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Conserved domains on  [gi|37622345|ref|NP_003413|]
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myeloid zinc finger 1 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein; zinc finger and BTB domain-containing protein( domain architecture ID 12210801)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
40-152 7.79e-53

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 178.27  E-value: 7.79e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345     40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 37622345    120 DGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSF 152
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-716 1.83e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 358 CDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGR--SFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEE------ 429
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlsssss 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 430 HRRVHTGEQP--------------------FRCAECGQSFRQR-----SNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGP 484
Cdd:COG5048 116 NSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 485 FPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRR 561
Cdd:COG5048 196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 562 IHTGER-------PFACAECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYHCG 628
Cdd:COG5048 276 NESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 629 ECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHTGERPYAC--PECGKAFRQRPTLT 697
Cdd:COG5048 356 LLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLI 435

                       410
                ....*....|....*....
gi 37622345 698 QHLRTHRREKPFACQDCGR 716
Cdd:COG5048 436 PHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
40-152 7.79e-53

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 178.27  E-value: 7.79e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345     40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 37622345    120 DGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSF 152
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 40-128 1.03e-42

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 149.18  E-value: 1.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345    40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 37622345   120 DGLRREPGG 128
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 40-124 7.87e-38

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 135.47  E-value: 7.87e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345  40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:cd07936   1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                ....*
gi 37622345 120 DGLRR 124
Cdd:cd07936  81 EDLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-716 1.83e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 358 CDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGR--SFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEE------ 429
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlsssss 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 430 HRRVHTGEQP--------------------FRCAECGQSFRQR-----SNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGP 484
Cdd:COG5048 116 NSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 485 FPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRR 561
Cdd:COG5048 196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 562 IHTGER-------PFACAECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYHCG 628
Cdd:COG5048 276 NESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 629 ECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHTGERPYAC--PECGKAFRQRPTLT 697
Cdd:COG5048 356 LLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLI 435

                       410
                ....*....|....*....
gi 37622345 698 QHLRTHRREKPFACQDCGR 716
Cdd:COG5048 436 PHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-692 6.47e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.47e-06
                          10        20
                  ....*....|....*....|....*.
gi 37622345   667 NLTQHRRIHTGERPYACPECGKAFRQ 692
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 652-700 4.08e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.01  E-value: 4.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 37622345  652 PFACPECGQSFRQHANLTQHrrIHTGERPYACPECGKAFRQRPTLTQHL 700
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
40-152 7.79e-53

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 178.27  E-value: 7.79e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345     40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 37622345    120 DGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSF 152
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 40-128 1.03e-42

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 149.18  E-value: 1.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345    40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 37622345   120 DGLRREPGG 128
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 40-124 7.87e-38

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 135.47  E-value: 7.87e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345  40 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALV 119
Cdd:cd07936   1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                ....*
gi 37622345 120 DGLRR 124
Cdd:cd07936  81 EDLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-716 1.83e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 358 CDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGR--SFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEE------ 429
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlsssss 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 430 HRRVHTGEQP--------------------FRCAECGQSFRQR-----SNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGP 484
Cdd:COG5048 116 NSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 485 FPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRR 561
Cdd:COG5048 196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 562 IHTGER-------PFACAECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYHCG 628
Cdd:COG5048 276 NESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 629 ECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHTGERPYAC--PECGKAFRQRPTLT 697
Cdd:COG5048 356 LLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLI 435

                       410
                ....*....|....*....
gi 37622345 698 QHLRTHRREKPFACQDCGR 716
Cdd:COG5048 436 PHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-684 3.66e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 382 RPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRV--HTGEQPFRCAECGQ------------ 447
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrtHHNNPSDLNSKSLPlsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 448 ---SFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSecRESFARRAVLLEHQAVHtgdksfGCVECGERFGR 524
Cdd:COG5048 112 sssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN--SSSVNTPQSNSLHPPLP------ANSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 525 RSVLLQHRrVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACAECGkaFRQRPTLTQHLRVHTGEKPFACPECGQ 604
Cdd:COG5048 184 LSLLISSN-VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSSSSASES 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 605 RFSQRLKLTRHQRTHTG---------EKPYHCGECGLGFTQVSRLTEHQR--IHTGE--RPFACPE--CGQSFRQHANLT 669
Cdd:COG5048 261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                       330
                ....*....|....*
gi 37622345 670 QHRRIHTGERPYACP 684
Cdd:COG5048 341 RHILLHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-590 4.10e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 4.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 363 KVFSQRSNLLRHQKIHTGER-PFVCSECGRSFSRSSHLLRHQLT--HTEE--RPFVCG--DCGQGFVRSARLEEHRRVHT 435
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 436 GEQPFRC--AECGQSFRQRSNLLQHQRIHGDppgpgakppappgapeppgpfpcsecresfarraVLLEHQAVHTGDKSF 513
Cdd:COG5048 348 SISPAKEklLNSSSKFSPLLNNEPPQSLQQY----------------------------------KDLKNDKKSETLSNS 393

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 37622345 514 gcveCGERFGRRSVLLQHRRVHSGERP--FACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKaFRQRPTLTQHLRV 590
Cdd:COG5048 394 ----CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
515-664 4.44e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 515 CVECGERFGRRSVLLQHRR--VHSGE--RPFACAE--CGQSFRQRSNLTQHRRIHTGERPFAC--AECGKAFRQ----RP 582
Cdd:COG5048 292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEP 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37622345 583 TLTQHLRVH-TGEKPFAC--PECGQRFSQRLKLTRHQRTHTGEKPYHC--GECGLGFTQVSRLTEHQRIHTGERPFaCPE 657
Cdd:COG5048 372 PQSLQQYKDlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL-LCS 450


                ....*..
gi 37622345 658 CGQSFRQ 664
Cdd:COG5048 451 ILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
651-722 6.39e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 6.39e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37622345 651 RPFACPECGQSFRQHANLTQHRRIHTGERPYAC--PECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQST 722
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-692 6.47e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.47e-06
                          10        20
                  ....*....|....*....|....*.
gi 37622345   667 NLTQHRRIHTGERPYACPECGKAFRQ 692
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
555-580 3.63e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.63e-05
                          10        20
                  ....*....|....*....|....*.
gi 37622345   555 NLTQHRRIHTGERPFACAECGKAFRQ 580
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
584-608 6.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.16e-05
                          10        20
                  ....*....|....*....|....*
gi 37622345   584 LTQHLRVHTGEKPFACPECGQRFSQ 608
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 384-406 8.67e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 8.67e-05
                          10        20
                  ....*....|....*....|...
gi 37622345   384 FVCSECGRSFSRSSHLLRHQLTH 406
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
639-664 1.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 37622345   639 RLTEHQRIHTGERPFACPECGQSFRQ 664
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
612-636 2.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|....*
gi 37622345   612 LTRHQRTHTGEKPYHCGECGLGFTQ 636
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 652-700 4.08e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.01  E-value: 4.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 37622345  652 PFACPECGQSFRQHANLTQHrrIHTGERPYACPECGKAFRQRPTLTQHL 700
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHV 119
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 440-462 6.53e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.53e-04
                          10        20
                  ....*....|....*....|...
gi 37622345   440 FRCAECGQSFRQRSNLLQHQRIH 462
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
602-676 7.35e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.35e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37622345 602 CGQRFSQRLKLTRHQRTHTgEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHT 676
Cdd:COG5048  12 NNSVLSSTPKSTLKSLSNA-PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-378 7.64e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 7.64e-04
                          10        20
                  ....*....|....*....|.
gi 37622345   358 CDVCGKVFSQRSNLLRHQKIH 378
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 681-703 1.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|...
gi 37622345   681 YACPECGKAFRQRPTLTQHLRTH 703
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 37622345   426 RLEEHRRVHTGEQPFRCAECGQSFRQ 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
679-732 1.58e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 37622345 679 RPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQST--KLIQHQRVHS 732
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 653-675 1.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|...
gi 37622345   653 FACPECGQSFRQHANLTQHRRIH 675
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 1.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|...
gi 37622345   541 FACAECGQSFRQRSNLTQHRRIH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 597-619 2.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|...
gi 37622345   597 FACPECGQRFSQRLKLTRHQRTH 619
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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