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Conserved domains on  [gi|371122113|ref|NP_001243050|]
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S100P-binding protein [Homo sapiens]

Protein Classification

S100PBPR domain-containing protein( domain architecture ID 10634196)

S100PBPR domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
S100PBPR pfam15427
S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to ...
22-402 0e+00

S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridization shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.


:

Pssm-ID: 464711  Cd Length: 389  Bit Score: 696.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   22 APFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGE-----DDGGHVEKGERGSQILLDTPR 96
Cdd:pfam15427   2 APFSWGSLDEDELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDSSNEHSSWEggllkDDGGHVEKGERGSQILLDTPQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   97 EKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT-VAPFNPTVCDALLDKDETDSSKDTEKLS 175
Cdd:pfam15427  82 EKNSLYSLGPVAETPGLFKLPQLSTSVGHGPTPTKPLNRRFVLEKNLIKVTvVAPFNPTVCDAVLDKDKTDSSKDTEKPS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  176 SLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS-SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSC 254
Cdd:pfam15427 162 SLGEEMREDGLSPNESKLCTESEGISPNNSAWDGPQLSSpSNNNFQQTVSDKNMPDSKKPTPVFSQISDHSETPNVGSSW 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  255 RNGGSHKSSCEMRSLVVSTSSNKqDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIE 334
Cdd:pfam15427 242 RNGGSHKSSCEVRFPVVSSSSNK-DVLDKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSDLEQQKQIYLRSVIAHIE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371122113  335 DPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQWVDRNMRSHHRFQRL 402
Cdd:pfam15427 321 DPVDSNQGALGELYALMDQVHHMQNQKWQHPSDLTMRNYARfRQKPLQRYSLTQWVDRNKRSHHRFQRL 389
 
Name Accession Description Interval E-value
S100PBPR pfam15427
S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to ...
22-402 0e+00

S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridization shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.


Pssm-ID: 464711  Cd Length: 389  Bit Score: 696.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   22 APFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGE-----DDGGHVEKGERGSQILLDTPR 96
Cdd:pfam15427   2 APFSWGSLDEDELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDSSNEHSSWEggllkDDGGHVEKGERGSQILLDTPQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   97 EKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT-VAPFNPTVCDALLDKDETDSSKDTEKLS 175
Cdd:pfam15427  82 EKNSLYSLGPVAETPGLFKLPQLSTSVGHGPTPTKPLNRRFVLEKNLIKVTvVAPFNPTVCDAVLDKDKTDSSKDTEKPS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  176 SLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS-SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSC 254
Cdd:pfam15427 162 SLGEEMREDGLSPNESKLCTESEGISPNNSAWDGPQLSSpSNNNFQQTVSDKNMPDSKKPTPVFSQISDHSETPNVGSSW 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  255 RNGGSHKSSCEMRSLVVSTSSNKqDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIE 334
Cdd:pfam15427 242 RNGGSHKSSCEVRFPVVSSSSNK-DVLDKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSDLEQQKQIYLRSVIAHIE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371122113  335 DPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQWVDRNMRSHHRFQRL 402
Cdd:pfam15427 321 DPVDSNQGALGELYALMDQVHHMQNQKWQHPSDLTMRNYARfRQKPLQRYSLTQWVDRNKRSHHRFQRL 389
 
Name Accession Description Interval E-value
S100PBPR pfam15427
S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to ...
22-402 0e+00

S100P-binding protein; S100PBPR is a family of proteins found in eukaryotes, and localized to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridization shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.


Pssm-ID: 464711  Cd Length: 389  Bit Score: 696.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   22 APFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGE-----DDGGHVEKGERGSQILLDTPR 96
Cdd:pfam15427   2 APFSWGSLDEDELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDSSNEHSSWEggllkDDGGHVEKGERGSQILLDTPQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113   97 EKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT-VAPFNPTVCDALLDKDETDSSKDTEKLS 175
Cdd:pfam15427  82 EKNSLYSLGPVAETPGLFKLPQLSTSVGHGPTPTKPLNRRFVLEKNLIKVTvVAPFNPTVCDAVLDKDKTDSSKDTEKPS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  176 SLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS-SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSC 254
Cdd:pfam15427 162 SLGEEMREDGLSPNESKLCTESEGISPNNSAWDGPQLSSpSNNNFQQTVSDKNMPDSKKPTPVFSQISDHSETPNVGSSW 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371122113  255 RNGGSHKSSCEMRSLVVSTSSNKqDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIE 334
Cdd:pfam15427 242 RNGGSHKSSCEVRFPVVSSSSNK-DVLDKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSDLEQQKQIYLRSVIAHIE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371122113  335 DPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQWVDRNMRSHHRFQRL 402
Cdd:pfam15427 321 DPVDSNQGALGELYALMDQVHHMQNQKWQHPSDLTMRNYARfRQKPLQRYSLTQWVDRNKRSHHRFQRL 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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