|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
6-796 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 689.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 6 VHNSLKPGPpVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILMHHFGFKVNFVI--------IIKARRKR 77
Cdd:PTZ00399 42 VNNSLTGGK-VEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMnitdiddkIIKRAREE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 78 LLElekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvkmh 157
Cdd:PTZ00399 121 KLS----------------------------------------------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 158 lsnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtIFTDLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQI 237
Cdd:PTZ00399 124 ------------------------------------------IFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEI 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 238 VAFVQKIIDKGFAYEANGSVYFDIAAFEKAGNTYARLRPESRNDKALQEEGEGSLSKSLEGKKRPGDFALWKKSKPGEPY 317
Cdd:PTZ00399 162 VDFIQKIIDNGFAYESNGSVYFDVEAFRKAGHVYPKLEPESVADEDRIAEGEGALGKVSGEKRSPNDFALWKASKPGEPS 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 318 WPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgEHTWVNYFLHMGHLSIAGSKM 397
Cdd:PTZ00399 242 WDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFD-----KHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 398 SKSLKNFQTIQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADNWENTVDNFFTNIKAKLAAagPTVDGIKDLSLE 477
Cdd:PTZ00399 317 SKSLKNFITIRQAL-SKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRE--SELTSPQKWTQH 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 478 DsraRGLIEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDKSgEPSLQALEAVARWVTKIVGIFGldasaqp 557
Cdd:PTZ00399 394 D---FELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGE-QPSAPLLRSVAQYVTKILSIFG------- 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 558 pydglgwaaagaastanldpraavqpyaaayakvkadvqalnLTEASVqnlleqqnpeaefaELEKSGERDIEKLALPYL 637
Cdd:PTZ00399 463 ------------------------------------------LVEGSD--------------GLGSQGQNSTSENFKPLL 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 638 RATSRLRDELRAIA-----AGLEPQAKKAVLALSDRIRDYDLTDLGVQLDDQADKPSLIKFVPAAKLVAAREEKAALLAE 712
Cdd:PTZ00399 487 EALLRFRDEVRDAAkaemkLISLDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPSVWKLDDKEELQREKEEKEALKEQ 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 713 KARQKEEARKAREKAEEEKWAKAKVPPQEMFKGDA-KYLEWDADGLPTKLADGSEVPKSQAKKLKKDWDRQKKLHDEYLA 791
Cdd:PTZ00399 567 KRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEdKYSAFDETGLPTHDADGEEISKKERKKLSKEYDKQAKLHEEYLA 646
|
....*
gi 367039653 792 KFGAS 796
Cdd:PTZ00399 647 KGGKS 651
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
3-688 |
1.91e-127 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 389.08 E-value: 1.91e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 3 SITVHNSL---KpgppVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILMHHfGFKVNFV---------II 70
Cdd:COG0215 1 TLKLYNTLtrkK----EEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLRYL-GYKVTYVrnitdvddkII 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 71 IKARRkrllelekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgEGKPgda 150
Cdd:COG0215 76 KRAAE--------------------------------------------------------------------EGES--- 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 151 eakvkmhlsnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRV 230
Cdd:COG0215 85 --------------------------------------------------IWELAERYIAAFHEDMDALGVLPPDIEPRA 114
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 231 TEYVPQIVAFVQKIIDKGFAYEANGSVYFDIAAFEKagntYARLrpeSRNDkaLQEEGEGSLSKSLEGKKRPGDFALWKK 310
Cdd:COG0215 115 TEHIPEMIELIERLIEKGHAYEADGDVYFDVRSFPD----YGKL---SGRN--LDDLRAGARVEVDEEKRDPLDFALWKA 185
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 311 SKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgeHTWVNYFLHMGHL 390
Cdd:COG0215 186 AKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATG------KPFARYWMHNGFL 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 391 SIAGSKMSKSLKNFQTIQDALAtTYTARNMRIVFLMGRWndgveisqdmRKQADnwentvdnfFTNikAKLAAAGPTVD- 469
Cdd:COG0215 260 TVNGEKMSKSLGNFFTVRDLLK-KYDPEVLRFFLLSAHY----------RSPLD---------FSE--EALEEAEKALEr 317
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 470 ---GIKDLSLEDSRARGLIEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDKSGEPSLQALEAVARWVTKIV 546
Cdd:COG0215 318 lynALRRLEEALGAADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDKAALAALAALLRALGGVL 397
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 547 GIFGLDASAqppydglgwaaagaastanldpraavqpyaaayakvKADVQALNLTEASVQNLLEQqnpeaefaeleksge 626
Cdd:COG0215 398 GLLLLEPEA------------------------------------WQGAAEDELLDALIEALIEE--------------- 426
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 367039653 627 rdieklalpylratsrlRDELRAiaaglepqAKKavLALSDRIRDyDLTDLGVQLDDQADKP 688
Cdd:COG0215 427 -----------------RAEARK--------AKD--FARADRIRD-ELAALGIVLEDTPDGT 460
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
17-445 |
6.16e-113 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 345.12 E-value: 6.16e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 17 PFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARRkrllelekekpy 87
Cdd:pfam01406 1 FFVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYL-QALGYDVQFVqnftdiddkIIKRARQ------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 88 taeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgEGKPgdaeakvkmhlsnmdsaaks 167
Cdd:pfam01406 68 --------------------------------------------------------EGES-------------------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 168 lrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDK 247
Cdd:pfam01406 72 ---------------------------------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKK 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 248 GFAYEA-NGSVYFDIAAFEkagnTYARLRPESRNDKALQEEGEGSlskslEGKKRPGDFALWKKSKPGEPYWPSPWGAGR 326
Cdd:pfam01406 119 GYAYVSdNGDVYFDVSSFP----DYGKLSGQNLEQLEAGARGEVS-----EGKRDPLDFALWKASKEGEPSWDSPWGKGR 189
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 327 PGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFhecGKGehtWVNYFLHMGHLSIAGSKMSKSLKNFQT 406
Cdd:pfam01406 190 PGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF---DKQ---LANYWLHNGHVMIDGEKMSKSLGNFFT 263
|
410 420 430
....*....|....*....|....*....|....*....
gi 367039653 407 IQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADN 445
Cdd:pfam01406 264 IRDVL-KRYDPEILRYFLLSVHYRSPLDFSEELLEQAKS 301
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
16-526 |
7.77e-99 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 314.32 E-value: 7.77e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 16 VPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARRKrllelekekp 86
Cdd:TIGR00435 12 EEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYL-RYLGYKVQYVqnitdiddkIIKRAREN---------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 87 ytAEQVRELVFKAFQAYaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvkmhlsnmdsaak 166
Cdd:TIGR00435 81 --GESVYEVSERFIEAY--------------------------------------------------------------- 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 167 slrdgsgfdgaeevllpyldslyketidtsdqtiftdltqamekaFNDdMAALNVLPPDAVTRVTEYVPQIVAFVQKIID 246
Cdd:TIGR00435 96 ---------------------------------------------FED-MKALNVLPPDLEPRATEHIDEIIEFIEQLIE 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 247 KGFAYEA-NGSVYFDIAAFEkagnTYARLrpeSRNDKALQEEGEGSLSKslEGKKRPGDFALWKKSKPGEPYWPSPWGAG 325
Cdd:TIGR00435 130 KGYAYVSdNGDVYFDVSKFK----DYGKL---SKQDLDQLEAGARVDVD--EAKRNKLDFVLWKSSKEGEPKWDSPWGKG 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 326 RPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFhecGKgehTWVNYFLHMGHLSIAGSKMSKSLKNFQ 405
Cdd:TIGR00435 201 RPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF---GK---QLAKYWMHNGFLMIDNEKMSKSLGNFF 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 406 TIQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADN-WEntvdnfftNIKAKLAAAGPTVDGIKDLSLEDSrargl 484
Cdd:TIGR00435 275 TVRDVL-KNYDPEILRYFLLSVHYRSPLDFSEELLEAAKNaLE--------RLYKALRVLDTSLAYSGNQSLNKF----- 340
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 367039653 485 iEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDK 526
Cdd:TIGR00435 341 -PDEKEFEARFVEAMDDDLNTANALAVLFELAKSINLTFVSK 381
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
5-431 |
1.84e-60 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 203.58 E-value: 1.84e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 5 TVHNSLKpGPPVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARr 75
Cdd:cd00672 1 RLYNTLT-RQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYL-EDLGYKVRYVqnitdiddkIIKRAR- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 76 krllelekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvK 155
Cdd:cd00672 78 -------------------------------------------------------------------------------E 78
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 156 MHLSnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRVteyvp 235
Cdd:cd00672 79 EGLS-----------------------------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV----- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 236 qivafvqkiidkgfayeangsvyfdiaafekagntyarlrpesrndkalqeegegslskslegkkrpgdfalwkkskpge 315
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 316 pywpspwgagrpgWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgeHTWVNYFLHMGHLSIAGS 395
Cdd:cd00672 113 -------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATG------KPFARYWLHTGHLTIDGE 173
|
410 420 430
....*....|....*....|....*....|....*.
gi 367039653 396 KMSKSLKNFQTIQDALAtTYTARNMRIVFLMGRWND 431
Cdd:cd00672 174 KMSKSLGNFITVRDALK-KYDPEVLRLALLSSHYRS 208
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
6-796 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 689.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 6 VHNSLKPGPpVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILMHHFGFKVNFVI--------IIKARRKR 77
Cdd:PTZ00399 42 VNNSLTGGK-VEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMnitdiddkIIKRAREE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 78 LLElekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvkmh 157
Cdd:PTZ00399 121 KLS----------------------------------------------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 158 lsnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtIFTDLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQI 237
Cdd:PTZ00399 124 ------------------------------------------IFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEI 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 238 VAFVQKIIDKGFAYEANGSVYFDIAAFEKAGNTYARLRPESRNDKALQEEGEGSLSKSLEGKKRPGDFALWKKSKPGEPY 317
Cdd:PTZ00399 162 VDFIQKIIDNGFAYESNGSVYFDVEAFRKAGHVYPKLEPESVADEDRIAEGEGALGKVSGEKRSPNDFALWKASKPGEPS 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 318 WPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgEHTWVNYFLHMGHLSIAGSKM 397
Cdd:PTZ00399 242 WDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFD-----KHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 398 SKSLKNFQTIQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADNWENTVDNFFTNIKAKLAAagPTVDGIKDLSLE 477
Cdd:PTZ00399 317 SKSLKNFITIRQAL-SKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRE--SELTSPQKWTQH 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 478 DsraRGLIEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDKSgEPSLQALEAVARWVTKIVGIFGldasaqp 557
Cdd:PTZ00399 394 D---FELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGE-QPSAPLLRSVAQYVTKILSIFG------- 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 558 pydglgwaaagaastanldpraavqpyaaayakvkadvqalnLTEASVqnlleqqnpeaefaELEKSGERDIEKLALPYL 637
Cdd:PTZ00399 463 ------------------------------------------LVEGSD--------------GLGSQGQNSTSENFKPLL 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 638 RATSRLRDELRAIA-----AGLEPQAKKAVLALSDRIRDYDLTDLGVQLDDQADKPSLIKFVPAAKLVAAREEKAALLAE 712
Cdd:PTZ00399 487 EALLRFRDEVRDAAkaemkLISLDKKKKQLLQLCDKLRDEWLPNLGIRIEDKPDGPSVWKLDDKEELQREKEEKEALKEQ 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 713 KARQKEEARKAREKAEEEKWAKAKVPPQEMFKGDA-KYLEWDADGLPTKLADGSEVPKSQAKKLKKDWDRQKKLHDEYLA 791
Cdd:PTZ00399 567 KRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEdKYSAFDETGLPTHDADGEEISKKERKKLSKEYDKQAKLHEEYLA 646
|
....*
gi 367039653 792 KFGAS 796
Cdd:PTZ00399 647 KGGKS 651
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
3-688 |
1.91e-127 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 389.08 E-value: 1.91e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 3 SITVHNSL---KpgppVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILMHHfGFKVNFV---------II 70
Cdd:COG0215 1 TLKLYNTLtrkK----EEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLRYL-GYKVTYVrnitdvddkII 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 71 IKARRkrllelekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgEGKPgda 150
Cdd:COG0215 76 KRAAE--------------------------------------------------------------------EGES--- 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 151 eakvkmhlsnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRV 230
Cdd:COG0215 85 --------------------------------------------------IWELAERYIAAFHEDMDALGVLPPDIEPRA 114
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 231 TEYVPQIVAFVQKIIDKGFAYEANGSVYFDIAAFEKagntYARLrpeSRNDkaLQEEGEGSLSKSLEGKKRPGDFALWKK 310
Cdd:COG0215 115 TEHIPEMIELIERLIEKGHAYEADGDVYFDVRSFPD----YGKL---SGRN--LDDLRAGARVEVDEEKRDPLDFALWKA 185
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 311 SKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgeHTWVNYFLHMGHL 390
Cdd:COG0215 186 AKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATG------KPFARYWMHNGFL 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 391 SIAGSKMSKSLKNFQTIQDALAtTYTARNMRIVFLMGRWndgveisqdmRKQADnwentvdnfFTNikAKLAAAGPTVD- 469
Cdd:COG0215 260 TVNGEKMSKSLGNFFTVRDLLK-KYDPEVLRFFLLSAHY----------RSPLD---------FSE--EALEEAEKALEr 317
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 470 ---GIKDLSLEDSRARGLIEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDKSGEPSLQALEAVARWVTKIV 546
Cdd:COG0215 318 lynALRRLEEALGAADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDKAALAALAALLRALGGVL 397
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 547 GIFGLDASAqppydglgwaaagaastanldpraavqpyaaayakvKADVQALNLTEASVQNLLEQqnpeaefaeleksge 626
Cdd:COG0215 398 GLLLLEPEA------------------------------------WQGAAEDELLDALIEALIEE--------------- 426
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 367039653 627 rdieklalpylratsrlRDELRAiaaglepqAKKavLALSDRIRDyDLTDLGVQLDDQADKP 688
Cdd:COG0215 427 -----------------RAEARK--------AKD--FARADRIRD-ELAALGIVLEDTPDGT 460
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
17-445 |
6.16e-113 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 345.12 E-value: 6.16e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 17 PFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARRkrllelekekpy 87
Cdd:pfam01406 1 FFVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYL-QALGYDVQFVqnftdiddkIIKRARQ------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 88 taeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgEGKPgdaeakvkmhlsnmdsaaks 167
Cdd:pfam01406 68 --------------------------------------------------------EGES-------------------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 168 lrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDK 247
Cdd:pfam01406 72 ---------------------------------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKK 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 248 GFAYEA-NGSVYFDIAAFEkagnTYARLRPESRNDKALQEEGEGSlskslEGKKRPGDFALWKKSKPGEPYWPSPWGAGR 326
Cdd:pfam01406 119 GYAYVSdNGDVYFDVSSFP----DYGKLSGQNLEQLEAGARGEVS-----EGKRDPLDFALWKASKEGEPSWDSPWGKGR 189
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 327 PGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFhecGKGehtWVNYFLHMGHLSIAGSKMSKSLKNFQT 406
Cdd:pfam01406 190 PGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF---DKQ---LANYWLHNGHVMIDGEKMSKSLGNFFT 263
|
410 420 430
....*....|....*....|....*....|....*....
gi 367039653 407 IQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADN 445
Cdd:pfam01406 264 IRDVL-KRYDPEILRYFLLSVHYRSPLDFSEELLEQAKS 301
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
16-526 |
7.77e-99 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 314.32 E-value: 7.77e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 16 VPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARRKrllelekekp 86
Cdd:TIGR00435 12 EEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYL-RYLGYKVQYVqnitdiddkIIKRAREN---------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 87 ytAEQVRELVFKAFQAYaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvkmhlsnmdsaak 166
Cdd:TIGR00435 81 --GESVYEVSERFIEAY--------------------------------------------------------------- 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 167 slrdgsgfdgaeevllpyldslyketidtsdqtiftdltqamekaFNDdMAALNVLPPDAVTRVTEYVPQIVAFVQKIID 246
Cdd:TIGR00435 96 ---------------------------------------------FED-MKALNVLPPDLEPRATEHIDEIIEFIEQLIE 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 247 KGFAYEA-NGSVYFDIAAFEkagnTYARLrpeSRNDKALQEEGEGSLSKslEGKKRPGDFALWKKSKPGEPYWPSPWGAG 325
Cdd:TIGR00435 130 KGYAYVSdNGDVYFDVSKFK----DYGKL---SKQDLDQLEAGARVDVD--EAKRNKLDFVLWKSSKEGEPKWDSPWGKG 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 326 RPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFhecGKgehTWVNYFLHMGHLSIAGSKMSKSLKNFQ 405
Cdd:TIGR00435 201 RPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF---GK---QLAKYWMHNGFLMIDNEKMSKSLGNFF 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 406 TIQDALaTTYTARNMRIVFLMGRWNDGVEISQDMRKQADN-WEntvdnfftNIKAKLAAAGPTVDGIKDLSLEDSrargl 484
Cdd:TIGR00435 275 TVRDVL-KNYDPEILRYFLLSVHYRSPLDFSEELLEAAKNaLE--------RLYKALRVLDTSLAYSGNQSLNKF----- 340
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 367039653 485 iEELEQAKKDVDAALRNSFDTPGAMQVILRLVRDANIYMNDK 526
Cdd:TIGR00435 341 -PDEKEFEARFVEAMDDDLNTANALAVLFELAKSINLTFVSK 381
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
18-427 |
5.53e-61 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 215.95 E-value: 5.53e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 18 FVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARrkrllELEkEKPYT 88
Cdd:PLN02946 73 FKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYL-KHLGYEVRYVrnftdvddkIIARAN-----ELG-EDPIS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 89 aeqvrelvfkafqayaasnlplltgadlpaldehsyLQRRdaaygsvlaggtlsgegkpgdaeakvkmhlsnmdsaaksl 168
Cdd:PLN02946 146 ------------------------------------LSRR---------------------------------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 169 rdgsgfdgaeevllpYLDSlyketidtsdqtiftdltqamekaFNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDKG 248
Cdd:PLN02946 150 ---------------YCEE------------------------FLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 249 FAYEANGSVYFDIAAFEkagnTYARLrpesrNDKALQEEGEGSLSKSLEGKKRPGDFALWKKSKPGEPYWPSPWGAGRPG 328
Cdd:PLN02946 191 CAYRVDGDVYFSVDKFP----EYGKL-----SGRKLEDNRAGERVAVDSRKKNPADFALWKAAKEGEPFWDSPWGPGRPG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 329 WHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSeayfheCGKGEHTWVNYFLHMGHLSIAGSKMSKSLKNFQTIQ 408
Cdd:PLN02946 262 WHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQS------CAACCDSNISYWIHNGFVTVDSEKMSKSLGNFFTIR 335
|
410
....*....|....*....
gi 367039653 409 DALaTTYTARNMRIvFLMG 427
Cdd:PLN02946 336 QVI-DLYHPLALRL-FLLG 352
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
5-431 |
1.84e-60 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 203.58 E-value: 1.84e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 5 TVHNSLKpGPPVPFVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFV---------IIIKARr 75
Cdd:cd00672 1 RLYNTLT-RQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYL-EDLGYKVRYVqnitdiddkIIKRAR- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 76 krllelekekpytaeqvrelvfkafqayaasnlplltgadlpaldehsylqrrdaaygsvlaggtlsgegkpgdaeakvK 155
Cdd:cd00672 78 -------------------------------------------------------------------------------E 78
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 156 MHLSnmdsaakslrdgsgfdgaeevllpyldslyketidtsdqtiFTDLTQAMEKAFNDDMAALNVLPPDAVTRVteyvp 235
Cdd:cd00672 79 EGLS-----------------------------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV----- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 236 qivafvqkiidkgfayeangsvyfdiaafekagntyarlrpesrndkalqeegegslskslegkkrpgdfalwkkskpge 315
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 316 pywpspwgagrpgWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAYFHecgkgeHTWVNYFLHMGHLSIAGS 395
Cdd:cd00672 113 -------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATG------KPFARYWLHTGHLTIDGE 173
|
410 420 430
....*....|....*....|....*....|....*.
gi 367039653 396 KMSKSLKNFQTIQDALAtTYTARNMRIVFLMGRWND 431
Cdd:cd00672 174 KMSKSLGNFITVRDALK-KYDPEVLRLALLSSHYRS 208
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
3-538 |
6.13e-53 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 191.67 E-value: 6.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 3 SITVHNSLkpGPPVP-FVPREEGKVSWYACGPTTYDLSHLGHARNYVSTDIIRRILmHHFGFKVNFVIIIkarrkrllel 81
Cdd:PRK14536 2 ALRLYNTL--GRQQEeFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTL-HFLGYRVTHVMNI---------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 82 ekekpytaeqvrelvfkafqayaasnlplltgADLPALDEhsylqrrDAAygsvlaggtlSGEgkpgdaeakvkmhlsnm 161
Cdd:PRK14536 69 --------------------------------TDVGHLTD-------DAD----------SGE----------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 162 DSAAKSLRDGsgfdgAEEVLlpyldslyketidtsdqtiftDLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQIVAFV 241
Cdd:PRK14536 83 DKMVKSAQEH-----GKSVL---------------------EIAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALI 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 242 QKIIDKGFAYEANGSVYFDIAAFEKagntYARLRPESRNDkaLQEEGEGSLSKSlegKKRPGDFALWKKSKPGEPY---W 318
Cdd:PRK14536 137 KRLEARGHTYCAGGNVYFDIRTFPS----YGSLASAAVED--LQAGARIEHDTN---KRNPHDFVLWFTRSKFENHaltW 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 319 PSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQSEAyfhECGKgehTWVNYFLHMGHLSIAGSKMS 398
Cdd:PRK14536 208 DSPWGRGYPGWHIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEA---ATGK---PWVRYWLHHEFLLMNKGKMS 281
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 399 KSLKNFQTIQDALATTYTARNMRIVFLMGRWNDGVEISQDMRKQAdnwENTVDNFFTNIKAKLAAAGPTVDGIKDLSLED 478
Cdd:PRK14536 282 KSAGQFLTLSSLQEKGFQPLDYRFFLLGGHYRSQLAFSWEALKTA---KAARRSLVRRVARVVDAARATTGSVRGTLAEC 358
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 367039653 479 SRARGLIEELEQAKK---DVDAALRNSFDTPGAMQVILRLVRDANIYMNDKSGepSLQALEAV 538
Cdd:PRK14536 359 AAERVAESRASESELlltDFRAALEDDFSTPKALSELQKLVKDTSVPPSLCLS--VLQAMDTV 419
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
212-534 |
7.57e-50 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 180.69 E-value: 7.57e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 212 FNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDKGFAYEANGS----VYFDIAAFEKAGNtyarlrpESRNDKALQEE 287
Cdd:TIGR03447 110 FREDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYIVEGPeypdVYFSIDATEQFGY-------ESGYDRATMLE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 288 --GEGSLSKSLEGKKRPGDFALWKKSKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHdnELAQ 365
Cdd:TIGR03447 183 lfAERGGDPDRPGKRDPLDALLWRAAREGEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHH--EFSA 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 366 SEAyfhECGKGEHTWVNYFLHMGHLSIAGSKMSKSLKNFQTIQDALATTYTARNMRIVFLMGRWNdgveisqdmrkqaDN 445
Cdd:TIGR03447 261 AHA---EAATGVRRMARHYVHAGMIGLDGEKMSKSLGNLVFVSKLRAAGVDPAAIRLGLLAGHYR-------------QD 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 446 WENTvDNFFTNIKAKL-----AAAGPTVDgikdlsledsRARGLIEELEQakkdvdaALRNSFDTPGAMQVILRLVRDAN 520
Cdd:TIGR03447 325 RDWT-DAVLAEAEARLarwraALALPDAP----------DATDLIARLRQ-------HLANDLDTPAALAAVDGWAADAL 386
|
330
....*....|....
gi 367039653 521 IYMNDKSGEPSLQA 534
Cdd:TIGR03447 387 SYGGSDTEAPALVA 400
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
212-532 |
6.63e-49 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 177.43 E-value: 6.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 212 FNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDKGFAYEANGS----VYFDIAAFEKAGNtyarlrpESRNDKALQEE 287
Cdd:PRK12418 83 FREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYVVDDEeypdVYFSVDATPQFGY-------ESGYDRATMLE 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 288 --GEGSLSKSLEGKKRPGDFALWKKSKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHdnELAQ 365
Cdd:PRK12418 156 lfAERGGDPDRPGKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLGSGFDIQGGGSDLIFPHH--EFSA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 366 SEAyfhECGKGEHTWVNYFLHMGHLSIAGSKMSKSLKNFQTIQDALATTYTARNMRIVFLMGRWndgveisqdmrkqADN 445
Cdd:PRK12418 234 AHA---EAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVFVSRLRAAGVDPAAIRLALLAGHY-------------RAD 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 446 WENTvDNFFTNIKAKL-----AAAGPTVDgikdlsledsRARGLIEEleqakkdVDAALRNSFDTPGAMQVILRLVRDAN 520
Cdd:PRK12418 298 REWT-DAVLAEAEARLarwraAAALPAGP----------DAADVVAR-------VRAALADDLDTPGALAAVDGWATDAL 359
|
330
....*....|..
gi 367039653 521 IYMNDKSGEPSL 532
Cdd:PRK12418 360 EGGGDDAAAPAL 371
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
203-538 |
1.63e-46 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 177.22 E-value: 1.63e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 203 DLTQAMEKAFNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDKGFAY-EANGSVYFDIAAFekagNTYARLRPESRND 281
Cdd:PRK14535 313 ELTARFIQAMHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYpAANGDVYYAVREF----AAYGQLSGKSLDD 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 282 KALQEEGEgslsksLEGKKR-PGDFALWKKSKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHD 360
Cdd:PRK14535 389 LRAGERVE------VDGFKRdPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHE 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 361 NELAQS-EAYFHECG----KGEH-----TWVNYFLHMGHLSIAGSKMSKSLKNFQTIQDALaTTYTARNMRIVFLMGRWN 430
Cdd:PRK14535 463 NEIAQSvGATGHTCGhhhaQTHHgqsiaSHVKYWLHNGFIRVDGEKMSKSLGNFFTIREVL-KQYDPEVVRFFILRAHYR 541
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 431 DGVEISQdmrKQADNWENTVDNFFTNIKAKLAAAGPTVDGIKDLSledsrarglieeleqakKDVDAALRNSFDTPGAMQ 510
Cdd:PRK14535 542 SPLNYSD---AHLDDAKGALTRLYTTLKNTPAAEFMLSENVNDYT-----------------RRFYAAMNDDFGTVEAVA 601
|
330 340
....*....|....*....|....*...
gi 367039653 511 VILRLVRDANiYMNDKSGEPSLQALEAV 538
Cdd:PRK14535 602 VLFELAGEVN-KTNDAQLAGCLKALGGI 628
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
210-409 |
6.94e-34 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 136.13 E-value: 6.94e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 210 KAFNDDMAALNVLPPDAVTRVTEYVPQIVAFVQKIIDKGFAYEANGSVYFDIAAFekagNTYARLRPESRNDKALQEEGE 289
Cdd:PRK14534 103 EAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTYFVNGNVYFDTSCF----KSYGQMAGINLNDFKDMSVSR 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 290 GSLSKSlegKKRPGDFALW---KKSKPGEPYWPSPWGAGRPGWHIECSVMASDKLGQQMDIHSGGIDLAFPHHDNELAQS 366
Cdd:PRK14534 179 VEIDKS---KRNKSDFVLWftnSKFKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIA 255
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 367039653 367 EAYFHEcgkgehTWVNYFLHMGHLSIAGSKMSKSLKNFQTIQD 409
Cdd:PRK14534 256 ECYLNK------KWCDMFVHGEFLIMEYEKMSKSNNNFITIKD 292
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
328-401 |
1.73e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.39 E-value: 1.73e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 367039653 328 GWHIECSVMASDKLGQQMDIHSGGIDLAFpHHDNELAQSeayfhECGKGEHtwVNYFLHMGHLSIA-GSKMSKSL 401
Cdd:cd00802 77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELL-----KKAGGPA--RPFGLTFGRVMGAdGTKMSKSK 143
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
388-542 |
2.86e-03 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 41.39 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 388 GHLSIAGSKMSKSLKNFQTIQDAlATTYTARNMRIvFLMGrwndGVEISQDMrkqadNW-----ENTVDNF--FTNIKAK 460
Cdd:PRK12300 569 GFVLLEGKKMSKSKGNVIPLRKA-IEEYGADVVRL-YLTS----SAELLQDA-----DWrekevESVRRQLerFYELAKE 637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 367039653 461 LAAAGptvdGIKDLSLEDsraRGLIEELEQAKKDVDAALrNSFDTPGAMQVILRLV-RDANIYMNDKSGEPSLQALEAVA 539
Cdd:PRK12300 638 LIEIG----GEEELRFID---KWLLSRLNRIIKETTEAM-ESFQTRDAVQEAFYELlNDLRWYLRRVGEANNKVLREVLE 709
|
...
gi 367039653 540 RWV 542
Cdd:PRK12300 710 IWI 712
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
377-434 |
7.25e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 40.05 E-value: 7.25e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 367039653 377 EHTWVNYFLHMGHLSIAGSKMSKSLKNFQTIQDALaTTYTARNMRivFLMGRWNDGVE 434
Cdd:PLN02959 699 EEHWPRGFRCNGHLMLNSEKMSKSTGNFLTLRQAI-EEFSADATR--FALADAGDGVD 753
|
|
| |
