|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
28-396 |
2.07e-84 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 263.32 E-value: 2.07e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVT 187
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 188 GIAYFLFGLWLLATLERKGRFQQPDRslLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSgIADAAQ 267
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAE--KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI-LGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 268 LVAGLVLVNTMTIILFQFPTLKLLESvplFTRTRLGMALMGLAQVGFMFTPEA-FPLGWYLACFVLSMGEVIAFPTLNVQ 346
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVER---FRLRKILMIGILLFAIGFAVLAFAnTLAVLILAMIVLTLGEMLVFPAVQTL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 378796952 347 IDRLAPAHLRGSYFGAAAL-YSLGFAIAPLAGGMMIEYLNAQWLYGLCFVL 396
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALaWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-374 |
5.57e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 127.15 E-value: 5.57e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIG 110
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 190 AYFLFGLWLLATLERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIadAAQLV 269
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL--SALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 270 AGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQID 348
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWlLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 378796952 349 RLAPAHLRGSYFGAAAL-YSLGFAIAP 374
Cdd:pfam07690 318 DLAPKEERGTASGLYNTaGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-397 |
1.35e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 121.14 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIG 110
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE-RGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 190 AYFLFGLWLLATLERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLV 269
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 270 AgLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDR 349
Cdd:cd17325 239 L-LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL--LLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 378796952 350 LAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLS 397
Cdd:cd17325 316 IVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-373 |
1.12e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.68 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 26 FPVWTVLIGTLFARTSFFMAWPFLVVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFA 105
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLF 184
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER-RGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 185 IVTGIAYFLFGLWLLATLERKGRFQQpdrsllPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIAD 264
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAAR------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 265 AAQlVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEafPLGWYLACFVLSMGEVIAFPTLN 344
Cdd:COG2814 242 ASA-AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQ 318
|
330 340 350
....*....|....*....|....*....|
gi 378796952 345 VQIDRLAPAHLRGSYFGAA-ALYSLGFAIA 373
Cdd:COG2814 319 ALVAELAPPEARGRASGLYnSAFFLGGPLA 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-383 |
6.57e-23 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 100.36 E-value: 6.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 33 IGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKW-----------VMVSGTLI 101
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 102 ATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP- 180
Cdd:COG2211 97 LLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 181 ------QVLFIVTGIAYFLFGLWLLATLERKGRFQQPdrslLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLP 254
Cdd:COG2211 177 daalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEE----KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 255 QVIVRSgIADAAQLVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGWYLACFVLSM 334
Cdd:COG2211 253 YYFKYV-LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 378796952 335 GEVIAFPTLNVQIDRLAPAHL-------RGSYFGAAAL-YSLGFAIAPLAGGMMIEY 383
Cdd:COG2211 332 GLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFaIKLGQALAGALAGLLLAL 388
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-404 |
6.41e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 93.79 E-value: 6.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 53 LYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMI 132
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 133 EAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAyFLFGLWLLATLERKGRfqQPD 212
Cdd:cd17474 105 GPLALTLIGD-LFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAAL-IPVAFLAILFLLPEPK--EKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 213 RSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLvaGLVL-VNTMTIILFQFPTLKLL 291
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII--GLLFaGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 292 ES-VPLFTRTRLGMALMGLAQVGFMFTPEafpLGWYL-ACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSL 368
Cdd:cd17474 259 KKrFGARRILVIGLLLYALSLLLLGFVPS---LALLLiAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....*.
gi 378796952 369 GFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVLL 404
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
47-390 |
2.94e-18 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 85.95 E-value: 2.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 47 PFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:PRK10054 28 PFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALIN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 127 LMRPMIEAPGKAVIGDNL-PDEKDRELALNvrYFLLNLGGAIGPLIGITLALAHPQVLF----IVTGIAYFLFGLWL--- 198
Cdd:PRK10054 108 CAYSVFSTVLKAWFADNLsSTSKTKIFSLN--YTMLNIGWTVGPPLGTLLVMQSINLPFwlaaICSAFPLVFIQIWVqrs 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 199 LATLERKGRFQQPDRSLLpnfsatlrvisKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLVAGLVL-VNT 277
Cdd:PRK10054 186 EKAIATETGSVWSPSVLL-----------QDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSDFAEKVVAVVLpVNA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 278 MTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFpLGWYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRG 357
Cdd:PRK10054 255 AMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSL-LLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKA 333
|
330 340 350
....*....|....*....|....*....|...
gi 378796952 358 SYFGAAALYSLGFAIAPLAGGMMIEYLNAQWLY 390
Cdd:PRK10054 334 SYFSAQSLGWLGAAINPLVSGVILTTLPPWSLF 366
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
37-397 |
6.08e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.79 E-value: 6.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 37 FARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIW 116
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 117 QFFIMIVLTGLMRPMIEAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAYFLFGL 196
Cdd:cd06174 86 LLLLGRFLLGLGSGLIDPAVLALIAD-LFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 197 WLLATL-----ERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGiADAAQLVAG 271
Cdd:cd06174 165 AAILLLlvvpdPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG-GLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 272 LVLVNTMTIILFQFPTLKLLeSVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGWYLACFVLSMGEVIAFPTLNVQIDRLA 351
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLS-DRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 378796952 352 PAHLRGSYFG-AAALYSLGFAIAPLAGGMMI-EYLNAQWLYGLCFVLS 397
Cdd:cd06174 323 PPEIRGTAFGlLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-403 |
1.27e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 83.80 E-value: 1.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIG 110
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFIMIVLTGLMRPMIeAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAF-TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 190 ayFLFGLWLLATLeRKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLanFLMMFVYGQVESSLPQVIVRSGIADaaqlv 269
Cdd:cd17489 159 --LALLALLLVFL-VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL--FLASIAYGAISTFLPLYAAERGISN----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 270 AGLVL-VNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPeaFPLGWYLACFVLSMGEVIAFPTLNVQID 348
Cdd:cd17489 229 AGLFFtVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG--SPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 378796952 349 RLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVL 403
Cdd:cd17489 307 DLVPPHRRGAANGTfFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-397 |
2.51e-17 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 83.05 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFARTSFFMAWPFLVVFLYQDYHAtATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMV-----SGTLIAT 103
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGS-ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIladllRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEK-DRELALNVryFLLNLGGAIGPLI-GITLALAHPQ 181
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQlVRANALNS--LATQLARIIGPALgGLLVALLGPG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 182 VLFIVTGIAYFLFGLWLLA-TLERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPqVIVRS 260
Cdd:cd06173 159 GAFAINALSFLLSALLLLFiRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLP-LLAKE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 261 GIADAAQLVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLgwYLACFVLSMGEVIAF 340
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL--LAALFLLGLAGGLFN 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 378796952 341 PTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLS 397
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVyNALNSGAMPLGALLAGLLADALGLSAVFLLAGALL 373
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-405 |
1.76e-16 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 80.31 E-value: 1.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVfLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVR-EFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGLSNQIWQFFIMIVLTGLMRPMIeAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVT 187
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIAD-ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 188 GIAYFLFGLwLLATLerkgrfqqpdrsLLPNFSatlrviskdnvfvKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQ 267
Cdd:cd17330 158 AAALALLNL-VLVLF------------FLPPLR-------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 268 LVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLaqvGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQ 346
Cdd:cd17330 212 IGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII---GLLLLPFASSVPLlVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 347 IDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVLLG 405
Cdd:cd17330 289 LSKSVPSKEQGKAQGiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-416 |
6.12e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.15 E-value: 6.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFARTSFFMAW---PFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFA 105
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWylwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH-PQVLF 184
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 185 IVTGIAYFLFGLWLLATLERKGRFQQPDRSLLPnfsATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRS---G 261
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASL---RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfglS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 262 IADAAQLVAGLVLVNTMTIILFQFptlkLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGwYLACFVLSMGEVIAFP 341
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGW----LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF-LVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 342 TLNVQIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIE----YLNAQWLYGLCFVLshdGFVLLGAARARNGGERE 416
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGlVGAAGGLGGFLGPLLFGALLDatgsYTAAFLVFAVLALV---ALVLTLLLYRRPRRAAA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-199 |
3.20e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 3 KSKEKGIESSESLFQWERVGRFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYS 82
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 83 GYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLN 162
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG-RGTAMGLFNTAFS 334
|
170 180 190
....*....|....*....|....*....|....*...
gi 378796952 163 LGGAIGPLI-GITLALAHPQVLFIVTGIAYFLFGLWLL 199
Cdd:cd17325 335 LGMVLGPLLgGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-397 |
2.06e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 74.14 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 20 RVGRFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGT 99
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 100 LIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLALAH 179
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP-PKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 180 P-QVLFIVTGIAYFLFGLWllatlerkgrfqqpdrsllpnfsatlrviskdnVFVKMMLANFLMMFVYGQVESSLPQVIV 258
Cdd:COG2271 162 GwRAAFLILGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 259 RS---GIADAAQLVAGLVLVNTMTIILFQFPTLKllesvpLFTRTRLGMALMGLAQVGFMFTPEAFPLGW--YLACFVLS 333
Cdd:COG2271 209 EVrglSLAQAGLLLSLPFLAGIVGSLLGGWLSDR------LGRRRKLVLAIGLLLAALALLLLALLPSPAlaIALLFLAG 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378796952 334 MGEVIAFPTLNVQIDRLAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLS 397
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVnTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-396 |
2.12e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.42 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 25 NFPVWTVLIGTLFARTSFFMA-WPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIAT 103
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATAlWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRelALNVRYFLLNLGGAIGPLIGITLALAHP--- 180
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS--RLNLLHAFFSLGALLGPLLGGLLILLGLsls 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 181 -QVLFIVTGIAYFLFGLWLLATlerKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVR 259
Cdd:COG0738 163 wHLPYLILAVLLLLLALLFLRS---KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 260 SGIADAAQlvAGLVLVNTM-TIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGWylACFVLSMGEVI 338
Cdd:COG0738 240 VLGLSEAT--AALGLSLFWgGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALI--GLALVGLGLSL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 339 AFPTLNVQIDRLAPAH--LRGSYFGAAAlySLGFAIAPLAGGMMIEYLNAQWLYGLCFVL 396
Cdd:COG0738 316 MFPTIFSLALDGLGKRtaAAVSAVLIMG--IVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-381 |
2.60e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 59 ATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKA 138
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 139 VIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAYFLFGLWLLATLERKGRFQQPDRSLlpn 218
Cdd:cd17473 112 LIGD-YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPG--- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 219 fSATLRVISKDNVFVKMMLANFLMMFVYGQVeSSLPQVIVRSGIADAAQlvAGLVL-VNTMTIIL--FQFPTLKLLESVP 295
Cdd:cd17473 188 -AATAAALPWKRVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGGGSAAL--IGLALaIASLAGAIgaLLFGRLKRRLGKR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 296 LFtrTRLGMALMGLAQVGFMFTPeaFPLGWYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAP 374
Cdd:cd17473 264 RL--LAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIvTSAFFLGQFLSP 339
|
....*..
gi 378796952 375 LAGGMMI 381
Cdd:cd17473 340 LVLGPLV 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
18-199 |
9.09e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 66.03 E-value: 9.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 18 WERVGRFNFPVWTVLIGTLFARTSFFmAWPFLVvFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVS 97
Cdd:cd17370 192 KTSLKKLPKAFWLYLLAVALFALGNF-SFAFLI-LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 98 GTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLI-GITLA 176
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL-RGTAYGLFNTVVGIGWLLASLIaGYLWD 348
|
170 180
....*....|....*....|...
gi 378796952 177 LAHPQVLFIVTGIAYFLFGLWLL 199
Cdd:cd17370 349 LISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-201 |
1.05e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.03 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 25 NFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATF 104
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVryFLLNLGGAIGPLIGiTLALAHPQVLF 184
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL--AAYNLGGALGAALG-GLVLDHGGWAG 353
|
170
....*....|....*..
gi 378796952 185 IVTGIAYFLFGLWLLAT 201
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
28-404 |
3.64e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 3.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMV-SGTLIATFAY 106
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFL-VVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLViLGYGLSALAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 107 TGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIG---ITLALAHPQVL 183
Cdd:cd17370 80 PLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSG-RGKAFGLHRALDTLGAVLGPLLAallLYLLGGNYRTI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 184 FIVTGIAYFLFGLWLLATLERKGRfqqPDRSLLPNFSATLRVISKDnvFVKMMLANFLMMFVYgqveSSLPQVIVRSGIA 263
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPR---PPKLRKKSKKTSLKKLPKA--FWLYLLAVALFALGN----FSFAFLILRAQEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 264 DAAQLVAGLVLVNTMTI-ILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEafPLGWYLACFVLSMGEVIAFPT 342
Cdd:cd17370 230 GLSAALIPLLYALFNLVyALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS--LWLLLLGFILWGLYMGAQESI 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 378796952 343 LNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVLL 404
Cdd:cd17370 308 ERAAVADLVPAELRGTAYGLfNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-207 |
1.08e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.97 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 26 FPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGR--KWVMVSGTLIAT 103
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGP-LIGITLALAHPQV 182
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPlLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....*
gi 378796952 183 LFIVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
40-245 |
1.52e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 40 TSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFF 119
Cdd:cd17475 9 SLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 120 IMIVLTGLM-RPMIEAPGKAVIGdnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLW 197
Cdd:cd17475 89 VLLFLVGAGyGSVQPGGGRAIMR--WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGwRAAFVVAGLVSILAAVL 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 378796952 198 LLATLeRKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFV 245
Cdd:cd17475 167 FWLFY-REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAP 213
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
53-247 |
4.33e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.10 E-value: 4.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 53 LYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMI 132
Cdd:cd17328 25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 133 EAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHP--QVLFIVTGIAYFLFGLWLLATLE--RKGRF 208
Cdd:cd17328 105 SPIAPTIIADLFPKEK-RTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwRWAFRVTGVLGVLLAILLLLFVRepPRGAA 183
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 378796952 209 QQPDR--SLLPNFSATLRVISKDNVFVKMMLANFLMMFVYG 247
Cdd:cd17328 184 EGGVMakSTATSFLADLKALAKNPSFILSTLGFTAVSFVTG 224
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-199 |
1.51e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 3 KSKEKGIESSESLFQWERVGRFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYS 82
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 83 GYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLN 162
Cdd:cd06173 265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL-RGRVFSVYNALNS 343
|
170 180 190
....*....|....*....|....*....|....*...
gi 378796952 163 LGGAIGPLIGITLALAH-PQVLFIVTGIAYFLFGLWLL 199
Cdd:cd06173 344 GAMPLGALLAGLLADALgLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-203 |
4.09e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 4.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 32 LIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGTLIATFAYTGIG 110
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFIM-IVLTGLMR---PMIEAPGKAVIgdNLPDEKDRELALNVRYFLLNLGGAIGPLIG-ITLALAHPQVLFI 185
Cdd:cd17471 82 FLRNYWVLLLVgVVLLSLGAaafPQLFALAREYA--DRSSGRDATLFNSVLRAAFSLAWVIGPPLAfLLLDVLGFTGLFL 159
|
170
....*....|....*...
gi 378796952 186 VTGIAYFLFGLWLLATLE 203
Cdd:cd17471 160 LAALLYLVVALLVLFLLP 177
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-380 |
4.39e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 57.96 E-value: 4.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTS---FFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIAT 103
Cdd:COG2807 15 GRWLLLLAIVLVALNlrpAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEkdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQ 181
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALAAGLTVPLAAALgwRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 182 VLFIVTGIAYFLFGLWLLATLERKGRFQQPDRsllpnfSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSG 261
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPA------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 262 I--ADAAQLVAGLVLVNTMTIILFQFPTLKLLESVPLFTrtrLGMALMGLAQVGFMFTPEAFPLGWylaCFVLSMGEVIA 339
Cdd:COG2807 247 LsaATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL---LLGLLGLAGLLGLLLAPGSLPWLW---AVLLGLGQGGL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 378796952 340 FPT-LNVQIDRLAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMM 380
Cdd:COG2807 321 FPLaLTLIGLRARTPAEAAALSGMAqSVGYLLAALGPLLVGAL 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
9-128 |
1.20e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.41 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 9 IESSESLFQWERVGRFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK 88
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 378796952 89 FGRKWVMVSGTLIATFAYTGIGLSNQIWQfFIMIVLTGLM 128
Cdd:cd17478 257 FGRRRVIIASLLLAAPFLLLFLLTPGIWS-YILLVLAGFL 295
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
31-384 |
1.50e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.13 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIG 110
Cdd:cd17355 7 VTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFI-MIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNvryfLLNLGGAIGPLIGITLALAHPQ-------V 182
Cdd:cd17355 87 LATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERR-RGLALG----ILTAGGGLGSLVFLPLGAALIEafgwrtaL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 183 LFIVTGIAYFLFGLWLLATLERKGRFQQPDR-SLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSG 261
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYDdASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 262 I--ADAAQLVAGLVLVNTMTIILFQFptlkLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLGW-YLACFVLSMGEVI 338
Cdd:cd17355 242 IspAAAAVALALIGLFNIVGRLLSGW----LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLlFAALFGLGWGATV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 378796952 339 AFPTLNVQidRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIEYL 384
Cdd:cd17355 318 PLTAALAA--RYFGARSYGTLFGlVFAPHQLGSALGPWLGGLLYDRT 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-396 |
3.43e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 55.25 E-value: 3.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVfLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIG-PLIGITLALAHPQVLFIV 186
Cdd:cd17324 80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK-RGRAIGLVFSGLTLGLVLGrPLGGLLGQLLGWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 187 TGIAYFLFGLWLLATLERKGRFQQPDRSLLPNFSATLRviskDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAA 266
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLR----NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 267 QlVAGLVLVNTMTIILFQFPTLKLLESVPlFTRTRLGMALMGLAQVGFMFTPEAfPLGWYLACFVLSMGEVIAFPTLNVQ 346
Cdd:cd17324 235 A-IIGLLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPS-PLLLLVGLVLWGLGFFAAHSALQTR 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 378796952 347 IDRLAPAHL-RGSYFGAAALYsLGFAIAPLAGGMMIEYLNAQWLYGLCFVL 396
Cdd:cd17324 312 VLRLAPEARgLASSLYLAAYN-LGGALGAALGGLVLDHGGWAGVGWVGAAL 361
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-226 |
3.77e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.87 E-value: 3.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 52 FLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPM 131
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 132 IEAPGKAVIgdNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAYFLFGLWLLATLERKGRFQQP 211
Cdd:cd17478 101 FHPEGARLA--SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170
....*....|....*
gi 378796952 212 DRSLLPNFSATLRVI 226
Cdd:cd17478 179 KAAAKSSARSTLKGV 193
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
31-378 |
1.32e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.42 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLYQDYHATATEV----GAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAY 106
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 107 TGIGLSNQIWQFFIMIVLTGLMRPMIEApGKAVIGDNLPDEKDrELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFI 185
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPN-ATALIASQTPKEKS-GWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 186 VTGIayFLFGLWLLATLERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIvrsgiada 265
Cdd:cd17391 159 ITGG--LLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYI-------- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 266 AQLVAGLVLVNTMTIILFQFPTLKLLESVPLFTR--TRLGMA---LMGLAQVGFMFTPEAF-----PLGWYLACFVLSMG 335
Cdd:cd17391 229 RQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKlgDRIGHHrilLGALLASALLYIPQAFvqtpwQLGILRFLLGLATG 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 378796952 336 EVIafPTLNVQIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGG 378
Cdd:cd17391 309 GLL--PAINSLLAKITPKEVAGRIFGyNQSFQYLGNVAGPLLGS 350
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
31-390 |
1.62e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 31 VLIGTLFARTSFFMAWPFLVVFLYQdYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIG 110
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 111 LSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGdNLPDEKDRELALNVRYFLLNLGGAIGPLIgITLALAHPQVLFIVTGIA 190
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLN-ALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 191 YFLFGLWLLATLERKGRFQQPDRSLLPNfsatlrviskdnvFVKMMLANFLMMFVYGQVESS----LPQVIVRSGI--AD 264
Cdd:cd17477 158 LLLALVPLLLTRRAAPEIEEAESISLRR-------------LLRIAPLALLGAFVAGFLEGAfyslLPLYGLRLGLsvAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 265 AAQLVAGLVLVNtmtiILFQFPTLKLLESVPLFtRTRLGMALMGLAQVGFMFTPEAFPLGWYLACFVLSMGEVIAFPT-L 343
Cdd:cd17477 225 AALLLAAFVLGG----LLLQWPLGWLADRFDRR-RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLaL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 378796952 344 NVQIDRLAPAHLRGSYFGAAALYSLGFAIAPLAGGMMIEYLNAQWLY 390
Cdd:cd17477 300 ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLF 346
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-172 |
5.50e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.42 E-value: 5.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTSFFMAWpFLVVFLYQD-----YHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLI 101
Cdd:cd17504 178 NVLLANITALLAGFGMFMVF-QLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378796952 102 ATFAYTGIGLSNQ-IWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEkDRELALNVRYFLLNLGGAIGPLIG 172
Cdd:cd17504 257 SAVGLLLLALLHSsLWALVVALLLIGIGLGLAFASLPNIVVESVPPD-RTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-196 |
7.69e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 7.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAY 106
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 107 TGIGLS--NQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRE------LALNVRYFLLNLGGAIGPLI-GITLAL 177
Cdd:COG2211 309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALaGLLLAL 388
|
170 180
....*....|....*....|....
gi 378796952 178 AH-----PQVLFIVTGIAYFLFGL 196
Cdd:COG2211 389 FGyvagaAQSPSALTGIRLLFFLL 412
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
41-377 |
9.89e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.40 E-value: 9.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 41 SFFMAWPFLVVF---LYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQ 117
Cdd:cd17333 7 SNGLTDALLGILgpsLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 118 FFIMIVLTGLMRPMIEAPGKAVIGDNLPdeKDRELALNVRYFLLNLGGAIGPLIG--ITLALAHPQVLFIVTGIAYFLFG 195
Cdd:cd17333 87 FVVLMFLAGLGAGILDTGANTFVGALFE--ESSATRLNVLHGFFGLGALIGPLIAtsLLTSELSWSWAYLIIGLIYLLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 196 L-WLLATLERKGRFQQPDRSllpNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESS--LPQVIVRSGiaDAAQLVAGL 272
Cdd:cd17333 165 IlILLTLFPELPSARNPQQS---VGAFSASASRLLRNPSIILGALALFLYVGAETAFSswVPSYLVEKK--HVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 273 VLVNTMTII-----LFQFPTLKLLESVPLFTRTRLGMALMglaqvgFMFTPEAFPLGWYLACFVLSMGEVIAFPTLN-VQ 346
Cdd:cd17333 240 LLSGFWVGItigrlLGGPISRRIKPHTLLVLSGSGALLGL------LILLLAPTLVVGLVATALLGLFMAALFPTILsLG 313
|
330 340 350
....*....|....*....|....*....|.
gi 378796952 347 IDRLAPAHLRGSYFGAAALYSLGFAIAPLAG 377
Cdd:cd17333 314 ISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
29-200 |
1.02e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.60 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFAR----TSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLI--- 101
Cdd:cd17369 227 WRALLLAIGLRlaenVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLaal 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 102 -ATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDekdrelalNVRY----FLLNLGGAIG----PLIG 172
Cdd:cd17369 307 fAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPT--------RVRYtgasLGYQLGAILGggfaPLIA 378
|
170 180
....*....|....*....|....*...
gi 378796952 173 ITLALAHpqvlFIVTGIAYFLFGLWLLA 200
Cdd:cd17369 379 TALVAAT----GSWWPVALYLAALAVIS 402
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-314 |
1.17e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVfLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIV 186
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARE-RGRALGLWGAAIGLGLALGPLLGGLLVAALGwRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 187 TGIAYFLFGLWLLATLERKGRFQQPDRSLLPNFSATLRviskdnVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAA 266
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAAL------ALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 378796952 267 QLVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGF 314
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-207 |
1.18e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGL-SNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLALA--HPQVLF 184
Cdd:COG2223 287 LLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP-TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAF 365
|
170 180
....*....|....*....|...
gi 378796952 185 IVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-196 |
2.18e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.35 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGTLIATFA 105
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQVL 183
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI-RGTAFGLLNTFGFLGGAIGPLLAGFLLAATfgLTGA 362
|
170
....*....|...
gi 378796952 184 FIVTGIAYFLFGL 196
Cdd:cd06174 363 FLVLAVLLLLAAI 375
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
29-390 |
5.01e-06 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 48.52 E-value: 5.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTG 108
Cdd:PRK11646 13 YFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFAT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 109 IGLSNQIWQFFIMIVLTGLMRPMIEAPGKA-VIGDNLPDEKDRelalnvRYFLLNLGGAIGPLIGITLA---LAHPQVLF 184
Cdd:PRK11646 93 MAIAHEPWLLWLSCILSGLGGTLFDPPRTAlVIKLIRPHQRGR------FFSLLMMQDSAGAVIGALLGswlLQYDFRLV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 185 IVTGIAYF----LFGLWLLATLerkgRFQQPDRSLLPNFSATLRviskDNVFVK--MMLANFLMMFVygQVESSLPqvIV 258
Cdd:PRK11646 167 CATGAVLFvlaaAFNAWLLPAY----KLSTVRTPVREGMTRVLR----DKRFVTyvLTLTGYYMLAV--QVMLMLP--IM 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 259 RSGIADAAQLVAGLVLVNTMTIILFQFPTLKLLES-VPLFTRTRLGMALMGLAQVGFMFTPEAFPLGWYLACFVLsmGEV 337
Cdd:PRK11646 235 VNDIAGSPSAVKWMYAIEACLSLTLLYPIARWSEKrFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYI--GSI 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 378796952 338 IAFPTLNVQIDRLAPAHLRGSYfgaaalysLGFAIAPLAGGMMIEYLNAQWLY 390
Cdd:PRK11646 313 IAEPARETLSASLADARARGSY--------MGFSRLGLALGGAIGYIGGGWLF 357
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
27-127 |
6.95e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.93 E-value: 6.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAY 106
Cdd:cd17471 200 RLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFY 279
|
90 100
....*....|....*....|.
gi 378796952 107 TGIGLSNQIWQFFIMIVLTGL 127
Cdd:cd17471 280 LGLALATSLWQLIALQLLNAI 300
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-200 |
7.44e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 7.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 25 NFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATF 104
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQV 182
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPEL-RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTggLSG 354
|
170
....*....|....*...
gi 378796952 183 LFIVTGIAYFLFGLWLLA 200
Cdd:cd17473 355 AFLILGVLALVLAIVLLL 372
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
30-407 |
1.05e-05 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 47.82 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 30 TVLIGTLFARTSFFM-----AWpflvvfLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSG------ 98
Cdd:pfam05977 14 VIWIASLASNLGTLMqdvaaSW------LMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGqlllal 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 99 --TLIATFAYTGIglsNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLP-DEKDRELALNVRYFllNLGGAIGPLI-GIT 174
Cdd:pfam05977 88 vsTLLTLLAGLGL---LSPWLLLGLTFLGGIGTALMDPAWQASVPELVPrRDLPAAVALNSVGY--NIARSVGPALgGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 175 LALAHPQVLFIVTGIAYFlFGLWLLATLERKGRFQQ-PDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSL 253
Cdd:pfam05977 163 LAAFGPAFTFALNALSYF-AVIAALWRWKRAAPASPlPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 254 PQVivrsgiadAAQLVAGLVLVntMTIILFQFPTLKLLESVPL-FTRTRLGM-ALMGLAQVGFMFTPEAFPL--GWYLAC 329
Cdd:pfam05977 242 PLV--------ARDLLDGDAIF--YGILLGAVGVGAILGALSLpRLRERLGSdRLVLLASVVTALVLLSLALapNLWLAI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 330 FVLSMGE---VIAFPTLNVQIDRLAPAHLRGSyfgAAALYSLGFAIAPLAGGmmieylnaqWLYGLcfVLSHDG--FVLL 404
Cdd:pfam05977 312 PVLLLGGaawITALTTLNVAVQLSVPRWVRGR---ALAVYQTVFFGGMAAGS---------WLWGA--VAEALSvtGALL 377
|
...
gi 378796952 405 GAA 407
Cdd:pfam05977 378 GAA 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
48-202 |
1.20e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 48 FLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:cd17474 220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378796952 127 LMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLI-GITLALAHPQVLFIVTGIAyFLFGLWLLATL 202
Cdd:cd17474 300 LGLGLNLPLLTTLVTELAPEEE-RGTASSLYNFVRFLGQAVGPLLfGLLLEIFGLSAPFLVGAAI-ALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
67-210 |
1.85e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.58 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 67 MLATSALVGSLTG-LYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLP 145
Cdd:TIGR00895 56 FLFSAGLIGMAFGaLFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAP 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378796952 146 DeKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATLERKGRFQQ 210
Cdd:TIGR00895 136 K-RFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGwRSLFYVGGIAPLLLLLLLMRFLPESIDFLV 200
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
55-373 |
2.13e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17321 24 RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 135 PGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLI-GITLALAHPQVLFIVTGIayflFGLWLLAtlerkgrfqqpdr 213
Cdd:cd17321 104 ASLALIAATFPGER-RGRALGLWGAVVGIGAALGPLLgGLLLELFGWRWIFLINVP----IGLVALL------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 214 sLLPNFSATlrviskdnvfvkmMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlvAGLVLVnTMTIILFQFPTL--KLL 291
Cdd:cd17321 166 -LARTFSGA-------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ--AGLALL-PLALAMLVAAPLagRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 292 ESVPLFTRTRLGMALMGLAQVGFMFTPEAFPLG-WYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLG 369
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWlLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGIlNTARQLG 308
|
....
gi 378796952 370 FAIA 373
Cdd:cd17321 309 GALG 312
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
48-342 |
2.24e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 48 FLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG------RKWVMVSG---TLIATFAYTGIGLSN--QIW 116
Cdd:cd17332 21 YLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgrfRPWLLWGAiplALLFVLLFTTPDGSGtgKLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 117 QFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIG----PLIGITLALAHPQVLFIVTGIAY- 191
Cdd:cd17332 101 YALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVtvlpPPLVAYFGGGNASRGYFLTALIIg 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 192 --FLFGLWLLATLERKGRFQQPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAA-QL 268
Cdd:cd17332 181 iiGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAElVL 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378796952 269 VAGLVLVNTMTIILFQFPTLKLLESVPLFtrtRLGMALMGLAQVGFMFTPEAFPLGWYLACFVLSMGEVIAFPT 342
Cdd:cd17332 261 LLLLILSGALLALLPWPPLKKRFGKKKAF---FIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLL 331
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-405 |
2.50e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.04 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 47 PFLVVFlYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGTLIATFAYTGIGLSNQI-WQFFIMIVL 124
Cdd:cd17335 18 PFLSVY-LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIfWLLLLLVIL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 125 TGLM----RPMIEAPGKAVIGDNlpdekdrelalNVRYFLLNLGGAIG-----PLIGITLALAH----PQVLFIVTGIay 191
Cdd:cd17335 97 GAFFsapvVPLVDSITLQYLGEE-----------RERYGKQRLWGSIGfgiaaLLVGILIDRSStyknYTIAFYVFAV-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 192 FLFGLWLLATlerKGRFQQPDRSLLPNFSAtLRVISKDNVFVKMMLANFLMMFVYGQVESSLpqVIVRSGIADAAQLVAG 271
Cdd:cd17335 164 LMLLALLLAL---KFPFRPKHPEPNENTGG-LLALLRNPRVLAFLLVAFLMGFGHGLIYSFL--FWHLQDLGGSKTLIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 272 LVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAfplgWYL--------ACFVLSMGEVIAFptl 343
Cdd:cd17335 238 LWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENP----WLVlpiellhgLTFALVWAAAVSY--- 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378796952 344 nvqIDRLAPAHLRGSYFG--AAALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVLLG 405
Cdd:cd17335 311 ---ASAAAPPGLRATAQGllQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-207 |
2.66e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 46.30 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYT 107
Cdd:COG2270 240 LLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRElalnvrYF-LLNLGG----AIGP-LIGITLALAHPQ 181
Cdd:COG2270 320 AAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAE------FFgLYALSGkaasFLGPlLFGLVTQLTGSQ 393
|
170 180
....*....|....*....|....*.
gi 378796952 182 VLFIVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2270 394 RLGILSLIVFFVIGLVLLLRVKVPRG 419
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-172 |
5.48e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 5.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17323 27 EDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLA 106
|
90 100 110
....*....|....*....|....*....|....*...
gi 378796952 135 PGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIG 172
Cdd:cd17323 107 IGAGTIAD-LFTPEERGKAMGVYSLGPLLGPALGPIIG 143
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-202 |
7.05e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.57 E-value: 7.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFARTSFFM---AWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFA 105
Cdd:cd17312 2 WRIFLGVFLGYAAYYVcrkNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGdNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLF 184
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLG-NWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGwRAAF 160
|
170
....*....|....*...
gi 378796952 185 IVTGIAYFLFGLWLLATL 202
Cdd:cd17312 161 LVPGIVGLVVAIILFFFL 178
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-169 |
1.06e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 3 KSKEKGIESSESLFQWERVGRFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYS 82
Cdd:pfam07690 176 ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 83 GYLSDKFGRK---WVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYF 159
Cdd:pfam07690 256 GRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE-RGTASGLYNT 334
|
170
....*....|
gi 378796952 160 LLNLGGAIGP 169
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-196 |
1.38e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIA---TF 104
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgilAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMieAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGP-LIGITLALAHPQVL 183
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGV--WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPpLIALLLASTGGTGV 336
|
170
....*....|...
gi 378796952 184 FIVTGIAYFLFGL 196
Cdd:cd17316 337 PALILALLAIVAL 349
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-193 |
1.44e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 23 RFNFPVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLT-GLYSGYLSDKFGRKWVMVSGTLI 101
Cdd:cd17330 171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 102 ATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDeKDRELALNVRYFLLNLGGAIGPLI-GITLALAHP 180
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS-KEQGKAQGIIQSLQSLARIIGPLLaGPLYSFLGP 329
|
170
....*....|...
gi 378796952 181 QVLFIVTGIAYFL 193
Cdd:cd17330 330 GVPFLLAAGLLLI 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
231-397 |
1.55e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 231 VFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAqlVAGLVLVNTMTIILFQFPTLKLLESVPLFTRTRLGMALMGLA 310
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ--AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 311 QVGFMFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIEYLNAQWL 389
Cdd:COG2814 89 SLLCALAPSLWLL--LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLlGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
....*...
gi 378796952 390 YGLCFVLS 397
Cdd:COG2814 167 FLVNAVLA 174
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
63-199 |
3.52e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.60 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 63 EVGAMLATSALVGSLTG---LYS----GYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIeAP 135
Cdd:cd17390 25 SLGASPTVIGLIGSVYGalqLFSsplvGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQ-SL 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378796952 136 GKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITL----------ALAHPQVLFIVTGIAYFLFG-LWLL 199
Cdd:cd17390 104 CKAYLSD-LVSEQERSRVLGRFNAASSLGFILGPVVGGHLaetdggfyyvALLCSAIFILNAGLVWFLLSkLWDL 177
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
47-375 |
3.80e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 47 PFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:cd17388 23 PTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 127 LMRPMIeAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIV----TGIAYFLFGLWLLATL 202
Cdd:cd17388 103 ITGATG-AVAAAYIAD-VTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVaaglNGLNFLLGLFVLPESL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 203 ERKGRFQQPDRSLLPnfSATLRVISKDNVFVKMMLANFLMMFVyGQVESSLPQVIVRSGIADAAQLVAGLVLVNTMTIIL 282
Cdd:cd17388 181 PPERRRAFRWRRANP--FGSLRWLTGFPGLLGLLAVFFLIQLI-GQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHAL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 283 FQ-FPTLKLLESVPLFTRTRLGMALMGLAQVGFMFTPEAFplgWYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFG 361
Cdd:cd17388 258 FQaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGW---MVFPILILLALGGIAGPALQGLLSRQVPENEQGELQG 334
|
330
....*....|....*
gi 378796952 362 A-AALYSLGFAIAPL 375
Cdd:cd17388 335 VlTSLTSLTSIIGPL 349
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-202 |
4.34e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.36 E-value: 4.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 37 FARTSFFMAWPFLVvflyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIW 116
Cdd:TIGR00881 9 LVRKNFALAMPYLV----EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 117 QFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIgITLALAHP---QVLFIVTGIAYFL 193
Cdd:TIGR00881 85 VMAALWALNGIFQGMGWPPCGRTVTKWFS-RSERGTWVSFWNCSHNVGGGLLPPL-VLFGIAELyswHWVFIVPGIIAII 162
|
....*....
gi 378796952 194 FGLWLLATL 202
Cdd:TIGR00881 163 VSLICFLLL 171
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
23-128 |
4.37e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 23 RFNFPVWTVLIGTLFARTSFFMAWPFLVVFL-----------YQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGR 91
Cdd:cd17313 231 IMPRSLLRLLLVIFFWWIAFFPFELFFTDYMgeevyhgtsaaSSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGR 310
|
90 100 110
....*....|....*....|....*....|....*..
gi 378796952 92 KWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLM 128
Cdd:cd17313 311 KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
29-407 |
4.92e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 42.18 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGS--LTGLYSGYLSDKF-GRKWVMVSGTLIATFA 105
Cdd:cd17346 5 YTLFFTEMWERFSYYGMRAILILYLTAQLGDGFSEADAASIYGAYTALvyLTPIIGGWLADKVlGARRTVFIGGILMALG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQI-WQFFIMIVL----TGLMRPMIEApgkaVIGDNLP-DEKDRELALNVRYFLLNLGGAIGPLIGITLALAH 179
Cdd:cd17346 85 YLLLALSPFSvSMLYLGLALiivgNGLFKPNISS----LVGKLYDeNDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 180 P-QVLFIVTGIAyFLFGLWLLATLERKgrfqqpdrsllpnFSATLRVIskdnVFVKMMLANFLMMFVYGQVESSLPQVI- 257
Cdd:cd17346 161 GyHYGFGLAAVG-MLLGLLIFLLGRKK-------------LLERKKML----AIIILFLFAVVFWAIYEQAGTSLALFAd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 258 --VRSGIADAAQLVAGLVLVNTMTIILFQFPTLKLL-------ESVPLFTRTRLGMALMGLA----QVGFMFTPEAFPLG 324
Cdd:cd17346 223 enVDRLLGGFTIPPSWFQSLNPLFIILLAPILAALWtklgkrgKDPSIPTKFALGLLLLGLSfllmVLAASFAGGSGKVS 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 325 WY---LACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGaaaLYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGF 401
Cdd:cd17346 303 ALwlvLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMG---LWFLASALGNILAGYLAGFYAQPKDPLASALVYTDYF 379
|
....*.
gi 378796952 402 VLLGAA 407
Cdd:cd17346 380 GLIGVI 385
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
60-127 |
9.35e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 41.43 E-value: 9.35e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378796952 60 TATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGTLIATFAYTGIG------LSNQIWQFFIMIVLTGL 127
Cdd:cd17385 234 SPGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLLGL 308
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
60-198 |
9.57e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 60 TATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGL-SNQIWQFFIMIVLTGLMRPMIEAPGKA 138
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLvPGLPLALLVLLFLWGGAAGPLYTLALA 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378796952 139 VIGDNLPDekDRELALNVRY-FLLNLGGAIGPLI-GITLALAHPQVLFIVTGIAYFLFGLWL 198
Cdd:cd17477 301 LAGDRLPG--DELVAANAALlLLYGLGSVIGPLLaGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
68-202 |
9.73e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.03 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 68 LATSALVGSLTG-LYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPd 146
Cdd:cd17365 39 VGSAALFGMAIGaLLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAP- 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 378796952 147 EKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATL 202
Cdd:cd17365 118 ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGwRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-175 |
1.01e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 32 LIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAY---TG 108
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTlllAF 263
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378796952 109 IGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITL 175
Cdd:cd17503 264 LTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQ-IGDATALFNTIRQLGGSIGTALLATL 329
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
44-195 |
1.37e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 44 MAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGTLIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 123 VLTGLMRPMIeAPGKAVIGDNLPDEKDReLALNVRYFLLNLGGAIGPLI---------------GITLALAHPQVLFIVT 187
Cdd:cd17341 96 FLLGFAGANF-ASGQPWASFWFPKEKIG-GAAGGIAGAGNMGVAVSQLLapliagaivfdggfvGWRNAFFVPGILLAIA 173
|
....*...
gi 378796952 188 GIAYFLFG 195
Cdd:cd17341 174 AVLVLLFG 181
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
33-204 |
1.54e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.67 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 33 IGTLFARTSFFMAWPFLVVFLYQdyhATATEVGAMLATSALVGSLTGLYS-------GYLSDKFGRKWVMVSGTLIATFA 105
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQ---LGVTGHSALNMWSGLVFSITFLFSaiaspfwGGLADRKGRKIMLLRSALGMGIV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEApGKAVIGDNLPDEKDrELALNVRYFLLNLGGAIGPLIGITLALAH--PQVL 183
Cdd:PRK09874 98 MVLMGLAQNIWQFLILRALLGLLGGFVPN-ANALIATQVPRNKS-GWALGTLSTGGVSGALLGPLAGGLLADSYglRPVF 175
|
170 180
....*....|....*....|.
gi 378796952 184 FIVTGIAYFLFGLWLLATLER 204
Cdd:PRK09874 176 FITASVLFLCFLVTLFCIREN 196
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-380 |
2.50e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17320 27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 135 PGKAVIGDNLPDEKdrelaLNVRYFLLNLGGAIGPLI-----GITLALAHPQVLFI---VTGIAYFLFGLWLLATLERKG 206
Cdd:cd17320 107 VARAIVRDLYSGAE-----LAKIFSLLMMILAIAPALapllgGLLLLFFGWRAIFVflaLLGLLLLLLVLLFLPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 207 RFQQPDRSLLPNFSATLrvisKDNVFVKMML---ANFLMMFVYgqvESSLPQVIVRSGIADAAQlVAGLVLVNTMTIILF 283
Cdd:cd17320 182 KRKPLLSSLLRAYKRVL----KNRRFLGYALalgLSFAGLFAY---LAAAPFIYIEQLGLSPAQ-FGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 284 QFPTLKLLESVPLFTRTRLGMALMGLAQVGFMFT-----PEAFPLGWYLACFVLSMGevIAFPTLNVQIDRLAPaHLRGS 358
Cdd:cd17320 254 SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGFG--LIFPNATSLALEPFP-HVAGT 330
|
330 340
....*....|....*....|..
gi 378796952 359 yfGAAALYSLGFAIAPLAGGMM 380
Cdd:cd17320 331 --ASALLGFLQFLIGALAGALV 350
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
52-127 |
2.74e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 39.86 E-value: 2.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378796952 52 FLYQDYHATATEVGaMLATSALVGSLTG-LYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGL 127
Cdd:cd17359 26 FLQTDFNLTPFLEG-LVVSSALLGAAIGaLFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGL 101
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
83-207 |
4.28e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 39.04 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 83 GYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLn 162
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVL- 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 378796952 163 LGGAIGPLIGITL-ALAHPQVLFIVTG----IAYFLFGLWLLATLERKGR 207
Cdd:PRK15403 151 VAPIIGPLSGAALmHFVHWKVLFAIIAvmglIAFVGLLLAMPETVKRGAV 200
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
29-196 |
4.42e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.15 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 29 WTVLIGTLFA-------RTSFFMAWPFLVvflyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLI 101
Cdd:cd17345 2 WQVFLGIFIGyagyylvRNNFSLAQPYLI----EQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 102 ATFAYTGIGLSN----QIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAI-GPLIGITLA 176
Cdd:cd17345 78 SAIINILIGFVPsatsSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFS-KKERGTWTSIWNISHNVGGGLvGPLAGLGLA 156
|
170 180
....*....|....*....|...
gi 378796952 177 L---AHPQVLFIVTGIAYFLFGL 196
Cdd:cd17345 157 IfgdGWWRGAFIFPAIIAIIVAV 179
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
43-397 |
4.73e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.12 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 43 FMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17472 13 FLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 123 VLTGLmrPMIEAPGKAVIGDNLPDEK-DRELAL--NVRYFLLNLGGAIGPLIGITLALahpQVLFIVTGIAYFLFGLWLL 199
Cdd:cd17472 93 ALQGS--GAISSVVMALLADLTREENrTKAMALigASIGIAFAISMVLGPLLAAHLGV---SGLFLITAILSLVSLLILL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 200 ATLERKGRFQQPDRSLLPNFSATLrvisKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlvaGLVLVNTMT 279
Cdd:cd17472 168 FFVPDPPKIVQISEKEKKKLKKLL----KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL---WKVYLPAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 280 IILF-QFPTLKLLE----SVPLFtrtRLGMALMGLAQVGFMFTPEAFPLgwylacfvLSMGEVIAF-------PTLNVQI 347
Cdd:cd17472 241 IGFIlMVPFVIYAEkkgkMKQVF---VSSILLIAVGFLLLLFAATSLWL--------LIIGLIIFFigfnlleALLPSLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 378796952 348 DRLAPAHLRGSyfgAAALYS----LGFAIAPLAGGMMIEYLNAQWLYGLCFVLS 397
Cdd:cd17472 310 SKIAPKEYRGT---AMGIYNtsqfLGSFLGGALGGLLWGLLGYSSVFLTILILA 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-168 |
5.36e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 27 PVWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAY 106
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378796952 107 ---TGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIG 168
Cdd:cd17321 249 lllALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEK-AGAASGILNTARQLGGALG 312
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-198 |
5.40e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.70 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 28 VWTVLIGTLFARTSFFMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGR-KWVMVSGTLIATFAY 106
Cdd:cd17502 169 ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILMSVGA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 107 ---TGIGLSNQIWQFFIMIVLTGL-MRPMIEAPGKAVIgdNLPDEKDRELALNVRYFLLNLGGAIGpligitLALAHPQV 182
Cdd:cd17502 249 gllTTLTLDTSKWLLIGYLILLGLgLGIGFQQPLVAVQ--NAVPPADVGVATATNTFFRSLGGTLG------VAITDVFL 320
|
170
....*....|....*.
gi 378796952 183 LFIVTGIAYFLFGLWL 198
Cdd:cd17502 321 VALALAALAFLLSLFL 336
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
43-127 |
6.61e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 43 FMAWPFLVVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94
|
....*
gi 378796952 123 VLTGL 127
Cdd:cd17371 95 ALAGL 99
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
47-403 |
7.84e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 47 PFLVVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVLT 125
Cdd:cd17490 17 PFLSPYA-ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 126 GLMRPMIEAPGKAVIGDNLPDEKDRELALNVryFLLNLGGAIGPLIGiTLALAHP--QVLFIVTGIAYFLfGLWLLATLE 203
Cdd:cd17490 96 GIAAATWVSFTVLYASYFPPDEAAKAMGLIN--LVNNLGQLIAFLIG-GLIAEHFgmRAPFLLAALAGVL-GFILSLFIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 204 RKGRfqqPDRSLLPNFSATLRVISKDNVFVKMMLANFLMMFVYGQVESSLPQVivrsgiadAAQLVAGLVLVNTMTIILF 283
Cdd:cd17490 172 EERR---EKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLI--------AKQLGASSFQLGLLSIIYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 284 QFPTLKLLESVPLFTRTR-------LGMALMGLAQVGFMFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDRLAPAHLR 356
Cdd:cd17490 241 LPNALASLLSGTLFYKKLgerntiiIGFLLLGAYCFLIPFAPNLTLL--YLLQALNGFGTGILFPLLMSLSIEGVPAEQR 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 378796952 357 GSYFGA-AALYSLGFAIAPLAGGMMIEYLNAQWLYGLCFVLSHDGFVL 403
Cdd:cd17490 319 STAMGFfQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
56-373 |
8.18e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 8.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 56 DYHATATEVgAMLATSALVGSLTGL-YSGYLSDKFGRKWVMVSGTLIATFAYTGIGLSNQIWQFFIMIVL----TGLMRP 130
Cdd:cd17503 25 DLGASLDTV-QWVITSYLLALAIMIpLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILqgfgGGVLIP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 131 MieapGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIG--ITLALAHPQVLFIVTGIAyfLFGLWLLATLErkgrf 208
Cdd:cd17503 104 L----AQTILLRIYPPEK-RGAAMGLVGLVILLAPAIGPTLGgwLTDNLSWRWIFYINLPIG--ILALLLAPLLD----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 209 qqpdrsllpnfsatLRVIsKDNVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAaqLVAGLVL----VNTMTIILFQ 284
Cdd:cd17503 172 --------------LRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA--FESGLVLapggLASAILSPLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378796952 285 FPTLKLLESVPLFTrtrLGMALMGLAQVGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSyfgAA 363
Cdd:cd17503 235 GRLLDKFGPRLLLL---AGLLLLALGTLLLAFLTPDTSLWLiILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGD---AT 308
|
330
....*....|....
gi 378796952 364 ALYS----LGFAIA 373
Cdd:cd17503 309 ALFNtirqLGGSIG 322
|
|
| |
