Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 354459530  254 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 294
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 354459530  164 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 208
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|.
gi 354459530    3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20
                  ....*....|....*....|....*....
gi 354459530   43 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 71
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 354459530  396 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 436
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 354459530  254 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 294
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 354459530  164 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 208
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 354459530  298 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 340
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|.
gi 354459530    3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20
                  ....*....|....*....|....*....
gi 354459530   43 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 71
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 354459530   3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 354459530  79 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 111
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 354459530     3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 191 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 264
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 265 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 329
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 354459530 330 LAHPFSLAVFEDKVFW-TDIINEAI 353
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 354459530   144 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 182
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 354459530  41 NECLDNNG-GCSHVCNDLKIGYECLCPDGFQLvaqRRCE 78
Cdd:cd00054    3 DECASGNPcQNGGTCVNTVGSYRCSCPPGYTG---RNCE 38

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 354459530  254 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 294
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 354459530  164 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 208
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 354459530  298 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 340
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|.
gi 354459530    3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20
                  ....*....|....*....|....*....
gi 354459530   43 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 71
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 354459530   3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 354459530  79 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 111
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 354459530     3 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 33
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 191 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 264
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 265 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 329
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 354459530 330 LAHPFSLAVFEDKVFW-TDIINEAI 353
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 201 PDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKK----- 269
Cdd:cd05819   10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSGdgqfnePAGVAVDS-DGNLYVADTGN-HRIQKfdpdg 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 270 GGLNGVDIYSLVTENIQWPNGITLDLlSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVF-EDKVFW 345
Cdd:cd05819   86 NFLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGNIYV 164

                 ....*
gi 354459530 346 TDIIN 350
Cdd:cd05819  165 ADTGN 169

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 354459530  82 ECQDPDTCS--QLCVNLEGGYKCQCEEGFQLDPH 113
Cdd:cd00053    1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34

Epidermal growth factor-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 354459530    82 ECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPH 113
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 354459530  77 CEDIDECQD-PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA 116
Cdd:cd01475  184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 162 ASNRIYWSDLsqrmicstqldRAHGVSSYD------TVISRDIQAPDGLAVDWiHSNIYWTDSVLGtVSVADTKGVKRKT 235
Cdd:COG3386   17 PDGRLYWVDI-----------PGGRIHRYDpdggavEVFAEPSGRPNGLAFDP-DGRLLVADHGRG-LVRFDPADGEVTV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354459530 236 LFRENGSKPRA---IVVDPvHGFMYWTDwgTPAKIKKGGLngvdiY--------SLVTENIQWPNGITLDLLSGRLYWVD 304
Cdd:COG3386   84 LADEYGKPLNRpndGVVDP-DGRLYFTD--MGEYLPTGAL-----YrvdpdgslRVLADGLTFPNGIAFSPDGRTLYVAD 155

                        170       180
                 ....*....|....*....|..
gi 354459530 305 SKLHSISSIDVNG----GNRKT 322
Cdd:COG3386  156 TGAGRIYRFDLDAdgtlGNRRV 177

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 354459530  41 NECLDNNG-GCSHVCNDLKIGYECLCPDGFQLvaqRRCE 78
Cdd:cd00054    3 DECASGNPcQNGGTCVNTVGSYRCSCPPGYTG---RNCE 38