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Conserved domains on  [gi|377652548|gb|AFB71165|]
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SAM domain and HD domain-containing protein 1 [Mandrillus leucophaeus]

Protein Classification

SAM domain-containing protein( domain architecture ID 12966159)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdhJ COG1078
HD superfamily phosphohydrolase [General function prediction only];
115-457 1.98e-77

HD superfamily phosphohydrolase [General function prediction only];


:

Pssm-ID: 440696 [Multi-domain]  Cd Length: 340  Bit Score: 249.71  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 115 MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALGEKQPElqISER 194
Cdd:COG1078    1 MKIIRDPVHGYIEVDELELDLIDTPEFQRLRRIKQLGLAYLVYPGAEHTRFEHSLGVMHLARRALDRLRRKGVE--IDEE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 195 DILCVQIAGLCHDLGHGPFSHMFDGRFiplarpEVKWTHEQGSVMmfehLINSNGIKPVMEHYGLIPEEDICFIkeqivg 274
Cdd:COG1078   79 ERELVRAAALLHDIGHGPFSHAFEEVL------LTGVDHEEITLR----IIEENEINGILEKHGIDPELVADII------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 275 plespvkgvlwpyKGRPERKsFLYEIVSnkrNGIDVDKWDYFARDCHHLGIQN-NFDYKRFIKFARVceVDDELRIcaRD 353
Cdd:COG1078  143 -------------KGEYPNK-FLRQLIS---SQLDADRMDYLLRDSYYTGVSYgNIDLERLIRMLRV--VDDELVV--EE 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 354 KEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKAdnyIEITGAGGKKYRIstaidDMEAYTKLTDNIFLEIL-- 431
Cdd:COG1078  202 KGIYAVESFLIARYLMYWQVYFHKTSRAAEVMLRRALERA---KELYDEGELENPL-----DLEDFLRLDDYDLLSALke 273

                        330       340
                 ....*....|....*....|....*...
gi 377652548 432 --YSTDPKLKDareILKQIEYRNLFKYV 457
Cdd:COG1078  274 wqDHPDPILSD---LARRLLNRKLFKRV 298
SAM_HD cd09508
SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily ...
 41-110 1.40e-30

SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon).


:

Pssm-ID: 188907  Cd Length: 70  Bit Score: 113.95  E-value: 1.40e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  41 DYKTWGPEQVCVFLRRGGFGEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQRSGQI 110
Cdd:cd09508    1 DFRSWDPEDVCQFLRGNGFGEPELLEIFRENEITGAHLPDLTESRLEKLGVSSLGERLKLLKCLQKLSQI 70
 
Name Accession Description Interval E-value
YdhJ COG1078
HD superfamily phosphohydrolase [General function prediction only];
115-457 1.98e-77

HD superfamily phosphohydrolase [General function prediction only];


Pssm-ID: 440696 [Multi-domain]  Cd Length: 340  Bit Score: 249.71  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 115 MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALGEKQPElqISER 194
Cdd:COG1078    1 MKIIRDPVHGYIEVDELELDLIDTPEFQRLRRIKQLGLAYLVYPGAEHTRFEHSLGVMHLARRALDRLRRKGVE--IDEE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 195 DILCVQIAGLCHDLGHGPFSHMFDGRFiplarpEVKWTHEQGSVMmfehLINSNGIKPVMEHYGLIPEEDICFIkeqivg 274
Cdd:COG1078   79 ERELVRAAALLHDIGHGPFSHAFEEVL------LTGVDHEEITLR----IIEENEINGILEKHGIDPELVADII------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 275 plespvkgvlwpyKGRPERKsFLYEIVSnkrNGIDVDKWDYFARDCHHLGIQN-NFDYKRFIKFARVceVDDELRIcaRD 353
Cdd:COG1078  143 -------------KGEYPNK-FLRQLIS---SQLDADRMDYLLRDSYYTGVSYgNIDLERLIRMLRV--VDDELVV--EE 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 354 KEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKAdnyIEITGAGGKKYRIstaidDMEAYTKLTDNIFLEIL-- 431
Cdd:COG1078  202 KGIYAVESFLIARYLMYWQVYFHKTSRAAEVMLRRALERA---KELYDEGELENPL-----DLEDFLRLDDYDLLSALke 273

                        330       340
                 ....*....|....*....|....*...
gi 377652548 432 --YSTDPKLKDareILKQIEYRNLFKYV 457
Cdd:COG1078  274 wqDHPDPILSD---LARRLLNRKLFKRV 298
SAM_HD cd09508
SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily ...
 41-110 1.40e-30

SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon).


Pssm-ID: 188907  Cd Length: 70  Bit Score: 113.95  E-value: 1.40e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  41 DYKTWGPEQVCVFLRRGGFGEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQRSGQI 110
Cdd:cd09508    1 DFRSWDPEDVCQFLRGNGFGEPELLEIFRENEITGAHLPDLTESRLEKLGVSSLGERLKLLKCLQKLSQI 70
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 162-335 2.22e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 70.83  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 162 HNRFEHSLGVGYLAGCLVRALGekqpelqISERDILCVQIAGLCHDLGHGPFSHMFdgrfiplarpevkwtHEQGSVMMF 241
Cdd:cd00077    1 EHRFEHSLRVAQLARRLAEELG-------LSEEDIELLRLAALLHDIGKPGTPDAI---------------TEEESELEK 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 242 EHLINSNGIKpvmehYGLIPEEDICFIKEqIVGPLESPVKGVLWPYKGRPERKSflYEIVSNKRNGIDVDKWDYFARDCH 321
Cdd:cd00077   59 DHAIVGAEIL-----RELLLEEVIKLIDE-LILAVDASHHERLDGLGYPDGLKG--EEITLEARIVKLADRLDALRRDSR 130

                        170
                 ....*....|....*
gi 377652548 322 HLGIQ-NNFDYKRFI 335
Cdd:cd00077  131 EKRRRiAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 160-245 5.77e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 63.08  E-value: 5.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548   160 ASHNRFEHSLGVGYLAGCLVRALGEKqpelqiserDILCVQIAGLCHDLGHGPFSHMFDGRFIPLarpevkWTHEQGSVM 239
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELGLL---------DIELLLLAALLHDIGKPGTPDSFLVKTSVL------EDHHFIGAE 65


                   ....*.
gi 377652548   240 MFEHLI 245
Cdd:smart00471  66 ILLEEE 71
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 42-105 1.48e-09

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 54.22  E-value: 1.48e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377652548    42 YKTWGPEQVCVFLRRGGFGEpaLLKNIRENKITGALLPCLD-ESHFENLGVSSLGERKKLLSYIQ 105
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQ--YADNFRKNGIDGALLLLLTsEEDLKELGITKLGHRKKILKAIQ 63
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 164-266 2.61e-09

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 54.93  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  164 RFEHSLGVGYLAGCLVRALGEKQPELqiserdilcVQIAGLCHDLGHGPFS-----------HMFDGRFIPLARPEVKWt 232
Cdd:pfam01966   1 RLEHSLRVALLARELAEELGELDREL---------LLLAALLHDIGKGPFGdekpefeiflgHAVVGAEILRELEKRLG- 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 377652548  233 heqgsVMMFEHLINS-NGIKPVMEHYGLIPEEDIC 266
Cdd:pfam01966  71 -----LEDVLKLILEhHESWEGAGYPEEISLEARI 100
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 44-106 2.30e-07

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 48.03  E-value: 2.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 377652548   44 TWGPEQVCVFLRrgGFGEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:pfam00536   2 GWSVEDVGEWLE--SIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQR 62
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 134-215 3.77e-05

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 46.45  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 134 RIIDTPQFQRLRYIKQlgggyyVFPGAS----HNRFEHSLGVGylagCLVRALG--------EKQPELQISERDI-LCVQ 200
Cdd:PRK01096  34 RIIFSGSFRRLQRKTQ------VHPLAKndhiHTRLTHSLEVS----CVGRSLGmrvgetlkEEKLPDWISPADIgAIVQ 103

                         90
                 ....*....|....*
gi 377652548 201 IAGLCHDLGHGPFSH 215
Cdd:PRK01096 104 SACLAHDIGNPPFGH 118
 
Name Accession Description Interval E-value
YdhJ COG1078
HD superfamily phosphohydrolase [General function prediction only];
115-457 1.98e-77

HD superfamily phosphohydrolase [General function prediction only];


Pssm-ID: 440696 [Multi-domain]  Cd Length: 340  Bit Score: 249.71  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 115 MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALGEKQPElqISER 194
Cdd:COG1078    1 MKIIRDPVHGYIEVDELELDLIDTPEFQRLRRIKQLGLAYLVYPGAEHTRFEHSLGVMHLARRALDRLRRKGVE--IDEE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 195 DILCVQIAGLCHDLGHGPFSHMFDGRFiplarpEVKWTHEQGSVMmfehLINSNGIKPVMEHYGLIPEEDICFIkeqivg 274
Cdd:COG1078   79 ERELVRAAALLHDIGHGPFSHAFEEVL------LTGVDHEEITLR----IIEENEINGILEKHGIDPELVADII------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 275 plespvkgvlwpyKGRPERKsFLYEIVSnkrNGIDVDKWDYFARDCHHLGIQN-NFDYKRFIKFARVceVDDELRIcaRD 353
Cdd:COG1078  143 -------------KGEYPNK-FLRQLIS---SQLDADRMDYLLRDSYYTGVSYgNIDLERLIRMLRV--VDDELVV--EE 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 354 KEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKAdnyIEITGAGGKKYRIstaidDMEAYTKLTDNIFLEIL-- 431
Cdd:COG1078  202 KGIYAVESFLIARYLMYWQVYFHKTSRAAEVMLRRALERA---KELYDEGELENPL-----DLEDFLRLDDYDLLSALke 273

                        330       340
                 ....*....|....*....|....*...
gi 377652548 432 --YSTDPKLKDareILKQIEYRNLFKYV 457
Cdd:COG1078  274 wqDHPDPILSD---LARRLLNRKLFKRV 298
SAM_HD cd09508
SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily ...
 41-110 1.40e-30

SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon).


Pssm-ID: 188907  Cd Length: 70  Bit Score: 113.95  E-value: 1.40e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  41 DYKTWGPEQVCVFLRRGGFGEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQRSGQI 110
Cdd:cd09508    1 DFRSWDPEDVCQFLRGNGFGEPELLEIFRENEITGAHLPDLTESRLEKLGVSSLGERLKLLKCLQKLSQI 70
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 162-335 2.22e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 70.83  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 162 HNRFEHSLGVGYLAGCLVRALGekqpelqISERDILCVQIAGLCHDLGHGPFSHMFdgrfiplarpevkwtHEQGSVMMF 241
Cdd:cd00077    1 EHRFEHSLRVAQLARRLAEELG-------LSEEDIELLRLAALLHDIGKPGTPDAI---------------TEEESELEK 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 242 EHLINSNGIKpvmehYGLIPEEDICFIKEqIVGPLESPVKGVLWPYKGRPERKSflYEIVSNKRNGIDVDKWDYFARDCH 321
Cdd:cd00077   59 DHAIVGAEIL-----RELLLEEVIKLIDE-LILAVDASHHERLDGLGYPDGLKG--EEITLEARIVKLADRLDALRRDSR 130

                        170
                 ....*....|....*
gi 377652548 322 HLGIQ-NNFDYKRFI 335
Cdd:cd00077  131 EKRRRiAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 160-245 5.77e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 63.08  E-value: 5.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548   160 ASHNRFEHSLGVGYLAGCLVRALGEKqpelqiserDILCVQIAGLCHDLGHGPFSHMFDGRFIPLarpevkWTHEQGSVM 239
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELGLL---------DIELLLLAALLHDIGKPGTPDSFLVKTSVL------EDHHFIGAE 65


                   ....*.
gi 377652548   240 MFEHLI 245
Cdd:smart00471  66 ILLEEE 71
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 49-106 3.64e-10

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 55.71  E-value: 3.64e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 377652548  49 QVCVFLRRGGFGEpaLLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:cd09487    1 DVAEWLESLGLEQ--YADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 42-105 1.48e-09

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 54.22  E-value: 1.48e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377652548    42 YKTWGPEQVCVFLRRGGFGEpaLLKNIRENKITGALLPCLD-ESHFENLGVSSLGERKKLLSYIQ 105
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQ--YADNFRKNGIDGALLLLLTsEEDLKELGITKLGHRKKILKAIQ 63
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 164-266 2.61e-09

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 54.93  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  164 RFEHSLGVGYLAGCLVRALGEKQPELqiserdilcVQIAGLCHDLGHGPFS-----------HMFDGRFIPLARPEVKWt 232
Cdd:pfam01966   1 RLEHSLRVALLARELAEELGELDREL---------LLLAALLHDIGKGPFGdekpefeiflgHAVVGAEILRELEKRLG- 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 377652548  233 heqgsVMMFEHLINS-NGIKPVMEHYGLIPEEDIC 266
Cdd:pfam01966  71 -----LEDVLKLILEhHESWEGAGYPEEISLEARI 100
SAM_BOI-like_fungal cd09535
SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal ...
 43-106 2.00e-07

SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal subfamily is a potential protein-protein interaction domain. Proteins of this subfamily are apparently scaffold proteins, since most contain SH3 and PH domains, which are also protein-protein interaction domains, in addition to SAM domain. BOI-like proteins participate in cell cycle regulation. In particular BOI1 and BOI2 proteins of budding yeast S.cerevisiae are involved in bud formation, and POB1 protein of fission yeast S.pombe plays a role in cell elongation and separation. Among binding partners of BOI-like fungal subfamily members are such proteins as Bem1 and Cdc42 (they are known to be involved in cell polarization and bud formation).


Pssm-ID: 188934  Cd Length: 65  Bit Score: 48.32  E-value: 2.00e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377652548  43 KTWGPEQVCVFLRRGGFgEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:cd09535    1 RSWSPEQVAEWLLSAGF-DDSVCEKFRENEITGDILLELDLEDLKELDIGSFGKRFKLWNEIKS 63
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 44-106 2.30e-07

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 48.03  E-value: 2.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 377652548   44 TWGPEQVCVFLRrgGFGEPALLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:pfam00536   2 GWSVEDVGEWLE--SIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQR 62
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
42-106 4.67e-07

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 47.26  E-value: 4.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 377652548   42 YKTWGPEQVCVFLRRGGFGEpaLLKNIRENKITGA-LLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:pfam07647   1 VESWSLESVADWLRSIGLEQ--YTDNFRDQGITGAeLLLRLTLEDLKRLGITSVGHRRKILKKIQE 64
SAM_Ste11_fungal cd09534
SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a ...
 45-106 6.27e-06

SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a protein-protein interaction domain. Proteins of this subfamily have SAM domain at the N-terminus and protein kinase domain at the C-terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response. MAP triple kinase Ste11 from S.cerevisia is known to interact with Ste20 kinase and Ste50 regulator. These kinases are able to form homodimers interacting through their SAM domains as well as heterodimers or heterogenous complexes when either SAM domain of monomeric or homodimeric form of Ste11 interacts with Ste50 regulator.


Pssm-ID: 188933  Cd Length: 62  Bit Score: 44.12  E-value: 6.27e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 377652548  45 WGPEQVCVFLRRGGFGEpaLLKNIRENKITGALLPCLDESHFENLGVSSLGERKKLLSYIQR 106
Cdd:cd09534    1 WDEEFVEEWLNELNCGQ--YLDIFEKNLITGDLLLELDKEALKELGITKVGDRIRLLRAIKS 60
SAM_WDSUB1 cd09505
SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins ...
 44-105 1.07e-05

SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins is a putative protein-protein interaction domain. Proteins of this group contain multiple domains: SAM, one or more WD40 repeats and U-box (derived version of the RING-finger domain). Apparently the WDSUB1 subfamily proteins participate in protein degradation through ubiquitination, since U-box domain are known as a member of E3 ubiquitin ligase family, while SAM and WD40 domains most probably are responsible for an E2 ubiquitin-conjugating enzyme binding and a target protein binding.


Pssm-ID: 188904  Cd Length: 72  Bit Score: 43.46  E-value: 1.07e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 377652548  44 TWGPEQVCVFLRRGGFGEpaLLKNIRENKITGALLPCL-DESHFENLGVSSLGERKKLLSYIQ 105
Cdd:cd09505    4 DWSEEDVCTWLRSIGLEQ--YVEVFRANNIDGKELLNLtKESLSKDLKIESLGHRNKILRKIE 64
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 134-215 3.77e-05

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 46.45  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548 134 RIIDTPQFQRLRYIKQlgggyyVFPGAS----HNRFEHSLGVGylagCLVRALG--------EKQPELQISERDI-LCVQ 200
Cdd:PRK01096  34 RIIFSGSFRRLQRKTQ------VHPLAKndhiHTRLTHSLEVS----CVGRSLGmrvgetlkEEKLPDWISPADIgAIVQ 103

                         90
                 ....*....|....*
gi 377652548 201 IAGLCHDLGHGPFSH 215
Cdd:PRK01096 104 SACLAHDIGNPPFGH 118
SAM_Samd3 cd09526
SAM domain of Samd3 subfamily; SAM (sterile alpha motif) domain of the Samd3 subfamily is a ...
 43-109 1.12e-04

SAM domain of Samd3 subfamily; SAM (sterile alpha motif) domain of the Samd3 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates dimerization/oligomerization. Exact function of proteins belonging to this subfamily is unknown.


Pssm-ID: 188925  Cd Length: 66  Bit Score: 40.42  E-value: 1.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 377652548  43 KTWGPEQVCVFLRRGGFGEpaLLKNIRENKITGALLPCLDESHFENLgVSSLGERKKLLSYIQRSGQ 109
Cdd:cd09526    2 ETWSVEQVCNWLVEKNLGE--LVPRFQEEEVSGAALLALNDRMVQQL-VKKIGHQAVLMDLIKKYKQ 65
YqeK COG1713
Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase [Signal ...
 161-208 6.68e-03

Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase [Signal transduction mechanisms, General function prediction only];


Pssm-ID: 441319 [Multi-domain]  Cd Length: 184  Bit Score: 38.18  E-value: 6.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 377652548 161 SHNRFEHSLGVGYLAGCLVRALGEkqpelqiserDILCVQIAGLCHDL 208
Cdd:COG1713   15 SPKRYEHTLGVAETAVELAERYGV----------DVEKAELAGLLHDY 52
PRK03007 PRK03007
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 163-215 7.21e-03

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235098 [Multi-domain]  Cd Length: 428  Bit Score: 39.16  E-value: 7.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 377652548 163 NRFEHSLGVGYLAGCLVRALGeKQPELqiserdilcVQIAGLCHDLGHGPFSH 215
Cdd:PRK03007  70 TRLTHSLEVAQIGRGIAAGLG-CDPDL---------VDLAGLAHDIGHPPYGH 112
HD_assoc_2 pfam19276
HD associated region; This entry represents a region that forms part of a larger HD domain. ...
 374-502 9.11e-03

HD associated region; This entry represents a region that forms part of a larger HD domain.According to the original paper describing the HD domain this family represents cluster 1.


Pssm-ID: 466023  Cd Length: 222  Bit Score: 38.24  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377652548  374 YQHKVGNIIDTMitdaFLKAdnyieitgaggKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPklkDAREILKQIEYRNL 453
Cdd:pfam19276  42 YQHHVARIAKAM----LRRA-----------LERLIEEGDLDAEELRRMDDADLLVALRNSEG---YTAEIARRLDERDL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 377652548  454 FK---YVGETQ-PTEQEKIKKEDYESLPKEVAAakpkellEVKLEAEDFIVDV 502
Cdd:pfam19276 104 YKravYAELDDvPDDVLDADHEEIRRAEREIAE-------RAGVDPEYVIVDI 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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