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Conserved domains on  [gi|37548599|gb|AAN08403|]
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CI [Salmonella phage PSP3]

Protein Classification

phage repressor protein CI( domain architecture ID 10537110)

phage repressor protein CI is a repressor of lysogeny

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 106-169 8.16e-27

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


:

Pssm-ID: 311152  Cd Length: 65  Bit Score: 99.33  E-value: 8.16e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37548599   106 VLRRILDAYGFTMQKELGDLLGISSGTISTWVRRDFFPGDVVVTCALDTDTSLEWLATGKGQMR 169
Cdd:pfam07022   2 VIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Peptidase_S24_S26 super family cl10465
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ...
 180-279 8.38e-24

The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.


The actual alignment was detected with superfamily member pfam16452:

Pssm-ID: 447902  Cd Length: 101  Bit Score: 92.77  E-value: 8.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37548599   180 SIKKSRLESGELKDAGTWHPDPSMIPSNSGELIFVDGVAASWLVDSSASNISNGRWLIDIDGALDVFDVIRLPGGKVRLS 259
Cdd:pfam16452   2 NIKKVKLIGGELYDDGDLSLDGKLLDDDLKNPLVILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVS 81

                          90       100
                  ....*....|....*....|
gi 37548599   260 NKSAEFECNITDITPAGVVV 279
Cdd:pfam16452  82 GGEVPFECGVDDIKALGRVM 101
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 16-76 8.33e-21

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


:

Pssm-ID: 311152  Cd Length: 65  Bit Score: 83.53  E-value: 8.33e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37548599    16 GVLERLMSAYGVKMQKDLADLLGIAKHSVSGWVQRDAIPGNVIVRCCLDTGADINWLVNGE 76
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGD 61
 
Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 106-169 8.16e-27

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 99.33  E-value: 8.16e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37548599   106 VLRRILDAYGFTMQKELGDLLGISSGTISTWVRRDFFPGDVVVTCALDTDTSLEWLATGKGQMR 169
Cdd:pfam07022   2 VIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Phage_CI_C pfam16452
Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor ...
 180-279 8.38e-24

Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor functions in oligomer formation.


Pssm-ID: 435345  Cd Length: 101  Bit Score: 92.77  E-value: 8.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37548599   180 SIKKSRLESGELKDAGTWHPDPSMIPSNSGELIFVDGVAASWLVDSSASNISNGRWLIDIDGALDVFDVIRLPGGKVRLS 259
Cdd:pfam16452   2 NIKKVKLIGGELYDDGDLSLDGKLLDDDLKNPLVILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVS 81

                          90       100
                  ....*....|....*....|
gi 37548599   260 NKSAEFECNITDITPAGVVV 279
Cdd:pfam16452  82 GGEVPFECGVDDIKALGRVM 101
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 16-76 8.33e-21

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 83.53  E-value: 8.33e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37548599    16 GVLERLMSAYGVKMQKDLADLLGIAKHSVSGWVQRDAIPGNVIVRCCLDTGADINWLVNGE 76
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGD 61
 
Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 106-169 8.16e-27

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 99.33  E-value: 8.16e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37548599   106 VLRRILDAYGFTMQKELGDLLGISSGTISTWVRRDFFPGDVVVTCALDTDTSLEWLATGKGQMR 169
Cdd:pfam07022   2 VIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Phage_CI_C pfam16452
Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor ...
 180-279 8.38e-24

Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor functions in oligomer formation.


Pssm-ID: 435345  Cd Length: 101  Bit Score: 92.77  E-value: 8.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37548599   180 SIKKSRLESGELKDAGTWHPDPSMIPSNSGELIFVDGVAASWLVDSSASNISNGRWLIDIDGALDVFDVIRLPGGKVRLS 259
Cdd:pfam16452   2 NIKKVKLIGGELYDDGDLSLDGKLLDDDLKNPLVILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVS 81

                          90       100
                  ....*....|....*....|
gi 37548599   260 NKSAEFECNITDITPAGVVV 279
Cdd:pfam16452  82 GGEVPFECGVDDIKALGRVM 101
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 16-76 8.33e-21

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 83.53  E-value: 8.33e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37548599    16 GVLERLMSAYGVKMQKDLADLLGIAKHSVSGWVQRDAIPGNVIVRCCLDTGADINWLVNGE 76
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGD 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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