Cat8p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
Zn(II)2Cys6 transcription factor( domain architecture ID 11086775)
Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Fungal_trans | pfam04082 | Fungal specific transcription factor domain; This domain is found in a number of fungal ... |
529-692 | 1.11e-29 | ||||
Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR. : Pssm-ID: 397964 Cd Length: 262 Bit Score: 119.52 E-value: 1.11e-29
|
||||||||
Zn_clus | pfam00172 | Fungal Zn(2)-Cys(6) binuclear cluster domain; |
67-105 | 6.69e-15 | ||||
Fungal Zn(2)-Cys(6) binuclear cluster domain; : Pssm-ID: 395120 [Multi-domain] Cd Length: 39 Bit Score: 69.63 E-value: 6.69e-15
|
||||||||
ZIP_Cat8 | cd15485 | Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ... |
107-133 | 1.03e-08 | ||||
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. : Pssm-ID: 271243 Cd Length: 27 Bit Score: 51.78 E-value: 1.03e-08
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
Fungal_trans | pfam04082 | Fungal specific transcription factor domain; This domain is found in a number of fungal ... |
529-692 | 1.11e-29 | ||||
Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR. Pssm-ID: 397964 Cd Length: 262 Bit Score: 119.52 E-value: 1.11e-29
|
||||||||
fungal_TF_MHR | cd12148 | fungal transcription factor regulatory middle homology region; This domain is present in the ... |
529-764 | 9.23e-23 | ||||
fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role. Pssm-ID: 213391 Cd Length: 410 Bit Score: 102.91 E-value: 9.23e-23
|
||||||||
Zn_clus | pfam00172 | Fungal Zn(2)-Cys(6) binuclear cluster domain; |
67-105 | 6.69e-15 | ||||
Fungal Zn(2)-Cys(6) binuclear cluster domain; Pssm-ID: 395120 [Multi-domain] Cd Length: 39 Bit Score: 69.63 E-value: 6.69e-15
|
||||||||
GAL4 | smart00066 | GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ... |
64-105 | 6.92e-15 | ||||
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi. Pssm-ID: 214501 [Multi-domain] Cd Length: 43 Bit Score: 69.70 E-value: 6.92e-15
|
||||||||
Fungal_trans | smart00906 | Fungal specific transcription factor domain; This domain is found in a number of fungal ... |
529-617 | 1.24e-13 | ||||
Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes. Pssm-ID: 214903 [Multi-domain] Cd Length: 93 Bit Score: 67.86 E-value: 1.24e-13
|
||||||||
GAL4 | cd00067 | GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ... |
64-99 | 1.61e-13 | ||||
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations Pssm-ID: 238023 [Multi-domain] Cd Length: 36 Bit Score: 65.76 E-value: 1.61e-13
|
||||||||
ZIP_Cat8 | cd15485 | Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ... |
107-133 | 1.03e-08 | ||||
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Pssm-ID: 271243 Cd Length: 27 Bit Score: 51.78 E-value: 1.03e-08
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
Fungal_trans | pfam04082 | Fungal specific transcription factor domain; This domain is found in a number of fungal ... |
529-692 | 1.11e-29 | ||||
Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR. Pssm-ID: 397964 Cd Length: 262 Bit Score: 119.52 E-value: 1.11e-29
|
||||||||
fungal_TF_MHR | cd12148 | fungal transcription factor regulatory middle homology region; This domain is present in the ... |
529-764 | 9.23e-23 | ||||
fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role. Pssm-ID: 213391 Cd Length: 410 Bit Score: 102.91 E-value: 9.23e-23
|
||||||||
Zn_clus | pfam00172 | Fungal Zn(2)-Cys(6) binuclear cluster domain; |
67-105 | 6.69e-15 | ||||
Fungal Zn(2)-Cys(6) binuclear cluster domain; Pssm-ID: 395120 [Multi-domain] Cd Length: 39 Bit Score: 69.63 E-value: 6.69e-15
|
||||||||
GAL4 | smart00066 | GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ... |
64-105 | 6.92e-15 | ||||
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi. Pssm-ID: 214501 [Multi-domain] Cd Length: 43 Bit Score: 69.70 E-value: 6.92e-15
|
||||||||
Fungal_trans | smart00906 | Fungal specific transcription factor domain; This domain is found in a number of fungal ... |
529-617 | 1.24e-13 | ||||
Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes. Pssm-ID: 214903 [Multi-domain] Cd Length: 93 Bit Score: 67.86 E-value: 1.24e-13
|
||||||||
GAL4 | cd00067 | GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ... |
64-99 | 1.61e-13 | ||||
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations Pssm-ID: 238023 [Multi-domain] Cd Length: 36 Bit Score: 65.76 E-value: 1.61e-13
|
||||||||
ZIP_Cat8 | cd15485 | Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ... |
107-133 | 1.03e-08 | ||||
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Pssm-ID: 271243 Cd Length: 27 Bit Score: 51.78 E-value: 1.03e-08
|
||||||||
bZIP_XBP1 | cd14691 | Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a ... |
104-140 | 2.90e-04 | ||||
Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain; XBP1, a member of the Basic leucine zipper (bZIP) family, is the key transcription factor that orchestrates the unfolded protein response (UPR). It is the most conserved component of the UPR and is critical for cell fate determination in response to ER stress. The inositol-requiring enzyme 1 (IRE1)-XBP1 pathway is one of the three major sensors at the ER membrane that initiates the UPR upon activation. IRE1, a type I transmembrane protein kinase and endoribonuclease, oligomerizes upon ER stress leading to its increased activity. It splices the XBP1 mRNA, producing a variant that translocates to the nucleus and activates its target genes, which are involved in protein folding, degradation, and trafficking. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. Pssm-ID: 269839 [Multi-domain] Cd Length: 58 Bit Score: 40.27 E-value: 2.90e-04
|
||||||||
ZIP_Sip4 | cd15486 | Leucine zipper Dimerization domain transcription factor Sip4p and similar fungal proteins; ... |
108-134 | 3.97e-03 | ||||
Leucine zipper Dimerization domain transcription factor Sip4p and similar fungal proteins; Sip4p binds to carbon source-responsive element (CSRE) motifs and activates transcription of target genes under conditions of glucose deprivation. Its function is modulated through phosphorylation by SNF1 protein kinase, a protein essential for expression of glucose-repressed genes in response to glucose deprivation. Sip4p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Pssm-ID: 271244 Cd Length: 27 Bit Score: 36.11 E-value: 3.97e-03
|
||||||||
bZIP_u3 | cd14812 | Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ... |
104-132 | 4.52e-03 | ||||
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; uncharacterized subfamily; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. Pssm-ID: 269874 [Multi-domain] Cd Length: 52 Bit Score: 36.42 E-value: 4.52e-03
|
||||||||
Blast search parameters | ||||
|