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Conserved domains on  [gi|356496747|ref|XP_003517227|]
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tubby-like F-box protein 5 [Glycine max]

Protein Classification

tubby-like F-box protein( domain architecture ID 17778958)

tubby-like F-box protein may participate in the abscisic acid (ABA) signaling pathway in plants

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  29109004|36589128|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-410 1.22e-139

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 398.87  E-value: 1.22e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  117 KQPGPRDSPIQCFIRRNR----ETSTYLLYIGLvpSENETDKLLLAAKKVRRATGTDFVISLVADDFFRSSNTYVGKLRS 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKsgmgLTPTYHLYLEL--SPGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  193 NFLGTKFTIYDSQPPQGAAIQPDNRSSrrFHSKQVSPrvpaCNYVVSTIAYELNVLRARGPRRMHCTMNSISVSAVQegg 272
Cdd:pfam01167  79 NFLGTKFTLYDNQPPYNGANPSKSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  273 nAPTPTSFPQIIDEPFspspalkgkgpirdldnaslpellpvQSQDSAEPLVLKNKAPRWHEQLQCWCLNFNGRVTVASV 352
Cdd:pfam01167 150 -VPIQPQSESSLLEDF--------------------------KSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASV 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 356496747  353 KNFQLVAavdpshnvsAAEQEKVILQFGKIGKDIFTMDYRYPLSAFQAFAICLSSFDT 410
Cdd:pfam01167 203 KNFQLVA---------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 8.80e-21

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438924  Cd Length: 45  Bit Score: 84.79  E-value: 8.80e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 356496747  55 WANLPPELLLDIIRRVEDSETTWPARAVVVYCGSVCKSWRAVTKE 99
Cdd:cd22153    1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-410 1.22e-139

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 398.87  E-value: 1.22e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  117 KQPGPRDSPIQCFIRRNR----ETSTYLLYIGLvpSENETDKLLLAAKKVRRATGTDFVISLVADDFFRSSNTYVGKLRS 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKsgmgLTPTYHLYLEL--SPGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  193 NFLGTKFTIYDSQPPQGAAIQPDNRSSrrFHSKQVSPrvpaCNYVVSTIAYELNVLRARGPRRMHCTMNSISVSAVQegg 272
Cdd:pfam01167  79 NFLGTKFTLYDNQPPYNGANPSKSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  273 nAPTPTSFPQIIDEPFspspalkgkgpirdldnaslpellpvQSQDSAEPLVLKNKAPRWHEQLQCWCLNFNGRVTVASV 352
Cdd:pfam01167 150 -VPIQPQSESSLLEDF--------------------------KSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASV 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 356496747  353 KNFQLVAavdpshnvsAAEQEKVILQFGKIGKDIFTMDYRYPLSAFQAFAICLSSFDT 410
Cdd:pfam01167 203 KNFQLVA---------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 8.80e-21

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 84.79  E-value: 8.80e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 356496747  55 WANLPPELLLDIIRRVEDSETTWPARAVVVYCGSVCKSWRAVTKE 99
Cdd:cd22153    1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 55-97 5.36e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 34.77  E-value: 5.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 356496747   55 WANLPPELLLDIIRRVEDSEttwparavVVYCGSVCKSWRAVT 97
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKD--------LLRLALVCRRWRELA 35
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-410 1.22e-139

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 398.87  E-value: 1.22e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  117 KQPGPRDSPIQCFIRRNR----ETSTYLLYIGLvpSENETDKLLLAAKKVRRATGTDFVISLVADDFFRSSNTYVGKLRS 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKsgmgLTPTYHLYLEL--SPGDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  193 NFLGTKFTIYDSQPPQGAAIQPDNRSSrrFHSKQVSPrvpaCNYVVSTIAYELNVLRARGPRRMHCTMNSISVSAVQegg 272
Cdd:pfam01167  79 NFLGTKFTLYDNQPPYNGANPSKSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356496747  273 nAPTPTSFPQIIDEPFspspalkgkgpirdldnaslpellpvQSQDSAEPLVLKNKAPRWHEQLQCWCLNFNGRVTVASV 352
Cdd:pfam01167 150 -VPIQPQSESSLLEDF--------------------------KSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASV 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 356496747  353 KNFQLVAavdpshnvsAAEQEKVILQFGKIGKDIFTMDYRYPLSAFQAFAICLSSFDT 410
Cdd:pfam01167 203 KNFQLVA---------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 8.80e-21

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 84.79  E-value: 8.80e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 356496747  55 WANLPPELLLDIIRRVEDSETTWPARAVVVYCGSVCKSWRAVTKE 99
Cdd:cd22153    1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 56-134 3.79e-06

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 44.58  E-value: 3.79e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 356496747  56 ANLPPELLLDIIRRVedsettwPARAVVVYCGSVCKSWRAVTKEIVKTPEQCGRLTFPISLKQPGPRDSPIQCFIRRNR 134
Cdd:cd22168    5 SDLPEDVLLEILSLV-------PARDLILSCRLVCSRWRDLVDLPTLWKRKCQREGFILKDWDGPPKDWKIFYFLRLER 76
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 55-97 5.36e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 34.77  E-value: 5.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 356496747   55 WANLPPELLLDIIRRVEDSEttwparavVVYCGSVCKSWRAVT 97
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKD--------LLRLALVCRRWRELA 35
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 58-96 6.13e-03

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 34.29  E-value: 6.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 356496747  58 LPPELLLDIIRRVedsettwPARAVVVYCGSVCKSWRAV 96
Cdd:cd22083    4 IPEELLLEILTHV-------PATSLITNCRLVCTLWRDI 35
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 55-99 8.23e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 34.11  E-value: 8.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 356496747  55 WANLPPELLLDIIRRVEDSETTWPARavvvycgSVCKSWRAVTKE 99
Cdd:cd22164    2 WLDLPDDLTASILSRLGAIDILTNAQ-------KVCKLWRRICKD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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