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Conserved domains on  [gi|350631785|gb|EHA20155|]
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hypothetical protein ASPNIDRAFT_124374 [Aspergillus niger ATCC 1015]

Protein Classification

aminoglycoside phosphotransferase family protein( domain architecture ID 1906910)

aminoglycoside phosphotransferase family protein catalyzes the phosphorylation of small molecule substrates such as aminoglycoside antibiotics and N-acetylhexosamine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YcbJ super family cl43802
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 132-193 1.53e-03

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


The actual alignment was detected with superfamily member COG3173:

Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.10  E-value: 1.53e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350631785 132 YRGTFEEKSQLLNFTIRLMTMLDSH-PLLGQsaqPTLWHTDLHMGNIYVAPEDsTRIVSIIDF 193
Cdd:COG3173  161 LRRALARTDDLPALRERLAAWLAANlPEWGP---PVLVHGDLRPGNLLVDPDD-GRLTAVIDW 219
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 132-193 1.53e-03

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.10  E-value: 1.53e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350631785 132 YRGTFEEKSQLLNFTIRLMTMLDSH-PLLGQsaqPTLWHTDLHMGNIYVAPEDsTRIVSIIDF 193
Cdd:COG3173  161 LRRALARTDDLPALRERLAAWLAANlPEWGP---PVLVHGDLRPGNLLVDPDD-GRLTAVIDW 219
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 135-209 5.63e-03

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 38.25  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350631785  135 TFEEKSQLLNFTIRLMTMLDSHPLLGQsaQPTLWHTDLHMGNIYVAPEDstRIVSIIDFQSLAVMP-----AFLQSRWPE 209
Cdd:pfam01636 139 AAELLDRLEELEERLLAALLALLPAEL--PPVLVHGDLHPGNLLVDPGG--RVSGVIDFEDAGLGDpaydlAILLNSWGR 214
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 132-193 1.53e-03

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.10  E-value: 1.53e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 350631785 132 YRGTFEEKSQLLNFTIRLMTMLDSH-PLLGQsaqPTLWHTDLHMGNIYVAPEDsTRIVSIIDF 193
Cdd:COG3173  161 LRRALARTDDLPALRERLAAWLAANlPEWGP---PVLVHGDLRPGNLLVDPDD-GRLTAVIDW 219
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 135-209 5.63e-03

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 38.25  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350631785  135 TFEEKSQLLNFTIRLMTMLDSHPLLGQsaQPTLWHTDLHMGNIYVAPEDstRIVSIIDFQSLAVMP-----AFLQSRWPE 209
Cdd:pfam01636 139 AAELLDRLEELEERLLAALLALLPAEL--PPVLVHGDLHPGNLLVDPGG--RVSGVIDFEDAGLGDpaydlAILLNSWGR 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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