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Conserved domains on  [gi|3688566|emb|CAA09716|]
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suv3 protein [Saccharomyces douglasii]

Protein Classification

SUV3 family DEAD/DEAH box RNA helicase( domain architecture ID 13027475)

SUV3 family DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to Saccharomyces cerevisiae ATP-dependent RNA helicase SUV3 that is required for intron-independent turnover and processing of mitochondrial RNA

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0016887|GO:0003723|GO:0003724|GO:0005524
PubMed:  20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 232-378 2.39e-79

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 250.17  E-value: 2.39e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  232 RHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRFQSEKVRCNLLTGEEVIRDlddkgNPAGLTSGTVEM 311
Cdd:cd17913   1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREV-----EGATHVSCTVEM 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3688566  312 VPINQKFDVVVLDEIQMMSDADRGWAWTNALLGVVSKEVHLVGEKSVLPLVKSIVKMTGDKLTINEY 378
Cdd:cd17913  76 ASISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 382-519 2.38e-61

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 202.02  E-value: 2.38e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  382 GKLSVEDKPVKdGIKGLRKGDCVVAFSKKKVLDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGE--YDIMVASDA 459
Cdd:cd18805   1 TPLSVESKPLG-SLRNLRPGDCVVAFSRKDIFSLKREIEKRTGLKCAVIYGALPPETRRQQARLFNDPEsgYDVLVASDA 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  460 IGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGRFKSKstsggVPQGFITSF 519
Cdd:cd18805  80 IGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSH-----FPEGEVTTL 134
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 666-710 5.86e-17

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


:

Pssm-ID: 463616  Cd Length: 47  Bit Score: 74.86  E-value: 5.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 3688566    666 YESLYNIITLYFWLSNRYPNYFIDMESAKDLKYFCEMIIFEKLDR 710
Cdd:pfam12513   3 LESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 232-378 2.39e-79

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 250.17  E-value: 2.39e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  232 RHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRFQSEKVRCNLLTGEEVIRDlddkgNPAGLTSGTVEM 311
Cdd:cd17913   1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREV-----EGATHVSCTVEM 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3688566  312 VPINQKFDVVVLDEIQMMSDADRGWAWTNALLGVVSKEVHLVGEKSVLPLVKSIVKMTGDKLTINEY 378
Cdd:cd17913  76 ASISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 382-519 2.38e-61

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 202.02  E-value: 2.38e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  382 GKLSVEDKPVKdGIKGLRKGDCVVAFSKKKVLDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGE--YDIMVASDA 459
Cdd:cd18805   1 TPLSVESKPLG-SLRNLRPGDCVVAFSRKDIFSLKREIEKRTGLKCAVIYGALPPETRRQQARLFNDPEsgYDVLVASDA 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  460 IGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGRFKSKstsggVPQGFITSF 519
Cdd:cd18805  80 IGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSH-----FPEGEVTTL 134
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
231-501 1.80e-31

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 131.21  E-value: 1.80e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  231 RRHIIMHIGPTNSGKTYRALQK----LKSVDRGYYAGPLRLLAREVYDRFQSE--KVRCNLLTGEEVIrdlddkgNP-AG 303
Cdd:COG4581  39 AGRSVLVAAPTGSGKTLVAEFAiflaLARGRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDASV-------NPdAP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  304 LTSGTVEMVPiNQKF---------DVVVLDEIQMMSDADRGWAWTNALLGvVSKEVHLVGEKS----VLPLVKSIVKMTG 370
Cdd:COG4581 112 IVVMTTEILR-NMLYregadledvGVVVMDEFHYLADPDRGWVWEEPIIH-LPARVQLVLLSAtvgnAEEFAEWLTRVRG 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  371 DKLTINEYER----------------LGKLSVEDK---PVKDGIKGLRKGDC----VVAFS---------KKKVLDLKLK 418
Cdd:COG4581 190 ETAVVVSEERpvplefhylvtprlfpLFRVNPELLrppSRHEVIEELDRGGLlpaiVFIFSrrgcdeaaqQLLSARLTTK 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  419 IEKD----------TNLK--------------VAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNLSIDRVVFT 474
Cdd:COG4581 270 EERAeireaidefaEDFSvlfgktlsrllrrgIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFT 349

                       330       340
                ....*....|....*....|....*..
gi 3688566  475 TNMKYNGEELMEMTSSQIKQIGGRAGR 501
Cdd:COG4581 350 KLSKFDGERHRPLTAREFHQIAGRAGR 376
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 666-710 5.86e-17

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 74.86  E-value: 5.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 3688566    666 YESLYNIITLYFWLSNRYPNYFIDMESAKDLKYFCEMIIFEKLDR 710
Cdd:pfam12513   3 LESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 398-503 2.13e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.55  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566    398 LRKGDCVVAFSKKKVLDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNL-SIDRVVFtTN 476
Cdd:pfam00271  12 KERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLpDVDLVIN-YD 90

                          90       100
                  ....*....|....*....|....*..
gi 3688566    477 MKYNgeelmemtSSQIKQIGGRAGRFK 503
Cdd:pfam00271  91 LPWN--------PASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
424-503 9.37e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 66.85  E-value: 9.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566     424 NLKVAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNL-SIDRVVFTTnmkyngeelMEMTSSQIKQIGGRAGRF 502
Cdd:smart00490  11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLpGVDLVIIYD---------LPWSPASYIQRIGRAGRA 81


                   .
gi 3688566     503 K 503
Cdd:smart00490  82 G 82
DEXDc smart00487
DEAD-like helicases superfamily;
221-354 1.28e-09

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 58.66  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566     221 AEWFSEARKIRRHIIMHiGPTNSGKTYR----ALQKLKSVDRGY--YAGPLRLLAREVYDRFQSE-----KVRCNLLTGE 289
Cdd:smart00487  14 KEAIEALLSGLRDVILA-APTGSGKTLAallpALEALKRGKGGRvlVLVPTRELAEQWAEELKKLgpslgLKVVGLYGGD 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3688566     290 EVIRDLDD-KGNPAGLTSGTVEMV--------PINQKFDVVVLDEIQMMSDADRGWAWTNaLLGVVSKEVHLVG 354
Cdd:smart00487  93 SKREQLRKlESGKTDILVTTPGRLldllendkLSLSNVDLVILDEAHRLLDGGFGDQLEK-LLKLLPKNVQLLL 165
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 238-354 4.47e-07

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 50.32  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566    238 IGPTNSGKT----YRALQKLKSVDRGYYA---GPLRLLAREVYDRFQS----EKVRCNLLTGEEVIRDLDDK-------- 298
Cdd:pfam00270  20 QAPTGSGKTlaflLPALEALDKLDNGPQAlvlAPTRELAEQIYEELKKlgkgLGLKVASLLGGDSRKEQLEKlkgpdilv 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 3688566    299 GNPAGLTSGTVEMVPInQKFDVVVLDEIQMMSDADRGWAWTnALLGVVSKEVHLVG 354
Cdd:pfam00270 100 GTPGRLLDLLQERKLL-KNLKLLVLDEAHRLLDMGFGPDLE-EILRRLPKKRQILL 153
PRK02362 PRK02362
ATP-dependent DNA helicase;
240-335 1.27e-05

ATP-dependent DNA helicase;


Pssm-ID: 235032 [Multi-domain]  Cd Length: 737  Bit Score: 48.80  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566   240 PTNSGKTYRA-LQKLKSVDRG---YYAGPLRLLAREVYDRFQ---SEKVRCNLLTGeevirDLDDKGnpAGLTS-----G 307
Cdd:PRK02362  47 PTASGKTLIAeLAMLKAIARGgkaLYIVPLRALASEKFEEFErfeELGVRVGISTG-----DYDSRD--EWLGDndiivA 119

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 3688566   308 TVEMV--------PINQKFDVVVLDEIQMMSDADRG 335
Cdd:PRK02362 120 TSEKVdsllrngaPWLDDITCVVVDEVHLIDSANRG 155
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 421-466 1.07e-03

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 42.52  E-value: 1.07e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 3688566  421 KDTNLKVAVIYGSLPPETRVQQAALFNNGEY--DIMVASDAIGMGLNL 466
Cdd:COG0553 570 EERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKAGGEGLNL 617
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 232-378 2.39e-79

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 250.17  E-value: 2.39e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  232 RHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRFQSEKVRCNLLTGEEVIRDlddkgNPAGLTSGTVEM 311
Cdd:cd17913   1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREV-----EGATHVSCTVEM 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3688566  312 VPINQKFDVVVLDEIQMMSDADRGWAWTNALLGVVSKEVHLVGEKSVLPLVKSIVKMTGDKLTINEY 378
Cdd:cd17913  76 ASISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 382-519 2.38e-61

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 202.02  E-value: 2.38e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  382 GKLSVEDKPVKdGIKGLRKGDCVVAFSKKKVLDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGE--YDIMVASDA 459
Cdd:cd18805   1 TPLSVESKPLG-SLRNLRPGDCVVAFSRKDIFSLKREIEKRTGLKCAVIYGALPPETRRQQARLFNDPEsgYDVLVASDA 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  460 IGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGRFKSKstsggVPQGFITSF 519
Cdd:cd18805  80 IGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSH-----FPEGEVTTL 134
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
231-501 1.80e-31

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 131.21  E-value: 1.80e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  231 RRHIIMHIGPTNSGKTYRALQK----LKSVDRGYYAGPLRLLAREVYDRFQSE--KVRCNLLTGEEVIrdlddkgNP-AG 303
Cdd:COG4581  39 AGRSVLVAAPTGSGKTLVAEFAiflaLARGRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDASV-------NPdAP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  304 LTSGTVEMVPiNQKF---------DVVVLDEIQMMSDADRGWAWTNALLGvVSKEVHLVGEKS----VLPLVKSIVKMTG 370
Cdd:COG4581 112 IVVMTTEILR-NMLYregadledvGVVVMDEFHYLADPDRGWVWEEPIIH-LPARVQLVLLSAtvgnAEEFAEWLTRVRG 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  371 DKLTINEYER----------------LGKLSVEDK---PVKDGIKGLRKGDC----VVAFS---------KKKVLDLKLK 418
Cdd:COG4581 190 ETAVVVSEERpvplefhylvtprlfpLFRVNPELLrppSRHEVIEELDRGGLlpaiVFIFSrrgcdeaaqQLLSARLTTK 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  419 IEKD----------TNLK--------------VAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNLSIDRVVFT 474
Cdd:COG4581 270 EERAeireaidefaEDFSvlfgktlsrllrrgIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFT 349

                       330       340
                ....*....|....*....|....*..
gi 3688566  475 TNMKYNGEELMEMTSSQIKQIGGRAGR 501
Cdd:COG4581 350 KLSKFDGERHRPLTAREFHQIAGRAGR 376
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 666-710 5.86e-17

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 74.86  E-value: 5.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 3688566    666 YESLYNIITLYFWLSNRYPNYFIDMESAKDLKYFCEMIIFEKLDR 710
Cdd:pfam12513   3 LESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 398-503 2.13e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.55  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566    398 LRKGDCVVAFSKKKVLDLKLKIEKDTNLKVAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNL-SIDRVVFtTN 476
Cdd:pfam00271  12 KERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLpDVDLVIN-YD 90

                          90       100
                  ....*....|....*....|....*..
gi 3688566    477 MKYNgeelmemtSSQIKQIGGRAGRFK 503
Cdd:pfam00271  91 LPWN--------PASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
424-503 9.37e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 66.85  E-value: 9.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566     424 NLKVAVIYGSLPPETRVQQAALFNNGEYDIMVASDAIGMGLNL-SIDRVVFTTnmkyngeelMEMTSSQIKQIGGRAGRF 502
Cdd:smart00490  11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLpGVDLVIIYD---------LPWSPASYIQRIGRAGRA 81


                   .
gi 3688566     503 K 503
Cdd:smart00490  82 G 82
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 240-338 5.39e-10

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 59.20  E-value: 5.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  240 PTNSGKT----YRALQKLKSVD-RGYYAGPLRLLAREVYD----RFQSEKVRCNLLTGEEVIRDLDDKGNPAGLTsgTVE 310
Cdd:cd17921  25 PTSSGKTliaeLAILRALATSGgKAVYIAPTRALVNQKEAdlreRFGPLGKNVGLLTGDPSVNKLLLAEADILVA--TPE 102

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 3688566  311 MV---------PINQKFDVVVLDEIQMMSDADRGWAW 338
Cdd:cd17921 103 KLdlllrnggeRLIQDVRLVVVDEAHLIGDGERGVVL 139
DEXDc smart00487
DEAD-like helicases superfamily;
221-354 1.28e-09

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 58.66  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566     221 AEWFSEARKIRRHIIMHiGPTNSGKTYR----ALQKLKSVDRGY--YAGPLRLLAREVYDRFQSE-----KVRCNLLTGE 289
Cdd:smart00487  14 KEAIEALLSGLRDVILA-APTGSGKTLAallpALEALKRGKGGRvlVLVPTRELAEQWAEELKKLgpslgLKVVGLYGGD 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3688566     290 EVIRDLDD-KGNPAGLTSGTVEMV--------PINQKFDVVVLDEIQMMSDADRGWAWTNaLLGVVSKEVHLVG 354
Cdd:smart00487  93 SKREQLRKlESGKTDILVTTPGRLldllendkLSLSNVDLVILDEAHRLLDGGFGDQLEK-LLKLLPKNVQLLL 165
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
240-501 2.19e-09

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 60.68  E-value: 2.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  240 PTNSGKT---YRALqkLKSVDRGY---YAGPLRLLAREVYDRFqsekvrcnlltgeevIRDLDDKGNPAGLTSG------ 307
Cdd:COG1204  46 PTASGKTliaELAI--LKALLNGGkalYIVPLRALASEKYREF---------------KRDFEELGIKVGVSTGdydsdd 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  308 -----------TVEMV--------PINQKFDVVVLDEIQMMSDADRGW-------------------------------- 336
Cdd:COG1204 109 ewlgrydilvaTPEKLdsllrngpSWLRDVDLVVVDEAHLIDDESRGPtlevllarlrrlnpeaqivalsatignaeeia 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  337 AWTNALL------------GVVS------KEVHLVGEKSVLPLVKSIVKMTG------------------------DKLT 374
Cdd:COG1204 189 EWLDAELvksdwrpvplneGVLYdgvlrfDDGSRRSKDPTLALALDLLEEGGqvlvfvssrrdaeslakkladelkRRLT 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  375 INEYERLGKLSVEDKPVKDG-------IKGLRKGdcvVAFSkkkvldlklkiekdtnlkvaviYGSLPPETR--VQQAal 445
Cdd:COG1204 269 PEEREELEELAEELLEVSEEthtneklADCLEKG---VAFH----------------------HAGLPSELRrlVEDA-- 321

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3688566  446 FNNGEYDIMVASDAIGMGLNLSIDRVVFTTNMKYNGEelmEMTSSQIKQIGGRAGR 501
Cdd:COG1204 322 FREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMV---PIPVLEFKQMAGRAGR 374
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 238-354 4.47e-07

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 50.32  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566    238 IGPTNSGKT----YRALQKLKSVDRGYYA---GPLRLLAREVYDRFQS----EKVRCNLLTGEEVIRDLDDK-------- 298
Cdd:pfam00270  20 QAPTGSGKTlaflLPALEALDKLDNGPQAlvlAPTRELAEQIYEELKKlgkgLGLKVASLLGGDSRKEQLEKlkgpdilv 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 3688566    299 GNPAGLTSGTVEMVPInQKFDVVVLDEIQMMSDADRGWAWTnALLGVVSKEVHLVG 354
Cdd:pfam00270 100 GTPGRLLDLLQERKLL-KNLKLLVLDEAHRLLDMGFGPDLE-EILRRLPKKRQILL 153
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
 445-501 6.70e-07

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 49.47  E-value: 6.70e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3688566  445 LFNNGEYDIMVASDAIGMGLNLSIDRVVFTTNMKYNGEELMEMTSSQIKQIGGRAGR 501
Cdd:cd18795  84 LFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGR 140
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 240-335 1.93e-06

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 48.87  E-value: 1.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  240 PTNSGKTYRA-LQKLKSVDRG---YYAGPLRLLAREVYDRFQSEK---VRCNLLTGeevirdlDDKGNPAGLTSGTVeMV 312
Cdd:cd18028  25 PTASGKTLIAeMAMVNTLLEGgkaLYLVPLRALASEKYEEFKKLEeigLKVGISTG-------DYDEDDEWLGDYDI-IV 96

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 3688566  313 PINQKFD--------------VVVLDEIQMMSDADRG 335
Cdd:cd18028  97 ATYEKFDsllrhspswlrdvgVVVVDEIHLISDEERG 133
PRK02362 PRK02362
ATP-dependent DNA helicase;
240-335 1.27e-05

ATP-dependent DNA helicase;


Pssm-ID: 235032 [Multi-domain]  Cd Length: 737  Bit Score: 48.80  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566   240 PTNSGKTYRA-LQKLKSVDRG---YYAGPLRLLAREVYDRFQ---SEKVRCNLLTGeevirDLDDKGnpAGLTS-----G 307
Cdd:PRK02362  47 PTASGKTLIAeLAMLKAIARGgkaLYIVPLRALASEKFEEFErfeELGVRVGISTG-----DYDSRD--EWLGDndiivA 119

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 3688566   308 TVEMV--------PINQKFDVVVLDEIQMMSDADRG 335
Cdd:PRK02362 120 TSEKVdsllrngaPWLDDITCVVVDEVHLIDSANRG 155
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 239-335 3.39e-04

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 41.62  E-value: 3.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  239 GPTNSGKTYRALQKLKSVDRGY-----YAGPLRLLAREVYDRFQSE---KVRCNLLTGEEviRDLDDKGNPAG---LTSG 307
Cdd:cd00046   8 APTGSGKTLAALLAALLLLLKKgkkvlVLVPTKALALQTAERLRELfgpGIRVAVLVGGS--SAEEREKNKLGdadIIIA 85

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 3688566  308 TVEMV--PINQ-------KFDVVVLDEIQMMSDADRG 335
Cdd:cd00046  86 TPDMLlnLLLRedrlflkDLKLIIVDEAHALLIDSRG 122
DEAD-like_helicase_N cd17912
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 234-355 6.68e-04

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


Pssm-ID: 350670 [Multi-domain]  Cd Length: 81  Bit Score: 39.04  E-value: 6.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  234 IIMHIGPTNSGKTYRALQKLKSVDR----GYYAGPLRLLAREvydrfqsekvrcnlltgeevirdlddkgnpagltsgtv 309
Cdd:cd17912   1 NILHLGPTGSGKTLVAIQKIASAMSsgksVLVVTPTKLLAHE-------------------------------------- 42

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 3688566  310 emvpinqkfDVVVLDEIQMMSDADRGWAW-TNALLGVVSKEVHLVGE 355
Cdd:cd17912  43 ---------ILIVIDEIQ*ILDPAAGWAWaTRALLGLKAEKVIGVGA 80
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 424-473 9.69e-04

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 39.77  E-value: 9.69e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 3688566  424 NLKVAVIYGSLPPETRVQQAALFNNGEYD--IMVASDAIGMGLNLSI-DRVVF 473
Cdd:cd18793  51 GIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAaNRVIL 103
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 421-466 1.07e-03

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 42.52  E-value: 1.07e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 3688566  421 KDTNLKVAVIYGSLPPETRVQQAALFNNGEY--DIMVASDAIGMGLNL 466
Cdd:COG0553 570 EERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKAGGEGLNL 617
DEXHc_Mtr4-like cd18024
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ...
 241-338 4.94e-03

DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350782 [Multi-domain]  Cd Length: 205  Bit Score: 38.96  E-value: 4.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3688566  241 TNSGKT----YRALQKLKSVDRGYYAGPLRLLAREVYDRFQSEKVRCNLLTGEEVIrdlddkgNP-AGLTSGTVEMV--- 312
Cdd:cd18024  56 TSAGKTvvaeYAIAQSLRDKQRVIYTSPIKALSNQKYRELQEEFGDVGLMTGDVTI-------NPnASCLVMTTEILrsm 128

                        90       100       110
                ....*....|....*....|....*....|.
gi 3688566  313 -----PINQKFDVVVLDEIQMMSDADRGWAW 338
Cdd:cd18024 129 lyrgsEIMREVAWVIFDEIHYMRDKERGVVW 159
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 453-505 9.86e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 35.76  E-value: 9.86e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 3688566  453 IMVASDAIGMGL-NLSIDRVVFTTNMKyngeelmemTSSQIKQIGGRAGRFKSK 505
Cdd:cd18785  25 ILVATNVLGEGIdVPSLDTVIFFDPPS---------SAASYIQRVGRAGRGGKD 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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