSYILFHSDKKIFDFLTSLGIDIN 186
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 489-516 3.31e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 3.31e-04
                            10        20
                    ....*....|....*....|....*...
gi 380805869    489 GDTALTYACENGHTDVADVLLQAGADLE 516
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 127-220 4.18e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.60  E-value: 4.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  127 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYL 206
Cdd:PHA02875  136 FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKI 215

                          90
                  ....*....|....
gi 380805869  207 DIVKLLLLHDADVN 220
Cdd:PHA02875  216 DIVRLFIKRGADCN 229
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 522-552 4.30e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 4.30e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 380805869   522 GRTPLMKAA-RAGHLCTVQFLISKGANVNRAT 552
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 257-476 4.37e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 44.75  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  257 ENGHTPLMEAasaghvevarvLLDhgagINTHSNEFKESALTLACYKGHLDmvRFLleaGADQEHKTDEMHTALMEACMD 336
Cdd:cd22194    92 DTGKTCLMKA-----------LLN----INENTKEIVRILLAFAEENGILD--RFI---NAEYTEEAYEGQTALNIAIER 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  337 GHVEVARLLLDSGAQVNMPA-----------DSF---ESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLmeaar 401
Cdd:cd22194   152 RQGDIVKLLIAKGADVNAHAkgvffnpkykhEGFyfgETPLALAACTNQPEIVQLLMEKESTDITSQDSrGNTVL----- 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  402 egHeemvALLLAqganinAQTEETQETALTlaccggfsEVADFLIKAGADIELGCS------TPLMEASQEGHLELVKYL 475
Cdd:cd22194   227 --H----ALVTV------AEDSKTQNDFVK--------RMYDMILLKSENKNLETIrnneglTPLQLAAKMGKAEILKYI 286


                  .
gi 380805869  476 L 476
Cdd:cd22194   287 L 287
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 522-549 4.91e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 4.91e-04
                           10        20
                   ....*....|....*....|....*...
gi 380805869   522 GRTPLMKAARAGHLCTVQFLISKGANVN 549
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1008-1037 5.74e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 5.74e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 380805869   1008 KGFTPLILAATAGHVGVVEILLDKGGDIEA 1037
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
245-300 5.77e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 5.77e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869   245 LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINThSNEFKESALTLA 300
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNL-KDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
1011-1063 5.88e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 5.88e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869  1011 TPLILAATAGHVGVVEILLDKGGDIEAQSERtKDTPLSLACSGGRQEVVDLLL 1063
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGN-GETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
451-496 5.95e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 5.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 380805869   451 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 496
Cdd:pfam13857   11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 462-550 5.95e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 5.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  462 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 541
Cdd:PHA02876  151 ERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAI 230


                  ....*....
gi 380805869  542 ISKGANVNR 550
Cdd:PHA02876  231 IDNRSNINK 239
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1111-1140 6.43e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 6.43e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 380805869  1111 GISPLMLAA-MNGHVPAVKLLLDMGSDINAQ 1140
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNAR 32
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1192-1298 6.89e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1192 EVGRVLLDKGADVNAPPVPSSrdtALTIAAdKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1271
Cdd:PLN03192  508 NVGDLLGDNGGEHDDPNMASN---LLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN 583

                          90       100
                  ....*....|....*....|....*..
gi 380805869 1272 VDAADNRKITPLMSAFRKGHVKVVQYL 1298
Cdd:PLN03192  584 VHIRDANGNTALWNAISAKHHKIFRIL 610
Ank_5 pfam13857
Ankyrin repeats (many copies);
1095-1152 7.60e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 7.60e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  1095 LLNAGAeINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQiETNRNTALTLA 1152
Cdd:pfam13857    1 LLEHGP-IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLK-DEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 980-1168 7.68e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 7.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869   980 LTLACAGGHEELVSVLIARDAKIEHRDKkgftpLILAATAGHVGVVE----ILLDKGGDI--------EAQSERTKD-TP 1046
Cdd:TIGR00870   57 FVAAIENENLELTELLLNLSCRGAVGDT-----LLHAISLEYVDAVEaillHLLAAFRKSgplelandQYTSEFTPGiTA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1047 LSLACSGGRQEVVDLLLARGAN------------KEHRNVSDYT--PLSLAASGGYVNIIKILLNAGAEInsRTGSKLGI 1112
Cdd:TIGR00870  132 LHLAAHRQNYEIVKLLLERGASvparacgdffvkSQGVDSFYHGesPLNAAACLGSPSIVALLSEDPADI--LTADSLGN 209

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  1113 SPLMLAAMNGHVPAV---------KLLLDMG--SDINAQIE--TNRN--TALTLACFQGRAEVVSLLLDRK 1168
Cdd:TIGR00870  210 TLLHLLVMENEFKAEyeelscqmyNFALSLLdkLRDSKELEviLNHQglTPLKLAAKEGRIVLFRLKLAIK 280
Ank_5 pfam13857
Ankyrin repeats (many copies);
1231-1283 7.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 7.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 380805869  1231 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1283
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
1145-1198 7.82e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 7.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 380805869  1145 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1198
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 968-1097 9.55e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.59  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  968 IDA-HTESNHD--TALTLACAGGHEELVSVLIARDAKIEHRDKKGF--------------TPLILAATAGHVGVVEILLD 1030
Cdd:cd22194   130 INAeYTEEAYEgqTALNIAIERRQGDIVKLLIAKGADVNAHAKGVFfnpkykhegfyfgeTPLALAACTNQPEIVQLLME 209

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869 1031 KGGDIEAQSERTKDTPL---------SLACSGGRQEVVDLLLARGANKE---HRNVSDYTPLSLAASGGYVNIIKILLN 1097
Cdd:cd22194   210 KESTDITSQDSRGNTVLhalvtvaedSKTQNDFVKRMYDMILLKSENKNletIRNNEGLTPLQLAAKMGKAEILKYILS 288
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 458-484 1.07e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 1.07e-03
                            10        20
                    ....*....|....*....|....*..
gi 380805869    458 TPLMEASQEGHLELVKYLLASGANVHA 484
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 327-354 1.34e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 1.34e-03
                            10        20
                    ....*....|....*....|....*...
gi 380805869    327 HTALMEACMDGHVEVARLLLDSGAQVNM 354
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 458-486 1.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 380805869   458 TPLMEAS-QEGHLELVKYLLASGANVHATT 486
Cdd:pfam00023    4 TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 304-558 1.63e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 42.94  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  304 GHLDMVRFLLEAGADQEHKTDEmhTALMEACM---DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 380
Cdd:cd21882     6 GLLECLRWYLTDSAYQRGATGK--TCLHKAALnlnDGVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYQGQTALHIAIEN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  381 RGANLeevndegytplmeaaregheemVALLLAQGANINAqteetqetaltlACCGgfsevaDFLIKAGADIELGCSTPL 460
Cdd:cd21882    84 RNLNL----------------------VRLLVENGADVSA------------RATG------RFFRKSPGNLFYFGELPL 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  461 MEASQEGHLELVKYLLASGANVHATTAT---GDTAL---------TYACENGHTDVADVLLQAGADLEH-------ESEG 521
Cdd:cd21882   124 SLAACTNQEEIVRLLLENGAQPAALEAQdslGNTVLhalvlqadnTPENSAFVCQMYNLLLSYGAHLDPtqqleeiPNHQ 203

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 380805869  522 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 558
Cdd:cd21882   204 GLTPLKLAAVEGKIVMFQHILQREFSGPYQPLSRKFT 240
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 195-222 1.70e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*....
gi 380805869   195 TPLM-AASSGGYLDIVKLLLLHDADVNSQ 222
Cdd:pfam00023    4 TPLHlAAGRRGNLEIVKLLLSKGADVNAR 32
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1008-1038 2.09e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 2.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 380805869  1008 KGFTPLILAAT-AGHVGVVEILLDKGGDIEAQ 1038
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNAR 32
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 489-517 2.14e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 2.14e-03
                           10        20
                   ....*....|....*....|....*....
gi 380805869   489 GDTALTYACENGHTDVADVLLQAGADLEH 517
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1076-1103 2.23e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 2.23e-03
                            10        20
                    ....*....|....*....|....*...
gi 380805869   1076 DYTPLSLAASGGYVNIIKILLNAGAEIN 1103
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 328-544 2.43e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 42.09  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  328 TALMEACM---DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAaLLIERganleevndegytplmeaaREGH 404
Cdd:cd22193    31 TCLMKALLnlnPGTNDTIRILLDIAEKTDNLKRFINAEYTDEYYEGQTALH-IAIER-------------------RQGD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  405 eeMVALLLAQGANINAQTeetqetaltlacCGGFsevadFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG---AN 481
Cdd:cd22193    91 --IVALLVENGADVHAHA------------KGRF-----FQPKYQGEGFYFGELPLSLAACTNQPDIVQYLLENEhqpAD 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869  482 VHATTATGDT---ALTYACENGHTDVA------DVLLQAGADLEHESE-------GGRTPLMKAARAGHLCTVQFLISK 544
Cdd:cd22193   152 IEAQDSRGNTvlhALVTVADNTKENTKfvtrmyDMILIRGAKLCPTVEleeirnnDGLTPLQLAAKMGKIEILKYILQR 230
PHA02946 PHA02946
ankyin-like protein; Provisional
 1227-1283 2.65e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 380805869 1227 KFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1283
Cdd:PHA02946   53 RFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPL 109
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 328-452 3.38e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.92  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  328 TALMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE---RGANLEEVND--EGYTPLMEAAR 401
Cdd:cd22192    19 SPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEaapELVNEPMTSDlyQGETALHIAVV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 380805869  402 EGHEEMVALLLAQGAN-INAQTEET------------QETALTLACCGGFSEVADFLIKAGADI 452
Cdd:cd22192    99 NQNLNLVRELIARGADvVSPRATGTffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGADI 162
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 163-256 3.39e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  163 LCLACSAGYYELAQVLLAMHANVEDRGNKGDiTPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 242
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGR-TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164

                          90
                  ....*....|....
gi 380805869  243 KVLLneGANIEDHN 256
Cdd:PTZ00322  165 QLLS--RHSQCHFE 176
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 365-471 3.39e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  365 LAACGGHVElAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAqTEETQETALTLACCGGFSEVADF 444
Cdd:PTZ00322   89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQL 166

                          90       100
                  ....*....|....*....|....*....
gi 380805869  445 LIK-AGADIELG-CSTPLMEASQEGHLEL 471
Cdd:PTZ00322  167 LSRhSQCHFELGaNAKPDSFTGKPPSLED 195
Ank_5 pfam13857
Ankyrin repeats (many copies);
1163-1220 3.40e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 3.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  1163 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPpvPSSRDTALTIA 1220
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLK--DEEGLTALDLA 56
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
701-786 3.73e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.97  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  701 EETEGKLNELGQRISAIEKaqlkslELIQGEPLNKdKIEELKKNREEQVQKKKKILKELQKV------ERQLQMKTQQQF 774
Cdd:PRK03918  528 EKLKEKLIKLKGEIKSLKK------ELEKLEELKK-KLAELEKKLDELEEELAELLKELEELgfesveELEERLKELEPF 600

                          90
                  ....*....|..
gi 380805869  775 TKEYLETKGQKD 786
Cdd:PRK03918  601 YNEYLELKDAEK 612
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1245-1274 3.83e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 380805869  1245 KGNTPLWLASNGGHFDVVQLLVQAGADVDA 1274
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 290-419 4.32e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.19  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  290 NEFKESALtLACY---KGHLDMVRFLLEAGADQEHKTDEMHTALMEACM----DGHVEVARLLLDSGAQVNMPADSFESP 362
Cdd:PHA02859   48 NDLYETPI-FSCLekdKVNVEILKFLIENGADVNFKTRDNNLSALHHYLsfnkNVEPEILKILIDSGSSITEEDEDGKNL 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380805869  363 L--TLAACGGHVELAALLIERGANLEEVNDEG----YTPLMeaaREGHEEMVALLLAQGANIN 419
Cdd:PHA02859  127 LhmYMCNFNVRINVIKLLIDSGVSFLNKDFDNnnilYSYIL---FHSDKKIFDFLTSLGIDIN 186
PHA02795 PHA02795
ankyrin-like protein; Provisional
 206-276 4.45e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 41.13  E-value: 4.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  206 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 276
Cdd:PHA02795  201 LEIYKLCIPYIEDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNGYTCLDVAVDRGSVIARR 271
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1195-1304 4.47e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.36  E-value: 4.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1195 RVLLDKGADVNAppVPSSRDTAL-TIAADKGHYK----FCELLIHRGAHIDVRNKKGNTPLW-LASNG--GHFDVVQLLV 1266
Cdd:PHA02798   55 KLFINLGANVNG--LDNEYSTPLcTILSNIKDYKhmldIVKILIENGADINKKNSDGETPLYcLLSNGyiNNLEILLFMI 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 380805869 1267 QAGADVDAADNRKITPLMSAFRKGH---VKVVQYLVK---EVNQ 1304
Cdd:PHA02798  133 ENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEkgvDINT 176
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1137-1263 4.53e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1137 INAQIeTNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKT--------------GLTPLMEAASGGYAEVGRVLL 1198
Cdd:cd22194   130 INAEY-TEEAyegqTALNIAIERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLM 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1199 DKGADVNappvpSSRDT-------ALTIAAD--KGHYKFCE------LLIHRGAHID-VRNKKGNTPLWLASNGGHFDVV 1262
Cdd:cd22194   209 EKESTDI-----TSQDSrgntvlhALVTVAEdsKTQNDFVKrmydmiLLKSENKNLEtIRNNEGLTPLQLAAKMGKAEIL 283


                  .
gi 380805869 1263 Q 1263
Cdd:cd22194   284 K 284
Ank_5 pfam13857
Ankyrin repeats (many copies);
1061-1118 4.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 4.99e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 380805869  1061 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSklGISPLMLA 1118
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE--GLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-220 5.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 5.04e-03
                            10        20
                    ....*....|....*....|....*.
gi 380805869    195 TPLMAASSGGYLDIVKLLLLHDADVN 220
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 295-318 5.09e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 5.09e-03
                            10        20
                    ....*....|....*....|....
gi 380805869    295 SALTLACYKGHLDMVRFLLEAGAD 318
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGAD 27
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1044-1267 6.10e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1044 DTPLSLACSGGR-QEVVDLLLarganKEHRNVSDYTPLSLAASGGYVN----IIKILLNAGAE------INSRTGSKL-- 1110
Cdd:TIGR00870   53 RSALFVAAIENEnLELTELLL-----NLSCRGAVGDTLLHAISLEYVDaveaILLHLLAAFRKsgplelANDQYTSEFtp 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1111 GISPLMLAAMNGHVPAVKLLLDMGSDINAQ------IETNRNTAL--------TLACFqGRAEVVSLLLDRKANVEHRAK 1176
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVPARacgdffVKSQGVDSFyhgesplnAAACL-GSPSIVALLSEDPADILTADS 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869  1177 TGLTPL----MEAA-SGGYAEVGRVLLDKGADVNAPPVPSSrdtaltiaadkghykfcELLIhrgahidVRNKKGNTPLW 1251
Cdd:TIGR00870  207 LGNTLLhllvMENEfKAEYEELSCQMYNFALSLLDKLRDSK-----------------ELEV-------ILNHQGLTPLK 262

                          250
                   ....*....|....*.
gi 380805869  1252 LASNGGHFDVVQLLVQ 1267
Cdd:TIGR00870  263 LAAKEGRIVLFRLKLA 278
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
696-767 6.32e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 6.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 380805869  696 LECIVEETEGKLNELGQRISAIEKaQLKSLELIQGEplnKDKIEELKKNREEQVQKKKKILKELQKVERQLQ 767
Cdd:PRK03918  257 LEEKIRELEERIEELKKEIEELEE-KVKELKELKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1008-1124 6.40e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 6.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1008 KGFTPLILAATAGHVGVVEILLDKGGDIeaQSERTKDT---------------PLSLACSGGRQEVVDLLLARGANKEHR 1072
Cdd:cd22192    88 QGETALHIAVVNQNLNLVRELIARGADV--VSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQ 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1073 NVSDYTP---LSLAASGGYV-NIIKILLNAGAEINSRTGSKL----GISPLMLAAMNGHV 1124
Cdd:cd22192   166 DSLGNTVlhiLVLQPNKTFAcQMYDLILSYDKEDDLQPLDLVpnnqGLTPFKLAAKEGNI 225
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1001-1069 6.98e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.49  E-value: 6.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380805869 1001 KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSeRTKDTPLSLACSGGRQEVVDLLLARGANK 1069
Cdd:PHA02989  248 KINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVS-KDGDTVLTYAIKHGNIDMLNRILQLKPGK 315
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 715-785 7.38e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 40.10  E-value: 7.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380805869  715 SAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLqmktqQQFTKEYLETKGQK 785
Cdd:COG4026   114 NAIIRAGLKSLQNIPEYNELREELLELKEKIDEIAKEKEKLTKENEELESEL-----EELREEYKKLREEN 179
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 328-354 7.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 7.41e-03
                           10        20
                   ....*....|....*....|....*..
gi 380805869   328 TALMEACMDGHVEVARLLLDSGAQVNM 354
Cdd:pfam13606    4 TPLHLAARNGRLEIVKLLLENGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1127-1278 8.87e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 8.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1127 VKLLLDMGSDINAqIETNRNTAL-----TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY---AEVGRVLL 1198
Cdd:PHA02798   54 VKLFINLGANVNG-LDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEILLFMI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380805869 1199 DKGADvnappvpssrdtalTIAADKGHYKFCELLIHRGAHIDVrnkkgntplwlasngghfDVVQLLVQAGADVDAADNR 1278
Cdd:PHA02798  133 ENGAD--------------TTLLDKDGFTMLQVYLQSNHHIDI------------------EIIKLLLEKGVDINTHNNK 180
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 226-252 9.20e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 9.20e-03
                           10        20
                   ....*....|....*....|....*..
gi 380805869   226 GNTALTYACAGGFVDIVKVLLNEGANI 252
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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