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Conserved domains on  [gi|354998604|gb|AER49930|]
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HNH endonuclease [Mycobacterium phage LHTSCC]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
23-73 1.19e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.59  E-value: 1.19e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354998604  23 RQPVLAAAGHRCQIRARGCLGKATDVDHI---RRGDDHSRSNLQAACNRCHGRK 73
Cdd:COG1403   11 RRAVLKRDNGRCQYCGRPFSGDALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
23-73 1.19e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.59  E-value: 1.19e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354998604  23 RQPVLAAAGHRCQIRARGCLGKATDVDHI---RRGDDHSRSNLQAACNRCHGRK 73
Cdd:COG1403   11 RRAVLKRDNGRCQYCGRPFSGDALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 26-74 4.29e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 35.53  E-value: 4.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 354998604  26 VLAAAGHRCQIRARGCLGKATDVDHI---RRGDDHSRSNLQAACNRCHGRKS 74
Cdd:cd00085    6 VLLARDGLCPYCGKPGGTEGLEVDHIiplSDGGNNDLDNLVLLCRKCHRKKH 57
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
23-73 1.19e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.59  E-value: 1.19e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354998604  23 RQPVLAAAGHRCQIRARGCLGKATDVDHI---RRGDDHSRSNLQAACNRCHGRK 73
Cdd:COG1403   11 RRAVLKRDNGRCQYCGRPFSGDALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 26-74 4.29e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 35.53  E-value: 4.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 354998604  26 VLAAAGHRCQIRARGCLGKATDVDHI---RRGDDHSRSNLQAACNRCHGRKS 74
Cdd:cd00085    6 VLLARDGLCPYCGKPGGTEGLEVDHIiplSDGGNNDLDNLVLLCRKCHRKKH 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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