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Conserved domains on  [gi|37704382|ref|NP_695021|]
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beta-defensin 119 isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Defensin_beta_2 super family cl29693
Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of ...
 14-50 3.99e-07

Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonization.


The actual alignment was detected with superfamily member pfam14862:

Pssm-ID: 475245  Cd Length: 55  Bit Score: 42.61  E-value: 3.99e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 37704382   14 IEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCR 50
Cdd:pfam14862 17 AAAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCR 53
 
Name Accession Description Interval E-value
Defensin_big pfam14862
Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic ...
 14-50 3.99e-07

Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.


Pssm-ID: 373348  Cd Length: 55  Bit Score: 42.61  E-value: 3.99e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 37704382   14 IEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCR 50
Cdd:pfam14862 17 AAAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCR 53
ComFA COG4098
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ...
 13-52 5.73e-03

Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];


Pssm-ID: 443274 [Multi-domain]  Cd Length: 451  Bit Score: 33.69  E-value: 5.73e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 37704382  13 AIEEPVISGKRHILRCM--GNSG--ICRASCKKNEQPYLYCRNC 52
Cdd:COG4098  34 VQTLPAIKKEPGKWRCQrcGNTDrkLFAFPCARCGQGCYYCRNC 77
 
Name Accession Description Interval E-value
Defensin_big pfam14862
Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic ...
 14-50 3.99e-07

Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.


Pssm-ID: 373348  Cd Length: 55  Bit Score: 42.61  E-value: 3.99e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 37704382   14 IEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCR 50
Cdd:pfam14862 17 AAAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCR 53
Defensin_beta_2 pfam13841
Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of ...
 27-56 1.52e-05

Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonization.


Pssm-ID: 463997  Cd Length: 30  Bit Score: 38.11  E-value: 1.52e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 37704382   27 RCMGNSGICRASCKKNEQPYLYCRNCQSCC 56
Cdd:pfam13841  1 KCWKGRGHCRKKCLKNEYYIGYCRNGTLCC 30
ComFA COG4098
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ...
 13-52 5.73e-03

Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];


Pssm-ID: 443274 [Multi-domain]  Cd Length: 451  Bit Score: 33.69  E-value: 5.73e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 37704382  13 AIEEPVISGKRHILRCM--GNSG--ICRASCKKNEQPYLYCRNC 52
Cdd:COG4098  34 VQTLPAIKKEPGKWRCQrcGNTDrkLFAFPCARCGQGCYYCRNC 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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