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Conserved domains on  [gi|357933652|ref|NP_001239556|]
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cadherin-16 isoform 2 precursor [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-417 1.09e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 314 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 391
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933652 392 VDlaGSESGLSSTCEVTVMVTDVNNH 417
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 429-530 3.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 429 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 508
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933652 509 elvGPGPGPAATATVTILVERV 530
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-304 1.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 216 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 287
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933652 288 YAEPLELQVVVMDENDN 304
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-206 2.03e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 102 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 181
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933652 182 LVQVKDMGDQPsgHQAIATVEISIV 206
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 540-627 2.16e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 540 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 615
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933652 616 PGLSTSATVVIH 627
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 37-96 8.93e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 8.93e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652    37 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 96
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-417 1.09e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 314 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 391
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933652 392 VDlaGSESGLSSTCEVTVMVTDVNNH 417
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 429-530 3.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 429 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 508
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933652 509 elvGPGPGPAATATVTILVERV 530
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-304 1.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 216 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 287
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933652 288 YAEPLELQVVVMDENDN 304
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 236-306 1.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357933652   236 SGGDVHYQLESQPP-GPFDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDYAEPLELQVVVMDENDNAP 306
Cdd:smart00112   9 ENGKVTYSILSGNDdGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-206 2.03e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 102 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 181
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933652 182 LVQVKDMGDQPsgHQAIATVEISIV 206
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 540-627 2.16e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 540 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 615
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933652 616 PGLSTSATVVIH 627
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 331-419 4.78e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652   331 SAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLAVDlaGSESGLSSTCEVT 408
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 357933652   409 VMVTDVNNHAP 419
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 37-96 8.93e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 8.93e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652    37 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 96
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-93 5.06e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 5.06e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357933652  37 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDEND 93
Cdd:cd11304   41 EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
313-412 6.35e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  313 PTVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSPEPeegaeNKAFELDPTSGSVTLgTAPL--HAGQSILLQVL 390
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDIST-TKPLdrESIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 357933652  391 AVDLAGseSGLSSTCEVTVMVT 412
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
428-528 6.67e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  428 PVTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNi 507
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|.
gi 357933652  508 eelvGPGPGPAATATVTILVE 528
Cdd:pfam00028  76 ----SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-206 2.37e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 2.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652   122 ASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQLLVQVKDMGDQPsgHQAIATV 201
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 357933652   202 EISIV 206
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
541-627 2.48e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  541 YETSIPVSTPAGSLLLTIQ---PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPGdTYTVLVEAQDTDKP 616
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTatdPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                          90
                  ....*....|.
gi 357933652  617 GLSTSATVVIH 627
Cdd:pfam00028  80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
215-298 6.77e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  215 PVHLAENLKV-VYPHSIAQVHWSGGD---VHYQLESQPPGP-FDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDY 288
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPngrIFYSILGGGPGGnFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 357933652  289 AEPLELQVVV 298
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
39-88 1.11e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 357933652   39 NTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHV 88
Cdd:pfam00028  42 GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 560-627 1.64e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 1.64e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357933652   560 PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQgAQPGDTYTVLVEAQDTDKPGLSTSATVVIH 627
Cdd:smart00112   5 ADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLD-REEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
103-205 3.11e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  103 YRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPQplpdMFQLDPHLGALALSpsgsTSLDHALEETYQLL 182
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG----NFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|...
gi 357933652  183 VQVKDMGDQPSghQAIATVEISI 205
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 314-417 1.09e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 314 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 391
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933652 392 VDlaGSESGLSSTCEVTVMVTDVNNH 417
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 429-530 3.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 429 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 508
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933652 509 elvGPGPGPAATATVTILVERV 530
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-304 1.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 216 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 287
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933652 288 YAEPLELQVVVMDENDN 304
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 236-306 1.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357933652   236 SGGDVHYQLESQPP-GPFDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDYAEPLELQVVVMDENDNAP 306
Cdd:smart00112   9 ENGKVTYSILSGNDdGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-206 2.03e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 102 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 181
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933652 182 LVQVKDMGDQPsgHQAIATVEISIV 206
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 540-627 2.16e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.57  E-value: 2.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 540 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 615
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933652 616 PGLSTSATVVIH 627
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 331-419 4.78e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652   331 SAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLAVDlaGSESGLSSTCEVT 408
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 357933652   409 VMVTDVNNHAP 419
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 37-96 8.93e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 8.93e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652    37 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 96
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-93 5.06e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 5.06e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357933652  37 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDEND 93
Cdd:cd11304   41 EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
313-412 6.35e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  313 PTVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSPEPeegaeNKAFELDPTSGSVTLgTAPL--HAGQSILLQVL 390
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDIST-TKPLdrESIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 357933652  391 AVDLAGseSGLSSTCEVTVMVT 412
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
428-528 6.67e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  428 PVTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNi 507
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|.
gi 357933652  508 eelvGPGPGPAATATVTILVE 528
Cdd:pfam00028  76 ----SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-206 2.37e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 2.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652   122 ASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQLLVQVKDMGDQPsgHQAIATV 201
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 357933652   202 EISIV 206
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
541-627 2.48e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  541 YETSIPVSTPAGSLLLTIQ---PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPGdTYTVLVEAQDTDKP 616
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTatdPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                          90
                  ....*....|.
gi 357933652  617 GLSTSATVVIH 627
Cdd:pfam00028  80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
215-298 6.77e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  215 PVHLAENLKV-VYPHSIAQVHWSGGD---VHYQLESQPPGP-FDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDY 288
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPngrIFYSILGGGPGGnFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 357933652  289 AEPLELQVVV 298
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
39-88 1.11e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 357933652   39 NTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHV 88
Cdd:pfam00028  42 GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 200-304 1.18e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.64  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652 200 TVEISIVENSWAPLEPVHLAENLkVVYPHSIAQVHWSGGDvhyqlesQPPGPFDVDTE-GMLHVTMELDREAQAEYQLQV 278
Cdd:cd00031    1 IPDGSAVEGRSRGSFRVSIPTDL-IASSGEIIKISAAGKE-------ALPSWLHWEPHsGILEGLEKLDREDKGVHYISV 72

                         90       100
                 ....*....|....*....|....*.
gi 357933652 279 RAQNSHGEDYAEPLELQVVVMDENDN 304
Cdd:cd00031   73 SAASLGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 560-627 1.64e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 1.64e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357933652   560 PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQgAQPGDTYTVLVEAQDTDKPGLSTSATVVIH 627
Cdd:smart00112   5 ADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLD-REEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
103-205 3.11e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  103 YRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPQplpdMFQLDPHLGALALSpsgsTSLDHALEETYQLL 182
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG----NFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|...
gi 357933652  183 VQVKDMGDQPSghQAIATVEISI 205
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 13-93 5.32e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.72  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933652  13 VIQLPLPLGRDEGHIV-LSGDSNTADQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDE 91
Cdd:cd00031   16 RVSIPTDLIASSGEIIkISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDE 95


                 ..
gi 357933652  92 ND 93
Cdd:cd00031   96 ND 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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