|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
80-496 |
1.32e-159 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 460.56 E-value: 1.32e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 80 KIDYCMFPLMCILYAVQFMDKISTSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNLGPVQFIFQRTshMSKMLAVFI 159
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFP--PSKWLSVFI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 160 VIWGMLLALHAAPTVkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQ 239
Cdd:cd17327 79 VLWGLLTLLTAAVKN-FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 240 DSYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRIRSNQQGFGNHEIKKYQIIEALKDVRTWL 319
Cdd:cd17327 158 GVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 320 YFLFTVSSNIPNGGISSFMSILLNSdFGYSSKETLLMGLPTGAVELVGCPLFGILAVyaankkipFWKYKLSWAIFAAVL 399
Cdd:cd17327 238 LFLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSD--------RFKKRGLFAIFACVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 400 ALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWTVSSINLVAYATANLAGPQTFIAKQAPKYH 479
Cdd:cd17327 309 ALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYI 388
|
410
....*....|....*..
gi 349579339 480 GAKVAMVVCYAVMIVLL 496
Cdd:cd17327 389 PGNIALLVCACVSIVLS 405
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
91-502 |
2.48e-141 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 413.66 E-value: 2.48e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 91 ILYAVQFMDKISTSSAAVMgLRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTShMSKMLAVFIVIWGMLLALHA 170
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQF-PGGWLLDRFG-ARKTLAVFIVIWGVFTGLQA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 171 APTvKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQdsyaikGWRTL 250
Cdd:TIGR00893 78 FAG-AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF------SWQWA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 251 FVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRIRSNQQGFGNHEIKKYQIIEALKDVRTWLYFLFTVSSNIP 330
Cdd:TIGR00893 151 FIIEGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 331 NGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANkkipfWKYKLSWAIFAAVLALIASCMLGFA 410
Cdd:TIGR00893 231 LGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLR-----RGKSLVFARKTAIIAGLVLSLLMFA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 411 TNS---KKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWTVSSINLVAyATANLAGPQTFIAKQAPKYHGAKVAMVV 487
Cdd:TIGR00893 306 TNYvniPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLG-NLGGIVGPIVIGAIAATTGSFAGALMVV 384
|
410
....*....|....*
gi 349579339 488 CYAVMIVLLSILLIV 502
Cdd:TIGR00893 385 AALALIGALSYLLLV 399
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
89-496 |
1.47e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 1.47e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 89 MCILYAVQFMDkISTSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTShMSKMLAVFIVIWGMLLAL 168
Cdd:cd06174 1 LLLGFFLTGLA-RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQP-LAGLLADRFG-RRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 169 HAAPTVkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYihqdSYAIKGWR 248
Cdd:cd06174 78 FAFAPS-FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----SSLGFGWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 249 TLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRirsnqqgfgnheikkyQIIEALKDVRTWLYFLFTVSSN 328
Cdd:cd06174 153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLK----------------LLKRVLKNPGLWLLLLAIFLVN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 329 IPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFWKYKLSWAIFAAVLALIASCMLG 408
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 409 FATNSkkarLAGAYLWYISPVSFICVLSNISANSSGyskkwTVSSINLVAYATANLAGP--QTFIAKQAPKYHGAKVAMV 486
Cdd:cd06174 297 LLLLL----LLGFGLGGLLPLSFALIAELFPPEIRG-----TAFGLLNTFGFLGGAIGPllAGFLLAATFGLTGAFLVLA 367
|
410
....*....|
gi 349579339 487 VCYAVMIVLL 496
Cdd:cd06174 368 VLLLLAAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
75-500 |
2.53e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.49 E-value: 2.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 75 RKLRWKIdycmFPLMCILYAVQFMDKISTSSAAVMgLRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTSHMsKM 154
Cdd:COG2271 5 SRYRWRI----LALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQI-PAGLLADRFGRR-RV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 155 LAVFIVIWGMLLALHA-APTvkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAY 233
Cdd:COG2271 78 LAIGLLLWGLATLLFGfATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 234 GVYIHQdsyaikGWRTLFVITGVITIFIGILiflwipddpskarflskreklmvvqrirsnqqgfgnheikkyqiiealk 313
Cdd:COG2271 156 WLLAAF------GWRAAFLILGLPGLLLALL------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 314 dvRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFwkyklswA 393
Cdd:COG2271 181 --RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-------L 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 394 IFAAVLALIASCMLGFATNSKKAR----LAGAYLWYISPVSFICVLSNISANSSGyskkwTVSSI-NLVAYATANLAGPQ 468
Cdd:COG2271 252 AIGLLLAALALLLLALLPSPALAIallfLAGFGLGGAFGLLWALAAELFPKKARG-----TASGLvNTFGFLGGALGPLL 326
|
410 420 430
....*....|....*....|....*....|..
gi 349579339 469 TFIAKQAPKYHGAKVAMVVCYAVMIVLLSILL 500
Cdd:COG2271 327 VGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
89-467 |
1.60e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 1.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 89 MCILYAVQFMDKISTSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTSHmSKMLAVFIVIWGMLLAL 168
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP-LAGRLSDRFGR-RRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 169 hAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVyihqdsYAIKGWR 248
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL------ASLFGWR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 249 TLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRIRsnqqgfgnheikkyqiiEALKDVRTWLYFLFTVSSN 328
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK-----------------ALLRDPVLWLLLALLLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 329 IpnGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIpfwkykLSWAIFAAVLALIASCMLG 408
Cdd:pfam07690 215 A--FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR------LLLALLLLILAALGLLLLS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 349579339 409 FATNSKKARLA----GAYLWYISPVSFICVLSNISANSSGyskkwTVSSINLVAYATANLAGP 467
Cdd:pfam07690 287 LTLSSLWLLLAllllGFGFGLVFPALNALVSDLAPKEERG-----TASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
78-270 |
1.41e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 87.24 E-value: 1.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 78 RWKIdycmFPLMCILYAVQFMDKISTSSAAVmGLRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTSHmSKMLAV 157
Cdd:cd17319 1 RWRI----IPLLFLAYVINYLDRVNISVAAP-TIMKDLGLSPTQYGLIASAFFLGYALFQV-PGGWLLDRFGA-RKVLAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 158 FIVIWGMLLALHAApTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSIlINAIAYGVYI 237
Cdd:cd17319 74 SMLLWSLFTALTGF-ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAA-IGPPLSGWLL 151
|
170 180 190
....*....|....*....|....*....|...
gi 349579339 238 HqdsyaIKGWRTLFVITGVITIFIGILIFLWIP 270
Cdd:cd17319 152 L-----LFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
88-463 |
2.51e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 83.48 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 88 LMCILYAVQFMDKISTSSAAVM--GLRTDLKMHGDQYSWVTSAFYFGYLFMNL--GPVQFIFQRTSHMSKMLAVFIViwg 163
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPAlpLIAADLGASPAQAGLVVTAYLLGAALGAPlaGRLADRFGRRRVLLLGLLLFAL--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 164 MLLALHAAPTvkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQdsya 243
Cdd:COG2814 88 GSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 244 ikGWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSKReklmvvqrirsnqqgfgnheikkyQIIEALKDVRTWLYFLF 323
Cdd:COG2814 162 --GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG------------------------SLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 324 TVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAvyaankkipfWKYKLSWAIFAAVLALIA 403
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA----------DRFGRRRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 404 SCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWTVSSINLVAYATAN 463
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
78-499 |
4.69e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.76 E-value: 4.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 78 RWKIdycmFPLMCILYAVQFMDkISTSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNL--GPVQFIFQRtshmSKML 155
Cdd:COG2223 3 RWRV----LLLATLAFFLAFGV-WYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIplGFLVDRFGP----RRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 156 AVFIVIWGMLLALHA-APTvkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAyg 234
Cdd:COG2223 74 LIGLLLLGIGLLLLAlAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 235 vyihqdSYAIK--GWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLmvvqrirsnqqgfgnheikkyQIIEAL 312
Cdd:COG2223 150 ------PLLIAafGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------------------DQLEAL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 313 KDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKipfwkyklsW 392
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR---------V 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 393 AIFAAVLALIASCMLGFATNSKKARLAGAYLWYI-----SPVSFICVLSNISANSSGyskkwTVSSINLVAYATANLAGP 467
Cdd:COG2223 274 LLIVFALMALGLLLLALALGSLWLFLVLFLLLGLalgggNGAVFALVPDIFPTKNAG-----AVYGLVGAAGGLGGFLGP 348
|
410 420 430
....*....|....*....|....*....|....
gi 349579339 468 QTF--IAKQAPKYHGAKVAMVVCYAVMIVLLSIL 499
Cdd:COG2223 349 LLFgaLLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
123-501 |
1.24e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.42 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 123 SWVTSAFYFGYLFMNL--GPVQFIFQRTSHMSKMLAVFIViwGMLLALHAaptVKYPSFIVLRVLLGCAESVVTPCFTII 200
Cdd:cd17324 37 GLLVSAYALGYALGALllGPLSDRIERRRLLLVLLLLFIL--GNLLAALA---PSFALLLLARALAGLAHGGFWAIAAAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 201 TAQYWKTEEQFTRVSIWFGMNGLGSILinAIAYGVYIHQdsyaIKGWRTLFVITGVITIFIGILIFLWIPDDPSKARFLS 280
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTLGLVL--GRPLGGLLGQ----LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 281 KREKlmvvqrirsnqqgfgnheikkyQIIEALKDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFG-YSSKETLLMGLp 359
Cdd:cd17324 186 GLLS----------------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGfSSSAIIGLLLL- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 360 TGAVELVGCPLFGILAvyaanKKIPfwkyKLSWAIFAAVLALIASCMLGFATNSkKARLAGAYLW----YISPVSFICVL 435
Cdd:cd17324 243 FGVAGVVGSPLAGRLA-----DRGG----RRALLIALLLLAAALLLLTLLGPSP-LLLLVGLVLWglgfFAAHSALQTRV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 349579339 436 SNISANSSGyskkwTVSSINLVAYATANLAGPqtFIAKQApkYHGAKVAMVVCYAVMIVLLSILLI 501
Cdd:cd17324 313 LRLAPEARG-----LASSLYLAAYNLGGALGA--ALGGLV--LDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
159-501 |
2.93e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 2.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 159 IVIWGML------LALHAAPTvkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILinAIA 232
Cdd:cd17325 63 LLLLGLLllavstLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLI--GPL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 233 YGVYIhqdsYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSkarflSKREKLMVVQRIRSNqqgfgnheikkyqIIEAL 312
Cdd:cd17325 139 LGGLL----ADALGYRAPFLVCAALALLALVLALLLLPEPRP-----PPNKRAVSAARLRSG-------------LRLLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 313 KDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVyaankKIPFWKyklsW 392
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD-----RIGRKP----L 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 393 AIFAAVLALIASCMLGFATNskkarlagayLWYISPVSFICVLSNISANSSGYS---------KKWTVSSINLVAYATAN 463
Cdd:cd17325 268 ILIGLLLSAVALLLLPLATS----------FWLLLLLLALLGLGLGLVFPATLAlladivppeGRGTAMGLFNTAFSLGM 337
|
330 340 350
....*....|....*....|....*....|....*...
gi 349579339 464 LAGPqtFIAKQAPKYHGAKVAMVVCYAVMIVLLSILLI 501
Cdd:cd17325 338 VLGP--LLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
154-438 |
8.42e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 8.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 154 MLAVFIVIWGMLLALhAAPTvkYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAY 233
Cdd:cd17316 70 ILTLLLFGLATLLIG-LLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 234 GVYIHqdSYAIKGWRTLFVITGVItIFIGILIFLwipddpskarflskreklmvvqrirsnqqgfgnheikkyqiiealk 313
Cdd:cd17316 147 LLIPL--LSGDWGWRILFLIGALP-ALLALLLRR---------------------------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 314 dvRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKipfwkyklsWA 393
Cdd:cd17316 178 --RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK---------TL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 349579339 394 IFAAVLALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNI 438
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
91-495 |
5.43e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.25 E-value: 5.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 91 ILYAVQFMDKISTSSAAVMG--LRTDLKMHGDQYSWVTSAFYFGYLFMNLgPVQFIFQRTSHMSKMLAVFIVIWGMLLAL 168
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIpaLKDAFGLSDAQAGLLLFAFFLGYLLASL-PAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 169 HAAPTvkYPSFIVLRVLLGCAESVV-TPCFTIITAQYwkTEEQFTRVSIWFGMNGLGSILINAIAyGVYIHQDSYAikGW 247
Cdd:COG0738 91 ALAPS--YPLLLLALFLLGLGLGLLdVAANPYVAALG--PETAASRLNLLHAFFSLGALLGPLLG-GLLILLGLSL--SW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 248 RTLFVITGVITIFIGILIFLW-IPDDPSKARFLSKREKlmvvqrirsnqqgfgnheikkyQIIEALKDVRTWLYFLFTVS 326
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAA----------------------SLKSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 327 SNIPNGGISSFMSILLNSDFGYSSKE-TLLMGLPTGAVeLVGCPLFGILAVYAANKKIpfwkyklswAIFAAVLALIASC 405
Cdd:COG0738 222 YVGAEGAIGDWLPLYLKDVLGLSEATaALGLSLFWGGM-TIGRFLGGFLLKRFGPVRL---------LRLSALLAAVGLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 406 MLGFATNSKKArLAGAYLWY--ISPVsFICVLSNISANSSGYSKKwTVSSINLVAYAtANLAGP--QTFIAKQAPkYHGA 481
Cdd:COG0738 292 LALLAPGPWLA-LIGLALVGlgLSLM-FPTIFSLALDGLGKRTAA-AVSAVLIMGIV-GGAIGPplIGFLADAFG-LRAA 366
|
410
....*....|....
gi 349579339 482 KVAMVVCYAVMIVL 495
Cdd:COG0738 367 FLVPLVCYLLILLL 380
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
153-277 |
1.94e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.39 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 153 KMLAVFIVIWG-MLLALHAAPTvkYPSFIVLRVLLGCAE-SVVTPCFTIITAQYwkTEEQFTRVSIWFGMNG-LGSILin 229
Cdd:cd17328 65 WILAVGILIWSaATLLSSFAPN--FWQLLLFRALVGIGEaSYSPIAPTIIADLF--PKEKRTRALGVFYFAIpLGSGL-- 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 349579339 230 AIAYGVYIHQdsyAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKAR 277
Cdd:cd17328 139 GYVVGGLVAQ---ATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAA 183
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
159-410 |
5.09e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 159 IVIWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIW-FGMNGLGSILINAIAYGVYI 237
Cdd:COG2211 93 LSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWrFAFAGLGGLLASVLPPPLVA 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 238 HQDSYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKARflskreklmvvqrirsnqqgfgnheiKKYQIIEALKDVRT 317
Cdd:COG2211 173 AFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE--------------------------EKVSLKESLKALLK 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 318 ----WLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAvyaanKKIPfwkyKLSWA 393
Cdd:COG2211 227 nrpfLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA-----KRFG----KKKAF 297
|
250
....*....|....*..
gi 349579339 394 IFAAVLALIASCMLGFA 410
Cdd:COG2211 298 IIGLLLAALGLLLLFFL 314
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
105-273 |
5.14e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 51.89 E-value: 5.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 105 SAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMnlgpvQFIFQRTShmSKMLAVFIVIWGMLLALHA----APTVKYPSFI 180
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVG-----KFISGFLS--DRSNIRRFMSAGLLLSALAnifmGFSTSLWFFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 181 VLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAyGVYIhqdsyAIKGWRTLFVITGVITIF 260
Cdd:cd17312 96 VLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILA-ASLA-----SYYGWRAAFLVPGIVGLV 169
|
170
....*....|...
gi 349579339 261 IGILIFLWIPDDP 273
Cdd:cd17312 170 VAIILFFFLRDSP 182
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
89-270 |
1.31e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 89 MCILYAvqfmDKISTSSAAVmGLRTDLKMHGDQYSWVTSAFYFGYLFMnlgpvQFIFQRTSHM---SKMLAVFIVIWGML 165
Cdd:cd17380 8 TCICYA----DRVNMPIAIV-PMAKEFGWSKTDQGLVLSSFFWGYALT-----QVLGGYLADRfggKKVLLLAVALWSLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 166 LALhaAPTVKYPS---FIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAyGVYIHQDsy 242
Cdd:cd17380 78 TLL--TPLLAYSSlplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIG-PLLLEYY-- 152
|
170 180
....*....|....*....|....*...
gi 349579339 243 aikGWRTLFVitgvitiFIGILIFLWIP 270
Cdd:cd17380 153 ---GWPSVFY-------FFGLLGLLWAL 170
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
207-416 |
4.55e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.00 E-value: 4.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 207 TEEQFTRVSIW-FGMNGLGSILINAIAYGVYIHQDSYAIK----GWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSK 281
Cdd:COG2270 138 TPEEIGRVSGLgWALGYLGGVLLLLINLALFLKPEAFGLPdageAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPR 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 282 REKLMVVQRIRsnqqgfgnheikkyQIIEALKDVRTWLYFLftVSSNIPNGGIS---SFMSILLNSDFGYSSKETLLMGL 358
Cdd:COG2270 218 GAVRAGFRELR--------------RTLRELRRYRDLLRFL--LAYFFYRDGVQtviAFAGIYAAGVLGFSTTELIVFGL 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 349579339 359 PTGAVELVGCPLFGILAVYAANKKipfwkyklswAIFAAVLALIASCMLGFATNSKKA 416
Cdd:COG2270 282 LVQIVAALGALLFGRLDDRIGPKR----------VILVSLVIWIVVCLAAYFLTTALA 329
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
159-412 |
6.23e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.51 E-value: 6.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 159 IVIWGMLL----ALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWF-----GMNG---LGSI 226
Cdd:TIGR00895 84 VLLWSILLfsvfTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFcgypiGAAVggfLAGW 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 227 LINAIaygvyihqdsyaikGWRTLFVITGVITIFIGILIFLWIPDdpsKARFLSKREK---LMVVQRIRSNQQGFGNHEI 303
Cdd:TIGR00895 164 LIPVF--------------GWRSLFYVGGIAPLLLLLLLMRFLPE---SIDFLVSKRPetvRRIVNAIAPQMQAEAQSAL 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 304 --------KKYQIIEALKDVRT-------WLYFLFTVSSNIpngGISSFMSILLnSDFGYSSKETLLMGLPTGAVELVGC 368
Cdd:TIGR00895 227 peqkstqgTKRSVFKALFQGKTaritvllWLLYFMLLVGVY---FLTNWLPKLM-VELGFSLSLAATGGALFNFGGVIGS 302
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 349579339 369 PLFGILAVYaANKKIPFWKYKLSwAIFAAV---------LALIASCMLGFATN 412
Cdd:TIGR00895 303 IIFGWLADR-LGPRVTALLLLLG-AVFAVLvgstlfsptLLLLLGAIAGFFVN 353
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
153-411 |
1.62e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 153 KMLAVFIVIWGMLLALhAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSI-WFGMN---GLGSILI 228
Cdd:cd17475 62 RVLAVGLLLMGAAALL-MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrQTGVPlggALAAALL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 229 NAIAYGVyihqdsyaikGWRTLFVITGVITIFIGILIFLWIPDDPSKARflsKREKLMVVQRIRSnqqgfgnheikkyqi 308
Cdd:cd17475 141 PPLALHY----------GWRAAFVVAGLVSILAAVLFWLFYREPPAASA---ATESASTLLRSLK--------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 309 iEALKDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSsketllmgLPTGAVELVGCPLFGILA----------VYA 378
Cdd:cd17475 193 -EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLS--------VVAAGALLAVAQLGGALGriglgrvsdrVFG 263
|
250 260 270
....*....|....*....|....*....|...
gi 349579339 379 ANKKIPfwkykLSWAIFAAVLALIASCMLGFAT 411
Cdd:cd17475 264 GRRRPV-----LVITAAIAAAALLVLSLLSPGT 291
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
70-267 |
1.72e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 70 TPEEDRKLRWKIdycmFPLMCILYAVQFMDKISTSSAAVmGLRTDLKMHGDQYSWVTSAFYFGYLFMnlgpvQFIFQRTS 149
Cdd:COG0477 4 TDAAPTRRRRRA----LLALALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIG-----LLLFGRLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 150 HM---SKMLAVFIVIWG---MLLALhaAPTVkyPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGL 223
Cdd:COG0477 74 DRygrKRVLLIGLLLFGlasLLCGL--APSP--ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 349579339 224 GSILINAIAYGVyihqdsYAIKGWRTLFVITGVITIFIGILIFL 267
Cdd:COG0477 150 GLALGPLLGGLL------VAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
120-270 |
7.21e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.30 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 120 DQYSWVTSAFYFGYLFMNLgPVQFIFQRTSHMsKMLAVFIVIWGMLLALH-AAPTVKYPSFIVLRVLLGCAESVVTPCFT 198
Cdd:cd17318 56 KTQGIILSSFFYGYILTQI-PGGYLAEKYGAK-RVLGYSILITALLTLLTpLAARGGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 349579339 199 IITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAyGVYIhqDSYaikGWRTLFVITGVITIFIGILIFLWIP 270
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLS-GFLC--ESL---GWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
159-403 |
2.98e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 159 IVIWGMLL--ALHAAPTV--KYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYG 234
Cdd:cd17473 67 LLIAGLLLygIGGVAGLFldSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 235 VyihqdsyAIKGWRTLFVITGV-ITIFIGILIFLWIPDDPSKARFLSKREKLmvvqrirsnqqgfgnheikkyqiiEALK 313
Cdd:cd17473 147 L-------AEIGWRAPFLVYLLaLPVLILVLLFLPEPARKSKSAASPGAATA------------------------AALP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 314 DVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKET-LLMGLPTGAVELVGcPLFGILAvyaanKKIPF-WKYKLS 391
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGA-LLFGRLK-----RRLGKrRLLAIG 269
|
250
....*....|..
gi 349579339 392 WAIFAAVLALIA 403
Cdd:cd17473 270 FALMALGFLLLA 281
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
157-402 |
4.24e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.67 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 157 VFIVIWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVY 236
Cdd:cd17371 68 VITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 237 ihQDSYAIKGWRTLFViTGVITIFIGILIFLWIPDDPskaRFLSKREKLMVVQRIRSNQQGFGnheikkyqiiealKDVR 316
Cdd:cd17371 148 --PLLPPEIAWRVLFL-LGALPALLVLFIRRFVKEPP---QWQAARAARRHFADRPSLRELFS-------------PPLL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 317 --TWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETL--LMGLPTGAveLVGCPLFGILAVYAANKkipfWKYKLSW 392
Cdd:cd17371 209 rtTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAgyLVVTILGG--FLGYLAGGFLADRIGRR----NNFALFA 282
|
250
....*....|
gi 349579339 393 AIFAAVLALI 402
Cdd:cd17371 283 LGSAISILLY 292
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
120-284 |
1.66e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.75 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 120 DQYSWVTSAFYFGYLfmnLGPVQFIFQRTSHMSKMLavfiVIWGM-----LLALHAAPTvKYPSFIVLRVLLGCAeSVVT 194
Cdd:cd06180 34 AQAGWIATANYAGYL---VGALLASFLRRRGRARRL----IRGGLlltvlLLAAMALTS-GFAALLALRFLAGAA-SAFV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 195 PCFTIITAQYWKTEEQFTRVSIW-FGMNGLGSILINAIAYGVYIHQDSyaikgWRTLFVITGVITIFIGILIFLWIPDDP 273
Cdd:cd06180 105 FVFGSNLVLHHATAAGRGHLIGLlFAGVGLGIALSGLLVPAGLGGGLS-----WRAGWLALALLSAVLLLLSFLLLRRGP 179
|
170
....*....|.
gi 349579339 274 SKARFLSKREK 284
Cdd:cd06180 180 SAPTEASAAES 190
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
112-273 |
1.76e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.82 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 112 RTDLKMHGDQYSWV--TSAFYFGYLFMNLGPVQFifqrtshmskmLAVFIVIWGML-LALHAAPTVkyPSFIVLRVLLGC 188
Cdd:TIGR00881 29 KTDLGLLLSSFSIAygISKFVMGSVSDRSNPRVF-----------LPIGLILCAIVnLFFGFSTSL--WVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 189 AESVVTPCFTIITAQYWKTEEQFTRVSIW-FGMNGLGSILINAIAYGVYIHQDsyaikgWRTLFVITGVITIFIGILIFL 267
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIAELYS------WHWVFIVPGIIAIIVSLICFL 169
|
....*.
gi 349579339 268 WIPDDP 273
Cdd:TIGR00881 170 LLRDSP 175
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
195-274 |
1.80e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 40.85 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 195 PCFTIITAQYWKTEEQFtRVSIWFGMNGLGSILINAIAYGVYIHQdsyaikGWRTLFVITGVITIFIGILIFLWIPDDPS 274
Cdd:PRK11663 131 VCAKLLTAWYSRTERGG-WWAIWNTAHNVGGALIPLVVGAIALHY------GWRYGMMIAGIIAIVVGLFLCWRLRDKPQ 203
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
178-322 |
2.57e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 40.29 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 178 SFIVLRVLLGCAESvvtpcfTIITAQYWkTEEQFTRVSI---------WFGMNGLGSILINAIAYGVYIHQDSYAIKGWR 248
Cdd:PLN00028 126 GFIAVRFFIGFSLA------TFVSCQYW-MSTMFNGKIVgtangiaagWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWR 198
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 349579339 249 TLFVITGVITIFIGILIfLWIPDD-PSKARFLSKREKLMVvqrirsnQQGFGNHeikkyqIIEALKDVRTWLYFL 322
Cdd:PLN00028 199 IAFFVPGLLHIIMGILV-LTLGQDlPDGNYRELKKSGTMP-------KDSFSKV------LRYGVTNYRTWILAL 259
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
159-434 |
3.05e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 159 IVIWGMLL----ALHAAPTVKYPSFIVLRVLLG---CAESVVTpcFTIITAQYwkTEEQFTRVsiwFGMNGLGSILINAI 231
Cdd:cd17320 66 VLLAGLLLfilaSLLCALASSIEQLLIARFLQGlgaAAGSVVA--RAIVRDLY--SGAELAKI---FSLLMMILAIAPAL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 232 A--YGVYIhqdsYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRirsnqqgfgnheikkyqii 309
Cdd:cd17320 139 AplLGGLL----LLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYK------------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 310 EALKDVRTWLYFLFTVSSnipNGGISSFMS---ILLNSDFGYSSKE-TLLMGLPTGAVelvgcplfgILAVYAANKKIPF 385
Cdd:cd17320 196 RVLKNRRFLGYALALGLS---FAGLFAYLAaapFIYIEQLGLSPAQfGLLFALNAIAL---------ILGSLLNGRLVRR 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 349579339 386 WKYKLSWAIFAAVLALIASCMLGFAtnskkARLAGAYLWYISPVSFICV 434
Cdd:cd17320 264 FGPRRLLRLGLLLLLAAALVLLLAA-----LLGGLSLWPLVAPLFLIFF 307
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-267 |
3.94e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 57 AMKLAEEAKEIEVTPEEDRKLRWKIDYCMFPLMcILYAVQFMDKISTSSAAVMGL-----RTDLKMHGDQYSWVTSAFYF 131
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPL-LRLLLLALALFALLGGALTVLlpllaKEVLGGGAAGYGLLLAAFGV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 132 GYLFMNLgpVQFIFQRTSHMSKMLAVFIVIWGMLLALHAAPTVKYPSFIVLrVLLGCAESVVTPCFTIItAQYWKTEEQF 211
Cdd:cd06173 256 GALLGAL--LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL-FLLGLAGGLFNVPLNTL-LQLRVPDELR 331
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 349579339 212 TRV-SIWF----GMNGLGSILINAIAYGVyihqdsyaikGWRTLFVITGVITIFIGILIFL 267
Cdd:cd06173 332 GRVfSVYNalnsGAMPLGALLAGLLADAL----------GLSAVFLLAGALLLLAALLLLL 382
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
164-271 |
5.54e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.63 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 164 MLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILinAIAYGVYIhqdsYA 243
Cdd:TIGR00880 39 VLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLL--GPPLGGVL----AQ 112
|
90 100
....*....|....*....|....*...
gi 349579339 244 IKGWRTLFVITGVITIFIGILIFLWIPD 271
Cdd:TIGR00880 113 FLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
164-273 |
8.98e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.76 E-value: 8.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 164 MLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIA-YGVYIhqdsY 242
Cdd:cd17345 83 ILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAgLGLAI----F 158
|
90 100 110
....*....|....*....|....*....|.
gi 349579339 243 AIKGWRTLFVITGVITIFIGILIFLWIPDDP 273
Cdd:cd17345 159 GDGWWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
123-270 |
9.54e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 9.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 349579339 123 SWVTSAFYFGYLFMNL--GPVQFIFQRtshmSKMLAVFIV---IWGMLLALhaAPTvkYPSFIVLRVLLG-CAESVVTPC 196
Cdd:cd17317 28 ALVQTIFFLGVLIGSLlfGYLADRFGR----RPVLLLGLVlqiVCGVLSAF--SPS--YELFLVLRFLVGvTSAGIFTVG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 349579339 197 FTIITAqyWKTEEQFTRVSIWFGMN-GLGSILINAIAygvyihqdsYAIKGWRTLFVITGVITIFIgILIFLWIP 270
Cdd:cd17317 100 FVLGME--IVGPKYRSFVGILFGLFwALGYMLLALLA---------YLIRDWRWLQLAISLPGLLF-LLLLWWLP 162
|
|
| |
