|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
1-596 |
3.13e-180 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 534.28 E-value: 3.13e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 1 MVSLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML---HRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEE 77
Cdd:COG1643 7 PPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALlelGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGET 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 78 VGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSDLKVLITSATL 157
Cdd:COG1643 87 VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPDLKLLVMSATL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 158 DGEKVSKFFADCPVLNVPGKLYPVEVLY-SRERPSSYLESSLKTALDIHIREPEGDILIFMTGQDDIEKLVSKLEDKVRA 236
Cdd:COG1643 167 DAERFARLLGDAPVIESSGRTYPVEVRYrPLPADERDLEDAVADAVREALAEEPGDILVFLPGEREIRRTAEALRGRLPP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 237 leegscmDAIILPLHGSLPPELQVRVFSPPPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMYSLDVVQ 316
Cdd:COG1643 247 -------DTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 317 ISKVQANQRAGRAGRTRPGKCYRLYPSriynDEFL---DVTVPEIQRSSLAGSVLYLKSLDLPDIDilKFDFLDPPSSES 393
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSE----EDFArrpAFTDPEILRADLASLILELAAWGLGDPE--DLPFLDPPPARA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 394 LQDALKQLFLIDAIDENGAITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSaETTLLPGQRktekkrkhti 473
Cdd:COG1643 394 IADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS-ERDPRRGAA---------- 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 474 snlpdGSGLGDHIQLLQIYECWDQTDFDIGWCKDnglqvrgmlfVRDVRKQLSQimqkiskgpldvRANGKREEFRQDYR 553
Cdd:COG1643 463 -----GSDLLARLNLWRRLREQQREFLSYLRLRE----------WRDLARQLRR------------LLGEGANEEPADYE 515
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 356512355 554 NLRKALCMGYANQLAERKMHHNGYRT---LGFqaqvvQVHPSSVLS 596
Cdd:COG1643 516 AIGLLLALAYPDRIARRRGEGGRYLLargRGA-----ALFPGSPLA 556
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
3-634 |
2.40e-130 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 416.09 E-value: 2.40e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 3 SLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQM---LHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEVG 79
Cdd:TIGR01967 65 NLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKIcleLGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 80 YAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVnIRSSDLKVLITSATLDG 159
Cdd:TIGR01967 145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL-PRRPDLKIIITSATIDP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 160 EKVSKFFADCPVLNVPGKLYPVEVLYsreRPssyLES-----------SLKTALDIHIREPEGDILIFMTGQDDIEklvs 228
Cdd:TIGR01967 224 ERFSRHFNNAPIIEVSGRTYPVEVRY---RP---LVEeqedddldqleAILDAVDELFAEGPGDILIFLPGEREIR---- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 229 kleDKVRALEEGSCMDAIILPLHGSLPPELQVRVFSPPppNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSG 308
Cdd:TIGR01967 294 ---DAAEILRKRNLRHTEILPLYARLSNKEQQRVFQPH--SGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTK 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 309 MYSLDVVQISKVQANQRAGRAGRTRPGKCYRLYPSRIYND--EFLDvtvPEIQRSSLAGSVLYLKSLDLPDIDilKFDFL 386
Cdd:TIGR01967 369 VQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSrpEFTD---PEILRTNLASVILQMLALRLGDIA--AFPFI 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 387 DPPSSESLQDALKQLFLIDAIDENGA---ITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSAETTL-LPGQ 462
Cdd:TIGR01967 444 EAPDPRAIRDGFRLLEELGALDDDEAepqLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPReRPME 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 463 RKTEKKRKHTISNLPDgsglGDHIQLLQIYECW-DQTDFDIG-----WCKD---NGLQVRGMlfvRDVRKQLSQIMQKis 533
Cdd:TIGR01967 524 KQQAADQAHARFKDPR----SDFLSRVNLWRHIeEQRQALSAnqfrnACRKqylNYLRVREW---QDIYRQLTQVVKE-- 594
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 534 kgpLDVRANgkreEFRQDYRNLRKALCMGYANQLAER--KMHHNGYRTLGFqaqvvQVHPSSVLSlddlGKFPDYVVYHE 611
Cdd:TIGR01967 595 ---LGLKLN----EEPADYDAIHKALLSGLLSQIGMKdeKHEYDGARGRKF-----HIFPGSPLF----KKPPKWVMAAE 658
|
650 660
....*....|....*....|...
gi 356512355 612 LIATPRPYMRNVCAVEMRWVIPI 634
Cdd:TIGR01967 659 LVETSKLYARLVAKIEPEWVEPV 681
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
3-634 |
5.65e-124 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 399.43 E-value: 5.65e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 3 SLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQM---LHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEVG 79
Cdd:PRK11131 72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKIcleLGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 80 YAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNiRSSDLKVLITSATLDG 159
Cdd:PRK11131 152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLP-RRPDLKVIITSATIDP 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 160 EKVSKFFADCPVLNVPGKLYPVEVLYsreRP---------SSYLESSLKtALDIHIREPEGDILIFMTGQDDIeklvskl 230
Cdd:PRK11131 231 ERFSRHFNNAPIIEVSGRTYPVEVRY---RPiveeaddteRDQLQAIFD-AVDELGREGPGDILIFMSGEREI------- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 231 EDKVRALEEGSCMDAIILPLHGSLPPELQVRVFSppPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMY 310
Cdd:PRK11131 300 RDTADALNKLNLRHTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQ 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 311 SLDVVQISKVQANQRAGRAGRTRPGKCYRLYPSRIYND--EFLDvtvPEIQRSSLAGSVLYLKSLDLPDIDilKFDFLDP 388
Cdd:PRK11131 378 RLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSrpEFTD---PEILRTNLASVILQMTALGLGDIA--AFPFVEA 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 389 PSSESLQDALKQLFLIDAIDENGA-----ITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSAETtllPGQR 463
Cdd:PRK11131 453 PDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQD---PRER 529
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 464 KTEKKR----KHTISNLPDGS-----GLGDHIQLLQI--------YECwdQTDFdigwckDNGLQVRGMlfvRDVRKQLS 526
Cdd:PRK11131 530 PMDKQQasdeKHRRFADKESDflafvNLWNYLQEQQKalssnqfrRLC--RTDY------LNYLRVREW---QDIYTQLR 598
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 527 QIMQKiskgpLDVRANGKreefRQDYRNLRKALCMGYANQLAER---KMHHNGYRTLGFqaqvvQVHPSSVLslddLGKF 603
Cdd:PRK11131 599 QVVKE-----LGIPVNSE----PAEYREIHTALLTGLLSHIGMKdaeKQEYTGARNARF-----SIFPGSGL----FKKP 660
|
650 660 670
....*....|....*....|....*....|.
gi 356512355 604 PDYVVYHELIATPRPYMRNVCAVEMRWVIPI 634
Cdd:PRK11131 661 PKWVMVAELVETSRLWGRIAARIEPEWIEPL 691
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
4-454 |
1.76e-110 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 352.92 E-value: 1.76e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLS-QMLHRRGYG-KIAITQPRRVAAVSVARRVAHELGVQLGEEVGYA 81
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPlALLDAPGIGgKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGYR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 82 IRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSDLKVLITSATLDGEK 161
Cdd:TIGR01970 81 VRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMSATLDGER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 162 VSKFFADCPVLNVPGKLYPVEVLYSRERPSSYLESSLKTALDIHIREPEGDILIFMTGQDDIEKLVSKLEDKVRAleegs 241
Cdd:TIGR01970 161 LSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEIRRVQEQLAERLDS----- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 242 cmDAIILPLHGSLPPELQVRVFSPPPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMYSLDVVQISKVQ 321
Cdd:TIGR01970 236 --DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQAS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 322 ANQRAGRAGRTRPGKCYRLYPSRiYNDEFLDVTVPEIQRSSLAGSVLYLKSLDLPDIDILKfdFLDPPSSESLQDALKQL 401
Cdd:TIGR01970 314 ATQRAGRAGRLEPGVCYRLWSEE-QHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLR--WLDAPPSVALAAARQLL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 356512355 402 FLIDAIDENGAITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSA 454
Cdd:TIGR01970 391 QRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEE 443
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
1-454 |
2.76e-92 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 304.54 E-value: 2.76e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 1 MVSLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLS-QMLHRRGY-GKIAITQPRRVAAVSVARRVAHELGVQLGEEV 78
Cdd:PRK11664 1 MSSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGInGKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 79 GYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLmrrLVNIRSS---DLKVLITSA 155
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALAL---LLDVQQGlrdDLKLLIMSA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 156 TLDGEKVSKFFADCPVLNVPGKLYPVEVLYSRERPSSYLESSLKTALDIHIREPEGDILIFMTGQDDIEKLVSKLEDKVR 235
Cdd:PRK11664 158 TLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASRVA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 236 AleegscmDAIILPLHGSLPPELQVRVFSPPPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMYSLDVV 315
Cdd:PRK11664 238 S-------DVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQ 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 316 QISKVQANQRAGRAGRTRPGKCYRLYpSRIYNDEFLDVTVPEIQRSSLAGSVLYLKSLDLPDIDILKfdFLDPPSSESLQ 395
Cdd:PRK11664 311 RISQASMTQRAGRAGRLEPGICLHLY-SKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLS--WLDQPPAAALA 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 356512355 396 DALKQLFLIDAIDENGAITSIGQKMAELPLEPSLAKTLMEANNYGclYEALTVAAMLSA 454
Cdd:PRK11664 388 AAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLAA 444
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
20-174 |
3.93e-79 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 249.30 E-value: 3.93e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 20 NPVVVVIGETGSGKSTQLSQMLHRRGY-----GKIAITQPRRVAAVSVARRVAHELGVQLGEEVGYAIRFEDRTSHSTRI 94
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLakggkGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 95 KYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSATLDGEKVSKFFADCPVLNV 174
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKR-PDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
4-174 |
7.20e-79 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 249.19 E-value: 7.20e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGK---IAITQPRRVAAVSVARRVAHELGVQLGEEVGY 80
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARggmIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 AIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRS----SDLKVLITSAT 156
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKeqklSPLKVIIMSAT 160
|
170
....*....|....*...
gi 356512355 157 LDGEKVSKFFADCPVLNV 174
Cdd:cd17978 161 LDADLFSEYFNGAPVLYI 178
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
179-341 |
7.02e-78 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 246.29 E-value: 7.02e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 179 YPVEVLY-----------SRERPSSYLESSLKTALDIHIREPEGDILIFMTGQDDIEKLVSKLEDKvraLEEGSCMDAII 247
Cdd:cd18791 1 FPVEVYYledilellgisSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREE---LLSPDLGKLLV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 248 LPLHGSLPPELQVRVFSPPPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMYSLDVVQISKVQANQRAG 327
Cdd:cd18791 78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157
|
170
....*....|....
gi 356512355 328 RAGRTRPGKCYRLY 341
Cdd:cd18791 158 RAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
4-174 |
5.33e-77 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 244.29 E-value: 5.33e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGY---GKIAITQPRRVAAVSVARRVAHELGVQLGEEVGY 80
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYtdyGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 AIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNiRSSDLKVLITSATLDGE 160
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVA-RRRDLKLIVTSATMDAD 159
|
170
....*....|....
gi 356512355 161 KVSKFFADCPVLNV 174
Cdd:cd17983 160 KFADFFGNVPIFTI 173
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
3-175 |
4.44e-76 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 242.00 E-value: 4.44e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 3 SLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGY---GKIAITQPRRVAAVSVARRVAHELGVQLGEEVG 79
Cdd:cd17971 5 SLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYtsrGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEVG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 80 YAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVnIRSSDLKVLITSATLDG 159
Cdd:cd17971 85 YTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTV-QKRPDLKLIVTSATLDA 163
|
170
....*....|....*.
gi 356512355 160 EKVSKFFADCPVLNVP 175
Cdd:cd17971 164 VKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
4-174 |
1.60e-71 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 230.38 E-value: 1.60e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQ-----MLHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEV 78
Cdd:cd17973 13 LPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQfvlddELPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 79 GYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNiRSSDLKVLITSATLD 158
Cdd:cd17973 93 GYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVR-RRPDLKLIVMSATLD 171
|
170
....*....|....*.
gi 356512355 159 GEKVSKFFADCPVLNV 174
Cdd:cd17973 172 AGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
4-174 |
2.98e-71 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 228.93 E-value: 2.98e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGY----GKIAITQPRRVAAVSVARRVAHELGVQLGEEVG 79
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYtkggGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 80 YAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSATLDG 159
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFR-PDLKLLISSATMDA 159
|
170
....*....|....*
gi 356512355 160 EKVSKFFADCPVLNV 174
Cdd:cd17974 160 EKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
4-174 |
8.09e-67 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 217.41 E-value: 8.09e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGK---IAITQPRRVAAVSVARRVAHELGVQLGEEVGY 80
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQhgmIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 AIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRS----SDLKVLITSAT 156
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkEHLKVVVMSAT 160
|
170
....*....|....*...
gi 356512355 157 LDGEKVSKFFADCPVLNV 174
Cdd:cd17984 161 LELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
4-166 |
3.72e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 210.79 E-value: 3.72e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGK----IAITQPRRVAAVSVARRVAHELGVQLGEEVG 79
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAggrvVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 80 YAIRFEDRTSH-STRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSATLD 158
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKR-GDLRLIVASATLD 159
|
....*...
gi 356512355 159 GEKVSKFF 166
Cdd:cd17980 160 AEKFRDFF 167
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
4-165 |
7.51e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 210.29 E-value: 7.51e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGK--------IAITQPRRVAAVSVARRVAHELGVqLG 75
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSpesdnpgmIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 76 EEVGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSD-------- 147
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLylqdqtvk 159
|
170
....*....|....*....
gi 356512355 148 -LKVLITSATLdgeKVSKF 165
Cdd:cd17982 160 pLKLVIMSATL---RVEDF 175
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
4-174 |
8.81e-59 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 195.75 E-value: 8.81e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQM---LHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEVGY 80
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKIcleLGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 AIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNiRSSDLKVLITSATLDGE 160
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLP-RRPDLKVIITSATIDAE 159
|
170
....*....|....
gi 356512355 161 KVSKFFADCPVLNV 174
Cdd:cd17989 160 RFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
4-174 |
1.20e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 189.96 E-value: 1.20e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEVGYAIR 83
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 84 FEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSATLDGEKVS 163
Cdd:cd17979 81 FERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLR-PDLKLILMSATINIELFS 159
|
170
....*....|.
gi 356512355 164 KFFADCPVLNV 174
Cdd:cd17979 160 GYFEGAPVVQV 170
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
4-172 |
1.36e-46 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 162.89 E-value: 1.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLS-QMLHRRGY--GKIAITQPRRVAAVSVARRVAHELGVQLGEEVGY 80
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWIagGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 AIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSDLKVLITSATLDGE 160
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSATLDGD 160
|
170
....*....|..
gi 356512355 161 KVSKFFADCPVL 172
Cdd:cd17990 161 GLAALLPEAPVV 172
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
4-174 |
1.76e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 160.08 E-value: 1.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML--------HRRGYGKIAITQPRRVAAVSVARRVAHELGVQLG 75
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLledlllngGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 76 -----EEVGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKV 150
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKR-SDLHL 159
|
170 180
....*....|....*....|....
gi 356512355 151 LITSATLDGEKVSKFFADCPVLNV 174
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
4-174 |
3.79e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 159.19 E-value: 3.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHR----RGYG---KIAITQPRRVAAVSVARRVAHELGVQLGE 76
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGarcNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 77 EVGYAIRFEDR-TSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSA 155
Cdd:cd17976 81 NVGYQVRLESRpPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLN-PELRVVLMSA 159
|
170
....*....|....*....
gi 356512355 156 TLDGEKVSKFFADCPVLNV 174
Cdd:cd17976 160 TGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
4-174 |
4.10e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 156.54 E-value: 4.10e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML----HRRGYG---KIAITQPRRVAAVSVARRVAHELG--VQL 74
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGsscRIVCTQPRRISAISVAERVAAERAesCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 75 GEEVGYAIRFEDRTSHS-TRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLIT 153
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFR-SDLKVILM 159
|
170 180
....*....|....*....|.
gi 356512355 154 SATLDGEKVSKFFADCPVLNV 174
Cdd:cd17981 160 SATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
3-174 |
5.48e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 154.99 E-value: 5.48e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 3 SLPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML-------HRRGYGKIAITQPRRVAAVSVARRVAHELGVQLG 75
Cdd:cd17972 58 LLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYIlddfiqnDRAAECNIVVTQPRRISAVSVAERVAFERGEEVG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 76 EEVGYAIRFEDRT--SHSTrIKYLTDGVLLRESLANpeLNEYSVIILDEAHERSLNTDILMGLMRRLVNIrSSDLKVLIT 153
Cdd:cd17972 138 KSCGYSVRFESVLprPHAS-ILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQA-YPDLRVILM 213
|
170 180
....*....|....*....|.
gi 356512355 154 SATLDGEKVSKFFADCPVLNV 174
Cdd:cd17972 214 SATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
4-181 |
3.15e-42 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 151.12 E-value: 3.15e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML-----HRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEV 78
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFIldhyyKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 79 GYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSDLKVLITSATLD 158
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRHVKIILMSATIS 160
|
170 180
....*....|....*....|...
gi 356512355 159 GEKVSKFFAdcpVLNVPGKLYPV 181
Cdd:cd17988 161 CKEFADYFT---TPNNPAYVFEV 180
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
4-174 |
2.94e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 148.45 E-value: 2.94e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQML-------HRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGE 76
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFIldnslqgPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 77 EVGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSAT 156
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQR-PDLKVILMSAT 159
|
170
....*....|....*...
gi 356512355 157 LDGEKVSKFFADCPVLNV 174
Cdd:cd17985 160 LNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
4-174 |
2.68e-39 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 142.66 E-value: 2.68e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQMLHRRGYGK-----IAITQPRRVAAVSVARRVAHELGVQLGEEV 78
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANgipcrIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 79 GYAIRFEDRTSHSTRIKYLTDGVLLRESLANPE-LNEYSVIILDEAHERSLNTDILMGLMRRLVNiRSSDLKVLITSATL 157
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQ-KHPNLKLILSSAAL 159
|
170
....*....|....*..
gi 356512355 158 DGEKVSKFFADCPVLNV 174
Cdd:cd17987 160 DVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
4-174 |
1.05e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 127.25 E-value: 1.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNPVVVVIGETGSGKSTQLSQ-------MLHRRgYGKIAITQPRRVAAVSVARRVAHELGVQLGE 76
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeyclSAHYQ-HGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 77 EVGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRsSDLKVLITSAT 156
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSR-PELKLVIITCP 158
|
170
....*....|....*...
gi 356512355 157 LDGEKVSKFFADCPVLNV 174
Cdd:cd17977 159 HLSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
4-174 |
4.01e-32 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 122.70 E-value: 4.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 4 LPIVQYEEKIIETVERNP-VVVVIGETGSGKSTQLSQ------MLHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGE 76
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQwcaefaLSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 77 EVGYAIRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNTDILMGLMRRlVNIRSSDLK-VLITSA 155
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKD-VRLQRPELRvVVVTSP 159
|
170
....*....|....*....
gi 356512355 156 TLDgEKVSKFFADCPVLNV 174
Cdd:cd17986 160 ALE-PKLRAFWGNPPVVHV 177
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
397-488 |
1.42e-22 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 92.69 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 397 ALKQLFLIDAIDENGAITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSAETTLLP------------GQRK 464
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQpnfldprsaakaARRR 80
|
90 100
....*....|....*....|....
gi 356512355 465 TEKKRKHTISNLPDGSGLGDHIQL 488
Cdd:pfam04408 81 RRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
9-180 |
2.40e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.55 E-value: 2.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 9 YEEKIIETVERNP-VVVVIGETGSGKSTQ----LSQMLHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLGEEVGY--- 80
Cdd:smart00487 12 YQKEAIEALLSGLrDVILAAPTGSGKTLAallpALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLygg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 81 ---AIRFEDRTSHSTRIKYLTDGVLLRESLANP-ELNEYSVIILDEAHERS--LNTDILMGLMRRLvnirSSDLKVLITS 154
Cdd:smart00487 92 dskREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL----PKNVQLLLLS 167
|
170 180
....*....|....*....|....*...
gi 356512355 155 ATL--DGEKVSKFFADCPVLNVPGKLYP 180
Cdd:smart00487 168 ATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
404-489 |
4.40e-19 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 81.93 E-value: 4.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 404 IDAIDENGAITSIGQKMAELPLEPSLAKTLMEANNYGCLYEALTVAAMLSAETTLLPGQRKTEKKRKHTISNlpdgsGLG 483
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEKREDADAARRRFAD-----PES 76
|
....*.
gi 356512355 484 DHIQLL 489
Cdd:smart00847 77 DHLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
555-634 |
7.83e-19 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 81.53 E-value: 7.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 555 LRKALCMGYANQLAERKMHHNGYRTLGFQaQVVQVHPSSVLSlDDLGKFPDYVVYHELIATPRPYMRNVCAVEMRWVIPI 634
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSDN-QRVFIHPSSVLF-NEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLF 78
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
5-377 |
4.63e-17 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 85.41 E-value: 4.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 5 PIVQyeEKIIETVERNPVVVVIGETGSGKSTQLSQML--------------------HRRgygKIAITQPRrvaaVSVAR 64
Cdd:PHA02653 166 PDVQ--LKIFEAWISRKPVVLTGGTGVGKTSQVPKLLlwfnylfggfdnldkidpnfIER---PIVLSLPR----VALVR 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 65 RVAHELGVQLG----EEVGYAIRF---EDRTSHSTRIKYltdGVLL---RESLANpeLNEYSVIILDEAHERSLNTDILM 134
Cdd:PHA02653 237 LHSITLLKSLGfdeiDGSPISLKYgsiPDELINTNPKPY---GLVFsthKLTLNK--LFDYGTVIIDEVHEHDQIGDIII 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 135 GLMRRLV-NIRSSdlkVLITsATL--DGEKVSKFFADCPVLNVPG-KLYPVEVLYSRERPS-----SYLESSLK---TAL 202
Cdd:PHA02653 312 AVARKHIdKIRSL---FLMT-ATLedDRDRIKEFFPNPAFVHIPGgTLFPISEVYVKNKYNpknkrAYIEEEKKnivTAL 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 203 DIHIREPEGDILIFMTGqddieklVSKLEDKVRALEEG-SCMDAIILplHGSLP--PELQVRVFSPPPPNcrrIIVATNI 279
Cdd:PHA02653 388 KKYTPPKGSSGIVFVAS-------VSQCEEYKKYLEKRlPIYDFYII--HGKVPniDEILEKVYSSKNPS---IIISTPY 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 280 AETSLTVDGVVYVIDSGyvkqRQYNPS----SGMYsldvvqISKVQANQRAGRAGRTRPGKCYRLY------PSRIYNDE 349
Cdd:PHA02653 456 LESSVTIRNATHVYDTG----RVYVPEpfggKEMF------ISKSMRTQRKGRVGRVSPGTYVYFYdldllkPIKRIDSE 525
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 356512355 350 FL----------DVTVPE---IQRSSLA---GSVLYLKSLDLPD 377
Cdd:PHA02653 526 FLhnyilyakyfNLTLPEdlfVIPSNLDrlrKTEEYIDSFNISI 569
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
198-331 |
5.20e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 63.00 E-value: 5.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 198 LKTALDIHIREPEGDILIFMTGQDDIEKLVSKLEDKVRaleegscmdaiILPLHGSLPPELQVRVFSPPPPNCRRIIVAT 277
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEAELLLEKEGIK-----------VARLHGDLSQEEREEILEDFRKGKIDVLVAT 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 356512355 278 NIAETSLTVDGVVYVIDSGYVkqrqYNPSsgmysldvvqiskvQANQRAGRAGR 331
Cdd:pfam00271 72 DVAERGLDLPDVDLVINYDLP----WNPA--------------SYIQRIGRAGR 107
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
247-331 |
1.98e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 60.30 E-value: 1.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 247 ILPLHGSLPPELQVRVFSPPPPNCRRIIVATNIAETSLTVDGVVYVIDSGYVkqrqynpssgmysldvvqISKVQANQRA 326
Cdd:smart00490 14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLP------------------WSPASYIQRI 75
|
....*
gi 356512355 327 GRAGR 331
Cdd:smart00490 76 GRAGR 80
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
11-158 |
9.04e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 49.16 E-value: 9.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 11 EKIIETVERNPVVVVIGETGSGKSTQ-----LSQMLHRRGYGKIAITQPRRVAA---VSVARRVAHELGVQLGEEV-GYA 81
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLAfllpaLEALDKLDNGPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLLgGDS 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 356512355 82 IRFEDRTSHSTRIKYLTDGVLLRESLANPELNEYSVIILDEAHERSLNT--DILMGLMRRLvnirSSDLKVLITSATLD 158
Cdd:pfam00270 85 RKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDMGfgPDLEEILRRL----PKKRQILLLSATLP 159
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
23-156 |
1.58e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 48.17 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 23 VVVIGETGSGKSTQLSQMLHRR---GYGKIAITQPRRVAAVSVARRVAHELGvqLGEEVGYAIRF---EDRTSHSTR--- 93
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLllkKGKKVLVLVPTKALALQTAERLRELFG--PGIRVAVLVGGssaEEREKNKLGdad 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 356512355 94 IKYLTDGVLLRESLAN--PELNEYSVIILDEAHERSLNTDILMGLMRRLVNIRSSDLKVLITSAT 156
Cdd:cd00046 82 IIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
22-152 |
2.53e-06 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 47.34 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 22 VVVVIGETGSGKST---QLSQMLHRRGYGKIAITQPRRVAAVSVARRVAHELGVQLgeevgyairfEDRTSHSTRIKYLT 98
Cdd:pfam13401 7 ILVLTGESGTGKTTllrRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLPL----------SGRLSKEELLAALQ 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 356512355 99 DgvLLRESLANPelneysVIILDEAHerSLNTDILMGLmRRLVNIRSSDLKVLI 152
Cdd:pfam13401 77 Q--LLLALAVAV------VLIIDEAQ--HLSLEALEEL-RDLLNLSSKLLQLIL 119
|
|
| SRP_G_like |
cd03115 |
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition ... |
22-173 |
8.91e-05 |
|
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognate receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.
Pssm-ID: 349769 [Multi-domain] Cd Length: 193 Bit Score: 43.90 E-value: 8.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 22 VVVVIGETGSGKST---QLSQMLHRRGYgKIAI--TQPRRVAAVSVARRVAHELGVQLgEEVGYAIRFEDrtshstriky 96
Cdd:cd03115 2 VILLVGLQGSGKTTtlaKLARYYQEKGK-KVLLiaADTFRAAAVEQLKTLAEKLGVPV-FESYTGTDPAS---------- 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 356512355 97 ltdgvLLRESLANPELNEYSVIILDEAHeRSLNTDILMGLMRRLVNIRSSDLKVLITSATL--DGEKVSKFFADCPVLN 173
Cdd:cd03115 70 -----IAQEAVEKAKLEGYDVLLVDTAG-RLQKDEPLMEELKKVKEVESPDEVLLVLDATTgqEALSQAKAFNEAVGLT 142
|
|
| ExeA |
COG3267 |
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ... |
18-151 |
2.05e-04 |
|
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 442498 [Multi-domain] Cd Length: 261 Bit Score: 43.62 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 18 ERNPVVVVIGETGSGKSTQLSQMLHR--RGYGKIAITQPrRVAAVSVARRVAHELGVQLgeevgyairfeDRTSHSTRIK 95
Cdd:COG3267 41 QGGGFVVLTGEVGTGKTTLLRRLLERlpDDVKVAYIPNP-QLSPAELLRAIADELGLEP-----------KGASKADLLR 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 356512355 96 YLTDgvLLRESLANpelNEYSVIILDEAHerSLNTDILMGLmRRLVNIRSSDLKVL 151
Cdd:COG3267 109 QLQE--FLLELAAA---GRRVVLIIDEAQ--NLPPETLEEL-RLLSNLETDSRKLL 156
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
29-124 |
1.18e-03 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 39.84 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356512355 29 TGSGKSTQLSqmlhrRGYGKIAITQPRRVAAVSVARRVAHELGVQL-GEEVGY---AIRFEDrtSHSTRIKYLTDGVLLR 104
Cdd:cd17931 10 PGAGKTTRVL-----PQIIREAIKKRLRTLVLAPTRVVAAEMYEALrGLPIRYrtgAVKEEH--GGNEIVDYMCHGTFTC 82
|
90 100
....*....|....*....|
gi 356512355 105 ESLANPELNEYSVIILDEAH 124
Cdd:cd17931 83 RLLSPKRVPNYNLIIMDEAH 102
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
273-341 |
2.83e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.91 E-value: 2.83e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 356512355 273 IIVATNIAETSLTVDGVVYVIDSGYVkqrqynpssgmysldvvqISKVQANQRAGRAGR--TRPGKCYRLY 341
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPP------------------SSAASYIQRVGRAGRggKDEGEVILFV 77
|
|
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