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Conserved domains on  [gi|357132318|ref|XP_003567777|]
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notchless protein homolog [Brachypodium distachyon]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-469 1.48e-111

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.34  E-value: 1.48e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  97 RCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 177 PKTGKQLGTpLTGHRKWITAVSWepvhlqSP-SRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYT 254
Cdd:COG2319  149 LATGKLLRT-LTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 255 GSEDCSIKVWETSQGKLVKTLQGHGHWVNSLALSteyvlrtgaydHTGKTyssaeemkeaalaryekmrgnaperLVSGS 334
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGRL-------------------------LASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 335 DDFTMFLWEPAiSKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRL 414
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 357132318 415 LLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 9-69 5.15e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.00  E-value: 5.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357132318    9 VLCQLVSPEGE--HLEAPVYLPHNVGPPQLQDIVNKLLHNEE---KLPYAFYIGDEELSLQLGAYM 69
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-469 1.48e-111

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.34  E-value: 1.48e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  97 RCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 177 PKTGKQLGTpLTGHRKWITAVSWepvhlqSP-SRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYT 254
Cdd:COG2319  149 LATGKLLRT-LTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 255 GSEDCSIKVWETSQGKLVKTLQGHGHWVNSLALSteyvlrtgaydHTGKTyssaeemkeaalaryekmrgnaperLVSGS 334
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGRL-------------------------LASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 335 DDFTMFLWEPAiSKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRL 414
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 357132318 415 LLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-469 2.16e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.20  E-value: 2.16e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 140 PLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWDPKTGKQLGTpLTGHRKWITAVSWepvhlQSPSRRFVSASKDGD 219
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAA-----SADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 220 ARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWETSQGKLVKTLQGHGHWVNSLAlsteyvlrtgaY 298
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-----------F 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 299 DHTGKTyssaeemkeaalaryekmrgnaperLVSGSDDFTMFLWEPAISKqPKARMTGHQKLVNHVYFSPDGQWLASASF 378
Cdd:cd00200  144 SPDGTF-------------------------VASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 379 DKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRLLLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVV 458
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 357132318 459 SGGKDRALKLW 469
Cdd:cd00200  278 SGSADGTIRIW 288
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 9-69 5.15e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.00  E-value: 5.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357132318    9 VLCQLVSPEGE--HLEAPVYLPHNVGPPQLQDIVNKLLHNEE---KLPYAFYIGDEELSLQLGAYM 69
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-264 1.32e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 105 HTEAVLAVSFSP-DGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNwVLCIAWSPD-GKHLVSGSKSGELILWDPKTGKQ 182
Cdd:PLN00181 574 HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKL 652

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 183 LGTPLTGHRKWITAVSWepvhlqSPSRRFVSASKDGDARIWDITTRKCVI------SLAGHTNAVTCVKWG-GDGLIYTG 255
Cdd:PLN00181 653 PLCTMIGHSKTVSYVRF------VDSSTLVSSSTDNTLKLWDLSMSISGInetplhSFMGHTNVKNFVGLSvSDGYIATG 726


                 ....*....
gi 357132318 256 SEDCSIKVW 264
Cdd:PLN00181 727 SETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-176 2.52e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.52e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357132318   137 TQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-134 4.20e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 4.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357132318   96 NRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWD 134
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 106-201 3.13e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.95  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  106 TEAVLAVSFSPDGRCLA---SGSGDTTVRFWDLNTqtplftckGHKNWV-----LCIA--WSPDGKHL-VSGSKSG--EL 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVasfpgMNGApaFSPDGSKLaVSLSKDGnpDI 260

                          90       100
                  ....*....|....*....|....*....
gi 357132318  173 ILWDPKTGKQlgTPLTGHRKWITAVSWEP 201
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-469 1.48e-111

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.34  E-value: 1.48e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  97 RCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 177 PKTGKQLGTpLTGHRKWITAVSWepvhlqSP-SRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYT 254
Cdd:COG2319  149 LATGKLLRT-LTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 255 GSEDCSIKVWETSQGKLVKTLQGHGHWVNSLALSteyvlrtgaydHTGKTyssaeemkeaalaryekmrgnaperLVSGS 334
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGRL-------------------------LASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 335 DDFTMFLWEPAiSKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRL 414
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 357132318 415 LLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
96-431 2.36e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 301.44  E-value: 2.36e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  96 NRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILW 175
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 176 DPKTGKQLGTpLTGHRKWITAVSWepvhlqSP-SRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIY 253
Cdd:COG2319  190 DLATGKLLRT-LTGHTGAVRSVAF------SPdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 254 TGSEDCSIKVWETSQGKLVKTLQGHGHWVNSLALSteyvlrtgaydHTGKTyssaeemkeaalaryekmrgnaperLVSG 333
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS-----------PDGKL-------------------------LASG 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 334 SDDFTMFLWEPAiSKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSR 413
Cdd:COG2319  307 SDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                        330
                 ....*....|....*...
gi 357132318 414 LLLSGSKDSTLKVWDIRT 431
Cdd:COG2319  386 TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
88-469 6.69e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 289.89  E-value: 6.69e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  88 AVFRIRPVNRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGS 167
Cdd:COG2319   18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 168 KSGELILWDPKTGKQLGTpLTGHRKWITAVSWepvhlqSP-SRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKW 246
Cdd:COG2319   98 ADGTVRLWDLATGLLLRT-LTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 247 GGDG-LIYTGSEDCSIKVWETSQGKLVKTLQGHGHWVNSLALSteyvlrtgaydHTGKtyssaeemkeaalaryekmrgn 325
Cdd:COG2319  171 SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-----------PDGK---------------------- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 326 apeRLVSGSDDFTMFLWEPAiSKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQ 405
Cdd:COG2319  218 ---LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 357132318 406 ISWSADSRLLLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:COG2319  294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-469 2.16e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.20  E-value: 2.16e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 140 PLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWDPKTGKQLGTpLTGHRKWITAVSWepvhlQSPSRRFVSASKDGD 219
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAA-----SADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 220 ARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWETSQGKLVKTLQGHGHWVNSLAlsteyvlrtgaY 298
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-----------F 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 299 DHTGKTyssaeemkeaalaryekmrgnaperLVSGSDDFTMFLWEPAISKqPKARMTGHQKLVNHVYFSPDGQWLASASF 378
Cdd:cd00200  144 SPDGTF-------------------------VASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 379 DKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRLLLSGSKDSTLKVWDIRTRKLKQDLPGHADEVYAVDWSPDGEKVV 458
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 357132318 459 SGGKDRALKLW 469
Cdd:cd00200  278 SGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
113-469 6.90e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.98  E-value: 6.90e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 113 SFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWDPKTGKQLGTpLTGHRK 192
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT-LLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 193 WITAVSWEPvhlqsPSRRFVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWETSQGKL 271
Cdd:COG2319   80 AVLSVAFSP-----DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 272 VKTLQGHGHWVNSLALSteyvlrtgaydHTGKTyssaeemkeaalaryekmrgnaperLVSGSDDFTMFLWEPAiSKQPK 351
Cdd:COG2319  155 LRTLTGHSGAVTSVAFS-----------PDGKL-------------------------LASGSDDGTVRLWDLA-TGKLL 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 352 ARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSRLLLSGSKDSTLKVWDIRT 431
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 357132318 432 RKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-428 1.58e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 220.28  E-value: 1.58e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  96 NRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILW 175
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 176 DPKTGKQLGTpLTGHRKWITAVSWepvhlqSPSRRFV-SASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIY 253
Cdd:cd00200  121 DVETGKCLTT-LRGHTDWVNSVAF------SPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 254 TGSEDCSIKVWETSQGKLVKTLQGHGHWVNSLAlsteyvlrtgaydhtgktyssaeemkeaalaryekmrgnaperlvsg 333
Cdd:cd00200  194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA----------------------------------------------- 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 334 sddftmflwepaiskqpkarmtghqklvnhvyFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISWSADSR 413
Cdd:cd00200  227 --------------------------------FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK 274

                        330
                 ....*....|....*
gi 357132318 414 LLLSGSKDSTLKVWD 428
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-265 1.54e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.08  E-value: 1.54e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  94 PVNRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELI 173
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 174 LWDPKTGKQLGTpLTGHRKWITAVSWepvhlqSPSRR-FVSASKDGDARIWDITTRKCVISLAGHTNAVTCVKWGGDG-L 251
Cdd:cd00200  203 LWDLSTGKCLGT-LRGHENGVNSVAF------SPDGYlLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkR 275

                        170
                 ....*....|....
gi 357132318 252 IYTGSEDCSIKVWE 265
Cdd:cd00200  276 LASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 9-69 5.15e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.00  E-value: 5.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357132318    9 VLCQLVSPEGE--HLEAPVYLPHNVGPPQLQDIVNKLLHNEE---KLPYAFYIGDEELSLQLGAYM 69
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-264 1.32e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 105 HTEAVLAVSFSP-DGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNwVLCIAWSPD-GKHLVSGSKSGELILWDPKTGKQ 182
Cdd:PLN00181 574 HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKL 652

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 183 LGTPLTGHRKWITAVSWepvhlqSPSRRFVSASKDGDARIWDITTRKCVI------SLAGHTNAVTCVKWG-GDGLIYTG 255
Cdd:PLN00181 653 PLCTMIGHSKTVSYVRF------VDSSTLVSSSTDNTLKLWDLSMSISGInetplhSFMGHTNVKNFVGLSvSDGYIATG 726


                 ....*....
gi 357132318 256 SEDCSIKVW 264
Cdd:PLN00181 727 SETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-176 2.52e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.52e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357132318   137 TQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-134 5.91e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 5.91e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 357132318    97 RCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWD 134
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-134 4.20e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 4.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357132318   96 NRCSATIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWD 134
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-428 9.80e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 9.80e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357132318   389 TGKFIAAFRGHVADVYQISWSADSRLLLSGSKDSTLKVWD 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-176 1.44e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.44e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357132318  139 TPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWD 176
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
348-386 1.97e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.97e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357132318  348 KQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWN 386
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 347-386 1.98e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357132318   347 SKQPKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWN 386
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
390-428 4.96e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 4.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357132318  390 GKFIAAFRGHVADVYQISWSADSRLLLSGSKDSTLKVWD 428
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-265 9.05e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 9.05e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357132318   227 TRKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWE 265
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 366-454 1.68e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 53.89  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  366 FSPDGQWLASASfDKS--VKLW-----NGITGKFIAAfrGHVADVYQISWSADSRLLLSGSKDSTLKVWDIRTRKLKQ-D 437
Cdd:COG4946   350 WSPDGKSIAYFS-DASgeYELYiapadGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKvD 426

                          90
                  ....*....|....*..
gi 357132318  438 LPGHADEVYAVDWSPDG 454
Cdd:COG4946   427 TDGYGDGISDLAWSPDS 443
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 431-469 1.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 357132318   431 TRKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 327-442 2.57e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 327 PERLVSGSDDFTMFLWE-PAISKQ-----PKARMTGHQKLVNHVYFSPDGQ-WLASASFDKSVKLWNGITGKFIAAFRGH 399
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 357132318 400 VADVYQISWSADSRLLLSGSKDSTLKVWDIRTRKLKQDLPGHA 442
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 pfam00400
WD domain, G-beta repeat;
228-265 4.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.41e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 357132318  228 RKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWE 265
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
432-469 1.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357132318  432 RKLKQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKLW 469
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 121-288 2.07e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 121 LASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSP-DGKHLVSGSKSGELILWDPKTGKQLGTPLTghRKWITAVsw 199
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCV-- 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 200 epvhlQSPS---RRFVSASKDGDARIWDITTRKC-VISLAGHTNAVTCVKWGGDGLIYTGSEDCSIKVWETSQG------ 269
Cdd:PLN00181 624 -----QFPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgine 698

                        170
                 ....*....|....*....
gi 357132318 270 KLVKTLQGHGHWVNSLALS 288
Cdd:PLN00181 699 TPLHSFMGHTNVKNFVGLS 717
PTZ00421 PTZ00421
coronin; Provisional
 146-278 5.18e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 146 GHKNWVLCIAWSP-DGKHLVSGSKSGELILWD-PKTGKQLGTP-----LTGHRKWITAVSWEPvhlqSPSRRFVSASKDG 218
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHP----SAMNVLASAGADM 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 357132318 219 DARIWDITTRKCVISLAGHTNAVTCVKWGGDG-LIYTGSEDCSIKVWETSQGKLVKTLQGH 278
Cdd:PTZ00421 149 VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00421 PTZ00421
coronin; Provisional
 364-468 5.31e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 364 VYFSP-DGQWLASASFDKSVKLWN----GITGKF---IAAFRGHVADVYQISWSADSR-LLLSGSKDSTLKVWDIRTRKL 434
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGipeeGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                         90       100       110
                 ....*....|....*....|....*....|....
gi 357132318 435 KQDLPGHADEVYAVDWSPDGEKVVSGGKDRALKL 468
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 104-181 5.90e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 5.90e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357132318 104 GHTEAVLAVSFSPDGR-CLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGELILWDPKTGK 181
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
PTZ00420 PTZ00420
coronin; Provisional
 102-182 6.37e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 6.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 102 IAGHTEAVLAVSFSP-DGRCLASGSGDTTVRFWDL--------NTQTPLFTCKGHKNWVLCIAWSPDGKHLVSGSKSGEL 172
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                         90
                 ....*....|.
gi 357132318 173 I-LWDPKTGKQ 182
Cdd:PTZ00420 150 VnIWDIENEKR 160
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 104-157 1.65e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 357132318  104 GHTEAVLAVSFSPDGRCLASGSGDTTVRFWDLNTQTPLFTCKGHKNWVLCIAWS 157
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 350-429 2.72e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 350 PKARMTGHQKLVNHVYFSPDGQWLASASFDKSVKLWNGITGKFIAAFRGHVADVYQISW-SADSRLLLSGSKDSTLKVWD 428
Cdd:PLN00181 525 PVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWS 604


                 .
gi 357132318 429 I 429
Cdd:PLN00181 605 I 605
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 101-181 3.73e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  101 TIAGHTEAVLAVSFSPDGRCLASGSGDTTVRFWDL-----------NTQ------------TPLFTCKGHKNWVLCIAWS 157
Cdd:pfam20426 119 SIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekrsrNTQtefprkdhviaeTPFHILCGHDDIITCLYVS 198

                          90       100
                  ....*....|....*....|....
gi 357132318  158 PDGKHLVSGSKSGELILWDPKTGK 181
Cdd:pfam20426 199 VELDIVISGSKDGTCIFHTLREGR 222
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-224 5.99e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.99e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 357132318   179 TGKQLGTpLTGHRKWITAVSWEPvhlqsPSRRFVSASKDGDARIWD 224
Cdd:smart00320   1 SGELLKT-LKGHTGPVTSVAFSP-----DGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 112-462 1.03e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.03  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  112 VSFSPDGRCLA-----SGSgdttvrfWDL--------NTQTPLfTcKGHKNWVLCIAWSPDGKHLVSGSKSGELILWDPK 178
Cdd:COG4946   348 PAWSPDGKSIAyfsdaSGE-------YELyiapadgsGEPKQL-T-LGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLA 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  179 TGK--QLGTPLTGHRkwITAVSWepvhlqSPSRRFVSASKDGD-----ARIWDITTRKcVISLAGHTNAVTCVKWGGDG- 250
Cdd:COG4946   419 SGKvrKVDTDGYGDG--ISDLAW------SPDSKWLAYSKPGPnqlsqIFLYDVETGK-TVQLTDGRYDDGSPAFSPDGk 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  251 -LIYTGSEDcsikvWETSQGklvktlqghghwvnSLALSTEYVLRTGAYDhtgktyssaeemkeAALARyekmrgNAPER 329
Cdd:COG4946   490 yLYFLSSRD-----FNPTYG--------------DLDFDLAFPRTTRIYA--------------VPLRK------DAPSP 530

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  330 LVSGSDDFtmflwepAISKQPKARmtghqklvnhvyfSPDGQWLASASFDKSVKL-WNGITGKfIAAFRGHvADVYQISW 408
Cdd:COG4946   531 FAPESDEE-------AAKKEEDEK-------------KKKKKKDDKKKKPKPVKIdFDGIEDR-IVALPVP-AGNYSDLA 588

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 357132318  409 SADSRLL-----LSGSKDSTLKVWDIRTRKLKqDLpghADEVYAVDWSPDGEK--VVSGGK 462
Cdd:COG4946   589 AGKGGVLyllepVEGAPGGTLYRYDLEKRKTE-TL---ADGVSSYELSADGKKllVRSGGR 645
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 146-199 5.24e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 5.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 357132318  146 GHKNWVLCIAWSPDGKHLVSGSKSGELILWDPKTGKQLGTpLTGHRKWITAVSW 199
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH-FSAGSDLITCLGW 88
WD40 pfam00400
WD domain, G-beta repeat;
180-224 8.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 357132318  180 GKQLGTpLTGHRKWITAVSWEPvhlqsPSRRFVSASKDGDARIWD 224
Cdd:pfam00400   1 GKLLKT-LEGHTGSVTSLAFSP-----DGKLLASGSDDGTVKVWD 39
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 120-271 9.37e-04

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 41.93  E-value: 9.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  120 CLASGSGDTTVRFWDLNTQTPLFTCKGH-KNWVLCIAWSPDGKHLVSGSKSGELIL----WDPKTGKQLGTPLTGHRKWI 194
Cdd:pfam04762  91 CFASASGDIILVTYDPDPETTVVEIVGSiDSGITAAAWSPDEELLALVTGEGTVLLmtrdFEPISETSLDPDDLKISKHV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  195 TaVSWEPVHLQSPSRRFVSASKD---------GDARIWDITTRKCVISlaghtnavtcvkWGGDG-----LIYTGSEDCS 260
Cdd:pfam04762 171 S-VGWGKKETQFHGKGAKAAERPlrdptmpekVDEKLSSLDDHRVTIS------------WRGDGeyfavSSIEPETGSR 237

                         170
                  ....*....|...
gi 357132318  261 --IKVWEtSQGKL 271
Cdd:pfam04762 238 raIRVWS-REGAL 249
PTZ00420 PTZ00420
coronin; Provisional
 328-386 1.57e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 1.57e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357132318 328 ERLVSGSDDFTMFLWEPAIS-------KQPKARMTGHQKLVNHVYFSPDGQW-LASASFDKSVKLWN 386
Cdd:PTZ00420  88 EILASGSEDLTIRVWEIPHNdesvkeiKDPQCILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 381-469 2.11e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 381 SVKLWNGITGKFIAAFRGHVADVYQISWS-ADSRLLLSGSKDSTLKVWDIR-----TRKLKQD---LPGHADEVYAVDWS 451
Cdd:PTZ00420  55 AIRLENQMRKPPVIKLKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWN 134

                         90
                 ....*....|....*....
gi 357132318 452 PDGEKVV-SGGKDRALKLW 469
Cdd:PTZ00420 135 PMNYYIMcSSGFDSFVNIW 153
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 106-201 3.13e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.95  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  106 TEAVLAVSFSPDGRCLA---SGSGDTTVRFWDLNTqtplftckGHKNWV-----LCIA--WSPDGKHL-VSGSKSG--EL 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVasfpgMNGApaFSPDGSKLaVSLSKDGnpDI 260

                          90       100
                  ....*....|....*....|....*....
gi 357132318  173 ILWDPKTGKQlgTPLTGHRKWITAVSWEP 201
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 154-247 4.96e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318  154 IAWSPDGKHLVSGSKSGELILWDPKTGKQLGTPLTGHRKWITAVSWEPvhlqsPSRRFVSASKDGDARIWDITTRKCVIS 233
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAWRP-----DGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|....
gi 357132318  234 LAGHTNAVTCVKWG 247
Cdd:pfam12894  76 FSAGSDLITCLGWG 89
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 353-470 6.78e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 353 RMTGHQKLVNHVYFSPDGQWLA-SASFDKSVKLW----NGITGKFIAAFRGHVADvyqISWSADSRLLL-SGSKDSTLKV 426
Cdd:COG0823   25 RLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvdaDGGEPRRLTFGGGYNAS---PSWSPDGKRLAfVSRSDGRFDI 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 357132318 427 W--DIRTRKLKQdlpgHADEVYAVDWSPDGEKVV-SGGKDRALKLWM 470
Cdd:COG0823  102 YvlDLDGGAPRR----LTDGPGSPSWSPDGRRIVfSSDRGGRPDLYV 144
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 113-229 9.43e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 36.96  E-value: 9.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357132318 113 SFSPDGRCLA---SGSGDTTVRFWDLNTQTP-LFTCKGHKNWvlCIAWSPDGKHLVSGSKSG---ELILWDPKTGKQlgT 185
Cdd:COG0823   37 AWSPDGRRIAftsDRGGGPQIYVVDADGGEPrRLTFGGGYNA--SPSWSPDGKRLAFVSRSDgrfDIYVLDLDGGAP--R 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 357132318 186 PLTghrKWITAVSWepvhlqSP-SRRFV-SASKDGDARIW--DITTRK 229
Cdd:COG0823  113 RLT---DGPGSPSW------SPdGRRIVfSSDRGGRPDLYvvDLDGRK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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