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Conserved domains on  [gi|350606364|ref|NP_001004288|]
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integrin alpha-5 precursor [Danio rerio]

Protein Classification

integrin alpha( domain architecture ID 12192626)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 480-926 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 563.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   480 RPIVNTSAILNVYPIMINPEEKVCAisrgNETLHVSCVNLSFCLSANGKHLPN-HLEFNVEVQLDRLKQqqKGAVRRALF 558
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCT----LTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKK--KGLPPRVLF 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   559 LETQLPALHRTLTVPNGAR-VCSDTKIYLRDEkdFRDKLSPIFVALNFSL--NPQAAADRHGLQPILNYQTAELIEQKAQ 635
Cdd:pfam08441   75 LDSQQPSLTGTLVLLSQGRkVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   636 ILLDCGEDNICVPDLKLSVHGD----RKEVYMGDDNSLTLTFNAKNDGGGAYEAELYVVLPPEADYSGIaRNNESLTQLT 711
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLS 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   712 CSYETENQTRYLSCDLGNPMKSGTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNENNSQSEVVPYKLEVVVRSDVILQGV 791
Cdd:pfam08441  232 CTAKKENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGV 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   792 SRPDKVFFPPPNWKLTKNVMVEQNVGPSVQHTYELVNNGPSRISHTLLQLKCPMRLHSNRF-IYPLEVTTEGPVNCTTHN 870
Cdd:pfam08441  312 SKPDQVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWlLYLLDVQGQGKGECSPQN 391

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   871 IINPLNLKLQQSSTEqpPVRDSGHEHHIEKRDTHKGELSQLT---NLSCSSV-DCWTLMC 926
Cdd:pfam08441  392 EINPLNLTQSLESSK--PLRTSRVHHVVKRRDVLKSEKATQTasvLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 375-430 7.46e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.93  E-value: 7.46e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 350606364    375 MFARFGSSITPLGDLNQDGYNDVAISSPFGGEDK-QGLVLIYNGNAGGLREKPSQVI 430
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 309-357 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 350606364    309 MGSYYGYSVA-ATDINNDGMMDLLVGAPMfmvrdsDGRLEELGRVYVYMQ 357
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 47-104 1.37e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.37e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350606364     47 SGSYFGYSVDFY---MTDSSVSIIVGAPKANTSQpkitEGGSVFYCPWSLSQSQCSSIEFD 104
Cdd:smart00191    1 PGSYFGYSVAGVgdvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-484 2.33e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.33e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 350606364    446 FGYALRGGKDLDNNGYPDLIVGAFGADKAVLYRSRPIVN 484
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYF 43
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 260-294 1.45e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.10  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 350606364   260 MGYSVAVGEFTGDDDEDFVTGVPRGVRLH-GQVSIL 294
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 480-926 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 563.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   480 RPIVNTSAILNVYPIMINPEEKVCAisrgNETLHVSCVNLSFCLSANGKHLPN-HLEFNVEVQLDRLKQqqKGAVRRALF 558
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCT----LTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKK--KGLPPRVLF 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   559 LETQLPALHRTLTVPNGAR-VCSDTKIYLRDEkdFRDKLSPIFVALNFSL--NPQAAADRHGLQPILNYQTAELIEQKAQ 635
Cdd:pfam08441   75 LDSQQPSLTGTLVLLSQGRkVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   636 ILLDCGEDNICVPDLKLSVHGD----RKEVYMGDDNSLTLTFNAKNDGGGAYEAELYVVLPPEADYSGIaRNNESLTQLT 711
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLS 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   712 CSYETENQTRYLSCDLGNPMKSGTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNENNSQSEVVPYKLEVVVRSDVILQGV 791
Cdd:pfam08441  232 CTAKKENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGV 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   792 SRPDKVFFPPPNWKLTKNVMVEQNVGPSVQHTYELVNNGPSRISHTLLQLKCPMRLHSNRF-IYPLEVTTEGPVNCTTHN 870
Cdd:pfam08441  312 SKPDQVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWlLYLLDVQGQGKGECSPQN 391

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   871 IINPLNLKLQQSSTEqpPVRDSGHEHHIEKRDTHKGELSQLT---NLSCSSV-DCWTLMC 926
Cdd:pfam08441  392 EINPLNLTQSLESSK--PLRTSRVHHVVKRRDVLKSEKATQTasvLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 375-430 7.46e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.93  E-value: 7.46e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 350606364    375 MFARFGSSITPLGDLNQDGYNDVAISSPFGGEDK-QGLVLIYNGNAGGLREKPSQVI 430
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 309-357 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 350606364    309 MGSYYGYSVA-ATDINNDGMMDLLVGAPMfmvrdsDGRLEELGRVYVYMQ 357
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 313-355 7.94e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 7.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 350606364   313 YGYSVAATDINNDGMMDLLVGAPMFMVRDSdgrleelGRVYVY 355
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 47-104 1.37e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.37e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350606364     47 SGSYFGYSVDFY---MTDSSVSIIVGAPKANTSQpkitEGGSVFYCPWSLSQSQCSSIEFD 104
Cdd:smart00191    1 PGSYFGYSVAGVgdvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-484 2.33e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.33e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 350606364    446 FGYALRGGKDLDNNGYPDLIVGAFGADKAVLYRSRPIVN 484
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYF 43
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 379-415 5.40e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.73  E-value: 5.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 350606364   379 FGSSITpLGDLNQDGYNDVAISSPFGGEDKQGLVLIY 415
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 260-294 1.45e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.10  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 350606364   260 MGYSVAVGEFTGDDDEDFVTGVPRGVRLH-GQVSIL 294
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 256-297 9.02e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 9.02e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 350606364    256 DDTYMGYSVA-VGEFTGDDDEDFVTGVPRG--VRLHGQVSILNSS 297
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFGS 45
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 480-926 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 563.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   480 RPIVNTSAILNVYPIMINPEEKVCAisrgNETLHVSCVNLSFCLSANGKHLPN-HLEFNVEVQLDRLKQqqKGAVRRALF 558
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCT----LTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKK--KGLPPRVLF 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   559 LETQLPALHRTLTVPNGAR-VCSDTKIYLRDEkdFRDKLSPIFVALNFSL--NPQAAADRHGLQPILNYQTAELIEQKAQ 635
Cdd:pfam08441   75 LDSQQPSLTGTLVLLSQGRkVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   636 ILLDCGEDNICVPDLKLSVHGD----RKEVYMGDDNSLTLTFNAKNDGGGAYEAELYVVLPPEADYSGIaRNNESLTQLT 711
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLS 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   712 CSYETENQTRYLSCDLGNPMKSGTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNENNSQSEVVPYKLEVVVRSDVILQGV 791
Cdd:pfam08441  232 CTAKKENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGV 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   792 SRPDKVFFPPPNWKLTKNVMVEQNVGPSVQHTYELVNNGPSRISHTLLQLKCPMRLHSNRF-IYPLEVTTEGPVNCTTHN 870
Cdd:pfam08441  312 SKPDQVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWlLYLLDVQGQGKGECSPQN 391

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 350606364   871 IINPLNLKLQQSSTEqpPVRDSGHEHHIEKRDTHKGELSQLT---NLSCSSV-DCWTLMC 926
Cdd:pfam08441  392 EINPLNLTQSLESSK--PLRTSRVHHVVKRRDVLKSEKATQTasvLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 375-430 7.46e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.93  E-value: 7.46e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 350606364    375 MFARFGSSITPLGDLNQDGYNDVAISSPFGGEDK-QGLVLIYNGNAGGLREKPSQVI 430
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 309-357 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 350606364    309 MGSYYGYSVA-ATDINNDGMMDLLVGAPMfmvrdsDGRLEELGRVYVYMQ 357
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 313-355 7.94e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 7.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 350606364   313 YGYSVAATDINNDGMMDLLVGAPMFMVRDSdgrleelGRVYVY 355
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 47-104 1.37e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.37e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 350606364     47 SGSYFGYSVDFY---MTDSSVSIIVGAPKANTSQpkitEGGSVFYCPWSLSQSQCSSIEFD 104
Cdd:smart00191    1 PGSYFGYSVAGVgdvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-484 2.33e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.33e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 350606364    446 FGYALRGGKDLDNNGYPDLIVGAFGADKAVLYRSRPIVN 484
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYF 43
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 379-415 5.40e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.73  E-value: 5.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 350606364   379 FGSSITpLGDLNQDGYNDVAISSPFGGEDKQGLVLIY 415
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 388-466 4.68e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 44.91  E-value: 4.68e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350606364   388 DLNQDGYNDVAISSpfggeDKQGLVLIYNGNaGGLREKPSQVISGQWASAGLSAIpasfgyalrggkDLDNNGYPDLIV 466
Cdd:pfam13517    1 DLDGDGKLDLVVAN-----DGGLRLYLNNGD-GTFTFITSVSLGGGGGGLSVAVG------------DLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 321-399 7.54e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.44  E-value: 7.54e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350606364   321 DINNDGMMDLLVGapmfmvrdSDGRLeelgRVYVYMQKGPLDLIPQLPHLTGTQmfarfGSSITpLGDLNQDGYNDVAI 399
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGL----RLYLNNGDGTFTFITSVSLGGGGG-----GLSVA-VGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 260-294 1.45e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.10  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 350606364   260 MGYSVAVGEFTGDDDEDFVTGVPRGVRLH-GQVSIL 294
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 269-332 7.04e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 36.05  E-value: 7.04e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 350606364   269 FTGDDDEDFVTGVPRGVRLHgqvsiLNSSLDVLKMFTGEQMG-SYYGYSVAATDINNDGMMDLLV 332
Cdd:pfam13517    2 LDGDGKLDLVVANDGGLRLY-----LNNGDGTFTFITSVSLGgGGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 256-297 9.02e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 9.02e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 350606364    256 DDTYMGYSVA-VGEFTGDDDEDFVTGVPRG--VRLHGQVSILNSS 297
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFGS 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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