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Conserved domains on  [gi|365758890|gb|EHN00712|]
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Cat8p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 11086775)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 529-692 1.11e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


:

Pssm-ID: 397964  Cd Length: 262  Bit Score: 119.52  E-value: 1.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSAVLSVhsnPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:pfam04082  102 LYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVSPS---WKLWIEEAELRRRLFWACFYLDRLISLILGRPPLLSDSD 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   609 IECALPISDVEYKDQLSMENEkmknKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERISSEVAL----VHE 684
Cdd:pfam04082  179 IDLPLPCDDDDLWESDSADEV----TLPLISLESKSIKPPLFLIKLSKILSKILGSLLSIRSTLDQRDLQLKLswvrELE 254


                   ....*...
gi 365758890   685 NALDNWRN 692
Cdd:pfam04082  255 RALDNWRK 262
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
67-105 6.69e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


:

Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 69.63  E-value: 6.69e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 365758890    67 QACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRK 105
Cdd:pfam00172    1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
ZIP_Cat8 cd15485
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ...
 107-133 1.03e-08

Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


:

Pssm-ID: 271243  Cd Length: 27  Bit Score: 51.78  E-value: 1.03e-08
                          10        20
                  ....*....|....*....|....*..
gi 365758890  107 YPKGYTESLEERVRELEAENKRLLALC 133
Cdd:cd15485     1 FPRGYTESLEERVRILEDENQVLKAEL 27
 
Name Accession Description Interval E-value
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 529-692 1.11e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 119.52  E-value: 1.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSAVLSVhsnPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:pfam04082  102 LYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVSPS---WKLWIEEAELRRRLFWACFYLDRLISLILGRPPLLSDSD 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   609 IECALPISDVEYKDQLSMENEkmknKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERISSEVAL----VHE 684
Cdd:pfam04082  179 IDLPLPCDDDDLWESDSADEV----TLPLISLESKSIKPPLFLIKLSKILSKILGSLLSIRSTLDQRDLQLKLswvrELE 254


                   ....*...
gi 365758890   685 NALDNWRN 692
Cdd:pfam04082  255 RALDNWRK 262
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 529-764 9.23e-23

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 102.91  E-value: 9.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890  529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSavlsvhSNPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:cd12148   108 LYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPS------SLPGLSPFERELRRRLWWSLYILDRLLSLSLGRPPSISDED 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890  609 IECALPISDVEYKDQLSMENEKMKNKAkkiqlqgQVSSFSLQIIRFAKILGNILDSIFKRGMMDERISSEVALVHENALD 688
Cdd:cd12148   182 IDVPLPSNEDDELSPSSSPPPPPSEEP-------TSLSFFIALIRLARILGRILRLLYSPRASSPEDSLETILELDAELE 254

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 365758890  689 NWRNQLPEMYYFKITVNGTVNLDEIRAnnsrdietpfetkdiilfekkILLLFYFLAKSMIHLPVIATKPLSKNVD 764
Cdd:cd12148   255 EWRASLPPELRLDSSSLESPSLLPQRL---------------------LLHLLYHLLLILLHRPFLLRSLSSLSPS 309
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
67-105 6.69e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 69.63  E-value: 6.69e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 365758890    67 QACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRK 105
Cdd:pfam00172    1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 64-105 6.92e-15

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 69.70  E-value: 6.92e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 365758890     64 RIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRK 105
Cdd:smart00066    2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 529-617 1.24e-13

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 67.86  E-value: 1.24e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890    529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSAvlsvhsnpvLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:smart00906   12 LLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPSN---------SDLEERERRRRRFWWLYILDRLLSLSLGRPPLIDDDD 82


                    ....*....
gi 365758890    609 IECALPISD 617
Cdd:smart00906   83 IDVPLPSDL 91
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 64-99 1.61e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 65.76  E-value: 1.61e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 365758890   64 RIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRIS 99
Cdd:cd00067     1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Cat8 cd15485
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ...
 107-133 1.03e-08

Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271243  Cd Length: 27  Bit Score: 51.78  E-value: 1.03e-08
                          10        20
                  ....*....|....*....|....*..
gi 365758890  107 YPKGYTESLEERVRELEAENKRLLALC 133
Cdd:cd15485     1 FPRGYTESLEERVRILEDENQVLKAEL 27
 
Name Accession Description Interval E-value
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 529-692 1.11e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 119.52  E-value: 1.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSAVLSVhsnPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:pfam04082  102 LYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVSPS---WKLWIEEAELRRRLFWACFYLDRLISLILGRPPLLSDSD 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890   609 IECALPISDVEYKDQLSMENEkmknKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERISSEVAL----VHE 684
Cdd:pfam04082  179 IDLPLPCDDDDLWESDSADEV----TLPLISLESKSIKPPLFLIKLSKILSKILGSLLSIRSTLDQRDLQLKLswvrELE 254


                   ....*...
gi 365758890   685 NALDNWRN 692
Cdd:pfam04082  255 RALDNWRK 262
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 529-764 9.23e-23

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 102.91  E-value: 9.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890  529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSavlsvhSNPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:cd12148   108 LYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPS------SLPGLSPFERELRRRLWWSLYILDRLLSLSLGRPPSISDED 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890  609 IECALPISDVEYKDQLSMENEKMKNKAkkiqlqgQVSSFSLQIIRFAKILGNILDSIFKRGMMDERISSEVALVHENALD 688
Cdd:cd12148   182 IDVPLPSNEDDELSPSSSPPPPPSEEP-------TSLSFFIALIRLARILGRILRLLYSPRASSPEDSLETILELDAELE 254

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 365758890  689 NWRNQLPEMYYFKITVNGTVNLDEIRAnnsrdietpfetkdiilfekkILLLFYFLAKSMIHLPVIATKPLSKNVD 764
Cdd:cd12148   255 EWRASLPPELRLDSSSLESPSLLPQRL---------------------LLHLLYHLLLILLHRPFLLRSLSSLSPS 309
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
67-105 6.69e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 69.63  E-value: 6.69e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 365758890    67 QACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRK 105
Cdd:pfam00172    1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 64-105 6.92e-15

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 69.70  E-value: 6.92e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 365758890     64 RIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRK 105
Cdd:smart00066    2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 529-617 1.24e-13

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 67.86  E-value: 1.24e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 365758890    529 FYYLNVGDISAIYGIRGRIVSMAQQLRLHRCPSAvlsvhsnpvLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFD 608
Cdd:smart00906   12 LLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPSN---------SDLEERERRRRRFWWLYILDRLLSLSLGRPPLIDDDD 82


                    ....*....
gi 365758890    609 IECALPISD 617
Cdd:smart00906   83 IDVPLPSDL 91
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 64-99 1.61e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 65.76  E-value: 1.61e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 365758890   64 RIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRIS 99
Cdd:cd00067     1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Cat8 cd15485
Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p ...
 107-133 1.03e-08

Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; Cat8p binds to carbon source-responsive element (CSRE) motifs and activates target genes under conditions of glucose deprivation. It mediates the transcriptional control of at least nine genes (ACS1, FBP1, ICL1, IDP2, JEN1, MLS1, PCK1, SFC1, and SIP4) under non-fermentative growth conditions in yeast. Studies show another 25 genes or open reading frames whose expression at the transition between the fermentative and the oxidative metabolism (diauxic shift) is altered in the absence of Cat8p. This Cat8p-dependent control results in a parallel alteration in mRNA and protein synthesis. The biochemical functions of proteins encoded by Cat8p-dependent genes are essentially related to the first steps of ethanol utilization, the glyoxylate cycle, and gluconeogenesis. Cat8p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271243  Cd Length: 27  Bit Score: 51.78  E-value: 1.03e-08
                          10        20
                  ....*....|....*....|....*..
gi 365758890  107 YPKGYTESLEERVRELEAENKRLLALC 133
Cdd:cd15485     1 FPRGYTESLEERVRILEDENQVLKAEL 27
bZIP_XBP1 cd14691
Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a ...
 104-140 2.90e-04

Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain; XBP1, a member of the Basic leucine zipper (bZIP) family, is the key transcription factor that orchestrates the unfolded protein response (UPR). It is the most conserved component of the UPR and is critical for cell fate determination in response to ER stress. The inositol-requiring enzyme 1 (IRE1)-XBP1 pathway is one of the three major sensors at the ER membrane that initiates the UPR upon activation. IRE1, a type I transmembrane protein kinase and endoribonuclease, oligomerizes upon ER stress leading to its increased activity. It splices the XBP1 mRNA, producing a variant that translocates to the nucleus and activates its target genes, which are involved in protein folding, degradation, and trafficking. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269839 [Multi-domain]  Cd Length: 58  Bit Score: 40.27  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 365758890  104 RKaypKGYTESLEERVRELEAENKRLLALCDIKEQQI 140
Cdd:cd14691    21 RK---KARMDELEERVRELEEENQKLRAENESLRARN 54
ZIP_Sip4 cd15486
Leucine zipper Dimerization domain transcription factor Sip4p and similar fungal proteins; ...
 108-134 3.97e-03

Leucine zipper Dimerization domain transcription factor Sip4p and similar fungal proteins; Sip4p binds to carbon source-responsive element (CSRE) motifs and activates transcription of target genes under conditions of glucose deprivation. Its function is modulated through phosphorylation by SNF1 protein kinase, a protein essential for expression of glucose-repressed genes in response to glucose deprivation. Sip4p is a member of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271244  Cd Length: 27  Bit Score: 36.11  E-value: 3.97e-03
                          10        20
                  ....*....|....*....|....*..
gi 365758890  108 PKGYTESLEERVRELEAENKRLLALCD 134
Cdd:cd15486     1 PRGYTEVLENRVARLEALLSKLGANVD 27
bZIP_u3 cd14812
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ...
 104-132 4.52e-03

Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; uncharacterized subfamily; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269874 [Multi-domain]  Cd Length: 52  Bit Score: 36.42  E-value: 4.52e-03
                          10        20
                  ....*....|....*....|....*....
gi 365758890  104 RKaypKGYTESLEERVRELEAENKRLLAL 132
Cdd:cd14812    18 RK---KEEVEELEARVKELEAENRRLRQL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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