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Conserved domains on  [gi|34878726|ref|NP_919239|]
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T-box transcription factor TBX20 isoform a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 99-288 6.76e-160

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


:

Pssm-ID: 410319  Cd Length: 190  Bit Score: 448.80  E-value: 6.76e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 178
Cdd:cd20193   1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPET 258
Cdd:cd20193  81 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTASLVNLKSEEFRTFIFPET 160

                       170       180       190
                ....*....|....*....|....*....|
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 288
Cdd:cd20193 161 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 319-407 2.74e-05

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam05872:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 503  Bit Score: 46.27  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   319 EDVLGEESQTTQSRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIAT----PIPHPIQGSL--PPYSRLG 392
Cdd:pfam05872 307 DTVLGQLGNRVQHALRAFTPRDQKAVKAAADTFRPNPAFDTEEAITSLGTGEALVSTldekGAPSIVQRTLvrPPASRIG 386

                          90
                  ....*....|....*
gi 34878726   393 mPLTPSAIASSMQGS 407
Cdd:pfam05872 387 -PLTDEERAALVAAS 400
 
Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 99-288 6.76e-160

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 448.80  E-value: 6.76e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 178
Cdd:cd20193   1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPET 258
Cdd:cd20193  81 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTASLVNLKSEEFRTFIFPET 160

                       170       180       190
                ....*....|....*....|....*....|
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 288
Cdd:cd20193 161 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 101-287 3.40e-129

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 370.74  E-value: 3.40e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   101 CSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPA 180
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEPHSPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   181 RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHtasLLNLKSEEFRTFIFPETVF 260
Cdd:pfam00907  79 RVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRVGGD---EPSLPEENVKTFVFPETEF 155

                         170       180
                  ....*....|....*....|....*..
gi 34878726   261 TAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:pfam00907 156 IAVTAYQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
99-290 4.07e-109

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 319.98  E-value: 4.07e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726     99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRyaYHRSSWLVAGKADPPL 178
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYK--FNNGKWVVAGKAEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726    179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGH--IILNSMHKYQPRVHIIKKKDhtasLLNLKSEEFRTFIFP 256
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVEVDD----ISKEILSQFKTFVFP 154

                          170       180       190
                   ....*....|....*....|....*....|....
gi 34878726    257 ETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 290
Cdd:smart00425 155 ETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGR 188
HerA_C pfam05872
Helicase HerA-like C-terminal; HerA is a DNA helicase able to utilize either 3' or 5' ...
 319-407 2.74e-05

Helicase HerA-like C-terminal; HerA is a DNA helicase able to utilize either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus. This entry represents the C-terminal domain of HerA which seems to be involved in the conversion of ATP hydrolysis into DNA translocation.


Pssm-ID: 428657 [Multi-domain]  Cd Length: 503  Bit Score: 46.27  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   319 EDVLGEESQTTQSRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIAT----PIPHPIQGSL--PPYSRLG 392
Cdd:pfam05872 307 DTVLGQLGNRVQHALRAFTPRDQKAVKAAADTFRPNPAFDTEEAITSLGTGEALVSTldekGAPSIVQRTLvrPPASRIG 386

                          90
                  ....*....|....*
gi 34878726   393 mPLTPSAIASSMQGS 407
Cdd:pfam05872 387 -PLTDEERAALVAAS 400
 
Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 99-288 6.76e-160

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 448.80  E-value: 6.76e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 178
Cdd:cd20193   1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPET 258
Cdd:cd20193  81 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTASLVNLKSEEFRTFIFPET 160

                       170       180       190
                ....*....|....*....|....*....|
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 288
Cdd:cd20193 161 VFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 101-287 3.40e-129

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 370.74  E-value: 3.40e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   101 CSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPA 180
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEPHSPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   181 RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHtasLLNLKSEEFRTFIFPETVF 260
Cdd:pfam00907  79 RVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRVGGD---EPSLPEENVKTFVFPETEF 155

                         170       180
                  ....*....|....*....|....*..
gi 34878726   261 TAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:pfam00907 156 IAVTAYQNEEITQLKIDNNPFAKGFRD 182
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 103-287 1.95e-111

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 325.92  E-value: 1.95e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARL 182
Cdd:cd20187   6 LEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRYAFHSSSWLVAGKADPAMPGRI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 183 YVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHII---KKKDHTASLlnlkSEEFRTFIFPETV 259
Cdd:cd20187  86 HVHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVyvdPRKDSENSA----EENFKTFIFPETK 161

                       170       180
                ....*....|....*....|....*...
gi 34878726 260 FTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20187 162 FTAVTAYQNHRITQLKIASNPFAKGFRD 189
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
99-290 4.07e-109

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 319.98  E-value: 4.07e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726     99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRyaYHRSSWLVAGKADPPL 178
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYK--FNNGKWVVAGKAEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726    179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGH--IILNSMHKYQPRVHIIKKKDhtasLLNLKSEEFRTFIFP 256
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVEVDD----ISKEILSQFKTFVFP 154

                          170       180       190
                   ....*....|....*....|....*....|....
gi 34878726    257 ETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 290
Cdd:smart00425 155 ETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGR 188
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 99-287 1.31e-108

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 318.61  E-value: 1.31e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPL 178
Cdd:cd20189   1 IKVFLENRELWQKFHEVGTEMIITKAGRRMFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKF--HDSEWVVAGKAEPAM 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTAslLNLKSEEFRTFIFPET 258
Cdd:cd20189  79 PGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDQFGHIILNSMHKYQPRIHIVQADDNNA--FGSKNTAFSTHVFPET 156

                       170       180
                ....*....|....*....|....*....
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20189 157 AFIAVTAYQNHQITQLKIENNPFAKGFRG 185
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 102-287 6.85e-106

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 311.67  E-value: 6.85e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 102 SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNkrYRYAYHRSSWLVAGKADPPLPAR 181
Cdd:cd20188   6 ELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADD--CRYKFHNSRWMVAGKADPEMPKR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 182 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDhtasLLNLKSEEFRTFIFPETVFT 261
Cdd:cd20188  84 MYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRAND----ILKLPYSTFRTYVFKETEFI 159

                       170       180
                ....*....|....*....|....*.
gi 34878726 262 AVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20188 160 AVTAYQNEKITQLKIDNNPFAKGFRD 185
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 103-287 1.41e-104

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 308.74  E-value: 1.41e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARL 182
Cdd:cd20191   7 LQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNADAPVPPRV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 183 YVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHT---ASLLNLKSEEFRTFIFPETV 259
Cdd:cd20191  87 YIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTdlsPKKPVPPGEGVKTFSFPETV 166

                       170       180
                ....*....|....*....|....*...
gi 34878726 260 FTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20191 167 FTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 99-287 1.48e-95

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 285.44  E-value: 1.48e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPL 178
Cdd:cd20682   1 IQVELCSRELWLQFHNLGNEMIITKAGRRMFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRYVYHSSKWVVAGSGDVLP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNN-ELDQHGHIILNSMHKYQPRVHIIK-KKDHTASLLNLKSEEFRTFIFP 256
Cdd:cd20682  81 PANRYIHPDSPASGKYWMSQIVSFDKLKLTNNkEPKQKGQISLHSMHKYQPRIHIQPvEDDGRNVEKAINSSKALSFEFP 160

                       170       180       190
                ....*....|....*....|....*....|.
gi 34878726 257 ETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20682 161 ETSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 99-287 4.43e-94

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 281.34  E-value: 4.43e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNkrYRYAYHRSSWLVAGKADPPL 178
Cdd:cd20197   1 VRASLEDQDLWKKFHQIGTEMIITKSGRRMFPQCKIRVSGLLPYAKYVMLVDFVPVDN--FRYKWNKDQWEVAGKAEPQP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDhtasLLNLKSEEFRTFIFPET 258
Cdd:cd20197  79 PCRTYVHPDSPAPGSHWMKQPISFQKLKLTNNTLDQHGHIILHSMHRYQPRFHIVQADD----LFNVRWSLFQVFSFPET 154

                       170       180
                ....*....|....*....|....*....
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20197 155 VFTAVTAYQNEKITKLKIDNNPFAKGFRE 183
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 98-287 2.04e-92

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 277.57  E-value: 2.04e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  98 KIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPP 177
Cdd:cd20200   2 KVQVELQGSELWKRFHEIGTEMIITKAGRRMFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGNTDHS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 178 -LPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDH--TASLLNLKSEEFRTFI 254
Cdd:cd20200  82 cITPRLYVHPDSPCSGETWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYKPRVHVILQDSRfdLSQIQSLPAEGVKTFS 161

                       170       180       190
                ....*....|....*....|....*....|...
gi 34878726 255 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20200 162 FPETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 97-287 1.40e-90

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 273.08  E-value: 1.40e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  97 AKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADP 176
Cdd:cd20199   2 EEVRVDLQGADLWKRFHEIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 177 PLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIkKKDHTASLLNLKS----EEFRT 252
Cdd:cd20199  82 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVI-RKECGEELSPVKPipsgEGVKA 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 34878726 253 FIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20199 161 FSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 96-287 3.11e-88

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 266.98  E-value: 3.11e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  96 MAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKAD 175
Cdd:cd20198   4 MEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNAD 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 176 PPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIkKKDHTASLLNLK----SEEFR 251
Cdd:cd20198  84 SPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVI-RKDFSSDLSPTKpvptGDGVK 162

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 34878726 252 TFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20198 163 TFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 103-287 1.05e-87

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 265.35  E-value: 1.05e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAyHRSSWLVAGKADP--PLPA 180
Cdd:cd20681   5 LKNRDLWQQFHREGTEMIITKSGRRMFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYS-GNGGWVPAGGAEPqpPLPR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 181 RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKkkdhTASLLNLKSEEFRTFIFPETVF 260
Cdd:cd20681  84 RIYIHPDSPATGDHWMSQPISFSKVKLTNNTLDPQGNIVLTSMHKYQPRIHIVR----CSDTLALPWAPTASFTFPETEF 159

                       170       180
                ....*....|....*....|....*..
gi 34878726 261 TAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20681 160 IAVTAYQNERITKLKIDNNPFAKGFRE 186
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 99-287 9.72e-87

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 262.51  E-value: 9.72e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPL 178
Cdd:cd20190   1 VSLSLEDRELWKEFSSVGTEMIITKSGRRMFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKW--NKRRWEPSGKAEPHL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDhtasLLNLKSEEFRTFIFPET 258
Cdd:cd20190  79 PDRVYIHPDSPAPGAHWMRQPISFHKLKLTNNTLDPHGHLILHSMHKYQPRIHLVQSAD----LCSQHWGGMASFRFPET 154

                       170       180
                ....*....|....*....|....*....
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20190 155 TFIAVTAYQNPQITKLKIAANPFAKGFRE 183
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 99-279 6.04e-86

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 260.22  E-value: 6.04e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRyaYHRSSWLVAGKADPPL 178
Cdd:cd00182   1 ITVSLRNEELWKKFHELGTEMIVTKSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYK--FNNGKWVPSGKAEPPP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 -PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNN-ELDQHGHIILNSMHKYQPRVHIIKKKDHTASllnlkSEEFRTFIFP 256
Cdd:cd00182  79 ePSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNkEDKKEGHILLHSMHKYIPVLTIYEVDDNGLL-----SKLVKEFRFP 153

                       170       180
                ....*....|....*....|...
gi 34878726 257 ETVFTAVTAYQNQLITKLKIDSN 279
Cdd:cd00182 154 ETEFIAVTAYQNDEITQLKIDNN 176
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 102-287 3.34e-83

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 253.64  E-value: 3.34e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 102 SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPAR 181
Cdd:cd20196   4 SLENAELWKQFSSVGTEMIITKAGRRMFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRW--QGNSWEASGKAEPRLPDR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 182 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSeefrtFIFPETVFT 261
Cdd:cd20196  82 VYIHPDSPATGAHWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQPRVHVVRARDVLSWGGGCAS-----FTFPETQFI 156

                       170       180
                ....*....|....*....|....*.
gi 34878726 262 AVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20196 157 TVTAYQNPKITQLKINSNPFAKGFRE 182
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 102-287 3.77e-82

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 250.64  E-value: 3.77e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 102 SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAyhRSSWLVAGKADPPLPAR 181
Cdd:cd20192   4 TLEDRELWKKFHSLTNEMIVTKSGRRMFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYV--NGEWVPGGKAEPPPPSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 182 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNeLDQHGHIILNSMHKYQPRVHIIKKKDHTasllnlKSEEFRTFIFPETVFT 261
Cdd:cd20192  82 VYVHPDSPNFGAHWMKGPVSFSKVKLTNK-PNGEGQIMLNSLHKYEPRVHIVRVGSNN------HERLVSTFSFPETQFI 154

                       170       180
                ....*....|....*....|....*.
gi 34878726 262 AVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20192 155 AVTAYQNEEITALKIKYNPFAKAFLD 180
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 99-287 1.89e-79

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 244.27  E-value: 1.89e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  99 IACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPL 178
Cdd:cd20195   1 ITVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRW--NGRWWEPSGKAEPHV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 179 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIkKKDHTASLLNLKSEEFRTFIFPET 258
Cdd:cd20195  79 LGRVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVV-PADKEVDVIQLNGPDVHTFTFPQT 157

                       170       180
                ....*....|....*....|....*....
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20195 158 EFFAVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 98-287 7.39e-70

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 219.27  E-value: 7.39e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  98 KIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPP 177
Cdd:cd20194   1 KASVYLCNRDLWLKFHQHQTEMIITKQGRRMFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKF--QSGKWVPCGKAEGL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 178 LPA-RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASllnlKSEEFRTFIFP 256
Cdd:cd20194  79 PQGnRVYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVLNSMHKYQPRIHVIEVGGNGPN----EQRNLQTHSFP 154

                       170       180       190
                ....*....|....*....|....*....|.
gi 34878726 257 ETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20194 155 ETQFIAVTAYQNTDITQLKIDHNPFAKGFRD 185
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 98-287 5.14e-64

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 204.12  E-value: 5.14e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  98 KIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAyhRSSWLVAGKADPP 177
Cdd:cd20202   1 ELKVSLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYV--NGEWVPGGKPEPQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 178 LPARLYVHPDSPFTGEQLLKQMVSFEKVKLTnNELDQHGHIILNSMHKYQPRVHIIKKKDhTASLLNLKSeefrtfiFPE 257
Cdd:cd20202  79 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLT-NKLNGGGQIMLNSLHKYEPRIHIVRVGG-PQRMITSHS-------FPE 149

                       170       180       190
                ....*....|....*....|....*....|
gi 34878726 258 TVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20202 150 TQFIAVTAYQNEEITALKIKYNPFAKAFLD 179
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 98-287 3.97e-63

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 202.50  E-value: 3.97e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  98 KIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRyaYHRSSWLVAGKADPP 177
Cdd:cd20203   1 KLQVLLNNHPLWSKFHKHQTEMIITKQGRRMFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWR--YQGGKWVQCGKAEGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 178 LPA-RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHG---HIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEfRTF 253
Cdd:cd20203  79 MPGnRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNvtqMIVLQSLHKYQPRLHIVEVKEGETEEAYSSSKT-HTF 157

                       170       180       190
                ....*....|....*....|....*....|....
gi 34878726 254 IFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20203 158 TFPETQFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 92-287 9.12e-61

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 196.02  E-value: 9.12e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726  92 PSEEMAKIacSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAyhRSSWLVA 171
Cdd:cd20201   1 PTEKQLQV--SLEDAELWQRFKEVTNEMIVTKNGRRMFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYV--NGEWVPA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 172 GKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTnNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKseefr 251
Cdd:cd20201  77 GKPEPHSHSCVYIHPDSPNFGAHWMKAPISFSKVKLT-NKLNGGGQIMLNSLHKYEPQIHIVRVGGPHRMVTNCS----- 150

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 34878726 252 tfiFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20201 151 ---FPETQFIAVTAYQNEEITALKIKYNPFAKAFLD 183
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 103-288 1.07e-56

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 186.45  E-value: 1.07e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAyhRSSWLVAGK---ADPPLP 179
Cdd:cd20683   5 LEDADLWAQFHSVQNEMIITKSGRCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFR--NGRWNPIDKdqrGDDAFS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 180 A----------RLYVHPDSPFTGEQLLKQMVSFEKVKLTNNEL------------------DQHGHIILNSMHKYQPRVH 231
Cdd:cd20683  83 SgtadksvllpESYIHPDGPQTGAFWMANGISFAKIKLSNRQPnssdrdgpkenitnsisaLPDGHFFLTSFHKYQPRLH 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 34878726 232 IIKKKDHTASLLNLKseefrTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 288
Cdd:cd20683 163 LIQHSAGDHDDILST-----TFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 103-287 6.17e-55

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 181.03  E-value: 6.17e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPA-R 181
Cdd:cd20205   6 LCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRF--QGGKWVTCGKADNNMQGnK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 182 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNE---LDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEfRTFIFPET 258
Cdd:cd20205  84 VYVHPESPNTGAHWMRQEISFGKLKLTNNKganNNNTQMIVLQSLHKYQPRLHIVEVSEDGVEDLNDSSKT-QTFTFPEN 162

                       170       180
                ....*....|....*....|....*....
gi 34878726 259 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20205 163 QFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 103-287 1.60e-53

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 177.62  E-value: 1.60e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 103 LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPA-R 181
Cdd:cd20204   6 LCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRF--QGGKWVPCGKADTNVQGnR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726 182 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNE--LDQHGH-IILNSMHKYQPRVHIIK-KKDHTASllNLKSEEFRTFIFPE 257
Cdd:cd20204  84 VYMHPDSPNTGAHWMRQEISFGKLKLTNNKgaSNNNGQmVVLQSLHKYQPRLHVVEvNEDGTED--TSQPGRVQTFTFPE 161

                       170       180       190
                ....*....|....*....|....*....|
gi 34878726 258 TVFTAVTAYQNQLITKLKIDSNPFAKGFRD 287
Cdd:cd20204 162 TQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
HerA_C pfam05872
Helicase HerA-like C-terminal; HerA is a DNA helicase able to utilize either 3' or 5' ...
 319-407 2.74e-05

Helicase HerA-like C-terminal; HerA is a DNA helicase able to utilize either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus. This entry represents the C-terminal domain of HerA which seems to be involved in the conversion of ATP hydrolysis into DNA translocation.


Pssm-ID: 428657 [Multi-domain]  Cd Length: 503  Bit Score: 46.27  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878726   319 EDVLGEESQTTQSRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIAT----PIPHPIQGSL--PPYSRLG 392
Cdd:pfam05872 307 DTVLGQLGNRVQHALRAFTPRDQKAVKAAADTFRPNPAFDTEEAITSLGTGEALVSTldekGAPSIVQRTLvrPPASRIG 386

                          90
                  ....*....|....*
gi 34878726   393 mPLTPSAIASSMQGS 407
Cdd:pfam05872 387 -PLTDEERAALVAAS 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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