NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|371656955|gb|EHO22273|]
View 

hypothetical protein HMPREF9466_00116 [Fusobacterium necrophorum subsp. funduliforme 1_1_36S]

Protein Classification

TonB-dependent receptor( domain architecture ID 11446927)

TonB dependent receptor having a carboxypeptidase regulatory-like domain, may act as a channel to allow import of extracellular nutrients, such as iron-siderophore complexes or non-Fe compounds

Gene Ontology:  GO:0009279|GO:0055085
PubMed:  36944260|35464957
TCDB:  1.B.14

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CirA super family cl34327
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
34-527 2.70e-22

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1629:

Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 100.67  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  34 SSQVDTKKKSNSFYLHNSYDITDKFELSAGLRYEETKYKGNRKTRTHQMISLDpgtdwkkeaystidvldmytqtsdily 113
Cdd:COG1629  347 GADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDSASGS--------------------------- 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 114 terqnrtedqlgfmileklrrleelketgktiipmanlltayhRKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQ 193
Cdd:COG1629  400 -------------------------------------------RSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPTFGE 436

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 194 MTNKTFDPIhkvrVYWESNIQTEKMNNFEIGFRG-MLDQNITFSAAAFLSDTYDEIVSVVKDGNShdRREWRFVNIDKTR 272
Cdd:COG1629  437 LYANGTDPY----SVGNPDLKPETSTNYELGLRYrLLDGRLSLSLALFYSDVDNEILSVPLPNDS--GFSTYYTNAGKAR 510

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 273 RMGIELQSEQSF-ERLRLKESITYIHPKILSNDfkeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnh 351
Cdd:COG1629  511 SYGVELELSYQLtPGLSLNASYSYTDAKFDDDT----------------------------------------------- 543

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 352 fyqeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqydyeysleNGEFL 431
Cdd:COG1629  544 ---------------------------------------------------------------------------DGSAD 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 432 KEGDTIPLAPKIKATFGADYQFTDKLKLGMNFNYIGSYTTVEPARGYeiiktKVPSHLVSDFYGTYNWTEDFSIKFGINN 511
Cdd:COG1629  549 LDGNRLPGVPPLTANLGLTYEFPGGWSLGLGVRYVGDRYLDDANTQG-----APGGYTLVDLGAGYRFGDNLTLSLGVDN 623

                        490
                 ....*....|....*.
gi 371656955 512 VFNHEYNLRQDSTTAT 527
Cdd:COG1629  624 LFDKKYATSLSVRASN 639
 
Name Accession Description Interval E-value
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
34-527 2.70e-22

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 100.67  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  34 SSQVDTKKKSNSFYLHNSYDITDKFELSAGLRYEETKYKGNRKTRTHQMISLDpgtdwkkeaystidvldmytqtsdily 113
Cdd:COG1629  347 GADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDSASGS--------------------------- 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 114 terqnrtedqlgfmileklrrleelketgktiipmanlltayhRKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQ 193
Cdd:COG1629  400 -------------------------------------------RSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPTFGE 436

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 194 MTNKTFDPIhkvrVYWESNIQTEKMNNFEIGFRG-MLDQNITFSAAAFLSDTYDEIVSVVKDGNShdRREWRFVNIDKTR 272
Cdd:COG1629  437 LYANGTDPY----SVGNPDLKPETSTNYELGLRYrLLDGRLSLSLALFYSDVDNEILSVPLPNDS--GFSTYYTNAGKAR 510

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 273 RMGIELQSEQSF-ERLRLKESITYIHPKILSNDfkeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnh 351
Cdd:COG1629  511 SYGVELELSYQLtPGLSLNASYSYTDAKFDDDT----------------------------------------------- 543

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 352 fyqeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqydyeysleNGEFL 431
Cdd:COG1629  544 ---------------------------------------------------------------------------DGSAD 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 432 KEGDTIPLAPKIKATFGADYQFTDKLKLGMNFNYIGSYTTVEPARGYeiiktKVPSHLVSDFYGTYNWTEDFSIKFGINN 511
Cdd:COG1629  549 LDGNRLPGVPPLTANLGLTYEFPGGWSLGLGVRYVGDRYLDDANTQG-----APGGYTLVDLGAGYRFGDNLTLSLGVDN 623

                        490
                 ....*....|....*.
gi 371656955 512 VFNHEYNLRQDSTTAT 527
Cdd:COG1629  624 LFDKKYATSLSVRASN 639
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 1-542 3.94e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 90.97  E-value: 3.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955   1 MYFFEVKENTTFEDFIRFEETLNSPKSKTTSFVSSQVDTKKKSNSFYLHNSYD---ITDKFELSAGLRYEETKYKGNRKT 77
Cdd:cd01347  195 AGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDRYRKRASLGLEhdlNDTGWTLRANLSYSYTDNDGDPLI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  78 RThqMISLDPGTDWKKEAYSTIDVLDMYT---------QTSDILYT-------ERQNRTEDQLGFM------ILEKLR-- 133
Cdd:cd01347  275 LN--GGNNAAGGDLGRSGYSSERDTTQLGfdaglnapfGTGPVAHTltlgveyRREELDEKQTALYaqdtieLTDDLTlt 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 134 ---RLEELKETGKTIIPMAnllTAYHRKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTFdpIHKVRVYWE 210
Cdd:cd01347  353 lglRYDHYDQDSKDTIAGG---TTAKKSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGS--HGGTAAVGN 427

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 211 SNIQTEKMNNFEIGFRGMLDQNITFSAAAFLSDTYDEIVSvvKDGNSHDRREWRFVNIDKTRRMGIELQ-SEQSFERLRL 289
Cdd:cd01347  428 PNLKPEKSKQYELGLKYDPGDGLTLSAALFRIDIKNEIVS--TPTNTGLGLVTVYVNGGKARIRGVELEaSYDLTDGLGL 505

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 290 KESITYIHPKILSNDFKeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnhfyqeeyykknignkdamk 369
Cdd:cd01347  506 TGSYTYTDTEVKRTDGA--------------------------------------------------------------- 522

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 370 dyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqydyeyslengeflKEGDTIPLAPKIKATFGA 449
Cdd:cd01347  523 --------------------------------------------------------------TTGNRLPGIPKHTANLGL 540

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 450 DYQFT-DKLKLGMNFNYIGSYTTVEPARGYeiiKTKVPSHLVSDFYGTYNWTEDFSIKFGINNVFNHEY----NLRQDST 524
Cdd:cd01347  541 DYELPdEGLTAGGGVRYRGKQYADTANGNN---TVKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYytslSVRGSGL 617

                        570
                 ....*....|....*...
gi 371656955 525 TATPAPGRTYSAGFSYRF 542
Cdd:cd01347  618 YGYYGPGRTYYLSVSYKF 635
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 2-541 4.90e-19

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 89.83  E-value: 4.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955    2 YFFEVKENTTFEDFIRFEETLNSPKSKTTSFVSSQVDTKKKSNSFYLHNSYDITDKFELSAGLRYEETKYKGNRKTRTHq 81
Cdd:pfam00593 133 LLLGVELRTAGLDYRRLDDDAYDPYDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNGGG- 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955   82 misldpgtdwkkeaystidvldmytqtsdilyterqnrtedqlgfmileklrrleelketgktiipmanllTAYHRKEKN 161
Cdd:pfam00593 212 -----------------------------------------------------------------------DNFSRSYSA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  162 ISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTFDPIHKVRVYWESNIQTEKMNNFEIGFRgMLDQNITFSAAAFL 241
Cdd:pfam00593 221 FSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAGGNPDLKPETSDNYELGLK-YDDGRLSLSLALFY 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  242 SDTYDEIVSVVkDGNSHDRREWRFVNIDKTRRMGIELqsEQSFERLRLKESITYihpkilsndfkeevrkiakeqteqli 321
Cdd:pfam00593 300 IDIKNLITSDP-DGPGLGGTVYTYTNVGKARIRGVEL--ELSGRLWGLGLSGGG-------------------------- 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  322 hsrrnsieryfresmrdipdrekilremnhfyqeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagi 401
Cdd:pfam00593     --------------------------------------------------------------------------------

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  402 rnnlendrnyvenirkqYDYEYSLENGEFLKEGDTIPLAPKIKATFGADYQFTD---KLKLGMNFNYIGSYTTVEPARGY 478
Cdd:pfam00593 351 -----------------YTYTDADDDADADDTGNPLPNVPRHTANLGLTYDFPLggwGARLGARYVGSGERRYGDAANTF 413

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 371656955  479 eiiktKVPSHLVSDFYGTYNWTEDFSIKFGINNVFNHEYNLRQDSTTAT----PAPGRTYSAGFSYR 541
Cdd:pfam00593 414 -----KTPGYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYKRYYSSGGGNlggyPGPGRTFYLGLSYK 475
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 432-542 4.09e-12

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 68.98  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  432 KEGDTIPL---APKIKATFGADYQFTD-KLKLGMNFNYIGSYTTVE-PARGYEIIKTKV------PSHLVSDFYGTYNWT 500
Cdd:TIGR01786 588 KDSDTNPWlnaITPLKVVLGLGYDHPDeKWGVGLTLTFSGAKDAVDaYATYYENGEAAKagplrtPSYTVVDLYGYYKPN 667

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 371656955  501 EDFSIKFGINNVFNHEY----NLRQDSTTAT--PAPGRTYSAGFSYRF 542
Cdd:TIGR01786 668 KNLTLRFGVYNLLDRKYttweSARQAGPLATgyTAPGRNYKASVEYKF 715
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
434-542 1.36e-03

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 41.55  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 434 GDTIPLAPK--IKATFgaDYQFTDKLKLGMNFNYIG-------SYTTvEPARGYEiiKTKVPSHLVSDFYGTYNWTEDFS 504
Cdd:PRK13524 621 GDPLSIIPEytLNSTL--SWQATEDLSLQSTFTWYGkqkpkkyNYKG-QPVTGSA--TKEVSPYSIVGLSATYDVTKNVS 695

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 371656955 505 IKFGINNVFN----HEYNLRQDSTTATPA-------PGRTYSAGFSYRF 542
Cdd:PRK13524 696 LTGGVDNLFDkrlwREGNAQTTGDLIAGAgaytynePGRTYYMSLNTHF 744
 
Name Accession Description Interval E-value
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
34-527 2.70e-22

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 100.67  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  34 SSQVDTKKKSNSFYLHNSYDITDKFELSAGLRYEETKYKGNRKTRTHQMISLDpgtdwkkeaystidvldmytqtsdily 113
Cdd:COG1629  347 GADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDSASGS--------------------------- 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 114 terqnrtedqlgfmileklrrleelketgktiipmanlltayhRKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQ 193
Cdd:COG1629  400 -------------------------------------------RSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPTFGE 436

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 194 MTNKTFDPIhkvrVYWESNIQTEKMNNFEIGFRG-MLDQNITFSAAAFLSDTYDEIVSVVKDGNShdRREWRFVNIDKTR 272
Cdd:COG1629  437 LYANGTDPY----SVGNPDLKPETSTNYELGLRYrLLDGRLSLSLALFYSDVDNEILSVPLPNDS--GFSTYYTNAGKAR 510

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 273 RMGIELQSEQSF-ERLRLKESITYIHPKILSNDfkeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnh 351
Cdd:COG1629  511 SYGVELELSYQLtPGLSLNASYSYTDAKFDDDT----------------------------------------------- 543

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 352 fyqeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqydyeysleNGEFL 431
Cdd:COG1629  544 ---------------------------------------------------------------------------DGSAD 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 432 KEGDTIPLAPKIKATFGADYQFTDKLKLGMNFNYIGSYTTVEPARGYeiiktKVPSHLVSDFYGTYNWTEDFSIKFGINN 511
Cdd:COG1629  549 LDGNRLPGVPPLTANLGLTYEFPGGWSLGLGVRYVGDRYLDDANTQG-----APGGYTLVDLGAGYRFGDNLTLSLGVDN 623

                        490
                 ....*....|....*.
gi 371656955 512 VFNHEYNLRQDSTTAT 527
Cdd:COG1629  624 LFDKKYATSLSVRASN 639
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
42-542 5.38e-22

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 100.00  E-value: 5.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  42 KSNSFYLHNSYDITDKFELSAGLRYE--ETKYKGNRKTRThqmisldpGTDwkkeaystidvldmytqtsdilyTERQNR 119
Cdd:COG4772  379 DALAAYAQNRFELTGRLTLTPGLRYEhiRRDRTDRYSTRT--------GGD-----------------------DSGSNS 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 120 TEDqlgfmileklrrleelketgktIIPManlltayhrkeknisgdIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTF 199
Cdd:COG4772  428 YSE----------------------FLPG-----------------LGLLYQLTDNLQLYANVSRGFEPPTFGDLAYGNG 468

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 200 DPihkvrvyweSNIQTEKMNNFEIGFRGMLDQNITFSAAAFLSDTYDEIVSV-VKDGNShdrreWRFVNIDKTRRMGIEL 278
Cdd:COG4772  469 GN---------PDLKPEKSWNYELGTRGRIGNGLSAEVALFYIDYDNELGSCsAAGGDR-----STFTNAGETRHQGLEL 534

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 279 QSEQSF-----ERLRLKESITYIhpkilsndfkeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnhfy 353
Cdd:COG4772  535 ALDYDLlkgggLGLPLFAAYTYT--------------------------------------------------------- 557

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 354 qeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqyDYEYSLENGEFLKe 433
Cdd:COG4772  558 ------------------------------------------------------------------DAEFTSDFGPVFA- 570

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 434 GDTIPLAPKIKATFGADYQFtDKLKLGMNFNYIGSYTTVEPARGYEIIKTKVPSHLVSDFYGTYNWTEDFSIKFGINNVF 513
Cdd:COG4772  571 GNRLPYVPRHQLTAGLGYEH-GGWTANLNGRYVSEQFTDAANTVADGSFGKIPSYTVLDLSASYDFGKNLSLFAGVNNLF 649

                        490       500       510
                 ....*....|....*....|....*....|..
gi 371656955 514 NHEYNLR---QDSTTATPAPGRTYSAGFSYRF 542
Cdd:COG4772  650 DKRYIASrapNYAAGIRPGPPRTVYAGLRLKF 681
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 1-542 3.94e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 90.97  E-value: 3.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955   1 MYFFEVKENTTFEDFIRFEETLNSPKSKTTSFVSSQVDTKKKSNSFYLHNSYD---ITDKFELSAGLRYEETKYKGNRKT 77
Cdd:cd01347  195 AGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDRYRKRASLGLEhdlNDTGWTLRANLSYSYTDNDGDPLI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  78 RThqMISLDPGTDWKKEAYSTIDVLDMYT---------QTSDILYT-------ERQNRTEDQLGFM------ILEKLR-- 133
Cdd:cd01347  275 LN--GGNNAAGGDLGRSGYSSERDTTQLGfdaglnapfGTGPVAHTltlgveyRREELDEKQTALYaqdtieLTDDLTlt 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 134 ---RLEELKETGKTIIPMAnllTAYHRKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTFdpIHKVRVYWE 210
Cdd:cd01347  353 lglRYDHYDQDSKDTIAGG---TTAKKSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGS--HGGTAAVGN 427

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 211 SNIQTEKMNNFEIGFRGMLDQNITFSAAAFLSDTYDEIVSvvKDGNSHDRREWRFVNIDKTRRMGIELQ-SEQSFERLRL 289
Cdd:cd01347  428 PNLKPEKSKQYELGLKYDPGDGLTLSAALFRIDIKNEIVS--TPTNTGLGLVTVYVNGGKARIRGVELEaSYDLTDGLGL 505

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 290 KESITYIHPKILSNDFKeevrkiakeqteqlihsrrnsieryfresmrdipdrekilremnhfyqeeyykknignkdamk 369
Cdd:cd01347  506 TGSYTYTDTEVKRTDGA--------------------------------------------------------------- 522

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 370 dyidkyvkekidsildassiensrkeklkagirnnlendrnyvenirkqydyeyslengeflKEGDTIPLAPKIKATFGA 449
Cdd:cd01347  523 --------------------------------------------------------------TTGNRLPGIPKHTANLGL 540

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 450 DYQFT-DKLKLGMNFNYIGSYTTVEPARGYeiiKTKVPSHLVSDFYGTYNWTEDFSIKFGINNVFNHEY----NLRQDST 524
Cdd:cd01347  541 DYELPdEGLTAGGGVRYRGKQYADTANGNN---TVKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYytslSVRGSGL 617

                        570
                 ....*....|....*...
gi 371656955 525 TATPAPGRTYSAGFSYRF 542
Cdd:cd01347  618 YGYYGPGRTYYLSVSYKF 635
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 2-541 4.90e-19

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 89.83  E-value: 4.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955    2 YFFEVKENTTFEDFIRFEETLNSPKSKTTSFVSSQVDTKKKSNSFYLHNSYDITDKFELSAGLRYEETKYKGNRKTRTHq 81
Cdd:pfam00593 133 LLLGVELRTAGLDYRRLDDDAYDPYDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNGGG- 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955   82 misldpgtdwkkeaystidvldmytqtsdilyterqnrtedqlgfmileklrrleelketgktiipmanllTAYHRKEKN 161
Cdd:pfam00593 212 -----------------------------------------------------------------------DNFSRSYSA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  162 ISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTFDPIHKVRVYWESNIQTEKMNNFEIGFRgMLDQNITFSAAAFL 241
Cdd:pfam00593 221 FSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAGGNPDLKPETSDNYELGLK-YDDGRLSLSLALFY 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  242 SDTYDEIVSVVkDGNSHDRREWRFVNIDKTRRMGIELqsEQSFERLRLKESITYihpkilsndfkeevrkiakeqteqli 321
Cdd:pfam00593 300 IDIKNLITSDP-DGPGLGGTVYTYTNVGKARIRGVEL--ELSGRLWGLGLSGGG-------------------------- 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  322 hsrrnsieryfresmrdipdrekilremnhfyqeeyykknignkdamkdyidkyvkekidsildassiensrkeklkagi 401
Cdd:pfam00593     --------------------------------------------------------------------------------

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  402 rnnlendrnyvenirkqYDYEYSLENGEFLKEGDTIPLAPKIKATFGADYQFTD---KLKLGMNFNYIGSYTTVEPARGY 478
Cdd:pfam00593 351 -----------------YTYTDADDDADADDTGNPLPNVPRHTANLGLTYDFPLggwGARLGARYVGSGERRYGDAANTF 413

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 371656955  479 eiiktKVPSHLVSDFYGTYNWTEDFSIKFGINNVFNHEYNLRQDSTTAT----PAPGRTYSAGFSYR 541
Cdd:pfam00593 414 -----KTPGYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYKRYYSSGGGNlggyPGPGRTFYLGLSYK 475
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 161-314 5.70e-14

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 74.51  E-value: 5.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 161 NISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMtNKTFDPIHKVRVYWESNIQTEKMNNFEIGFRGML-DQNITFSAAA 239
Cdd:COG4771  399 AFSPRLGLRYDLSDNLTLRASYGRGFRAPSLAEL-YGSGTGTPGRYVLGNPDLKPETSDNYELGLEYRLgNGGLSLSLTG 477

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 371656955 240 FLSDTYDEIVSVVKDGNSHDRRewRFVNIDKTRRMGIELQSEQSF-ERLRLKESITYIHPKILSNDFKEEVRKIAK 314
Cdd:COG4771  478 FYTDIKDLIVLVPVGPGPGDVL--QYENVGKARTYGLELELKYRLgKGLTLTASYTYLDSKIDDGDTGEPLPNVPP 551
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 432-542 4.09e-12

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 68.98  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  432 KEGDTIPL---APKIKATFGADYQFTD-KLKLGMNFNYIGSYTTVE-PARGYEIIKTKV------PSHLVSDFYGTYNWT 500
Cdd:TIGR01786 588 KDSDTNPWlnaITPLKVVLGLGYDHPDeKWGVGLTLTFSGAKDAVDaYATYYENGEAAKagplrtPSYTVVDLYGYYKPN 667

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 371656955  501 EDFSIKFGINNVFNHEY----NLRQDSTTAT--PAPGRTYSAGFSYRF 542
Cdd:TIGR01786 668 KNLTLRFGVYNLLDRKYttweSARQAGPLATgyTAPGRNYKASVEYKF 715
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
433-542 8.54e-12

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 67.60  E-value: 8.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 433 EGDTIPLAPKIKATFGADYQFT-DKLKLGMNFNYIGSYTTVEPARgyeiikTKVPSHLVSDFYGTYNWTEDFSIKFGINN 511
Cdd:COG4774  534 VGNRLPNVPRHSASLWTTYDLPlPGLTLGGGVRYVGSRYADAANT------VKLPSYTRFDAGASYRLNKNLTLRLNVNN 607

                         90       100       110
                 ....*....|....*....|....*....|..
gi 371656955 512 VFNHEYNLR-QDSTTATPAPGRTYSAGFSYRF 542
Cdd:COG4774  608 LTDKRYYASaYGSGYVTPGAPRTVLLSASYRF 639
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 433-542 4.74e-10

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 62.22  E-value: 4.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 433 EGDTIPLAPKIKATFGADYQFTD----KLKLGMNFNYIGSyTTVEPARGYeiiktKVPSHLVSDFYGTYNWTEDFSIKFG 508
Cdd:COG4773  584 EGKRLTNVPRHTASLWTTYRFPSgalkGLGLGGGVRYVGE-RYGDAANTF-----TLPSYTLVDAGARYDLGKNWTLQLN 657

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 371656955 509 INNVFNHEY-NLRQDSTTATPAPGRTYSAGFSYRF 542
Cdd:COG4773  658 VNNLFDKKYyASSGSRGYVYYGAPRNVRLSLSYKF 692
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 433-542 2.24e-09

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 60.12  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  433 EGDTIPLAPKIKATFGADYQF---TDKLKLGMNFNYIGSYTTVEPARGyeiiktKVPSHLVSDFYGTYNWT--EDFSIKF 507
Cdd:TIGR01783 539 QGNTVPFVPKHTASLWASYAPpvgDNGLTLGGGVQYTGKAYVDGGNTG------KVPSYTVVDLSVRYDLTkkKNLTLAL 612

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 371656955  508 GINNVFNHEY----NLRQDSTTATPAPGRTYSAGFSYRF 542
Cdd:TIGR01783 613 NVNNLFDRDYytsgYRWGPSAYIYPGAPRTVGLSVSYDF 651
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 157-542 6.21e-05

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 45.85  E-value: 6.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  157 RKEKNISGDIGFTYRLNDTNKIYAKYERAFNTPLPTQMTNKTFDPIHKVRVYWESN--IQTEKMNNFEIGFR----GMLD 230
Cdd:TIGR01785 397 RSYSRWSPSLGLSYKPVDWLTLYASYSQGFRAPSIDELYGTGDHPGTPGGYTFAPNpnLKPETSKTWELGANlsfdNLLL 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  231 QNITFS--AAAFLSDTYDEI-VSVVKDGNSHDR--REWRFVNIDKTRRMGIELQSEQSFERLRLKESITYIHPKILSndf 305
Cdd:TIGR01785 477 DNDQLQfkVAYFYNDVKDFIdLTIGVTDNVTAGmnNITQYVNIDGARIRGIEASASYDAGLWATGLSYGYTIGKDQN--- 553

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  306 keevrkiakeqTEQlihsrrnsieryfresmrdipdrekilremnhfyqeeyYKKNIgnkdamkdyidkyvkekidsild 385
Cdd:TIGR01785 554 -----------TNQ--------------------------------------WLSNI----------------------- 561

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  386 assiensrkeklkagirnnlendrnyvenirkqydyeyslengeflkegdtiplaPKIKATFGADYQFTD-KLKLGMNFN 464
Cdd:TIGR01785 562 -------------------------------------------------------PPLKLVVTVGYRFPDrRLDLGAKAA 586

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955  465 YIGSY---TTVEPARGYEIIKTkvPSHLVSDFYGTYNWTE--DFSIKFGINNVFNHEYNLRQDstTATPAPGRTYSAGFS 539
Cdd:TIGR01785 587 YYERQsesPTTEDVAANGLLTT--PGYTVVDLYATYQPNAvkGLTVRFGVNNLTDRKYTPAQS--VPGAGPGRNFKGSVK 662


                  ...
gi 371656955  540 YRF 542
Cdd:TIGR01785 663 YQF 665
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
434-542 1.36e-03

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 41.55  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 434 GDTIPLAPK--IKATFgaDYQFTDKLKLGMNFNYIG-------SYTTvEPARGYEiiKTKVPSHLVSDFYGTYNWTEDFS 504
Cdd:PRK13524 621 GDPLSIIPEytLNSTL--SWQATEDLSLQSTFTWYGkqkpkkyNYKG-QPVTGSA--TKEVSPYSIVGLSATYDVTKNVS 695

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 371656955 505 IKFGINNVFN----HEYNLRQDSTTATPA-------PGRTYSAGFSYRF 542
Cdd:PRK13524 696 LTGGVDNLFDkrlwREGNAQTTGDLIAGAgaytynePGRTYYMSLNTHF 744
FadL COG2067
Long-chain fatty acid transport protein [Lipid transport and metabolism];
419-542 4.12e-03

Long-chain fatty acid transport protein [Lipid transport and metabolism];


Pssm-ID: 441670 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 419 YDYEYSLENGEFLKEGDTIPLA-PKIkATFGADYQFTDKLKLGMNFNYIGsYTTVEpargyEIIKTKVPSHLVSDFYGTY 497
Cdd:COG2067  225 ATFSGPASLGLFADTAGSADLDlPAT-LSLGVAYKLTDKLTLAADVTWTN-WSSFD-----ELAITFDNPVGSPDSVLPF 297

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 371656955 498 NWtED-FSIKFGINNVFNHEYNLR------------QDSTTATPAPGRT-YSAGFSYRF 542
Cdd:COG2067  298 NW-KDtWVYALGAEYKLNDKLTLRagyaydespvpdETRNPLIPDGDRHwLSLGAGYKL 355
FadL COG2067
Long-chain fatty acid transport protein [Lipid transport and metabolism];
447-542 6.42e-03

Long-chain fatty acid transport protein [Lipid transport and metabolism];


Pssm-ID: 441670 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371656955 447 FGADYQFTDKLKLGMNFNYIGS-----YTTVE-PArgyeiiktkVPSHLVSdFYGTYNWTEDFSIKFGINNVFNHEYNLR 520
Cdd:COG2067  307 LGAEYKLNDKLTLRAGYAYDESpvpdeTRNPLiPD---------GDRHWLS-LGAGYKLSKNLSLDLAYAYLFGKDRTIN 376

                         90       100
                 ....*....|....*....|....*...
gi 371656955 521 qDSTTATPAPGRT------YSAGFSYRF 542
Cdd:COG2067  377 -NTSTPGNLNGTYkasaniLGLSLSYKF 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH