|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
57-489 |
2.98e-112 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 337.24 E-value: 2.98e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 57 IGVISLLTFVTSLGSSMLAPAVPDVMRSLGSdNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATI 136
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHV-SEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVI 216
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 217 TIPMAVLTILSIVTLretyaPIllerkarrlrretgdrdlrsrsatpksqhevffyalvrplkmlltstvVMMLAFDVAV 296
Cdd:cd17323 160 AIISGFCLILIFLFL-----PI------------------------------------------------VLLLGLYVGL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 297 VYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRlsaPDETLPPESWLWPMIPAS 376
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKK---NGGKPEPEARLPPAFIGA 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 377 LLTPIGLLWYGWSLQAGLFPVVPLVGLGVFGFGMMGIFQPVQIYLVNAFPIHSASALAASNLLRSLVGALLPLGGHRMYD 456
Cdd:cd17323 264 FLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFN 343
|
410 420 430
....*....|....*....|....*....|...
gi 350633313 457 TMGLGWGNSLLAFIALAMAPVPIILMKFGERMR 489
Cdd:cd17323 344 NLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
46-446 |
1.36e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 146.66 E-value: 1.36e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 46 MNWSFWYRWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYN 125
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA-GLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 126 VSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSE 205
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 206 DVGWRWIFWVITIPMAVLTILSIVTLRETyapilLERKARRLRREtgdrdlrsrsatpksqhevffyalvrpLKMLLTST 285
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPES-----RPAARARLRGS---------------------------LRELLRRP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 286 VVMMLAFDVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlpp 365
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR------------- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 366 eswlwPMIPASLLTPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIHS-ASALAASNLLRSLVG 444
Cdd:COG2814 275 -----LLLIGLLLLALGLLLLALAGSLWLL----LLALFLLGFGFGLLFPLLQALVAELAPPEArGRASGLYNSAFFLGG 345
|
..
gi 350633313 445 AL 446
Cdd:COG2814 346 PL 347
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
60-475 |
6.59e-35 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 134.63 E-value: 6.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELEsFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd17320 4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQ-LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 220 MAVLTILSIVTLRETyapillerkarrlrretgdRDLRSRSATPKSQHEVFFYalvrplkmLLTSTVVMMLAFDVAVVYG 299
Cdd:cd17320 163 GLLLLLLVLLFLPET-------------------LPEEKRKPLLSSLLRAYKR--------VLKNRRFLGYALALGLSFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 300 YQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppesWLWPMIPASLLT 379
Cdd:cd17320 216 GLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR---------------LLRLGLLLLLAA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 380 PIGLLWYGWSLQAGLFPVVPLVGLGVFGFGMmgIFQPVQIYLVNAFPIHSASALAASNLLRSLVGALL-PLGGHRMYDTM 458
Cdd:cd17320 281 ALVLLLAALLGGLSLWPLVAPLFLIFFGFGL--IFPNATSLALEPFPHVAGTASALLGFLQFLIGALAgALVGLLPNGTA 358
|
410
....*....|....*...
gi 350633313 459 G-LGWGNSLLAFIALAMA 475
Cdd:cd17320 359 LpMGLLILVLGLLALLLL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
60-446 |
1.84e-30 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 121.90 E-value: 1.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQL-QWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 220 MAVLTILSivtlretyapillerkarrlrretgdrdlrsrsatpksqhevffyalvrplKMLLTSTVVMMLAFDVAVVyg 299
Cdd:cd17321 160 GLVALLLA---------------------------------------------------RTFSGAVLAAFLLGAALGG-- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 300 yqylVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppeswlwPMIPASLLT 379
Cdd:cd17321 187 ----LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL------------------VLVAGLLLT 244
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 350633313 380 PIGLLWYGWSLQAGLFPVVpLVGLGVFGFGMMGIFQPVQIYLVNAFPIH-SASALAASNLLRSLVGAL 446
Cdd:cd17321 245 AVGLLLLALLGADSSVWLL-LPGLVLLGLGLGLFATPLTNAALSSVPKEkAGAASGILNTARQLGGAL 311
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
60-448 |
3.82e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.60 E-value: 3.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVP-DVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEI-GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITI 218
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 219 PMAVLTILSIVTLRETYAPILLERKARRLRRETGDRDLRSRsatpksqhevffyalvrplkmlltstvVMMLAFDVAVVY 298
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD---------------------------PVLWLLLALLLF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 299 GYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKvaerkkgrlsapdetLPPESWLWPMIPASLL 378
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR---------------LGRRRRLLLALLLLIL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350633313 379 TPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIH-SASALAASNLLRSLVGALLP 448
Cdd:pfam07690 278 AALGLLLLSLTLSSLWL----LLALLLLGFGFGLVFPALNALVSDLAPKEeRGTASGLYNTAGSLGGALGP 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-446 |
2.12e-28 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 116.14 E-value: 2.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTV-QWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAG--VTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWvIT 217
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGgvLIPLAQT--ILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY-IN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 218 IPMAVLTILSivtlretyAPILlerkarrlrretgdrDLRsrsatpksqheVFFYalvrplKMLLTSTVVMMLAFdvAVV 297
Cdd:cd17503 157 LPIGILALLL--------APLL---------------DLR-----------LFKD------RNFTLGLLLSFLLG--LGL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 298 YGYQYLvfttLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERkkgrlsapdetlppeswlWPMIPASL 377
Cdd:cd17503 195 FGAMFL----LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPR------------------LLLLAGLL 252
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350633313 378 LTPIGLLWYGW-SLQAGLFPVVPLvgLGVFGFGMMGIFQPVQIYLVNAFPIHSAS-ALAASNLLRSLVGAL 446
Cdd:cd17503 253 LLALGTLLLAFlTPDTSLWLIILP--LFIRGLGMGLVFMPLNTLALNSLPPEQIGdATALFNTIRQLGGSI 321
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-477 |
3.10e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.75 E-value: 3.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 220 MAVLTILSIVTLRETYAPILLERKARRLRRETGDRDLRSrsatpksqhevffyalvRPLKMLLTSTVVMMLAFdvavvyg 299
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD-----------------RRLLALFLAIFVLAFAF------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 300 yqYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppeswlwPMIPASLLT 379
Cdd:cd17325 216 --GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP------------------LILIGLLLS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 380 PIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFP-IHSASALAASNLLRSLVGALLPLGGHRMYDTM 458
Cdd:cd17325 276 AVALLLLPLATSFWLL----LLLLALLGLGLGLVFPATLALLADIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
410
....*....|....*....
gi 350633313 459 GLGWGNSLLAFIALAMAPV 477
Cdd:cd17325 352 GFATPFLAAAALLLLAAVL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
52-483 |
6.30e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.50 E-value: 6.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 52 YRWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLF 131
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 132 LGATIGCALSTNVGMFLAFRLISG--CAGVTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGW 209
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGlgEAGFFPAALK--LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 210 RWIFWVITIPMAVLTILSivtlretyapillerkarrlrretgdrdlrsrsatpksqhevffyalvrplkmlltstvVMM 289
Cdd:COG2271 164 RAAFLILGLPGLLLALLR-----------------------------------------------------------FWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 290 LAFDVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKgrlsapdetlppeswl 369
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK---------------- 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 370 WPMIPASLLTPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIH-SASALAASNLLRSLVGALLP 448
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPSPALA----IALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGP 324
|
410 420 430
....*....|....*....|....*....|....*
gi 350633313 449 LGGHRMYDTMGLGWGNSLLAFIALAMAPVPIILMK 483
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-473 |
7.08e-27 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 111.49 E-value: 7.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 57 IGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATI 136
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISG--CAGVTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFW 214
Cdd:cd17324 80 LAALAPSFALLLLARALAGlaHGGFWAIAAA--YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 215 VITIPMAVLTILSIVTLRetyapillerkarrlrretgdrdlRSRSATPKSqhevffYALVRPLKMLLTSTVVMMLAFDV 294
Cdd:cd17324 158 AIAVLALLAALLLWRLLP------------------------SLPPKKPGS------LGLLSSLLLLLRNPRLRLAYLIT 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 295 AVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKvaeRKKGRLsapdetlppeswlwpMIP 374
Cdd:cd17324 208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR---GGRRAL---------------LIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 375 ASLLTPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIHSASALAASNLLRSLVGALLPLGGHRM 454
Cdd:cd17324 270 LLLLAAALLLLTLLGPSPLLL----LVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
410 420
....*....|....*....|..
gi 350633313 455 YDTMGL---GWGNSLLAFIALA 473
Cdd:cd17324 346 LDHGGWagvGWVGAALLLLALL 367
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
98-234 |
6.59e-26 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 102.73 E-value: 6.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 98 SIYVIGYALGPLIAAPMSE----IYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLM 173
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGlltdRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350633313 174 APEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVTLRET 234
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-475 |
1.90e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 107.66 E-value: 1.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQV-GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSeDVGWRWIFWVITI 218
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 219 PMAVLTILSIVTLREtyapillerkarrlrretgdrdlrsrsaTPKSQHEVFFYALVRPLKMLLTSTVVMMLAFDVAVVY 298
Cdd:cd17474 161 LIPVAFLAILFLLPE----------------------------PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 299 GYqYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKvaerkkgRLSApdetlppeswLWPMIPASLL 378
Cdd:cd17474 213 LY-FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-------RFGA----------RRILVIGLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 379 TPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGmMGIFQP-VQIYLVNAFPIHS-ASALAASNLLRSLVGALLPLGGHRMYD 456
Cdd:cd17474 275 YALSLLLLGFVPSLALL----LIAIVLFGLG-LGLNLPlLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
410
....*....|....*....
gi 350633313 457 TMGLGWGNSLLAFIALAMA 475
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAA 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
53-344 |
1.14e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 101.04 E-value: 1.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 53 RWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFL 132
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 133 GATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWI 212
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 213 FWvITIPMAVLTILSIVTLRETYAPILLerkarrLRRETGDRDLRSRSATPKSQHEVFFYALVRPLKMLLTSTVVMMLAF 292
Cdd:COG0477 171 FL-INAPLGLLALVLRLRLPESRGLLLA------LLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 350633313 293 DVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYA 344
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
60-405 |
3.80e-23 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 100.92 E-value: 3.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDnAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:TIGR00710 10 LGCLSILGPLGIDMYLPAFPEIAADLSTP-ASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:TIGR00710 89 LSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 220 MAVLTILSIVTLRETYAPIllerkarrlrretgdrdLRSRSATpksqhevffyaLVRPLKMLLTSTVVMMLAFDVAVVYG 299
Cdd:TIGR00710 169 GILLSALIFFILPETLPYE-----------------ARIQIST-----------YFETFLLLLKSKMFWGYALIYGASFG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 300 YQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRLSapdetlppeswLWPMIPASLLT 379
Cdd:TIGR00710 221 GFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMG-----------LILFAVSAVLL 289
|
330 340
....*....|....*....|....*.
gi 350633313 380 PIGLLWyGWSLQAGLFPVVPLVGLGV 405
Cdd:TIGR00710 290 EITAIL-GLGSWAMIIGPMMFVGIGN 314
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
58-446 |
6.06e-21 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 95.52 E-value: 6.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 58 GVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIG 137
Cdd:TIGR00711 5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQV-QWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 138 CALSTNVGMFLAFRLISGCAG--VTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWV 215
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGFGGgpLIPLSFS--TLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 216 ITIPMAVLTILSIVTLRE-------------------TYAPILLERKARRLRRETGDRDLRSRSATPKSQHEVFFYALVR 276
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRdkpaasenfdflgllllsvGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 277 PLKMLLTSTVVMMLAFDVAVVY------GYqYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAE 350
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYmsllglGL-YGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 351 RKkgrlsapdetlppeswlwPMIPASLLTPIGLLWYGWSLQAGLFPVVPLVGLGVFGFGMMGIFQPVQIYLVNAFPIH-S 429
Cdd:TIGR00711 321 RK------------------LVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHkI 382
|
410
....*....|....*..
gi 350633313 430 ASALAASNLLRSLVGAL 446
Cdd:TIGR00711 383 ARGSSLSNFTRQLGGSI 399
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
67-237 |
9.83e-20 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 90.74 E-value: 9.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 67 TSLGSSMLAPAVPDVMRSLGSDnAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGM 146
Cdd:PRK11102 3 MPLAIDMYLPALPVIAADFGVS-AGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 147 FLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIpMAVLTIL 226
Cdd:PRK11102 82 LIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLAL-AAILAAA 160
|
170
....*....|..
gi 350633313 227 SIVTL-RETYAP 237
Cdd:PRK11102 161 LVFFFiPETLPK 172
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
52-482 |
6.13e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 85.70 E-value: 6.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 52 YRWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLF 131
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 132 LGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRW 211
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 212 IFWVITIPMAVLTILSIVTLRETYAPILLERKARrlrretgdrdlrsrsatpksqhevffyalVRPLKMLLTSTVVMMLA 291
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------------------------LRDQLEALRDPRFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 292 FDVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppesWLWP 371
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR---------------VLLI 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 372 MIPASLLTPIGLLWYGWSLqaglfpVVPLVGLGVFGFGMMGIFQPVQIYLVNAFPI-HSASALAASNLLRSLVGALLPLG 450
Cdd:COG2223 277 VFALMALGLLLLALALGSL------WLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAVYGLVGAAGGLGGFLGPLL 350
|
410 420 430
....*....|....*....|....*....|..
gi 350633313 451 GHRMYDTMGlGWGNSLLAFIALAMAPVPIILM 482
Cdd:COG2223 351 FGALLDATG-SYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
62-225 |
7.03e-18 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 84.92 E-value: 7.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSdnAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGG--LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLISGC--AGVTPLALggGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWvITIP 219
Cdd:cd17502 81 PNMTMLIVGRAIQGIggGGLMSLAF--IIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY-INLP 157
|
....*.
gi 350633313 220 MAVLTI 225
Cdd:cd17502 158 IGGLAL 163
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
60-481 |
2.84e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.63 E-value: 2.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL-GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSE--DVGWRWIFWVIT 217
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 218 IPMAVLTILSIVTLRETyapillerkarrlrretgdrdlrsRSATPKSQHEVFFYALVRPLKMLLTSTVVMMLAFDVAVV 297
Cdd:cd06174 160 ALALLAAILLLLVVPDP------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 298 YGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKgrlsapdetlppeswlWPMIPASL 377
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP----------------LLLIGLLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 378 LTPIGLLWYGWSLQAGLFPVVPLVGLGVFGFGMMGIFQPVQIYLvnafPIHSASALAASNLLRSLVGALLPLGGHRMYDt 457
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP----PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA- 354
|
410 420
....*....|....*....|....
gi 350633313 458 MGLGWGNSLLAFIALAMAPVPIIL 481
Cdd:cd06174 355 ATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
61-232 |
1.18e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 78.39 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 61 SLLTFVTSLGSSMLAPAVPDVMRSLGsDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCAL 140
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFG-TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 141 STNVGMFLAFRLISGCA-GVTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:cd17504 81 APNLPVLIAGRALQGIGgAVFPLAFA--LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158
|
170
....*....|....
gi 350633313 220 MAVLTILS-IVTLR 232
Cdd:cd17504 159 AVLLAALVpLIDLR 172
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
71-481 |
1.85e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 75.03 E-value: 1.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 71 SSMLAPAVPDVMRSLGSDNAElESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAF 150
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAE-AGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 151 RLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAI----WGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPmAVLTIL 226
Cdd:cd17371 94 RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALP-ALLVLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 227 SIVTLRETyaPILLErkARRLRRETGDRDlrsrsatpkSQHEVFFYALVRPlkMLLTSTVvmmlafdVAVVYGYQYLVFT 306
Cdd:cd17371 173 IRRFVKEP--PQWQA--ARAARRHFADRP---------SLRELFSPPLLRT--TLLASLL-------ATGALGGYYGITT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 307 TLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRLSApdetlppeswlwpmipasLLTPIGLLWY 386
Cdd:cd17371 231 WLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA------------------LGSAISILLY 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 387 gwsLQAGLFPVVPLVGLGVFGFGMMGIFQPVQIYLVNAFPIH-SASALAASNLLRSLVGALLPLGGHRMYDTMGLGWGNS 465
Cdd:cd17371 293 ---FFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAvRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIA 369
|
410
....*....|....*.
gi 350633313 466 LLAFIALAMAPVPIIL 481
Cdd:cd17371 370 VFAAVYYIAGLVLALL 385
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
74-351 |
2.23e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.88 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 74 LAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLI 153
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLA-GLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 154 SGC--AGVTPLAlgGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYL-SEDVGWRWIFWVITIPMAVLTILSIVT 230
Cdd:cd17328 97 VGIgeASYSPIA--PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 231 LREtyapillerkARRLRRETGDRDLRSRSATPKSqhevffyalvrpLKMLLT--STVVMMLAFdVAVVYGYQYLVFTTL 308
Cdd:cd17328 175 VRE----------PPRGAAEGGVMAKSTATSFLAD------------LKALAKnpSFILSTLGF-TAVSFVTGALAFWAP 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 350633313 309 SYIF--QDVYHLSTGLSGLVYLG-DGIGTLLGIFSIGYASDKVAER 351
Cdd:cd17328 232 TFFLraFGVGDLSSADVGLIFGAiTCIAGVLGVLLGGILADRLRRK 277
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
82-229 |
3.83e-13 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 71.06 E-value: 3.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 82 MRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGcagvtp 161
Cdd:cd17359 27 LQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGG------ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 162 LALGGGS------IGDLMAPEKMGTA------MAIWG--LGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILS 227
Cdd:cd17359 101 LAVGGASalvpmyIAEVAPAEIRGRLvslnqlMIVFGqlLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGM 180
|
..
gi 350633313 228 IV 229
Cdd:cd17359 181 LF 182
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
53-236 |
1.12e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 69.14 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 53 RWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFL 132
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQY-GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 133 GATIGCALSTNVGMFLAFRLISGC--AGVTPLALGggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWR 210
Cdd:cd17319 80 LFTALTGFATSLTSLYVLRFLLGVaeAGFFPGAIK--ALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR 157
|
170 180
....*....|....*....|....*.
gi 350633313 211 WIFWVITIPMAVLTILSIVTLRETYA 236
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYLRQVWG 183
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
94-481 |
2.62e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.01 E-value: 2.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGcagvtpLALGGGSIGDL- 172
Cdd:cd17316 39 GLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG------IGIGGEYPGASt 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 173 ----MAPEKM-----GTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWvITIPMAVLTILsivtlretyapillerk 243
Cdd:cd17316 113 yvaeFAPSKRrgfalGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFL-IGALPALLALL----------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 244 arrLRRetgdrdlrsrsatpksqhevffyalvrplkmlltsTVVMMLAFdVAVVYGYQYLVFTTLSYIFQDVYHLSTGLS 323
Cdd:cd17316 175 ---LRR-----------------------------------RTLLLILL-WFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 324 GLVYLGDGIGTLLGIFSIGYASDKVaERKkgrlsapdetlppeswlWPMIPASLLTPIGLLWYGWSLQAGlfPVVPLVGL 403
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRI-GRK-----------------KTLVIGLILSGILALPLFYLLSGS--PTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 404 GVFGFGMMGIFQPVQIYLVNAFPIHS-ASALAASNLLRSLVGALLPLGGHRMYDTMGlGWGNSLLAFIALAMAPVPIIL 481
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTG-GTGVPALILALLAIVALIVAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-482 |
4.14e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.57 E-value: 4.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGC------AGVTPLALgggSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGyLSEDVGWRWI 212
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLglglldVAANPYVA---ALGPETAASRLNLLHAFFSLGALLGPLLGGLLIL-LGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 213 FWVITIPMAVLTILSIVTlretyapillerkarRLRRETGDRDlrSRSATPKSQHEVFfyalvrPLKMLLTSTVVMMLAF 292
Cdd:COG0738 167 YLILAVLLLLLALLFLRS---------------KLPEIEEEEE--EAAGSAASLKSLL------KNPRLLLGGLAIFLYV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 293 dvavvyGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppeswlwpM 372
Cdd:COG0738 224 ------GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR-------------------L 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 373 IPASLLTPIGLLWYGWSLQAglfPVVPLVGLGVFGFGMMGIFQPVQIYLVNAFPIHSASALAASNLLRSLVGALLPLGGH 452
Cdd:COG0738 279 LRLSALLAAVGLLLALLAPG---PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIG 355
|
410 420 430
....*....|....*....|....*....|
gi 350633313 453 RMYDTMGLGWgnsllAFIALAMAPVPIILM 482
Cdd:COG0738 356 FLADAFGLRA-----AFLVPLVCYLLILLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-263 |
1.64e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.69 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISG-CAGVTPLALGGGSIgDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITI 218
Cdd:cd17489 80 LATSVALLLVLRLIHGiGWGAFTTAAATLVA-DIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 350633313 219 pMAVLTILSIVTLRETYAPilleRKARRLRRETGDRDLRSRSATP 263
Cdd:cd17489 159 -LALLALLLVFLVKDPPPV----AAEEAEAGTRAFRRLVEKKVLP 198
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
60-475 |
4.79e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 64.14 E-value: 4.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGsdNAELESFVVSIYVIGYALGPLIAAP----MSEIYGRSIVYNVSNVLFLGAT 135
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFN--KLGASGYYVGLLQSSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 136 IGCALSTNVGMFLAFRLISGCAGVTpLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWV 215
Cdd:cd17330 79 VLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 216 ItipmAVLTILSIvtlretyapillerkarrlrretgdrdlrsrsatpksqheVFFYALVRPLKMLLTSTVVMMLAFDva 295
Cdd:cd17330 158 A----AALALLNL----------------------------------------VLVLFFLPPLRRLLLVYFLIALAFA-- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 296 vvyGYQylvfTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLL-GIFSIGYASDKVAERKKGRLSApdetlppeswlwpmip 374
Cdd:cd17330 192 ---GLE----SVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGL---------------- 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 375 asLLTPIGLLWYGWSLQAGLFPvvplVGLGVFGFGMMGIFQPVQIYLVNAFPIH-SASALAASNLLRSLVGALLPLGGHR 453
Cdd:cd17330 249 --LLAIIGLLLLPFASSVPLLV----LAAAILAFGTGIVFPALSALLSKSVPSKeQGKAQGIIQSLQSLARIIGPLLAGP 322
|
410 420
....*....|....*....|..
gi 350633313 454 MYDTMGLGWGNSLLAFIALAMA 475
Cdd:cd17330 323 LYSFLGPGVPFLLAAGLLLIAL 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-249 |
4.97e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.30 E-value: 4.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 52 YRWCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLF 131
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQL-GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 132 LGATIGCALSTNVGMFLAFRLISGcagvtpLALGGGsIGDLMA------PEKM-GTAMAIWGLGSLVAPVFAPIAGGYLS 204
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAG------LGLGGL-MPNLNAlvseyaPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLI 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 350633313 205 EDVGWRWIFWVITIPMAVLTILSIVTLRETYApILLERKARRLRR 249
Cdd:TIGR00895 166 PVFGWRSLFYVGGIAPLLLLLLLMRFLPESID-FLVSKRPETVRR 209
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
57-229 |
1.13e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 57 IGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATI 136
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVI 216
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|...
gi 350633313 217 TIPMAVLTILSIV 229
Cdd:cd17325 361 AALLLLAAVLFLL 373
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
74-236 |
1.15e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 62.98 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 74 LAPAVPDVMRSLG-SDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRL 152
Cdd:cd17315 16 INGALLYIAKDLGfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 153 ISG-----CAGVTPLALgggsigDLMAPEKM-GTAMAIWGLGSLVAPVFAPIAGGYLSED--VGWRWIFWVITIPmAVLT 224
Cdd:cd17315 96 LLGlgvglASVLVPLYI------SEIAPAKIrGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFALAAVP-ALLQ 168
|
170
....*....|..
gi 350633313 225 ILSIVTLRETYA 236
Cdd:cd17315 169 LLLMFFLPESRA 180
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
77-231 |
1.78e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 62.60 E-value: 1.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 77 AVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGc 156
Cdd:cd17365 21 VAPALAQDWGLSPAQL-GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 157 agvtpLALGG------GSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVT 230
Cdd:cd17365 99 -----LGLGAampnaiTLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT 173
|
.
gi 350633313 231 L 231
Cdd:cd17365 174 L 174
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-416 |
2.42e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.21 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGC--AGVTPLALggGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEdVGWRWIFWV- 215
Cdd:cd17473 83 LFLDSLYALLASRALLGIgvAGIMTLAT--ALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVy 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 216 -ITIPMAVLTILsivtlretyapiLLERKARRLRRETGDRDLRSRSATPKSQHEVFFYALvrplkmlltstvVMMLAFdv 294
Cdd:cd17473 160 lLALPVLILVLL------------FLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAF------------LAMLLF-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 295 avvygyqYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGifsiGYASDKVAERkkgrlsapdetlppesWLWPMIP 374
Cdd:cd17473 214 -------YVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG----ALLFGRLKRR----------------LGKRRLL 266
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 350633313 375 A--SLLTPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGmMGIFQP 416
Cdd:cd17473 267 AigFALMALGFLLLALASGLWVV----LLGAILAGLG-FGLLLP 305
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
59-226 |
2.48e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 62.64 E-value: 2.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGsdNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGCAGVTPLaLGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSE--DVGWRWIFWVI 216
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYIN 158
|
170
....*....|
gi 350633313 217 TIPMAVLTIL 226
Cdd:cd06179 159 AIFNALALIL 168
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
60-234 |
3.66e-10 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 61.85 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESfVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:PRK11652 13 LVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQA-VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGcagvtplaLGGGSIG--------DLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRW 211
Cdd:PRK11652 92 FAHSLTVLIAASAIQG--------LGTGVGGvmartlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRA 163
|
170 180
....*....|....*....|...
gi 350633313 212 IFWVITIPMAVLTILSIVTLRET 234
Cdd:PRK11652 164 CYLFLLLLGAGVTFSMARWMPET 186
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
59-240 |
1.48e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 59.58 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQL-SWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKM-GTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVIT 217
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRkNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
170 180
....*....|....*....|...
gi 350633313 218 IPMAVLTILSIVTLRETYAPILL 240
Cdd:cd17476 161 ILAAIVAVAAIFWTSPSFIAVLL 183
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
88-234 |
1.94e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.13 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 88 DNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGcAGVTPLALGGG 167
Cdd:cd17317 22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVG-VTSAGIFTVGF 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 350633313 168 SIGDLMAPEKMGTAMAI-----WGLGSLVAPVFApiaggYLSEDvgWRWIFWVITIPMAVLTILSIVTLRET 234
Cdd:cd17317 101 VLGMEIVGPKYRSFVGIlfglfWALGYMLLALLA-----YLIRD--WRWLQLAISLPGLLFLLLLWWLPRRT 165
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
94-235 |
7.97e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 7.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRS--IVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGD 171
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350633313 172 LMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVTLRETY 235
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
75-229 |
3.02e-08 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 56.21 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 75 APAVPDVMRSLGsdNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVL-FLGATIGCALSTNVGMFLAFRLI 153
Cdd:pfam06609 64 ASALPNILQDIG--QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIgLVGAIVGCTANKFNTLLAAMTLL 141
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 154 ---SGCAGVTPLAlgggsIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIV 229
Cdd:pfam06609 142 gvaAGPAGASPLF-----IGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIII 215
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
92-352 |
4.82e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 55.36 E-value: 4.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 92 LESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALST---NVGMFLAFRLISG-----CAGVTPLA 163
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGigvggASVLAPMY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 164 LGGgsigdlMAPEKMGTAMAI-----WGLGSLVAPVFApIAGGYLSEDVGWRWIFWVITIPmAVLTILSIVTLRETyaPI 238
Cdd:pfam00083 127 ISE------IAPKKLRGALGSlyqlaITFGILLAYIFG-LGLNKTSNSDGWRIPLGLQLVP-ALLLIIGLLFLPES--PR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 239 LLERKARRLRRETGDRDLRSRS-ATPKSQHEVFFYALVRPLKMLLTSTVVMMLAFDVAVVYGYQYLVFTTLSYIFQDVYH 317
Cdd:pfam00083 197 WLVEKGRLEEAREVLAKLRGVPdVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYY 276
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 350633313 318 LST-----GLSGLVYLGDGIGTLLGIFSIG--YASDKVAERK 352
Cdd:pfam00083 277 STTifenlGLSDSFLVTIIVGVVNFVFTFIaiFLVDRFGRRP 318
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
178-482 |
6.43e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 6.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 178 MGTAMAIWGLGSLVAPVFAPIAGGYLSED--VGWRWIFWVITIPMAVLTILSIVTLRETYAPillerkarrlrretgdrd 255
Cdd:COG2211 149 SSWRFAFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFLLTFFGTKERPVP------------------ 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 256 lrsrSATPKSQHEVFFYAL-VRPLKMLLTSTVVMMLAFdvavvygyqYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGT 334
Cdd:COG2211 211 ----EEEKVSLKESLKALLkNRPFLLLLLAYLLFFLAL---------ALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 335 LLGIFSIGYASDKVAERKkgrlsapdetlppeswlwPMIPASLLTPIGLLWYGWSLQAGLFPVVPLVGLGVFGFGMMGIF 414
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKK------------------AFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 415 QPVQI-------------------YLVNAFPIHSASALAAsnllrSLVGALLPLGGhrmYDTmGLGWGNSLLAFIALAMA 475
Cdd:COG2211 340 PWAMLadvvdydewktgrrreglyFGIFTFAIKLGQALAG-----ALAGLLLALFG---YVA-GAAQSPSALTGIRLLFF 410
|
....*..
gi 350633313 476 PVPIILM 482
Cdd:COG2211 411 LLPAVLL 417
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-475 |
8.65e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 8.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 64 TFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTN 143
Cdd:cd06173 8 QLLSALGDWIFTVALPWLVLQLTGSALLV-GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 144 VGMF-----LAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVIti 218
Cdd:cd06173 87 LGSLslwllLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 219 pmAVLTILSIVTLRetyapillerkarRLRRETGDRDLRSRSATPKSQHEVFFYALVRPLkmlltstvVMMLAFDVAVVY 298
Cdd:cd06173 165 --ALSFLLSALLLL-------------FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPL--------LRLLLLALALFA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 299 GYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKvaeRKKGRLsapdetlppeswlwpMIPASLL 378
Cdd:cd06173 222 LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR---RRRGRL---------------LLIGALL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 379 TPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIHS-ASALAASNLLRSLVGALLPLGGHRMYDT 457
Cdd:cd06173 284 LGLALLVLGLSPSLWLL----LAALFLLGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
410
....*....|....*...
gi 350633313 458 MGLGWGNSLLAFIALAMA 475
Cdd:cd06173 360 LGLSAVFLLAGALLLLAA 377
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
59-226 |
1.57e-07 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 53.87 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLT--FVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPlIAAPMSEIYGRSIVYNVSNVLFLGATI 136
Cdd:NF000060 19 MISLLLagFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVP-VSGLLLQWFTTRQLFTVSLIFSILGTF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWvI 216
Cdd:NF000060 98 IAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFW-I 176
|
170
....*....|
gi 350633313 217 TIPMAVLTIL 226
Cdd:NF000060 177 SLPFLVLALV 186
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
62-231 |
2.18e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 53.02 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSDnAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:PRK15402 20 LFEFATYIANDMIQPGMLAVVEDFNAG-AEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVItipmA 221
Cdd:PRK15402 99 QSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLF----A 174
|
170
....*....|
gi 350633313 222 VLTILSIVTL 231
Cdd:PRK15402 175 ALAALSFFGL 184
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
62-358 |
3.32e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 52.34 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQY-GYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLISGCA--GVTPlalGGGSIGDLMAPEKM-GTAMAIWGLGSLVAPVFA-PIAGGYLSEdVGWRWIFWVIT 217
Cdd:TIGR00893 80 GAYVSLYILRVLLGAAeaPFFP---GIILIVASWFPASErATAVSIFNSAQGLGGIIGgPLVGWILIH-FSWQWAFIIEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 218 IPMAVLTILSIVTLRET-YAPILLERKARRLRRETGDRDLRSRSATPKSQHEVFFYALVRplkmlltSTVVMMLAFDVAV 296
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPpQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDR-------RVWGLALGQFLVN 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 350633313 297 VYGYQYLVFTTLsYIFQDvYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRLSA 358
Cdd:TIGR00893 229 IGLGFFLTWFPT-YLVQE-RGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFA 288
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
65-236 |
1.05e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 51.27 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 65 FVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSiYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNV 144
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVS-YVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 145 GMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFwVITIPMAVLT 224
Cdd:PRK10504 99 NELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF-LINIPVGIIG 177
|
170
....*....|..
gi 350633313 225 ILSIVTLRETYA 236
Cdd:PRK10504 178 AIATLMLMPNYT 189
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
74-475 |
1.69e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 74 LAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLI 153
Cdd:COG2807 37 VGPLLPEIRADLGLSATQA-GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 154 SGCAGVTPLALGGGSIGDLmAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVTLRE 233
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRW-FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 234 TYAPILLERKARRLRretgdRDLRSRSAtpksqhevffyalvrplkmlltstVVMMLAFdvAVVYGYQYLVFTTLSYIFQ 313
Cdd:COG2807 195 RPAAAAAAPAAASLR-----SLWRSPLA------------------------WLLTLFF--GLQSLLYYAVVAWLPPILR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 314 DvYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKkgrlsapdetlppeswlWPMIPASLLTPIGLLWYGWSLQAG 393
Cdd:COG2807 244 D-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRR-----------------PLLLLLGLLGLAGLLGLLLAPGSL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 394 lfpvvPLVGLGVFGFGMMGIFQPVQIYLVNAFPI--HSASALAASNLLRSLVGALLPLGGHRMYDTMGlGWGNSLLAFIA 471
Cdd:COG2807 306 -----PWLWAVLLGLGQGGLFPLALTLIGLRARTpaEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAALLLLAA 379
|
....
gi 350633313 472 LAMA 475
Cdd:COG2807 380 LAVL 383
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-229 |
2.02e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 60 ISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCA 139
Cdd:cd06173 213 LLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 140 LSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIP 219
Cdd:cd06173 293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGAL 372
|
170
....*....|
gi 350633313 220 MAVLTILSIV 229
Cdd:cd06173 373 LLLAALLLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-482 |
2.11e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 57 IGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATI 136
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDvGWRWIFWVI 216
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 217 TIPMAVLTILSIVTLRETyapillerkarRLRRETGDRDLRSRSATPKSQHEVFfyalvrpLKMLLTSTVVMMLAFdvav 296
Cdd:cd17329 160 AVLFLLAALVLLFLLPET-----------RPKRRAAEKTEILRGYKIVLRDRAF-------LLFLLASFLISLIYF---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 297 vygyqyLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGyasdKVAERKKGRLSapdetlppeswlwpMIPAS 376
Cdd:cd17329 218 ------QLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVA----RLVERFRLRKI--------------LMIGI 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 377 LLTPIGLLWYGWSLQAGLFpvvpLVGLGVFGFGMMGIFQPVQIYLVNAFPIHS-ASALAASNLLRSLVGALLPLGGHRMY 455
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVL----ILAMIVLTLGEMLVFPAVQTLVAALAPPDKrGSYMGFYALAWGLGRAIGPLVGGLLL 349
|
410 420
....*....|....*....|....*..
gi 350633313 456 DTMGLGWGNSLLAFIALAMAPVPIILM 482
Cdd:cd17329 350 DLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
94-433 |
2.36e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.63 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDlM 173
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA-L 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 174 APEKMGTAMAI----WGLGSLVAPvfaPIAGGYLSEDVGWRWIFWVItipMAVLTILSIVTLRetyapillerkarrlrr 249
Cdd:cd17333 113 FEESSATRLNVlhgfFGLGALIGP---LIATSLLTSELSWSWAYLII---GLIYLLLAILILL----------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 250 etgdrdLRSRSATPKSQHEVFFYALVRPLKMLLTSTVVMMLAFDVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLG 329
Cdd:cd17333 170 ------TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 330 DGIGTLLGIFSIGYASDKVAERKKGRLSApdetlppeswlwpmIPASLLTPIGLLWYGwslqaglfPVVPLVGLGVFGFG 409
Cdd:cd17333 244 FWVGITIGRLLGGPISRRIKPHTLLVLSG--------------SGALLGLLILLLAPT--------LVVGLVATALLGLF 301
|
330 340
....*....|....*....|....
gi 350633313 410 MMGIFQPVQIYLVNAFPIHSASAL 433
Cdd:cd17333 302 MAALFPTILSLGISNLPYAKGKGT 325
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
98-342 |
3.72e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 49.24 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 98 SIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGC--AGVTPLALgggsigDLMAp 175
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgiGGIWVQAV------VLNT- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 176 EKMGTAMAI---------WGLGSLVAPVFApiaggYLSEDvgWRWIFWVITIPMAVLTILS----------IVTLRETYA 236
Cdd:TIGR00898 207 EFLPKKQRAivgtliqvfFSLGLVLLPLVA-----YFIPD--WRWLQLAVSLPTFLFFLLSwfvpesprwlISQGRIEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 237 PILLERKARRLRRETGDRDLRSRS----ATPKSQHevFFYALVRPLKMLLTSTVVMMLAFDVAVVygYQYLVFTTlSYIF 312
Cdd:TIGR00898 280 LKILQRIAKINGKKLPAEVLSLSLekdlSSSKKQY--SFLDLFRTPNLRKTTLCLMMLWFTTAFS--YYGLVLDL-GNLG 354
|
250 260 270
....*....|....*....|....*....|
gi 350633313 313 QDVYhLSTGLSGLVYLGDGIGTLLGIFSIG 342
Cdd:TIGR00898 355 GNIY-LDLFISGLVELPAKLITLLLIDRLG 383
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
61-234 |
4.53e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 48.74 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 61 SLLTFvtsLGSSMLAPAVPDVMRSLGSdNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCAL 140
Cdd:PRK11043 15 SMLGF---LATDMYLPAFKAIQADLQT-SASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 141 STNVGMFLAFRLISG---C-AGVTPLALgggsIGDLMAPEK----MGTAMaiwglgSLVA--PVFAPIAGGYLSEDVGWR 210
Cdd:PRK11043 91 VESAAQLLVLRFVQAvgvCsAAVIWQAL----VIDRYPAQKanrvFATIM------PLVAlsPALAPLLGAWLLNHFGWQ 160
|
170 180
....*....|....*....|....
gi 350633313 211 WIFWVITIpMAVLTILSIVTLRET 234
Cdd:PRK11043 161 AIFATLFA-ITLLLILPTLRLKPS 183
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
62-234 |
7.70e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 48.28 E-value: 7.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSDNAeLESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:PRK15403 23 LYDFAAYLTTDLIQPGIINVVRDFNADVS-LAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMA 221
Cdd:PRK15403 102 TSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGL 181
|
170
....*....|...
gi 350633313 222 VLTILSIVTLRET 234
Cdd:PRK15403 182 IAFVGLLLAMPET 194
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
74-356 |
8.13e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.14 E-value: 8.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 74 LAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLI 153
Cdd:TIGR00881 14 FALAMPYLVEEIGLSKTDL-GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 154 SGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVF-APIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVTLR 232
Cdd:TIGR00881 93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLlPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 233 ETYAPILLeRKARRLRRETGDRDLRSRSATpKSQHEVFfyalvrpLKMLLTSTVVMMLAFDVAVVYGYQYLVFTTLSYIF 312
Cdd:TIGR00881 173 DSPQSCGL-PPAEEMPNEEPDGDAEKKEEE-LTKKQIF-------LQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYL 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 350633313 313 QDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRL 356
Cdd:TIGR00881 244 TQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPL 287
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
92-234 |
1.00e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 47.65 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 92 LESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGcagvtpLALGGGS--- 168
Cdd:cd17360 36 WQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG------LGVGIASmtv 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350633313 169 ---IGDLMAPEKMGTAMAIWGL----GSLVAPVfapIAGGYLSEDVGWRWIFWVITIPmAVLTILSIVTLRET 234
Cdd:cd17360 110 plyIAEAAPPRIRGRLVTINVLfitgGQFVAYV---INGAFSYLPGGWRWMLGLAAVP-AVLQFIGLLFLPES 178
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
62-235 |
1.10e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 47.71 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSDNAELEsFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:PRK10473 10 ALVLLYPAGIDMYLVGLPRIAADLNASEAQLH-IAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLI----SGCAGVTPLALgggsIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVIT 217
Cdd:PRK10473 89 ETSSLFLAGRFLqgigAGCCYVVAFAI----LRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMA 164
|
170
....*....|....*...
gi 350633313 218 IPMAVLTILSIVTLRETY 235
Cdd:PRK10473 165 AMGILVLLLSLFILKETR 182
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-249 |
1.26e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.26 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 64 TFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAP----MSEIYGRSIVYnVSNVLFLGATIGC- 138
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPiwgrLADRYGRKPML-LRASLGMAIVIGLm 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGcagvtplaLGGGSIGDLMA-------PEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRW 211
Cdd:cd17391 84 AFVTNVWQLLILRLLQG--------VFSGYVPNATAliasqtpKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRN 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 350633313 212 IFWVITIPMAVLTILSIVTLRETYAPILLERKARRLRR 249
Cdd:cd17391 156 VFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEV 193
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
95-348 |
1.38e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.27 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 95 FVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMA 174
Cdd:cd17312 42 IIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 175 PEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILsivtlretyapillerkarrlrretgdr 254
Cdd:cd17312 122 KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAII---------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 255 dlrsrsatpksqheVFFYALVRPlkmlltsTVVMMLAFDVAVVYGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGT 334
Cdd:cd17312 174 --------------LFFFLRDSP-------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGG 232
|
250
....*....|....
gi 350633313 335 LLGIFSIGYASDKV 348
Cdd:cd17312 233 IAGTILAGLLSDKL 246
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
98-231 |
1.65e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.21 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 98 SIYVIGYALG--PLIAA----PM---SEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVTPLALGggS 168
Cdd:cd17472 30 TPTLIGLALGiyGLTQAifqiPFgllSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--L 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350633313 169 IGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVItipmAVLTILSIVTL 231
Cdd:cd17472 108 LADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLIT----AILSLVSLLIL 166
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-235 |
2.57e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGS-SMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIG 137
Cdd:cd17341 2 HLSWLSFFLGFMVwFLFAPLGPVIRDDLGLSTSQI-GLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 138 CALS-TNVGMFLAFRLISGCAGVTpLALGGGSIGDLMAPEKMGTAMAI---WG-LGSLVAPVFAPIAGGYLSED---VGW 209
Cdd:cd17341 81 LALAvSSYWGLLVLGFLLGFAGAN-FASGQPWASFWFPKEKIGGAAGGiagAGnMGVAVSQLLAPLIAGAIVFDggfVGW 159
|
170 180
....*....|....*....|....*.
gi 350633313 210 RWIFWVITIPMAVLTILSIVTLRETY 235
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDDLP 185
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
78-229 |
3.47e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.06 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 78 VPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIY--GRSIVYnVSNVLFLGATIGCALSTNVGMFLAFRLISG 155
Cdd:cd17490 218 TPLIAKQLGASSFQL-GLLSIIYLLPNALASLLSGTLFYKKlgERNTII-IGFLLLGAYCFLIPFAPNLTLLYLLQALNG 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 156 CA-GVTPLALGGGSIGDLmAPEKMGTAM----AIWGLGSLVAPVFApiagGYLSEDVGWRWIFWVITIPMAVLTILSIV 229
Cdd:cd17490 296 FGtGILFPLLMSLSIEGV-PAEQRSTAMgffqAIYALGMFLGPVLV----GIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
94-228 |
5.20e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.72 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFL--GATIGCALS-TNVGMFLAFRLISGCA-----GVTPLALG 165
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVvsSLLMFLSKSaKSPELLIFGRFLVGIAcglstGFVPMYLQ 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350633313 166 GGSIGDLMAPEKMGTAMAIwGLGSLVAPVFApiAGGYLSEDVGWRWIFWVITIPMAVLTILSI 228
Cdd:cd17357 132 EISPSELRGALGSLTQIGV-TLGILLGQVFG--LPSVLGTETLWPYLLFFPGIPALLQLAALP 191
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
77-357 |
7.54e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 45.02 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 77 AVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGc 156
Cdd:cd17343 25 VLPSLMNELGLDKSDL-GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNG- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 157 agvtpLALGGG--SIGDLM----APEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSIVT 230
Cdd:cd17343 103 -----LAQGLGwpPCAKILrkwfSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 231 LREtyapillerkarrlrrETGDRDLRSRSATPKSQHEVFFYALVRPLKMLLTSTVVMMLAFDVAVVYGYQYLVFT-TLS 309
Cdd:cd17343 178 IKN----------------EPSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDwGQL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 350633313 310 YIFQDVyHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRLS 357
Cdd:cd17343 242 FLIQDK-GQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSR 288
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
94-255 |
1.51e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGC--AGVTP-LALgggSIG 170
Cdd:cd17327 44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLfeSGVFPgFIL---YLG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 171 DLMAPEKMGTAMAIWGLGSLVAPVFapiaGGYLSEDV----------GWRWIFWV---ITIPMAVLTILSIVTLrETYAP 237
Cdd:cd17327 121 MWYKREEQAKRIAFFYAAAGLGSIF----GGLLAYGVfkilgvgglaGWRWLFIIeglITIIIGLVIFFWLPDN-PSKAW 195
|
170 180
....*....|....*....|...
gi 350633313 238 ILLER-----KARRLRRETGDRD 255
Cdd:cd17327 196 FLTEEekelaVERLRANQTGKGD 218
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
89-232 |
1.99e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 89 NAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISG--CAGVTPLALG- 165
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGlgLSLMFPTIFSl 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 350633313 166 GGSIGDLMAPEKMGTAMAIWGLGSLVAPVFApiagGYLSEDVGWRWIFWVITIPMAVLTILSIVTLR 232
Cdd:COG0738 324 ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLI----GFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-477 |
2.53e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.38 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 68 SLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMF 147
Cdd:cd17475 9 SLVAQGIPALAPFLQEDLHLSLAQV-GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 148 LAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAI--WGL---GSLVAPVFAPIAGGYlsedvGWRWIFWVITIPMAV 222
Cdd:cd17475 88 LVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrqTGVplgGALAAALLPPLALHY-----GWRAAFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 223 LTILSIVTLRETYAPILLERKARRLRReTGDRDLRSrsatpksqhevffyalvRPLKMLLTSTVVMMLAfdvavvygyQY 302
Cdd:cd17475 163 AAVLFWLFYREPPAASAATESASTLLR-SLKEVLRN-----------------RDVWLIAIAGALLVAP---------QF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 303 LVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRlsapdetlppeswlwPMIPASLLTPIG 382
Cdd:cd17475 216 ALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRP---------------VLVITAAIAAAA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 383 LLWYGWSLQAGLFPVVPLV--GLGVFGFGmmgiFQPVQIYLV--NAFPIHSASALAASNLLRSLVGALLP-LGGHRMYDT 457
Cdd:cd17475 281 LLVLSLLSPGTPLWLLVLLliLLGLFAIG----WNGLYLTLVaeSAGPEQAGTALGLANTINFIGIAIGPpLFGLLVDAT 356
|
410 420
....*....|....*....|
gi 350633313 458 MGLGWGNSLLAFIALAMAPV 477
Cdd:cd17475 357 HSYAPAWLALALLLVLAALL 376
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
94-291 |
2.77e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 43.37 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVG---MFLAFRLISG-CAG----VTPLALG 165
Cdd:cd17432 53 SLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKsfeMIIVGRFLVGiNAGislnVVPMYLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 166 GgsigdlMAPEK----MGTAMAIW-GLGSLVAPVFApiaggyLSE----DVGWRWIFWVITIPmAVLTILSIVTLRETYA 236
Cdd:cd17432 133 E------SAPKNlrgaVGLVPAIFiTLGILLGQVLG------LREllgnEEGWPLLLALTGVP-ALLQLLTLPFFPESPR 199
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 237 PILLER-------KARRLRRETGDRD-----LRSRSATPKSQHEVFFYALVR--PLKMLLTSTVVMMLA 291
Cdd:cd17432 200 YLLIEKgdeeaarKALQRLRGKEDVDdemeeMLEEQRAEKGVGTVSVLELFRdrSVRWQLISIIVLMAG 268
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
59-226 |
6.91e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.18 E-value: 6.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMR----SLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGA 134
Cdd:cd17358 6 VANLGSFSFGIAVGWSSPALPSLMSdnslSLPLTVAQF-SWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 135 TIGCALSTNVGMFLAFRLISGCAGvtplalGGGS------IGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSedvg 208
Cdd:cd17358 85 WLLIAFAKDVWMLYLGRFLAGFGG------GAASvvvpvyIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP---- 154
|
170
....*....|....*...
gi 350633313 209 WRWIFWVITIPMAVLTIL 226
Cdd:cd17358 155 WRTLALIGAIPPVVFLIL 172
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-226 |
8.36e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 78 VPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEI-YGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGC 156
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 157 AGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTIL 226
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
88-229 |
8.43e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 41.85 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 88 DNAELESFVVSIYVIGyALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCA-----GVTPL 162
Cdd:cd17361 49 DDQLLQLFTSSLYLAG-LVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGvgfgnQAVPL 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 350633313 163 ALGGgsigdlMAPEK------MGTAMAIwGLGSLVAPVFapiagGYLSEDV---GWRWIFWVITIPMAVLTILSIV 229
Cdd:cd17361 128 YLSE------MAPAKlrgalnIGFQLAI-TIGILIANLI-----NYGTSKIkpnGWRLSLGLAAVPALILLLGSLF 191
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
47-232 |
8.60e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 8.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 47 NWSFWyrwchigVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNV 126
Cdd:COG2223 204 DPRFW-------LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 127 SNVLFLGATIGCALSTN--VGMFLAFRLISGCAGVTpLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLS 204
Cdd:COG2223 277 VFALMALGLLLLALALGslWLFLVLFLLLGLALGGG-NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
170 180
....*....|....*....|....*....
gi 350633313 205 EDVG-WRWIFWVITIPMAVLTILSIVTLR 232
Cdd:COG2223 356 DATGsYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
62-477 |
1.24e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 62 LLTFVTSLGSSMLAPAVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALS 141
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALI-GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 142 TNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAI----WGLGSLVAPVFAPIAGGylsedVGWRWiFWVIt 217
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLystvLGLGFALGPLLLALVGT-----AGALP-FLIA- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 218 ipmAVLTILSIVtlretyaPILLERKARRLRRETGDRDLRsrsatpksqhevffyALVRPLKMLLTstvvmmlafdVAVV 297
Cdd:cd17477 155 ---AVLLLLALV-------PLLLTRRAAPEIEEAESISLR---------------RLLRIAPLALL----------GAFV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 298 YGYQYLVFTTLSYIFQDVYHLSTGLSGLVYLGDGIGTLLGIFSIGYASDKVAERKKGRLSApdetlppeswlWPMIPASL 377
Cdd:cd17477 200 AGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA-----------LLGALAAL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 378 LTPIgllwygwslqAGLFPVVPLVGLGVFGfGMMGIFQPVQIYLVNAF--PIHSASALAASNLLRSLVGALLPLGGHRMY 455
Cdd:cd17477 269 LLPL----------VPGLPLALLVLLFLWG-GAAGPLYTLALALAGDRlpGDELVAANAALLLLYGLGSVIGPLLAGALM 337
|
410 420
....*....|....*....|..
gi 350633313 456 DTMGLGWGNSLLAFIALAMAPV 477
Cdd:cd17477 338 DAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
94-232 |
1.46e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.72 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCAL---------STNVGMFLAFRLISGcagvtPLAL 164
Cdd:cd17312 222 GWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALfwffphnklLSIVLLFLIGFFVGG-----PINL 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 165 GGGSIGDLMAPEK-MGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIpMAVLTILSIVTLR 232
Cdd:cd17312 297 IGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLIS-AALLSVLLLLSLW 364
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
55-229 |
1.68e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 55 CHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVL-FLG 133
Cdd:cd17333 199 PSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGaLLG 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 134 ATIGCALSTNVGMFLAFRLIS-GCAGVTPLALGGGSIgdlMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWI 212
Cdd:cd17333 279 LLILLLAPTLVVGLVATALLGlFMAALFPTILSLGIS---NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA 355
|
170
....*....|....*..
gi 350633313 213 FWVITIPMAVLTILSIV 229
Cdd:cd17333 356 MLLITILYAIIFVLALL 372
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
77-238 |
1.99e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.72 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 77 AVPDVMRSLGSDNAELeSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGc 156
Cdd:PRK11551 37 AAPRMAQEFGLDVAQM-GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTG- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 157 agvtplaLG-GGSIGDLMA-------PEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITIPMAVLTILSI 228
Cdd:PRK11551 115 -------VGlGGALPNLIAltseavgPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLM 187
|
170
....*....|
gi 350633313 229 VTLRETYAPI 238
Cdd:PRK11551 188 RWLPESRAFA 197
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
54-226 |
2.38e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 54 WCHIGVISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLG 133
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 134 ATIGCALSTNVGMFLAFRLISGCAG--VTPLALggGSIGDLMAPEKMGTAMAIWG----LGSLVAP-VFAPIAGGYLSED 206
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFglLLPTLN--SWAMSLVPPELRGRAMGIVTsaffLGQFLSPlVLGPLVNLTGGLS 353
|
170 180
....*....|....*....|
gi 350633313 207 VGWRwIFWVITIPMAVLTIL 226
Cdd:cd17473 354 GAFL-ILGVLALVLAIVLLL 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
94-228 |
3.40e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 94 SFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGCAGVT-PLALgggSIGDL 172
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASfPVTV---VLAQE 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350633313 173 MAPEKMGTAMAI-----WGLGSLVAPVFapiagGYLSEDVGWRWIFWVITIPMAVLTILSI 228
Cdd:cd17478 310 LLPGNVGLASGLmmglsFGLGGIGAPVL-----GALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
59-231 |
4.10e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAeleSFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFLGATIGC 138
Cdd:cd17489 198 PPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 139 ALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPIAGGYLSEDVGWRWIFWVITI 218
Cdd:cd17489 275 SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
170
....*....|...
gi 350633313 219 PMAVLTILSIVTL 231
Cdd:cd17489 355 VVLLALVLYIFLL 367
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
93-235 |
5.61e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.16 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 93 ESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLFL-GATIGCALSTNVGMFLAFRLISG-CAGVTPlALGGGSIG 170
Cdd:cd17356 47 QGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIiGAIIQVAAIGKWYQLIVGRIIAGlGVGFAS-VLVPVYQS 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350633313 171 DLMAPEKMGTAMAIWGL----GSLVApVFAPIAGGYLSEDVGWRwIFWVITIPMAVLTILSIVTLRETY 235
Cdd:cd17356 126 EVAPKHIRGTLVSLYQLaitiGILVA-YCINYGTHKLDGSAQWR-IPLGLQIVWGLLLLIGMFFLPESP 192
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
45-238 |
7.47e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.75 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 45 PMNWSFwyrwcHIGVISLLTFVTSLGSSMLAPAVPDVMRSLG-SDNAELESFVVSIYVIGYaLGPLIAAP----MSEIYG 119
Cdd:PRK09874 9 PINWKR-----NLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGvTGHSALNMWSGLVFSITF-LFSAIASPfwggLADRKG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 120 RSIVYNVSNVLFLGATIGCALSTNVGMFLAFRLISGC-AGVTPLAlgGGSIGDLMAPEKMGTAMAIWGLGSLVAPVFAPI 198
Cdd:PRK09874 83 RKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLlGGFVPNA--NALIATQVPRNKSGWALGTLSTGGVSGALLGPL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 350633313 199 AGGYLSEDVGWRWIFWVITIPMAVLTILSIVTLRETYAPI 238
Cdd:PRK09874 161 AGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPV 200
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
59-228 |
9.81e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 59 VISLLTFVTSLGSSMLAPAVPDVMRSLGSDNAELESFVVSIYVIGYALGPLIAAPMSEIYGRSIVYNVSNVLF--LGATI 136
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgiLALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350633313 137 GCALSTNVGMFLAFRLISGCAGVTPLALGGGSIGDLMAPEKMGTAMAI-WGLGSLVAPVFAPIAGGYLSEDVGWRWIFWV 215
Cdd:cd17316 261 FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
170
....*....|...
gi 350633313 216 ITIPMAVLTILSI 228
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| |
