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Conserved domains on  [gi|353738530|gb|AER19538|]
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glucosamine-6-phosphate isomerase [Streptococcus suis D12]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10105361)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 8.86e-116

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


:

Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 330.22  E-value: 8.86e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  11 EGATVALDILREKMNG-GAKVLGLATGSSPLEFYK-LI---RESDLDFSNVTSVNLDEYVGLGEESDQSYIHFMKENLFN 85
Cdd:cd01399    2 EMSEAAAELIAELIREkPPAVLGLATGSTPLGVYEeLIelhKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  86 DKPFK--QSYLPNGLATDVVAETERYNKILAE-HPVDFQILGIGRNGHIGFNEPGAPFDGQTHLVELAPSTIEANARFFA 162
Cdd:cd01399   82 HIDIKpeNIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 353738530 163 DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 8.86e-116

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 330.22  E-value: 8.86e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  11 EGATVALDILREKMNG-GAKVLGLATGSSPLEFYK-LI---RESDLDFSNVTSVNLDEYVGLGEESDQSYIHFMKENLFN 85
Cdd:cd01399    2 EMSEAAAELIAELIREkPPAVLGLATGSTPLGVYEeLIelhKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  86 DKPFK--QSYLPNGLATDVVAETERYNKILAE-HPVDFQILGIGRNGHIGFNEPGAPFDGQTHLVELAPSTIEANARFFA 162
Cdd:cd01399   82 HIDIKpeNIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 353738530 163 DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-233 4.16e-106

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 306.32  E-value: 4.16e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVE----GATVALDILREKMN-GGAKVLGLATGSSPLEFYKLI----RESDLDFSNVTSVNLDEYVGLGEES 71
Cdd:COG0363    2 MRVIIFPDAEElaaaAAERAAERIAEAIAeKGRAVLGLAGGSTPLGLYEELarlhKEGGLDWSRVHVFNLDEYVGLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  72 DQSYIHFMKENLFNDKPFKQS--YLPNGLATDVVAETERYNKILAEHP-VDFQILGIGRNGHIGFNEPGAPFDGQT-HLV 147
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPEniHIPDGEAEDPEAAAARYEALIAEAGgIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 148 ELAPSTIEANARFFADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQ 227
Cdd:COG0363  162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                 ....*.
gi 353738530 228 AAASKL 233
Cdd:COG0363  242 AAASLL 247
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-233 8.76e-99

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 288.27  E-value: 8.76e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVEGATVALDILREKMN------GGAKVLGLATGSSPLEFYK-LI---RESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINaflptkERPFVLGLATGSSPLETYKaLIelhKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  71 SDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAETERY-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTHLV 147
Cdd:PRK00443  81 HPESYRYFMRENFFDhvDIPPENINLLNGNAPDPEAECRRYeEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 148 ELAPSTIEANARFFA-DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:PRK00443 161 TLTEDTRIANSRFFDgDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240


                 ....*..
gi 353738530 227 QAAASKL 233
Cdd:PRK00443 241 EAAASEL 247
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-233 3.70e-75

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 228.16  E-value: 3.70e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530    1 MKIHVVNNQVEGATVALDILREKMNGGAK------VLGLATGSSPLEFYK-LIR---ESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPtaarpfVLGLPTGGTPIGTYKqLIElhqAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   71 SDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAETERY-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTHLV 147
Cdd:TIGR00502  81 HPESYHSFMHNNFFQhiDIKPENINILNGNAPDLEAECRRYeEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  148 ELAPSTIEANARFF-ADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:TIGR00502 161 TLTEDTIQANSRFFeGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240


                  ....*..
gi 353738530  227 QAAASKL 233
Cdd:TIGR00502 241 ENATQEL 247
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-223 3.85e-11

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 60.71  E-value: 3.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   13 ATVALDILREKmnGGAkVLGLATGSSPLEFYKLIRES--DLDFSNVtsvnldeYVGLGEE------SDQSYIHFMKENLF 84
Cdd:pfam01182  15 AEALEAALAER--GRF-TLALSGGSTPKPLYELLAAApaRLDWSRV-------HVFWGDErcvppdDPDSNYGMAREALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   85 NDKPFKQS--YLPNGLATDVVAETERYNKILAEH------PV-DFQILGIGRNGHI--GFnePGAP-FDGQTHLVelAPS 152
Cdd:pfam01182  85 SHVPIPASnvHPIPASAADPEEAAAAYEAELRELlpdlelPVfDLVLLGMGPDGHTasLF--PGSPaLEETDRLV--VAV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 353738530  153 TieanarffaDPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKAtVEGAVTEDVPASVLQNHDNVIL 223
Cdd:pfam01182 161 T---------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRR-ALAGDPDPLPAALVRPGAGETV 221
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 8.86e-116

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 330.22  E-value: 8.86e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  11 EGATVALDILREKMNG-GAKVLGLATGSSPLEFYK-LI---RESDLDFSNVTSVNLDEYVGLGEESDQSYIHFMKENLFN 85
Cdd:cd01399    2 EMSEAAAELIAELIREkPPAVLGLATGSTPLGVYEeLIelhKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  86 DKPFK--QSYLPNGLATDVVAETERYNKILAE-HPVDFQILGIGRNGHIGFNEPGAPFDGQTHLVELAPSTIEANARFFA 162
Cdd:cd01399   82 HIDIKpeNIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 353738530 163 DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-233 4.16e-106

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 306.32  E-value: 4.16e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVE----GATVALDILREKMN-GGAKVLGLATGSSPLEFYKLI----RESDLDFSNVTSVNLDEYVGLGEES 71
Cdd:COG0363    2 MRVIIFPDAEElaaaAAERAAERIAEAIAeKGRAVLGLAGGSTPLGLYEELarlhKEGGLDWSRVHVFNLDEYVGLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  72 DQSYIHFMKENLFNDKPFKQS--YLPNGLATDVVAETERYNKILAEHP-VDFQILGIGRNGHIGFNEPGAPFDGQT-HLV 147
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPEniHIPDGEAEDPEAAAARYEALIAEAGgIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 148 ELAPSTIEANARFFADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQ 227
Cdd:COG0363  162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                 ....*.
gi 353738530 228 AAASKL 233
Cdd:COG0363  242 AAASLL 247
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-233 8.76e-99

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 288.27  E-value: 8.76e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVEGATVALDILREKMN------GGAKVLGLATGSSPLEFYK-LI---RESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINaflptkERPFVLGLATGSSPLETYKaLIelhKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  71 SDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAETERY-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTHLV 147
Cdd:PRK00443  81 HPESYRYFMRENFFDhvDIPPENINLLNGNAPDPEAECRRYeEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 148 ELAPSTIEANARFFA-DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:PRK00443 161 TLTEDTRIANSRFFDgDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240


                 ....*..
gi 353738530 227 QAAASKL 233
Cdd:PRK00443 241 EAAASEL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 2-233 6.80e-76

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 241.47  E-value: 6.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   2 KIHVV--NNQVEGA-TVALDI---LREKMNGGAK-VLGLATGSSPLEFY-KLIR---ESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:PRK02122  27 KIPTDifESSEEASrAVAQEIatlIRERQAEGKPcVLGLATGSSPIGVYaELIRmhrEEGLSFKNVITFNLDEYYPMQPD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  71 SDQSYIHFMKENLFN--DKPFKQSYLPNG-LATDVVAETER-Y-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTH 145
Cdd:PRK02122 107 SLQSYHRFMKENLFDhvDIPPENIHIPDGtIPKEEIDEYCRdYeEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 146 LVELAPSTIEANARFFADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILIL 225
Cdd:PRK02122 187 LVTLDHITRRDAASDFFGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVL 266


                 ....*...
gi 353738530 226 DQAAASKL 233
Cdd:PRK02122 267 DLAAASEL 274
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-233 3.70e-75

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 228.16  E-value: 3.70e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530    1 MKIHVVNNQVEGATVALDILREKMNGGAK------VLGLATGSSPLEFYK-LIR---ESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPtaarpfVLGLPTGGTPIGTYKqLIElhqAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   71 SDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAETERY-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTHLV 147
Cdd:TIGR00502  81 HPESYHSFMHNNFFQhiDIKPENINILNGNAPDLEAECRRYeEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  148 ELAPSTIEANARFF-ADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:TIGR00502 161 TLTEDTIQANSRFFeGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240


                  ....*..
gi 353738530  227 QAAASKL 233
Cdd:TIGR00502 241 ENATQEL 247
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-234 7.14e-73

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 221.94  E-value: 7.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVEGATVALDILREKMNG---GAK---VLGLATGSSPLEFY----KLIRESDLDFSNVTSVNLDEYVGLGEE 70
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDfkpTSDrpfVLGLPTGSTPLPTYqeliRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  71 SDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAETERY-NKILAEHPVDFQILGIGRNGHIGFNEPGAPFDGQTHLV 147
Cdd:PTZ00285  81 HPQSYHYFMKENFFDhvDIKEENRHILNGTAPDLEEECRRYeEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 148 ELAPSTIEANARFFA-DPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:PTZ00285 161 SLNQETIDANARFFGnDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240


                 ....*...
gi 353738530 227 QAAASKLA 234
Cdd:PTZ00285 241 EDATLELK 248
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-234 7.55e-35

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 124.09  E-value: 7.55e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   1 MKIHVVNNQVEGATVALDILREKMNGGAKV-LGLATGSSPLEFYKLI----RESDlDFSNVTSVNLDEYVGLGEESDQSY 75
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVnLAITAGSTPKGMYEYLitlvKGKA-WYDNVHYYNFDEIPFRGKEGEGVT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  76 IHFMKENLFNDKPFKQSYLpNGLATDVVAETERynKILAEHPVDFQILGIGRNGHIGFNEPG-APFDGQTHLVELAPSTI 154
Cdd:PRK12358  80 ITNLRNLFFTPAGIKEENI-HKLTIDNYREHDQ--KLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETVEVPIQGEMV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 155 E--ANARFFADPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILDQAAASK 232
Cdd:PRK12358 157 DivAHGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEAAAAE 236


                 ..
gi 353738530 233 LA 234
Cdd:PRK12358 237 LA 238
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 17-226 5.26e-33

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 119.16  E-value: 5.26e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  17 LDILREKMNGgakVLGLATGSSPLEFYKLIRE----SDLDFSNVTSVNLDEYVGLGEESDQSYIHFMKENLFND-KPFKQ 91
Cdd:PRK09762  21 LAVIRSKPDA---VICLATGATPLLTYHYLVEkihqQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPlGLRED 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  92 SYLP-NGLATDVvAETERYNKILAEH-PVDFQILGIGRNGHIGFNEPGAPFDGQTHLVELAPSTIEANarFFADPEEVPK 169
Cdd:PRK09762  98 QLISfRSEEINE-TECERVTNLIARKgGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHE--MLKTAGRPVT 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 353738530 170 QAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILILD 226
Cdd:PRK09762 175 RGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFICLID 231
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 31-225 1.59e-16

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 75.29  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  31 LGLATGSSPLEFYKLIRESD-LDFSNVTsvnldeyVGLGEE------SDQSYIHFMKENLFNDKPFKQSYL---PNGLAT 100
Cdd:cd01400   27 LALSGGSTPKPLYELLAAAPaLDWSKVH-------VFLGDErcvppdDPDSNYRLAREALLSHVAIPAANIhpiPTELGP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 101 DVVAEteRYNKILAEH-----PVDFQILGIGRNGHIG--FnePGAPfdgqthlvELAPSTiEANARFFADPEEVPKQAIS 173
Cdd:cd01400  100 EDAAA--AYEKELRALfggvpPFDLVLLGMGPDGHTAslF--PGHP--------ALLEET-DRLVVAVTDSPKPPPERIT 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 353738530 174 MGIANIMAAKTIVLMAYGQEKADAIKATVEGAVTEDVPAS-VLQNHDNVILIL 225
Cdd:cd01400  167 LTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAArVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-223 3.85e-11

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 60.71  E-value: 3.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   13 ATVALDILREKmnGGAkVLGLATGSSPLEFYKLIRES--DLDFSNVtsvnldeYVGLGEE------SDQSYIHFMKENLF 84
Cdd:pfam01182  15 AEALEAALAER--GRF-TLALSGGSTPKPLYELLAAApaRLDWSRV-------HVFWGDErcvppdDPDSNYGMAREALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530   85 NDKPFKQS--YLPNGLATDVVAETERYNKILAEH------PV-DFQILGIGRNGHI--GFnePGAP-FDGQTHLVelAPS 152
Cdd:pfam01182  85 SHVPIPASnvHPIPASAADPEEAAAAYEAELRELlpdlelPVfDLVLLGMGPDGHTasLF--PGSPaLEETDRLV--VAV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 353738530  153 TieanarffaDPEEVPKQAISMGIANIMAAKTIVLMAYGQEKADAIKAtVEGAVTEDVPASVLQNHDNVIL 223
Cdd:pfam01182 161 T---------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRR-ALAGDPDPLPAALVRPGAGETV 221
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 30-224 1.39e-10

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 58.13  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530  30 VLGLATGSSPLEFYKLIRESDL--DFSNVTSVNLDEYVGLgEESDQSYIHFMKENLFN--DKPFKQSYLPNGLATDVVAE 105
Cdd:cd00458   23 VIGLGTGSTPAYFYKLLGEKLKrgEISDIVGFPTDERYVP-LDSDQSNFRQAKLLAFEhdIIPASNVHYVDTSLPIEKAC 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 106 TERYNKIL-AEHPVDFQILGIGrnghigfnepgapfdgqthlvelapstieanarffadpeevpkqaismgianiMAAKT 184
Cdd:cd00458  102 EKYEREILdQVDAIDLAVDGAG-----------------------------------------------------YRAGT 128

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 353738530 185 IVLMAYGQEKADAIKATVEGAVTEDVPASVLQNHDNVILI 224
Cdd:cd00458  129 VIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVI 168
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
155-233 4.89e-04

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 40.50  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353738530 155 EANARFF-ADPEEVP----KQAISMGIANIMAAKTIVLMAYGQEKADAIKATVEGAvtedvpasvLQNHdnviLILDQAA 229
Cdd:COG2390  229 DICGRFFdADGRIVDtplnDRTIGISLEDLRRIPRVIAVAGGEEKAEAILAALRGG---------YINV----LITDEAT 295


                 ....
gi 353738530 230 ASKL 233
Cdd:COG2390  296 ARAL 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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