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Conserved domains on  [gi|349869]
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Chain B, PROTEIN (GAL4)

Protein Classification

GAL4 and ZIP_Gal4p-like domain-containing protein( domain architecture ID 11086833)

GAL4 and ZIP_Gal4p-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.16e-09

Fungal Zn(2)-Cys(6) binuclear cluster domain;


:

Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 48.06  E-value: 1.16e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 349869      9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRS 47
Cdd:pfam00172  1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
ZIP_Gal4p-like super family cl22421
Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of ...
 50-65 2.09e-07

Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of transcriptional activators contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Included in this family are Saccharomyces cerevisiae Gal4p, Hap1p, Put3p, Ppr1p and Sip4p, Neurospora crassa acu-15, and Colletotrichum acutatum Nir1, among others. Gal4p functions in the induction of GAL genes in the presence of galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Hap1p promotes transcription of genes required for respiration and controlling oxidative damage in response to heme. Put3p activates the transcription of the PUT1 and PUT2 genes in the presence of proline, allowing yeast cells to use proline as a nitrogen source. Ppr1p activates transcription of the URA1, URA3, and URA4 genes, which encode enzymes involved in the regulation of pyrimidine levels. Sip4p activates target genes under conditions of glucose deprivation. Acu-15 is involved in regulating acetate utilization while Nir1 plays a role during nitrogen-starvation conditions.


The actual alignment was detected with superfamily member cd14654:

Pssm-ID: 277561  Cd Length: 47  Bit Score: 42.21  E-value: 2.09e-07
                       10
               ....*....|....*.
gi 349869   50 TRAHLTEVESRLERLE 65
Cdd:cd14654  1 TRAHLTEVENRLEKLE 16
 
Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.16e-09

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 48.06  E-value: 1.16e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 349869      9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRS 47
Cdd:pfam00172  1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 9-47 2.24e-08

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 44.66  E-value: 2.24e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 349869       9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRS 47
Cdd:smart00066  5 KACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 9-41 1.24e-07

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 42.65  E-value: 1.24e-07
                       10        20        30
               ....*....|....*....|....*....|...
gi 349869    9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYS 41
Cdd:cd00067  4 RACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 50-65 2.09e-07

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 42.21  E-value: 2.09e-07
                       10
               ....*....|....*.
gi 349869   50 TRAHLTEVESRLERLE 65
Cdd:cd14654  1 TRAHLTEVENRLEKLE 16
Gal4_dimer pfam03902
Gal4-like dimerization domain;
50-65 1.66e-03

Gal4-like dimerization domain;


Pssm-ID: 397816  Cd Length: 44  Bit Score: 32.42  E-value: 1.66e-03
                         10
                 ....*....|....*.
gi 349869     50 TRAHLTEVESRLERLE 65
Cdd:pfam03902  1 TRAHLTEVENRVTQLE 16
 
Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.16e-09

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 48.06  E-value: 1.16e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 349869      9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRS 47
Cdd:pfam00172  1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 9-47 2.24e-08

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 44.66  E-value: 2.24e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 349869       9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRS 47
Cdd:smart00066  5 KACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 9-41 1.24e-07

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 42.65  E-value: 1.24e-07
                       10        20        30
               ....*....|....*....|....*....|...
gi 349869    9 QACDICRLKKLKCSKEKPKCAKCLKNNWECRYS 41
Cdd:cd00067  4 RACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 50-65 2.09e-07

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 42.21  E-value: 2.09e-07
                       10
               ....*....|....*.
gi 349869   50 TRAHLTEVESRLERLE 65
Cdd:cd14654  1 TRAHLTEVENRLEKLE 16
Gal4_dimer pfam03902
Gal4-like dimerization domain;
50-65 1.66e-03

Gal4-like dimerization domain;


Pssm-ID: 397816  Cd Length: 44  Bit Score: 32.42  E-value: 1.66e-03
                         10
                 ....*....|....*.
gi 349869     50 TRAHLTEVESRLERLE 65
Cdd:pfam03902  1 TRAHLTEVENRVTQLE 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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