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Conserved domains on  [gi|356540464|ref|XP_003538709|]
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protein DETOXIFICATION 49 [Glycine max]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 65-502 1.28e-172

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 494.40  E-value: 1.28e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  65 EVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLG 144
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 145 LAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13132   81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLVSVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTWPGVSLKgILSGWKSLLNLAIPSCISVCL 304
Cdd:cd13132  161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSRE-AFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 305 EWWWYEIMILLCGLLiNPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSA 384
Cdd:cd13132  240 EWWAFEILVLLAGLL-PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFF 464
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 356540464 465 AGFDFKGLWLGLLAAQASCMFTMLIVLARTNWEGQVQR 502
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 65-502 1.28e-172

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 494.40  E-value: 1.28e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  65 EVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLG 144
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 145 LAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13132   81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLVSVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTWPGVSLKgILSGWKSLLNLAIPSCISVCL 304
Cdd:cd13132  161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSRE-AFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 305 EWWWYEIMILLCGLLiNPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSA 384
Cdd:cd13132  240 EWWAFEILVLLAGLL-PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFF 464
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 356540464 465 AGFDFKGLWLGLLAAQASCMFTMLIVLARTNWEGQVQR 502
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
69-489 3.44e-58

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 199.21  E-value: 3.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  69 IANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:COG0534   10 LLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 149 RTIVLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSIL 227
Cdd:COG0534   89 QALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 228 LHVPINYFLVSVLKLGIKGIALGAVWTN-FNLVVSLILYIWVSGVYKKTWPGVSLKgiLSGWKSLLNLAIPSCISVCLEW 306
Cdd:COG0534  169 LNIVLDPLLIFGGGLGVAGAALATVISQaVSALLLLYYLFRKRSLLRLRLRDLRPD--RKILKRILRIGLPAGLQQLAES 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 307 wwyeIMILLCGLLINP--QATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSA 384
Cdd:COG0534  247 ----LGFLVLNALVARlgTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFF 464
Cdd:COG0534  323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFL 402

                        410       420
                 ....*....|....*....|....*
gi 356540464 465 aGFDFKGLWLGLLAAQASCMFTMLI 489
Cdd:COG0534  403 -GLGLTGVWLALPIGEVLRALLLLL 426
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 75-417 8.04e-48

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 169.35  E-value: 8.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464   75 PMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAiGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVLL 154
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  155 LLTSVLISFLWLNMKK-LLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVPIN 233
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDpLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  234 YFLVsVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTwpGVSLKGILSGWKS----LLNLAIPSCISVCLEWWWY 309
Cdd:TIGR00797 160 YILI-FGKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKI--GLKWEGLLKPDWEvlkrLLKLGLPIAFRVILESLSF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  310 EIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSALFFAV 389
Cdd:TIGR00797 237 ALLALLVARL--GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314

                         330       340
                  ....*....|....*....|....*...
gi 356540464  390 SVRQAWASMFTRDAEIIALTSMVLPIIG 417
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLIFVA 342
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 63-494 4.67e-33

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 131.09  E-value: 4.67e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  63 LNEVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGgsLAIGfANI--TGYSILSGLAMGMEPICGQAFGAKRF 140
Cdd:PRK01766   8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAA--VAIG-TSIwlPVILFGHGLLLALTPIVAQLNGAGRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 141 KLLGLAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQE----DIATEAQSFILFSIPDLVaqsLLHPLRIYLRSQSITL 216
Cdd:PRK01766  85 ERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEpevaDIAVGYLHALLWGIPAYL---LYQVLRSFIDGLGKTK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 217 PLTYTASLSILLHVPINYFLVSVlKLGIK-------GIALGAV-WTNFnlvVSLILYIWVSGVYK-----KTWPGVSLKG 283
Cdd:PRK01766 162 PTMVIGFLGLLINIPLNYIFIYG-KFGFPelggvgcGVATAIVyWVMF---LAMLIYIKRARRFRdfrlfKGLYKPDWAV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 284 ilsgWKSLLNLAIPSCISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENP 363
Cdd:PRK01766 238 ----IKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 364 KKAKVAALVGLCISYGLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGA 443
Cdd:PRK01766 312 LDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 356540464 444 NINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLART 494
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
MatE pfam01554
MatE; The MatE domain
 75-235 2.36e-31

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 118.82  E-value: 2.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464   75 PMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVLL 154
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  155 LLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVPIN 233
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 356540464  234 YF 235
Cdd:pfam01554 160 YL 161
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 65-502 1.28e-172

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 494.40  E-value: 1.28e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  65 EVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLG 144
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 145 LAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13132   81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLVSVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTWPGVSLKgILSGWKSLLNLAIPSCISVCL 304
Cdd:cd13132  161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSRE-AFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 305 EWWWYEIMILLCGLLiNPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSA 384
Cdd:cd13132  240 EWWAFEILVLLAGLL-PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFF 464
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 356540464 465 AGFDFKGLWLGLLAAQASCMFTMLIVLARTNWEGQVQR 502
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
69-489 3.44e-58

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 199.21  E-value: 3.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  69 IANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:COG0534   10 LLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 149 RTIVLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSIL 227
Cdd:COG0534   89 QALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 228 LHVPINYFLVSVLKLGIKGIALGAVWTN-FNLVVSLILYIWVSGVYKKTWPGVSLKgiLSGWKSLLNLAIPSCISVCLEW 306
Cdd:COG0534  169 LNIVLDPLLIFGGGLGVAGAALATVISQaVSALLLLYYLFRKRSLLRLRLRDLRPD--RKILKRILRIGLPAGLQQLAES 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 307 wwyeIMILLCGLLINP--QATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSA 384
Cdd:COG0534  247 ----LGFLVLNALVARlgTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFF 464
Cdd:COG0534  323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFL 402

                        410       420
                 ....*....|....*....|....*
gi 356540464 465 aGFDFKGLWLGLLAAQASCMFTMLI 489
Cdd:COG0534  403 -GLGLTGVWLALPIGEVLRALLLLL 426
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 65-493 1.14e-49

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 176.92  E-value: 1.14e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  65 EVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFaNITGYSILSGLAMGMEPICGQAFGAKRFKLLG 144
Cdd:cd13131    1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL-WFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 145 LAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13131   80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLVS----VLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTWPGVSLKGI-LSGWKSLLNLAIPSC 299
Cdd:cd13131  160 ALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPdWARLKELLRLGLPIG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 300 ISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVG--LCIS 377
Cdd:cd13131  240 LTIFFEVSLFAAVALLMGRL--GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGlgLGVG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 378 YGLGFSALFFAvsVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPV 457
Cdd:cd13131  318 FAALTALLLLL--FPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPL 395

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 356540464 458 AVRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLAR 493
Cdd:cd13131  396 GYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRR 431
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 75-417 8.04e-48

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 169.35  E-value: 8.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464   75 PMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAiGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVLL 154
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  155 LLTSVLISFLWLNMKK-LLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVPIN 233
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDpLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  234 YFLVsVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTwpGVSLKGILSGWKS----LLNLAIPSCISVCLEWWWY 309
Cdd:TIGR00797 160 YILI-FGKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKI--GLKWEGLLKPDWEvlkrLLKLGLPIAFRVILESLSF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  310 EIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSALFFAV 389
Cdd:TIGR00797 237 ALLALLVARL--GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314

                         330       340
                  ....*....|....*....|....*...
gi 356540464  390 SVRQAWASMFTRDAEIIALTSMVLPIIG 417
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLIFVA 342
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 69-496 1.72e-38

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 146.12  E-value: 1.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  69 IANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:cd13137    3 IWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 149 RTIVLLLLTSVLISFLWLNMKKLLI-LCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSIL 227
Cdd:cd13137   82 QSLLLALLLSLPLALLGLLFAEPLLrLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 228 LHVPINYFLV----SVLKLGIKGIALGAVWTNFnLVVSLILYIWVSGVYKKTWPGVSLKGILSGWKSLLNLAIPSCISVc 303
Cdd:cd13137  162 LNIVLDYVLIfglwGFPGLGVAGAALATVISRV-VGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 304 LEWWWYEIMILLCGLLINPQAtVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYG-LGF 382
Cdd:cd13137  240 LLRSLGFLVLLAIVASYGTAA-LAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLfMGL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 383 SALFFAVsVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLS 462
Cdd:cd13137  319 LGLLLFI-FAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLG 397

                        410       420       430
                 ....*....|....*....|....*....|....
gi 356540464 463 FFAGFDFKGLWLGLLAAQASCMFTMLIVLARTNW 496
Cdd:cd13137  398 FVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 63-494 4.67e-33

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 131.09  E-value: 4.67e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  63 LNEVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGgsLAIGfANI--TGYSILSGLAMGMEPICGQAFGAKRF 140
Cdd:PRK01766   8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAA--VAIG-TSIwlPVILFGHGLLLALTPIVAQLNGAGRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 141 KLLGLAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQE----DIATEAQSFILFSIPDLVaqsLLHPLRIYLRSQSITL 216
Cdd:PRK01766  85 ERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEpevaDIAVGYLHALLWGIPAYL---LYQVLRSFIDGLGKTK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 217 PLTYTASLSILLHVPINYFLVSVlKLGIK-------GIALGAV-WTNFnlvVSLILYIWVSGVYK-----KTWPGVSLKG 283
Cdd:PRK01766 162 PTMVIGFLGLLINIPLNYIFIYG-KFGFPelggvgcGVATAIVyWVMF---LAMLIYIKRARRFRdfrlfKGLYKPDWAV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 284 ilsgWKSLLNLAIPSCISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENP 363
Cdd:PRK01766 238 ----IKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 364 KKAKVAALVGLCISYGLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGA 443
Cdd:PRK01766 312 LDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 356540464 444 NINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLART 494
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 66-497 7.28e-32

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 127.19  E-value: 7.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  66 VKCIANIALPMVLTGLL--LYSrsVISMLFLGR-VGELALAggslAIGFAN-----ITgySILSGLAMGMEPICGQAFGA 137
Cdd:cd13138    2 LKTLLLFALPLLLSNLLqqLYN--LVDLLIVGQfLGVAALA----AVSNGSpiiflLT--AIGMGLSMGGTILISQYIGA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 138 KRFKLLGLAMQRTIVLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFI---LFSIPDLVAQSLLHPLriyLRSQ- 212
Cdd:cd13138   74 KDEEKAKKAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLricFLGIPFIFGYNAYSAI---LRGLg 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 213 -SITlPLTYTAsLSILLHVPINYFLVSVLKLGIKGIALGAVWTNFNLVVSLILYIWVSG-VYKKTWPGVSLKGILSgwKS 290
Cdd:cd13138  151 dSKT-PLYFVI-IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKlPFKLSLKDFRFDKEIL--KE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 291 LLNLAIPSCISvclewwwyEIMILLCGLLINpqATVASMGVLI--------QTTALIYIFPSSLSFAVSTRVGNELGAEN 362
Cdd:cd13138  227 ILKIGLPSALQ--------QSLVSISFLIIN--SIVNSYGVVAsaaygianKINSFAFLPPSAIGQAVSTFVAQNIGAGK 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 363 PKKAKVAALVGLCISYGLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLG 442
Cdd:cd13138  297 IERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFP 376

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 356540464 443 ANINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLARTNWE 497
Cdd:cd13138  377 MIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
MatE pfam01554
MatE; The MatE domain
 75-235 2.36e-31

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 118.82  E-value: 2.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464   75 PMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVLL 154
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  155 LLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVPIN 233
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 356540464  234 YF 235
Cdd:pfam01554 160 YL 161
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 72-478 4.74e-29

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 119.53  E-value: 4.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  72 IALPMVLTGLLLYSRSVISMLFLGRVGELALAggslAIGFAN---ITGYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:cd13134    8 LAWPIFIELLLQMLLGTIDTFMLSRYSDNAVA----AVGVANqilFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 149 RTIVLLLLTSVLIS-FLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSIL 227
Cdd:cd13134   84 VALLFNLLLGLVFSlLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 228 LHVPINYFLV----SVLKLGIKGIALGavwTNFNLVVSLILYIWVsgVYKKTWPGVSLKGIL----SGWKSLLNLAIPSC 299
Cdd:cd13134  164 LNIVGNYLLIfgwfGLPKLGVAGVAIS---TVISRAVGLVLLFIL--LFRKLKIRFRLKDLRpfpkKLLKKILKIGLPSA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 300 ISVCLeWWWYEIMILLCGLLINPQAtVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAAL----VGLC 375
Cdd:cd13134  239 GEELS-YNLSQTVITAFIARLGTAA-LAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLkslkIGLL 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 376 ISYGLGFSALFFAVSVrqawASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGM 455
Cdd:cd13134  317 VSLAVALLLALFREPI----LGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISV 392

                        410       420
                 ....*....|....*....|...
gi 356540464 456 PVAVRLSFFAGFDFKGLWLGLLA 478
Cdd:cd13134  393 PLAYLLGIVLGLGLLGVWIAFAA 415
MatE pfam01554
MatE; The MatE domain
 297-458 5.81e-29

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 112.27  E-value: 5.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  297 PSCISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCI 376
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  377 SYGLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCfYLVGMP 456
Cdd:pfam01554  79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157


                  ..
gi 356540464  457 VA 458
Cdd:pfam01554 158 LN 159
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 73-491 8.80e-29

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 118.20  E-value: 8.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  73 ALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIV 152
Cdd:cd12082    1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 153 LLLLTSVLIS-FLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVP 231
Cdd:cd12082   80 LAILLGLLLAaLLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 232 INYFLV---SVLKLGIKGIALGAVWTNFNLVVSLILYIwvsgVYKKTWPGVSLKGI---LSGWKSLLNLAIPSCISVCLE 305
Cdd:cd12082  160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYL----RKGKKILKFKLSLLkpdLELLRRLLRIGLPSAIQNSLL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 306 WWWYEIMILLCGLLINPqATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSAL 385
Cdd:cd12082  236 SLGLLIIVAIVAAFGGA-AALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLG 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 386 FFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVAVrLSFFA 465
Cdd:cd12082  315 LLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAY-VLAYL 393

                        410       420
                 ....*....|....*....|....*.
gi 356540464 466 GFDFKGLWLGLLAAQASCMFTMLIVL 491
Cdd:cd12082  394 GLGLYGIWLALVISLILAALVLLLFF 419
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 69-478 2.36e-28

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 117.24  E-value: 2.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  69 IANIALPMVLTGLllySRSVISM---LFLGRVGELALAGGSLAiGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLGL 145
Cdd:cd13133    7 ILKIALPLVLSML---SQTVMGFtdrAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 146 AMQRTIVLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13133   83 VLWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLV----SVLKLGIKGIALGAVwtnFNLVVSLILYIWV--SGVYKKTWPGVSLKGI-LSGWKSLLNLAIP 297
Cdd:cd13133  163 MVVVNIVLDYALIfgklGFPAMGIAGAAIATV---IAEAVSLLFFLLLlfRRKNRRRFGLRRAWRFdRELLRRILRLGLP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 298 SCISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCIS 377
Cdd:cd13133  240 SGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 378 YGLGFSALFFAVSVRQAWASMFTRD---AEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVG 454
Cdd:cd13133  318 LAYMLLLGILFLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYL 397

                        410       420
                 ....*....|....*....|....
gi 356540464 455 MPVAVrLSFFAGFDFKGLWLGLLA 478
Cdd:cd13133  398 LPPAY-LLVVLGAGLAGAWTVETV 420
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 73-491 4.03e-22

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 98.74  E-value: 4.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  73 ALPMVLTGLLLYSRSVISMLFLGR-VGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTI 151
Cdd:cd13143   10 ALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMLL-MALGLMIGVGGASLISRRLGAGDREKANRIFSTAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 152 VLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHV 230
Cdd:cd13143   89 LLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 231 PINYFLVSVLKLGIKGIALGAVWTNFnlvVSLILYIWV----SGVYKKTWPGVSLKgiLSGWKSLLNLAIPSCISvclew 306
Cdd:cd13143  169 ILDPLFIFVLGLGIAGAALATVIAQL---ISLLLLLLYffrgKSLLKLSLLRFKLS--LKIIKEILALGFPSFLM----- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 307 wwyEIMILLCGLLINPQ-------ATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCIS-- 377
Cdd:cd13143  239 ---QLSSSVVTIVLNLTllgyggdIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVAli 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 378 YGLGFSALFFAVSvrQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPV 457
Cdd:cd13143  316 YGLVLFLILLLFP--EQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPL 393

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 356540464 458 AVRLSFFagFDFKGLWLGLLAAQ-ASCMFTMLIVL 491
Cdd:cd13143  394 LLILPRL--FGLDGIWLAFPLAEiLTLLLALILLK 426
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 72-496 1.07e-19

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 91.48  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  72 IALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAigFANI-TGYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRT 150
Cdd:cd13142   16 LAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSIS--WPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 151 IVLLLLTSVLISFLWLNMKK--LLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRS--QSITlPLTYTAsLSI 226
Cdd:cd13142   94 FSFVIILSLILAVLGYILSRplLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGigDTKT-PMKIMF-GSV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 227 LLHVPINYFLV----SVLKLGIKGIALGAVWTNFnlVVSLI-LYIWVSGVYKktwPGVSLKGILSGW---KSLLNLAIPS 298
Cdd:cd13142  172 LLNVILDPLLIfgigPFPGLGVAGAALATVISRG--IAAVIgLYLLFKGRVG---LKISLRDLKPDWewlKKIFRIGLPS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 299 CISVCLEWWWYEIMILLCGLLinPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISY 378
Cdd:cd13142  247 SIEQSARALGFTVMTALVAGF--GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIF 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 379 GLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGMPVA 458
Cdd:cd13142  325 LILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLA 404

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 356540464 459 VRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLARTNW 496
Cdd:cd13142  405 YLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
62-484 1.35e-17

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 85.18  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  62 ALNEVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIgfaniTGYSILS----------GLAMGMEPIC 131
Cdd:PRK00187   5 PTTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGA-----ASYSFVSifcvgviaavGTLVAIRHGA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 132 GQAFGAKRFKLLGLamqrtIVLLLLTSVLISFLWlNMKKLLILCGQQEDIATEAQSFIL---FSIPDLVAqslLHPLRIY 208
Cdd:PRK00187  80 GDIEGATRLAQAGL-----WLAWLLALVAALLLW-NLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLS---FMALRGF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 209 LRSQSITLPLTYTASLSILLHVPINYFLVSVL----KLGIKGIALGAVWTNFNLVVSLILYIwvsgvykKTWPGVSLKGI 284
Cdd:PRK00187 151 TSALGRAGPVMVISLAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYI-------RRHPAYAAYPL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 285 LSGW--------KSLLNLAIPSCISVCLEWWWYEIMILLCGLLINPQatVASMGVLIQTTALIYIFPSSLSFAVSTRVGN 356
Cdd:PRK00187 224 RKGLsrpsraalRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQ--LAAHQIALQIVSVAFMVPVGLSYAVTMRVGQ 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 357 ELGAENPKKAKVAALVGlcISYG----LGFSALFFAVSvrQAWASMFTR-----DAEIIALTSMVLPIIGLCELGNCPQT 427
Cdd:PRK00187 302 HYGAGRLLEARRAGRVG--IGFGavvmLLFAGLFWLLP--EAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQT 377

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 428 TVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGL---LAAQASCM 484
Cdd:PRK00187 378 IAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLalgLACAAVAL 437
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 73-440 4.12e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 80.65  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  73 ALPMVLTGLLLYSRSVISMLFLGRVGELALAG-GslAIGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTI 151
Cdd:cd13140   11 ALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAvG--TAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 152 VLLLLTSVLISFLWLNMKKLLI--LCGQQEDIATEAQSFILFSIPDLVAqSLLHPL--RIYLRSQSITLPLtYTASLSIL 227
Cdd:cd13140   89 QLNLLLGILYGLLLLLFAKPLIgfFNLGDAEVISLAITYLRIVALGLIF-SFLNPVftGIFNALGDSKTPF-IINAIGLV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 228 LHVPINYFLVSVL----KLGIKGIALGavwTNFNLVVSLILYIWVSGVYKKTWPGVSLKGILSG--WKSLLNLAIPSCIS 301
Cdd:cd13140  167 LNIILDPLLIFGFgpfpALGVAGAALA---TVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRkyIKEILKLGLPVALQ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 302 VCLewwwYEI--MILL-----CGllinpQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGL 374
Cdd:cd13140  244 SIL----FALisMILAriiasFG-----PVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTAL 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 356540464 375 CI--SYGLGFSALFFAVsvRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPK 440
Cdd:cd13140  315 KIasAIGLFATLLLFFF--GEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTK 380
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 67-478 7.01e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 73.48  E-value: 7.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  67 KCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAggslAIGFANITGYSILSGL---AMGMEPICGQAFGAKRFKLL 143
Cdd:cd13135    1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYS----AVGNVTTPFNTITGFLgsiSIGFTILGSQSVGAKDIKRI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 144 GLAMQRTIVLLLLTSVLISFLW-LNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTA 222
Cdd:cd13135   77 NDYAISSIVYNSIIGVILFLLWlFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 223 SLSILLHVPINYFLV----SVLKLGIKGIALGAVWTNfnlVVSLILYIWVSGVYKKTWPGVSLKGILSGWKSLLNLAIPS 298
Cdd:cd13135  157 IIKNLLNVILDYVLIfgnfGFPRLGIIGAAIATTIAN---VLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 299 CISVCLEWWWYEIMILLCGLLINP----QATVASMGVLIQTTALIYIFpsSLSFAVSTRVGNELGAENPKKAKVAalVGL 374
Cdd:cd13135  234 GLPLGGEEFLWNIGNLAVIRILNRigelALGIYTLVFGIENIVLMPMY--GYSSAALTLVGESIGKKDLKEALRI--GNI 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 375 CISYGLGFS--ALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINL-GCFY 451
Cdd:cd13135  310 CLGLGLLIYiaAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIiGTII 389

                        410       420
                 ....*....|....*....|....*..
gi 356540464 452 LVGmpVAVRLSFFAGFDFKGLWLGLLA 478
Cdd:cd13135  390 VVS--VALLLIFVFKLGLAGVYITLFI 414
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
58-267 1.83e-11

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 65.94  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  58 HFSLALNEVKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGA 137
Cdd:COG0534  220 DLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 138 KRFKLLGLAMQRTIVLLLLTSVLISFLWLNMKKLLI-LCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITL 216
Cdd:COG0534  299 GDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIgLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTR 378

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 356540464 217 PLTYTASLS-ILLHVPINYFLvSVLKLGIKGIALGAVWtnFNLVVSLILYIW 267
Cdd:COG0534  379 FPMIISLLRlWLVRLPLAYLL-AFLGLGLTGVWLALPI--GEVLRALLLLLR 427
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 69-493 6.03e-10

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 61.42  E-value: 6.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  69 IANIALPMVLTGLLLYSRSVISMLFLGRVGELA-LAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAM 147
Cdd:cd13136    5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIALL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 148 QRTIVLLLLTSVLISFL--WLnMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSIT-LPLTYTASL 224
Cdd:cd13136   84 VRALLLALAIGLLLILLqsPL-LALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTrTPLILQIVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILlHVPINYFLVSVLKLGIKGIALGAVwtnFNLVVSLILYIWVSGVYKKTWPGVSLKGILS--GWKSLLNLAIPSCI-S 301
Cdd:cd13136  163 NVV-NIVLDPLFVFGLGWGVAGAALATV---IAQYLGALLGLWLLRRRVRLLGKSLSRRLPSkaALKRLFKLNRDIFIrT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 302 VCLewwwyeimiLLCGLLINPQAT------VASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAA--LVG 373
Cdd:cd13136  239 LAL---------LAAFLFFTALAArlgdviLAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVArrLLQ 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 374 LCISYGLGFSALFFAVsvRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFyLV 453
Cdd:cd13136  310 WGLGLGVLLALLFFLG--GEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSL-AV 386

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 356540464 454 GMPVAVRLSFFAGFDfkGLWLGLLAAQASCMFTMLIVLAR 493
Cdd:cd13136  387 FLPLLFLLVPLWGNH--GLWLALILFMLLRGLTLALRLPR 424
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 67-496 7.67e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 61.09  E-value: 7.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  67 KCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAggslAIGFANIT---GYSILSGLAMGMEPICGQAFGAKRFKLL 143
Cdd:cd13139   14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIA----TVGLTESVltiVYSIAIGLSMAATALVARRIGEKDPEGA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 144 GLAMQRTIVLLLLTSVLISFL-WLNMKKLLILCGQQEDIATEAQSF---ILFSIPDLVAQSLLHPL-------RIYLRSq 212
Cdd:cd13139   90 GFAAVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYtriMFGGNGFIMLLFLINGIfrgagdaAIAMRS- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 213 sitlpLTYTASLSILLHVPINYFLVSVLKLGIKGIALGavwTNFNLVVSLILYIWVSGvYKKTWPGVSLKGILSGW---K 289
Cdd:cd13139  169 -----LWLANGLNIILDPLFIFGLGPIPAMGVTGAAIA---TTIGRSIGVLYQLYHLF-KGKGRIQIRRRHLKLDWaiiK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 290 SLLNLAIPSCISvclewwwYEIMILLCGLLINPQATVASMGVLIQTTAL-IYIF---PS-SLSFAVSTRVGNELGAENPK 364
Cdd:cd13139  240 KIIKIAVGGILQ-------FLIASSSWIFLVRIIAEFGSTALAGYTIAIrIIMFallPAwGLSNAAATLVGQNLGAGQPD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 365 KAKVAA-LVGLCISYGLGFSALFFaVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRG---TARPK 440
Cdd:cd13139  313 RAEKSVwRAGKYNMVFLGIVSLVF-FLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGagdTKTPT 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 356540464 441 LganINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGLLAAQASCMFTMLIVLARTNW 496
Cdd:cd13139  392 L---INLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 72-480 7.48e-09

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 58.08  E-value: 7.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  72 IALPMVLTGLLLYSRSVISMLFLGRVGELALAggslAIGFANITGYSILS---GLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:cd13149   14 LTLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLFLNSltiGLGIGASAVISRAIGAGDRNKAKRLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 149 RTIVLLLLTSVLISFLWL-NMKKLLILCGQQEDIATEAQSFILFSipdlvaqsllhplriYLRSQSITLPL--------- 218
Cdd:cd13149   90 DSLILSLLLSVIVSLLGLfTIPPLFSLLGASGEILPLIVEYMAIW---------------YLGLVFLVLPMvgnaiirat 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 219 --TYTASLSILLHVPINYFLVSVL--------KLGIKGIALGAVwtnfnLVVSLILYIWVSGVYKK----TWPGVSLKGI 284
Cdd:cd13149  155 gdTKRPSLVMLGAALVNVILDPILifgfgpipGMGIAGAAIATV-----ISRALGLGAALYFLHYHhrliDFSEPSLKAL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 285 LSGWKSLLNLAIPSCISVClewwwyeIMILLCGLLINPQAT-----VASMGVLIQTTALIYIFPSSLSFAVSTRVGNELG 359
Cdd:cd13149  230 FRSWKDILSIGIPAALSNI-------LTPLSAAFITALVATygpaaVAAFGVATRIESFAFIIVMALSSALGPFVGQNWG 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 360 AENPKKAKVAALVGL--CISYGLgFSALFFAVSVRQAwASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTA 437
Cdd:cd13149  303 AGQYERVQEGLKISLkfSLIYGA-ILGIVLALFAGWL-ASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALG 380

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 356540464 438 RPKLGANINLGCFYLVGMPVAVRLSFFAGfdFKGLWLGLLAAQ 480
Cdd:cd13149  381 KPLYSLGLNLIRVFLLYIPLAYVGSHLLG--FAGVFIGALAGN 421
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 88-497 3.29e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 56.07  E-value: 3.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  88 VISMLFLGRVGELALAGGSLA--IGFANItgySILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVLLLLTSVLISFLW 165
Cdd:cd13145   30 VVDTFFAGKISTEALAALSLSfpIFFIII---AIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 166 LNMKKLLI-LCGQQEDIATEAQSF---ILFSIPDLVAQSLLHPLriyLRSQSITLPLTYTASLSILLHVPINYFLV---- 237
Cdd:cd13145  107 LFAAPPLFrLLGAEGDYLDLALEYmdvIFAGSIFFLLNFGLNGI---LNAQGDTKSYRNFLIIGFFLNIILDPLFIfggg 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 238 SVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYKKTWPGvSLKGILSGWKSLLNLAIPSCISVclewwwyeIMILLCG 317
Cdd:cd13145  184 GIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLR-DFIPRLDVYKEILKQGFPASLNM--------MTIGLGI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 318 LLIN-------PQAtVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPkkAKVAALVGLCISYGL------GFSA 384
Cdd:cd13145  255 FVITyfvgqfgDEA-VAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKY--DRVRETYKKALKYGFvimvvaTVFL 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 385 LFFAVSVrqawASMFTRDAEII----------ALTSMVLPIIGLCelgncpqttvCGVLRGTARPKLGanINLGCFYLVG 454
Cdd:cd13145  332 LFFAEPL----MSLFTNDPAVIaigagylridALIFYAYVVLFIS----------VSVLQGLKRPIFA--LWIGLYRQLV 395

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 356540464 455 MPVAVR--LSFFAGFDFKGLWLGLLAAQAScmfTMLIVLARTNWE 497
Cdd:cd13145  396 GPALVFwlLVNVLGLGVTGIWWGIFTIVWS---AAIIALLYTRRV 437
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
 67-388 1.24e-07

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 54.08  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  67 KCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAggslAIGFAN---ITGYSILSGLAMGMEPICGQAFGAKRFKLL 143
Cdd:cd13147    9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALA----AIGFVFplfMIIIGLGNGLGAGASSAISRRIGAKDKEGA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 144 GLAMQRTIVLLLLTSVLISFLWL-NMKKLLILCGQQE--DIATE-AQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLT 219
Cdd:cd13147   85 DNAAVHSILLGLIISIILTIVLLpFLEPILVLMGAGEvlDLAVDyGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 220 YTASLSILLHvPInyfLVSVLKLGIKGIALGAVWTnfNLVVSLILYIWVSgVYKKTWPGVSLKGILSGW---KSLLNLAI 296
Cdd:cd13147  165 AGSILNIILD-PI---FIYTLGLGIAGAAWATVIS--MLISSLVLLYWFF-VKKDTYVSLSLKNFKFDKkivKDILKVGI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 297 PSCISVCLewwWYEIMILLCGLLINpqaTVASMGVLIQTTAL----IYIFPS-SLSFAVSTRVGNELGAENPKKAKVA-- 369
Cdd:cd13147  238 PASLEQLI---MSVLMIILNLILVI---VAGTDGVAVYTAGWrivsFAIIPLiGIATAVTSVTGAAYGARNYEKLKTAyn 311

                        330       340
                 ....*....|....*....|.
gi 356540464 370 --ALVGLCISYGLGFSALFFA 388
Cdd:cd13147  312 ysIKLGLIIELIIAILIFIFA 332
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 58-268 1.38e-07

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 54.00  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  58 HFSLALNEVKCIANIALPMVLTGLLLYsrsvISMLFL----GRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQ 133
Cdd:cd13138  216 DFRFDKEILKEILKIGLPSALQQSLVS----ISFLIInsivNSYGVVASAAYGIANKINSFA-FLPPSAIGQAVSTFVAQ 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 134 AFGAKRFKLLGLAMQRTIVL-LLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLR-S 211
Cdd:cd13138  291 NIGAGKIERAKKGLRTGIIIsLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRgL 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 356540464 212 QSITLPLTYTASLSILLHVPINYFLVSVLKLGIKGIALGAVWTNF-NLVVSLILYIWV 268
Cdd:cd13138  371 GKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNIlSAIICIIYYRKG 428
MATE_like_13 cd13141
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 66-418 6.89e-07

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240546 [Multi-domain]  Cd Length: 443  Bit Score: 51.55  E-value: 6.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  66 VKCIANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAiGFANITGYSILSGLAMGMEPICGQAFGAKRFKLLGL 145
Cdd:cd13141   10 PKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLA-GNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 146 AMQRTIVL-LLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRSQSITLPLTYTASL 224
Cdd:cd13141   89 VFNQSLLLaAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQIL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHVPINYFLV----SVLKLGIKGIALGAVWTNFNLVVSLILYIWVSGVYkKTWPGVSLKGILSGWKSLLNLAIPSci 300
Cdd:cd13141  169 AVLLNIILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKY-LRLDLALWRPDLPTWKRLLKIGLPS-- 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 301 svCLEWWWYEIMILLCGLLINPQATVASMGVLIQTTALIYIF-PS-SLSFAVSTRVGNELGAENPKKAKVAALVGLCISY 378
Cdd:cd13141  246 --GGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFlPAmAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTT 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 356540464 379 GLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGL 418
Cdd:cd13141  324 ALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSW 363
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 117-486 3.26e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 43.16  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 117 YSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIVL-LLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPD 195
Cdd:cd13146   60 LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALaLLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 196 LVAQSLLHPLRIYLRSQSITLPLTYTASLSILLHVPINYFLVSVLKLGIKGIALGAVWTNFnLVVSLILYIWVSGVykkt 275
Cdd:cd13146  140 VPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQA-ISLLYLLYVFLIGK---- 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 276 wPGVSLKGILSGWKSLLNLAIpscISVCLEWWWYEIMILLCGLLINPQATVASMGVLIQTT--------ALIYIFpsSLS 347
Cdd:cd13146  215 -SNVTIHIKLSNISSSVIVEI---LRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTlvgrldqfILIPIF--AIS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 348 FAVSTRVGNELGAENPKKAKVAALVGLCISYGLGFSALFFAVSVRQAWASMFTRDAEIIALTSMVLPIIGLCELGNCPQT 427
Cdd:cd13146  289 SALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISI 368

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 356540464 428 TVCGVLRGTARPKLGANINLGCFYLVGMPVAVRLSFFAGFDFKGLWLGLLAAQASCMFT 486
Cdd:cd13146  369 LVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALL 427
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 63-267 5.01e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 42.70  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  63 LNEVKCIANIALPMVLTGLLLYSRSVISMLFLGRV-GELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFK 141
Cdd:cd12082  215 LELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLA-FMPALGLAQAALPVVGQNLGAGNFD 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 142 -LLGLAMQRTIVLLLLTSVLISFLWLNMKKLLILCGQQEDIATEAQSFILFSIPDLVAQSLLHPLRIYLRS-QSITLPLT 219
Cdd:cd12082  294 rARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAaGRTLKSLI 373

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 356540464 220 YTASLSILLHVPINYFLVsVLKLGIKGIALGAVWTNFNLVVSLILYIW 267
Cdd:cd12082  374 VSLLSYWVVRLPLAYVLA-YLGLGLYGIWLALVISLILAALVLLLFFR 420
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 73-493 1.80e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 40.68  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464  73 ALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQRTIV 152
Cdd:cd13144   14 SIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 153 LLLLTSVL-ISFLWLNMKKLLILCGQQEDIATEAQSF---ILFSIPDLVAQSLLHPLriyLRSQSITLPLTYT----ASL 224
Cdd:cd13144   93 LALLSYLLfLLLGLFGVKPFFRLFTDDPEILEYGYAYlswCVIFSFGMFFQILCEKV---LQSTGNTITPMIAqligAII 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 225 SILLHvPINYF-LVSVLKLGIKGIALGAVwtnFNLVVSLILYIWVSGVYKKTWPGV--SLKGILSGWKSLLNLAIPSCIS 301
Cdd:cd13144  170 NIILD-PILIFgLFGFPAMGIAGAAIATV---IGQILAMFLAFFFLLRKNKDVQPDlrLFRPSLRIIKEIYAVGLPSIIM 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 302 VCLEwwwyEIMILLCG--LLINPQATVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYG 379
Cdd:cd13144  246 QAIS----SVMVFGLNkiLAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVV 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 380 L----GFSALFFAVSVrqawASMFTRDAEIIALTSMVLPIIGLCELGNCPQTTVCGVLRGTARPKLGANINLGCFYLVGM 455
Cdd:cd13144  322 ImlagGLLFQLFPDQL----LGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 356540464 456 PVAVRLSFFagFDFKGLWLGLLAAQASCMFTMLIVLAR 493
Cdd:cd13144  398 PLAWLLAKM--FGLNGVWWSFPIAEIVSFLLSLLFLKR 433
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 69-164 6.44e-03

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 38.77  E-value: 6.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464   69 IANIALPMVLTGLLLYSRSVISMLFLGRVGELALAGGSLAIGFANITgYSILSGLAMGMEPICGQAFGAKRFKLLGLAMQ 148
Cdd:TIGR00797 218 LLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPKRAKEVAR 296

                          90
                  ....*....|....*.
gi 356540464  149 RTIVLLLLTSVLISFL 164
Cdd:TIGR00797 297 VALKLSLLLGLVLAII 312
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 239-419 6.68e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 39.18  E-value: 6.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 239 VLKLGIKGIALGAVWTNFNLVVSLILYIWV-SGVYKKTWPGVSLKGILsgWKSLLNLAIPSCISVCLEwwwYEIMILLCG 317
Cdd:cd13148  189 LPRLGVAGAAVAAVLYYALAALVLLRYLASgRSRLRLRLRALRLERRL--FRDILRVGLLAALSPLQT---NLTVLLLTG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356540464 318 LL--INPQAtVASMGVLIQTTALIYIFPSSLSFAVSTRVGNELGAENPKKAKVAALVGLCISYGL-GFSALFFAVSvRQA 394
Cdd:cd13148  264 LVgrFGTAA-LAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVLaGAIGLVLALF-PEL 341

                        170       180
                 ....*....|....*....|....*
gi 356540464 395 WASMFTRDAEIIALTSMVLPIIGLC 419
Cdd:cd13148  342 WLGLFTHDPAVLAAGASYLRIVGPF 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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