NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|359385690|ref|NP_001240729|]
View 

zinc finger protein 331 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 359385690    5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 359385690 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048  350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048  258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 359385690 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048  418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 359385690    5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 6.43e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 6.43e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 359385690     6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLE 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 8.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 87.60  E-value: 8.31e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 359385690   6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 359385690 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048  350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048  258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 359385690 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048  418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 359385690  341 SLVKHERIHTGEKPYKCTECGKAFNC 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-168 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|...
gi 359385690  146 LSQHQKIHTGEKPYECKECKKAF 168
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 359385690    5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 6.43e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 6.43e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 359385690     6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLE 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 8.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 87.60  E-value: 8.31e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 359385690   6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 359385690 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048  350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048  258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 359385690 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048  418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-463 1.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 127 KENSFECKDCGKAFSRGYQLSQHQKIHTGEKPYEC--KECKKAF-RWGNQLTQHQKIHTGEKPYECKDCGKAFRWGSSLV 203
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 204 IHKRIHTGEKPYECKDCGKAFRRGDELTQHQRFHTGEKDYECKDC----GKTFSRVYKLIQHKRIHSGEKPYECKD--CG 277
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssVNTPQSNSLHPPLPANSLSKDPSSNLSllIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 278 KAFICG----------------SSLIQHKRIHTGEKPYECQECGKAFTRVNYLTQHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048  190 SNVSTSipsssensplsssysiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC--------------------------------KECGKACN 449
Cdd:COG5048  350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSETlsnscirnfkrdsnlslhiithlsfrpyncknPPCSKSFN 429

                        410
                 ....*....|....
gi 359385690 450 HLNHLREHQRIHNS 463
Cdd:COG5048  430 RHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-306 7.50e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 157 KPYECKECKKAFRWGNQLTQHQ--KIHTGE--KPYEC--KDCGKAFRWGSSLVIHKRIHTGEKPYECK--DCGKAFRRGD 228
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 229 ELTQHQRFH-----TGEKDYEC--KDCGKTFSRVYKLIQHKRIHSGEKPYECKD--CGKAFICGSSLIQHKRIHTGEKPY 299
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*..
gi 359385690 300 ECQECGK 306
Cdd:COG5048  448 LCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 359385690  341 SLVKHERIHTGEKPYKCTECGKAFNC 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 2.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 359385690  285 SLIQHKRIHTGEKPYECQECGKAFTR 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 4.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*.
gi 359385690  369 HLTQHERIHTGETPYKCKECGKAFIY 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-336 7.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.90e-04
                          10        20
                  ....*....|....*....|....
gi 359385690  313 YLTQHQKIHTGEKPHECKECGKAF 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 359385690  201 SLVIHKRIHTGEKPYECKDCGKAFRR 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-421 1.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 269 KPYECKDCGKAFICGSSLIQHKR--IHTGE--KPYEC--QECGKAFTRVNYLTQHQKIHTGEKPHECKEC-------GKA 335
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359385690 336 FRWGSSLVKHERIHTGEKPYKCT--ECGKAFNCGYHLTQHERIHTGETP--YKCKECGKAFIYGSSLVKHERIHTGVKPY 411
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 359385690 412 GCTECGKSFS 421
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*
gi 359385690  258 LIQHKRIHSGEKPYECKDCGKAFIC 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-196 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|...
gi 359385690  174 LTQHQKIHTGEKPYECKDCGKAF 196
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-168 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|...
gi 359385690  146 LSQHQKIHTGEKPYECKECKKAF 168
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 2.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 359385690  229 ELTQHQRFHTGEKDYECKDCGKTFSR 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH