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Conserved domains on  [gi|365767238|gb|EHN08723|]
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Ade1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10793931)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-305 1.17e-156

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


:

Pssm-ID: 237571  Cd Length: 296  Bit Score: 439.25  E-value: 1.17e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   1 MSITKTELDGiLPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIA 80
Cdd:PRK13961   2 STLMESDLPS-LPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTGID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  81 PgktifDYLPAklsePKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFT 160
Cdd:PRK13961  81 V-----DDVVP----ADEADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPIFT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 161 PSTKAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLTPDS 240
Cdd:PRK13961 152 PATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDED-GTLTLMDEVLTPDS 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 365767238 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGV-NGVKMPQDIVDRTRAKYIEAYETLTGSKWS 305
Cdd:PRK13961 231 SRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTaPAPPLPADVIEKTRAKYREALERLTGKSLD 296
 
Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-305 1.17e-156

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 439.25  E-value: 1.17e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   1 MSITKTELDGiLPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIA 80
Cdd:PRK13961   2 STLMESDLPS-LPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTGID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  81 PgktifDYLPAklsePKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFT 160
Cdd:PRK13961  81 V-----DDVVP----ADEADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPIFT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 161 PSTKAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLTPDS 240
Cdd:PRK13961 152 PATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDED-GTLTLMDEVLTPDS 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 365767238 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGV-NGVKMPQDIVDRTRAKYIEAYETLTGSKWS 305
Cdd:PRK13961 231 SRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTaPAPPLPADVIEKTRAKYREALERLTGKSLD 296
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-301 3.86e-153

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 429.66  E-value: 3.86e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  14 LVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIfdylpakl 93
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVEDLP-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  94 sEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGeHDEN 173
Cdd:cd01414   73 -EIKEPEDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HDEN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 174 ISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLTPDSSRFWNGASYKVGE 253
Cdd:cd01414  151 ISFEEAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDEN-GEIILIDEVLTPDSSRFWPADSYEPGK 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 365767238 254 SQDSYDKQFLRDWLTANKLNGVN--GVKMPQDIVDRTRAKYIEAYETLTG 301
Cdd:cd01414  230 EQPSFDKQFVRDWLEASGWDKQDppPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 12-303 4.39e-108

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 313.94  E-value: 4.39e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  12 LPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFL-SNDVRNHLVDiapgktifdylp 90
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLeDIGIPTHFIE------------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  91 aklsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKtgtvhGLKQPQGLKESQEFPEPIFTPSTKAEQGeH 170
Cdd:COG0152   72 ----------TLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKADEG-H 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 171 DENISPAQAAE--LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEkTNEIILVDEVlTPDSSRFWNGAS 248
Cdd:COG0152  136 DPNISEEHIVAlgLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDA-DGEIVLADEI-TPDSSRLWDADT 213

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 365767238 249 YKvgesqdSYDKQFLRDWLTANklngvngvkmpqdivdrTRAKYIEAYETLTGSK 303
Cdd:COG0152  214 YE------SLDKDRFRDWLGGN-----------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 14-274 2.41e-104

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 303.90  E-value: 2.41e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   14 LVARGKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVRNHLVDiapgktifdylpa 91
Cdd:pfam01259   1 LLYEGKVKDVYETdDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEiAGIPTHFIK------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   92 klsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSawkeyvktgtvhGLKQPQGLKESQEFPEPIFTPSTKAEQGeHD 171
Cdd:pfam01259  68 ---------SLSGREMLVKKVKIIPLEVVVRNYAAGS------------LGKRLPGLKEGTKLPEPIFEPSTKADAL-GD 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  172 ENISPAQAAEL--VGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEkTNEIILVDEVlTPDSSRFWNGASY 249
Cdd:pfam01259 126 PNINEEHIVALglATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDS-DGEIVLADEI-TPDSSRFWDADTY 203

                         250       260
                  ....*....|....*....|....*
gi 365767238  250 KvgESQDSYDKQFLRDWLTANKLNG 274
Cdd:pfam01259 204 E--KSQESLDKDRFRDDLGDVEEAY 226
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-301 3.95e-97

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 286.22  E-value: 3.95e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238    1 MSITKTeldgilPLVARGKVRDIYEVDAGTLL-FVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVrnhlvdi 79
Cdd:TIGR00081   1 MQIKKR------QKLYSGKAKDIYETDDPDLLrFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAG------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   80 apgktifdylpaklSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEyvktgtvhgLKQPQGLKESQEFPEPIF 159
Cdd:TIGR00081  68 --------------IPTHYIDLIEDREMLVKKLDIIPLEVIVRNIAAGSLLKR---------LGIPEGLELEQPLVEFIF 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  160 TPstkAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNeIILVDEVlTPD 239
Cdd:TIGR00081 125 KP---DEVGDPMLNESYAEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGN-LILADEV-SPD 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 365767238  240 SSRFWNGASYKVGesqdsydkqflrdwltanklngvnGVKMPQDIVDRTRAKYIEAYETLTG 301
Cdd:TIGR00081 200 TCRLWDKETYEVG------------------------APKLDKDIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-305 1.17e-156

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 439.25  E-value: 1.17e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   1 MSITKTELDGiLPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIA 80
Cdd:PRK13961   2 STLMESDLPS-LPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTGID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  81 PgktifDYLPAklsePKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFT 160
Cdd:PRK13961  81 V-----DDVVP----ADEADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPIFT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 161 PSTKAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLTPDS 240
Cdd:PRK13961 152 PATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDED-GTLTLMDEVLTPDS 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 365767238 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGV-NGVKMPQDIVDRTRAKYIEAYETLTGSKWS 305
Cdd:PRK13961 231 SRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTaPAPPLPADVIEKTRAKYREALERLTGKSLD 296
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-301 3.86e-153

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 429.66  E-value: 3.86e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  14 LVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIfdylpakl 93
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVEDLP-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  94 sEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGeHDEN 173
Cdd:cd01414   73 -EIKEPEDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HDEN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 174 ISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLTPDSSRFWNGASYKVGE 253
Cdd:cd01414  151 ISFEEAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDEN-GEIILIDEVLTPDSSRFWPADSYEPGK 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 365767238 254 SQDSYDKQFLRDWLTANKLNGVN--GVKMPQDIVDRTRAKYIEAYETLTG 301
Cdd:cd01414  230 EQPSFDKQFVRDWLEASGWDKQDppPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 12-303 4.39e-108

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 313.94  E-value: 4.39e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  12 LPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFL-SNDVRNHLVDiapgktifdylp 90
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLeDIGIPTHFIE------------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  91 aklsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKtgtvhGLKQPQGLKESQEFPEPIFTPSTKAEQGeH 170
Cdd:COG0152   72 ----------TLSGREMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKADEG-H 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 171 DENISPAQAAE--LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEkTNEIILVDEVlTPDSSRFWNGAS 248
Cdd:COG0152  136 DPNISEEHIVAlgLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDA-DGEIVLADEI-TPDSSRLWDADT 213

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 365767238 249 YKvgesqdSYDKQFLRDWLTANklngvngvkmpqdivdrTRAKYIEAYETLTGSK 303
Cdd:COG0152  214 YE------SLDKDRFRDWLGGN-----------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 14-274 2.41e-104

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 303.90  E-value: 2.41e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   14 LVARGKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVRNHLVDiapgktifdylpa 91
Cdd:pfam01259   1 LLYEGKVKDVYETdDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEiAGIPTHFIK------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   92 klsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSawkeyvktgtvhGLKQPQGLKESQEFPEPIFTPSTKAEQGeHD 171
Cdd:pfam01259  68 ---------SLSGREMLVKKVKIIPLEVVVRNYAAGS------------LGKRLPGLKEGTKLPEPIFEPSTKADAL-GD 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  172 ENISPAQAAEL--VGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEkTNEIILVDEVlTPDSSRFWNGASY 249
Cdd:pfam01259 126 PNINEEHIVALglATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDS-DGEIVLADEI-TPDSSRFWDADTY 203

                         250       260
                  ....*....|....*....|....*
gi 365767238  250 KvgESQDSYDKQFLRDWLTANKLNG 274
Cdd:pfam01259 204 E--KSQESLDKDRFRDDLGDVEEAY 226
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-301 3.95e-97

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 286.22  E-value: 3.95e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238    1 MSITKTeldgilPLVARGKVRDIYEVDAGTLL-FVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVrnhlvdi 79
Cdd:TIGR00081   1 MQIKKR------QKLYSGKAKDIYETDDPDLLrFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAG------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   80 apgktifdylpaklSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEyvktgtvhgLKQPQGLKESQEFPEPIF 159
Cdd:TIGR00081  68 --------------IPTHYIDLIEDREMLVKKLDIIPLEVIVRNIAAGSLLKR---------LGIPEGLELEQPLVEFIF 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  160 TPstkAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNeIILVDEVlTPD 239
Cdd:TIGR00081 125 KP---DEVGDPMLNESYAEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGN-LILADEV-SPD 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 365767238  240 SSRFWNGASYKVGesqdsydkqflrdwltanklngvnGVKMPQDIVDRTRAKYIEAYETLTG 301
Cdd:TIGR00081 200 TCRLWDKETYEVG------------------------APKLDKDIFRRTLGKLIEAYETVAR 237
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 14-300 1.96e-90

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 268.95  E-value: 1.96e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  14 LVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSN-DVRNHLVDIapgktifdylpak 92
Cdd:cd00476    1 TLYRGKTKIVYETKDGVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEaGIPTHFVER------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  93 lsepkyktqLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYvktgtvhglkqpQGLKESQEFPEPIFTPSTKAEQgEHDE 172
Cdd:cd00476   68 ---------LGPRTLLVDKLK*IPLEVVVRNRATGSFVKRY------------GGFKEGREFPPPLVEFFYKDDA-EHDP 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 173 NISPAQAAEL--VGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEIILVDEVLtPDSSRFWNGASYK 250
Cdd:cd00476  126 IVSEDQLERLgfIGKVDVER*KELAVKINTVLKKLFSPAGLELWDFKLEFGLDEE-GEIVLGDEIS-PDSSRLWRKGGEP 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 365767238 251 VGESQDsydkqflrdwltanklngvngvkMPQDIVDRTRAKYIEAYETLT 300
Cdd:cd00476  204 YDKDLF-----------------------RRRASLGQIIEKYEEVAELVR 230
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 3-303 7.34e-88

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 265.21  E-value: 7.34e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   3 ITKTELDGiLPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMEnSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIA-P 81
Cdd:PRK12607   7 LTEFNFPE-LPNVYRGKVRDNYDLPDGRRVMVATDRISAFDRVLP-AIPYKGQVLNQTAAFWFEATKDICPNHVLAVPdP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  82 GKTIfdylpAKLSEPkyktqledrsllvhkhklIPLEVIVRGYITGSAWKEYvKTG--TVHGLKQPQGLKESQEFPEPIF 159
Cdd:PRK12607  85 NVVV-----GKRCEP------------------FPVEMVVRGYLAGSTWRLY-KAGkrEMYGVTLPDGLRENQKLPEPII 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 160 TPSTKAEQGEHDENISPAQ--AAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDeKTNEIILVDEVLT 237
Cdd:PRK12607 141 TPTTKAEEGGHDEPISPEEilAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKD-ADGRIVLIDEIHT 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 365767238 238 PDSSRFWNGASY----KVGESQDSYDKQFLRDWLTANklNGVNGVK---MPQDIVDRTRAKYIEAYETLTGSK 303
Cdd:PRK12607 220 PDSSRYWYADGYeerfAAGEPQEQLDKEFVRQWLIER--CGPYGQEipeIPDEVIVSVSERYIELYEKITGET 290
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 3-303 5.89e-55

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 182.71  E-value: 5.89e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238   3 ITKTELD---GILPLVARGKVRDIYEVDAgTLLFVATDRISAYDVIMEnSIPEKGILLTKLSEFWFKFLSNDVRNHLVDi 79
Cdd:PLN02544  63 LTETNLDltvPGLGSRRRGKVRDIYDLGD-YLVLVTTDRQSAFDRVLA-SIPFKGQVLNQTSAWWFNNTKHITPNALVS- 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  80 APGKTIfdylpaklsepkyktqledrsLLVHKHKLIPLEVIVRGYITGSA----WKEYVKTGTVH-GLKQPQGLKESQEF 154
Cdd:PLN02544 140 SPDPNV---------------------TIAKKCSVFPVEFVVRGYMTGSTstslWTVYNKGVRNYcGNDLPDGMVKNQKL 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 155 PEPIFTPSTKAEqgEHDENISPAqaaELVGEDLSRR-----VAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKtNEI 229
Cdd:PLN02544 199 PANILTPTTKAA--DHDVPISPE---EIVEEGLMTQedfdeVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDAD-GTI 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 230 ILVDEVLTPDSSRFWNGASY----KVGESQDSYDKQFLRDWLtANKLNGVNGVKMPQ---DIVDRTRAKYIEAYETLTGS 302
Cdd:PLN02544 273 LLIDEVHTPDSSRYWLADSYeerhAAGLEPENIDKEFLRLWF-KENCDPYKDEVLPEapaELVCELSWRYIKLYETITGE 351


                 .
gi 365767238 303 K 303
Cdd:PLN02544 352 K 352
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 17-304 2.02e-29

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 114.39  E-value: 2.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  17 RGKVRDIY------EVDAGTLLFVATDRISAYDV-IMENSIPEKGILLTKLSEFWFKFL-SNDVRNHLVDIAPGKTIFDY 88
Cdd:PRK13959   1 MGSVKDFYvdeeptETDLGRGRFVFSDRYSVFDWgIMPDEIPDKGASLCTMGAYNFELLeEEGIKTHYIGVVEDGEVVRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  89 LPAKLS------------EPKYKTQLEDRSLLvHKHK----LIPLEVIVRGYI-TGSAWKEYVKTGTV----HGLKQPQG 147
Cdd:PRK13959  81 AEASEPpnemavkltqvpDLPFEGGSYDYDAY-HEAAgenyLIPLEVIFRNYVpVGSSLRDRIKEGKIkpedLGLDADEW 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 148 LKESQEFPEPIFTPSTKAEqgEHDENISPAQAAELVGedLSR----RVAELAVKLYSKCKDYAKEKGIIIADTKFEFGID 223
Cdd:PRK13959 160 PEEGVKLPEPIVEFSTKYE--EQDRYLSRKEADEIAG--LSRaeieELEELALKVDEIITEEAEKRGLIHEDGKIEFALY 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 224 EKtNEIILVDEVLTPDSSRFwngaSYKVGESQDSYDKQFLR--DW---LTANKLNGVNGVK---------MPQDIVDRTR 289
Cdd:PRK13959 236 EE-REIRVVDVVGTFDENRF----SYEGQELSKEVVRQYYRrtEWveaVKEAKEEDVADWRslcepdpppLPDEVVEAVS 310

                        330
                 ....*....|....*
gi 365767238 290 AKYIEAYETLTGSKW 304
Cdd:PRK13959 311 DLYKAGTNAYTGREW 325
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 15-267 4.45e-28

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 111.33  E-value: 4.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  15 VARGKVRDIY------------------EVDAGTLLFVATDRISAYDVIME-----NSIPEKGILLTKLSEFWFK-FLSN 70
Cdd:PRK13960  22 VHSGKVRSVYwlteedsrrlikekgynvPADAPLAIMVISDRISAFDCIWHgegglNGVPGKGAALNAISNHWFKlFKEN 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  71 DVR-NHLVDIaPGKTIFdylpaklsepkyktqledrslLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVH-GLKQPQGL 148
Cdd:PRK13960 102 GLAdSHILDI-PHPFVW---------------------IVQKARPVMIEAICRQYITGSMWRAYSKGEREFcGITLPEGL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 149 KESQEFPEPIFTPSTK---------AEQgeHDENISPAqaaelvgeDLSRRVAELA------VKLYSK--------CKDY 205
Cdd:PRK13960 160 EKDQKLPELLITPSTKgiltgipgvPEA--DDVNISRS--------DIEANYQAFNfssaddIDLYEKllkegfkvISDA 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 365767238 206 AKEKGIIIADTKFEFGI--DEKTNE-IILVDEVLTPDSSRFWNGASYKVGESQDSyDKQFLRDWL 267
Cdd:PRK13960 230 LAKLDQIFVDTKFEFGYvtDAAGNEkLIYMDEVGTPDSSRIWDGAAYRDGKIVEN-SKEGFRQFL 293
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 18-260 2.72e-27

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 106.00  E-value: 2.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  18 GKVRDIYEVD-AGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVRNHLVDiapgktifdylpaklse 95
Cdd:cd01415    5 GKAKIVYATDdPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEeNGIKTHFIE----------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  96 pkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYvktgtvhglkqpqGLKESQEFPEPIFTPSTKaeqgeHDE--- 172
Cdd:cd01415   68 -----KLSDREQLVKKVEIIPLEVVVRNIAAGSLVKRL-------------GIEEGTVLDPPIVEFYYK-----NDElgd 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 173 ---NISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDeKTNEIILVDEVlTPDSSRFWNgasy 249
Cdd:cd01415  125 pliNEDHILALGLATEEELKEIKELALKINEVLSEFFAEIGIILVDFKLEFGRD-KDGEIVLADEI-SPDTCRLWD---- 198

                        250
                 ....*....|.
gi 365767238 250 kvGESQDSYDK 260
Cdd:cd01415  199 --KETGEKLDK 207
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 14-244 2.22e-26

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 104.03  E-value: 2.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  14 LVARGKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVRNHLVDiapgktifdylpa 91
Cdd:PRK09362   6 LLYEGKAKIVYSTdDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEeAGIPTHFIE------------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  92 klsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYvktgtvhglkqpqGLKESQEFPEPIFTPSTKaeqgeHD 171
Cdd:PRK09362  73 ---------KLSDREQLVKKVEIIPLEVVVRNVAAGSLVKRL-------------GIEEGTVLPPPIVEFYYK-----ND 125

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 365767238 172 E------NISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDeKTNEIILVDEVlTPDSSRFW 244
Cdd:PRK09362 126 AlgdpmiNEDHILALGWATPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFGRD-KDGEIVLADEI-SPDTCRLW 202
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 14-265 5.07e-13

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 67.32  E-value: 5.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  14 LVARGKVRDIYEV--DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSN-DVRNHLVDiapgktifdylp 90
Cdd:cd01416    6 KLIEGKTKIVYELpdQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEaGIKTHFVK------------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238  91 aklsepkyktQLEDRSLLVHKHKLIPLEVIVRGYITGSAwkeyvktgtvhgLKQPQGLKESQEFPEP---IFtpstKAEQ 167
Cdd:cd01416   74 ----------QCSPTAFIARKCEMIPIEWVCRRIATGSF------------LKRNPGVKEGYRFSPPkleFF----YKDD 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 168 GEHDENISPAQ--AAELVGEDL-------------SRRVAELAVKLYskckdyaKEKGIIIADTKFEFGIDEKTNEIILV 232
Cdd:cd01416  128 ANHDPQWSEEQllEAKLNCGGLkigkkevdimtksTIAIFEILEKAW-------ATQDCTLVDMKIEFGVDVTTGEILLA 200

                        250       260       270
                 ....*....|....*....|....*....|...
gi 365767238 233 DeVLTPDSSRFWNGasykvGESQDSYDKQFLRD 265
Cdd:cd01416  201 D-VIDNDSWRLWPS-----GDKRLMKDKQVYRN 227
PRK13351 PRK13351
elongation factor G-like protein;
105-195 8.05e-04

elongation factor G-like protein;


Pssm-ID: 237358 [Multi-domain]  Cd Length: 687  Bit Score: 41.09  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365767238 105 RSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTG-TVHGLKQPqGLKESQEFPEPIFTPSTKAEQGEHDENISPAqAAELV 183
Cdd:PRK13351 351 RLFRLQGNKREEVDRAKAGDIVAVAGLKELETGdTLHDSADP-VLLELLTFPEPVVSLAVEPERRGDEQKLAEA-LEKLV 428

                         90
                 ....*....|..
gi 365767238 184 GEDLSRRVAELA 195
Cdd:PRK13351 429 WEDPSLRVEEDE 440
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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