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Conserved domains on  [gi|37731305|gb|AAN75265|]
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NADH dehydrogenase subunit II, partial (mitochondrion) [Melanoplus spretus]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-118 6.37e-28

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00160:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 335  Bit Score: 103.75  E-value: 6.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYPMMweeEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPM 80
Cdd:MTH00160  58 LKYFLIQALASIILLFSIILNMLNLMLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPL 134

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 37731305   81 MVLSYCMQLeTFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00160 135 ILLSYLINN-NFIIIIIILSAIIGAIGGLNQTSLRKIL 171
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-118 6.37e-28

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 103.75  E-value: 6.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYPMMweeEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPM 80
Cdd:MTH00160  58 LKYFLIQALASIILLFSIILNMLNLMLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPL 134

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 37731305   81 MVLSYCMQLeTFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00160 135 ILLSYLINN-NFIIIIIILSAIIGAIGGLNQTSLRKIL 171
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-118 4.12e-07

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 46.92  E-value: 4.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305     1 IKYFIVQAMASTMLLFSILLI--------------QMKYPMMWEEEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWI 66
Cdd:pfam00361  36 MKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSGLLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTP 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    67 NCLTL-MTWQKIAPMMVLSYCMQLET-------FMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:pfam00361 116 VSALLaATLVKAGGYGLIRRSLLYLPsspfiqqILLILAIISMLLGSLAALVQTDIKRLL 175
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 1-118 3.26e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 41.26  E-value: 3.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305   1 IKYFIVQAMASTMLLFSILLI------------------QMKYPMMWeeeMVPSMMVSSSLLLKIGAAPFHFWFPEVMST 62
Cdd:COG1007 156 LKYFLLGALSSGFLLYGISLLygatgslnlagiaaalaaGGANSPLL---LLGLVLVLAGLAFKLSAVPFHMWTPDVYEG 232

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37731305  63 STWINCLTLMTWQKIAPMMVL---------SYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:COG1007 233 APTPVTAFLATAPKIAAFAALlrllveafpGLAADWQLLLAVLAVLSMTVGNLAALAQTNVKRML 297
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-118 7.59e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 40.32  E-value: 7.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305     1 IKYFIVQAMASTMLLFSILLI----------QMKYPMMWEEEMVPSM-----MVSSSLLLKIGAAPFHFWFPEVMSTSTW 65
Cdd:TIGR01770 156 LKYFILGAFSSGLLLFGISLIygftgslnfeDLLLFLSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPT 235

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37731305    66 INCLTLMTWQKIAPMMVL---------SYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:TIGR01770 236 PVTAFFSIVPKIAIFAVFlrlflyilfGFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLL 297
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-118 6.37e-28

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 103.75  E-value: 6.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYPMMweeEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPM 80
Cdd:MTH00160  58 LKYFLIQALASIILLFSIILNMLNLMLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPL 134

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 37731305   81 MVLSYCMQLeTFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00160 135 ILLSYLINN-NFIIIIIILSAIIGAIGGLNQTSLRKIL 171
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-118 1.90e-23

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 92.30  E-value: 1.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYP---MMWEEEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKI 77
Cdd:MTH00041  57 IKYFLVQAFSAAILLNGALIQAWLSGswsINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKI 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 37731305   78 APMMVLSYCMQLETFMFTIV--ILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00041 137 APLILLISISNLLNSNILILcgILSVLVGGWGGLNQTQTRKIL 179
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-118 2.60e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 89.11  E-value: 2.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILL----------IQMKYPMmweeemvPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLT 70
Cdd:MTH00112  57 TKYFLTQAAASALILFSSTTnawntgqwdiTQLTNPT-------SCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALI 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 37731305   71 LMTWQKIAPMMVLSYCMQL--ETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00112 130 LSTWQKLAPLTLLLMTSNSlnPTLLLTLAILSTLIGGWGGLNQTQLRKIM 179
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-118 3.24e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 83.43  E-value: 3.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILL---IQMKYPMMWEEEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKI 77
Cdd:MTH00070  57 TKYFLTQASASALILFSSTInawFTGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 37731305   78 APMMVLSYCMQL--ETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00070 137 APMALLIQISHLlnSNLLIIMGLLSTLIGGWGGLNQTQLRKIM 179
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 2-118 3.40e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 83.32  E-value: 3.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    2 KYFIVQAMASTMLLFSIL----------LIQMKYPMmweeemvPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTL 71
Cdd:MTH00135  58 KYFLTQATAAAMILFASTtnawltgqwdIQQMSHPL-------PTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLIL 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 37731305   72 MTWQKIAPMMVLsycMQLE----TFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00135 131 STWQKLAPFALI---LQIAptnpTLLITLGLTSTLVGGWGGLNQTQLRKIL 178
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-118 1.86e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 81.43  E-value: 1.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQM---KYPMMWEEEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKI 77
Cdd:MTH00105  57 TKYFLTQATASMLLMMAIIINLMysgQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 37731305   78 APMMVL---SYCMQLeTFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00105 137 APLSILyqiSPSINP-NLLLTLAILSILIGGWGGLNQTQLRKIL 179
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-118 9.07e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 76.93  E-value: 9.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYPMMWEEEMVPSM---MVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKI 77
Cdd:MTH00200  57 TKYFIIQATASALLLFGGLLNAWTSGQWGISEMLGPLsetLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 37731305   78 APMMVLS--YCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00200 137 APFALLIqlAPALNSNILLLLGLLSVLVGGWGGLNQTQLRKIL 179
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-118 1.12e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 76.46  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLiqmkypMMWEEEMVPSM-MVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAP 79
Cdd:MTH00144  57 VKYFIIQSLGSSLLIFGSLI------MYNLSFSWFSMsLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAP 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 37731305   80 MMVLSYCMQLETFMFTIVILSI---IIGALGGLNQTSLRQIL 118
Cdd:MTH00144 131 LFLLSNFLDLYWLAYLLCVISVlsaLVGSIGGLNQTQVRALL 172
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 2-118 2.84e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 75.09  E-value: 2.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    2 KYFIVQAMASTMLLFSILLIQMKYPMmweeEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPMM 81
Cdd:MTH00197  52 KYFLFQEFGSALLLMGGSLSFSNLYL----SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLL 127

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 37731305   82 VLSYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00197 128 ILAFNSSSFMGLLICSVLSSLIGGIGGMNQSNIRQLL 164
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-118 2.99e-16

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 72.50  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLIQMKYPMMweeEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPM 80
Cdd:MTH00011  59 VKYFLAQALGSGLLLLGMTMMWSFPSLL---KNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPL 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 37731305   81 MVLSYCMQLE--TFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00011 136 SILFFFTSHNilPMMTSMAAMSALAGGLGGMNQTQLRPLL 175
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 1-118 6.74e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 51.94  E-value: 6.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILL---------IQMKYPMMWEEemVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTL 71
Cdd:MTH00199 151 LKYFVLGAVSSGLFLFGCALlygltgetsIQGINSILTGD--VGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALL 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 37731305   72 MTWQKIAPMMVLSYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00199 229 ATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIGALNQTKIKRLL 275
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 1-118 1.02e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 48.49  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLI--------------QMKYPMMWEEEMVP--SMMVSSSLLLKIGAAPFHFWFPEVMSTST 64
Cdd:MTH00196  47 LKYFVLGALSSGLFLFGCALLcgttgglhlsyinlVLNSGQSFSSVSVPigYLLIIVALLFKLSVAPFHMWAPDVYEGAP 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 37731305   65 WINCLTLMTWQKIAPMMVLSYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:MTH00196 127 TKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSLFVGAIGALNQTKIKRLL 180
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-118 4.12e-07

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 46.92  E-value: 4.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305     1 IKYFIVQAMASTMLLFSILLI--------------QMKYPMMWEEEMVPSMMVSSSLLLKIGAAPFHFWFPEVMSTSTWI 66
Cdd:pfam00361  36 MKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSGLLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTP 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    67 NCLTL-MTWQKIAPMMVLSYCMQLET-------FMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:pfam00361 116 VSALLaATLVKAGGYGLIRRSLLYLPsspfiqqILLILAIISMLLGSLAALVQTDIKRLL 175
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
1-118 5.16e-07

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 46.74  E-value: 5.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305    1 IKYFIVQAMASTMLLFSILLI------------------QMKYPMMWeeeMVPSMMVSSSLLLKIGAAPFHFWFPEV--- 59
Cdd:PRK05777 157 IKYFVLGALASGFLLYGMSLLygatgslsfagiakaladGSGNSLLL---LFGLVFLLVGLAFKLSAVPFHMWTPDVyeg 233

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 37731305   60 --------MSTSTwincltlmtwqKIAPMMVL---------SYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:PRK05777 234 aptpvtafLATAP-----------KIAAFAVLlrllvvafgGLSEDWQQVLAIIAIASMLVGNLAALSQTNIKRLL 298
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 37-118 2.10e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 44.85  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305   37 MMVSSSLLLKIGAAPFHFWFPEVMSTSTWINCLTLMTWQKIAPMMVLSYCMQLETFMFTIVILSIIIGALGGLNQTSLRQ 116
Cdd:MTH00198 303 LFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKLLLSVAIISLVVGAFGALNQTRIKR 382


                 ..
gi 37731305  117 IL 118
Cdd:MTH00198 383 LL 384
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 1-118 3.26e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 41.26  E-value: 3.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305   1 IKYFIVQAMASTMLLFSILLI------------------QMKYPMMWeeeMVPSMMVSSSLLLKIGAAPFHFWFPEVMST 62
Cdd:COG1007 156 LKYFLLGALSSGFLLYGISLLygatgslnlagiaaalaaGGANSPLL---LLGLVLVLAGLAFKLSAVPFHMWTPDVYEG 232

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37731305  63 STWINCLTLMTWQKIAPMMVL---------SYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:COG1007 233 APTPVTAFLATAPKIAAFAALlrllveafpGLAADWQLLLAVLAVLSMTVGNLAALAQTNVKRML 297
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-118 7.59e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 40.32  E-value: 7.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37731305     1 IKYFIVQAMASTMLLFSILLI----------QMKYPMMWEEEMVPSM-----MVSSSLLLKIGAAPFHFWFPEVMSTSTW 65
Cdd:TIGR01770 156 LKYFILGAFSSGLLLFGISLIygftgslnfeDLLLFLSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPT 235

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37731305    66 INCLTLMTWQKIAPMMVL---------SYCMQLETFMFTIVILSIIIGALGGLNQTSLRQIL 118
Cdd:TIGR01770 236 PVTAFFSIVPKIAIFAVFlrlflyilfGFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLL 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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