|
Name |
Accession |
Description |
Interval |
E-value |
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
1-391 |
4.43e-177 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 502.36 E-value: 4.43e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAELRRP 80
Cdd:COG0514 30 LAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAA---GIRAAFLNSSLSAEERREVLRALRAG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 vpSLKLLYLTPEKIVkSAEMADLLQTLYrnkmLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:COG0514 107 --ELKLLYVAPERLL-NPRFLELLRRLK----ISLFAIDEAHCISQWGHDFRPDYRRLGELRERLPNVPVLALTATATPR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFNRQNLTFEVRDKPlgsDVKAMEALYELISKTypRDAVGIVYCMTKQDSEDVANYLFDRG 240
Cdd:COG0514 180 VRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKP---PDDKLAQLLDFLKEH--PGGSGIVYCLSRKKVEELAEWLREAG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 241 LSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:COG0514 255 IRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLY 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 348679514 321 SARDISKMRSilFMPQKGMTKQTRAVHMEKLRAMAEYCEdDTTCRRQQLISYFGQKFQrSDCNRtCDNCRR 391
Cdd:COG0514 335 GPEDVAIQRF--FIEQSPPDEERKRVERAKLDAMLAYAE-TTGCRRQFLLRYFGEELA-EPCGN-CDNCLG 400
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
1-392 |
6.72e-162 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 463.09 E-value: 6.72e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAELRrp 80
Cdd:TIGR00614 24 LLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQAL---GIPATFLNSAQTKEQQLNVLTDLK-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 VPSLKLLYLTPEKIVKSAemaDLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:TIGR00614 99 DGKIKLLYVTPEKISASN---RLLQTLEERKGITLIAVDEAHCISQWGHDFRPDYKALGSLKQKFPNVPVMALTATASPS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFNRQNLTFEVRDKPlgsdVKAMEALYELISKTYPRDAvGIVYCMTKQDSEDVANYLFDRG 240
Cdd:TIGR00614 176 VREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKT----PKILEDLLRFIRKEFEGKS-GIIYCPSRKKVEQVAAELQKLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 241 LSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:TIGR00614 251 LAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECHLFY 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348679514 321 SARDISKMRSILFMPQKGMTKQtravHMEKLRAMAEYCEDDTTCRRQQLISYFGQKFQRSD-----CNRTCDNCRRT 392
Cdd:TIGR00614 331 APADMNRLRRLLMEEPDGNFRT----YKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNKSfcimgTEKCCDNCCKR 403
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
1-389 |
3.45e-133 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 394.05 E-value: 3.45e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAELRRP 80
Cdd:TIGR01389 26 LDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAA---GVAAAYLNSTLSAKEQQDIEKALVNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 vpSLKLLYLTPEKIvksaEMADLLQTLYRNKmLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:TIGR01389 103 --ELKLLYVAPERL----EQDYFLNMLQRIP-IALVAVDEAHCVSQWGHDFRPEYQRLGSLAERFPQVPRIALTATADAE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFNRQNLTFEVRDKPLGSDvkameALYELISKTypRDAVGIVYCMTKQDSEDVANYLFDRG 240
Cdd:TIGR01389 176 TRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQK-----FLLDYLKKH--RGQSGIIYASSRKKVEELAERLESQG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 241 LSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:TIGR01389 249 ISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGNLESYYQEAGRAGRDGLPAEAILLY 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 348679514 321 SARDISKMRSilFMPQKGMTKQTRAVHMEKLRAMAEYCEdDTTCRRQQLISYFGQKFQrSDCNRtCDNC 389
Cdd:TIGR01389 329 SPADIALLKR--RIEQSEADDDYKQIEREKLRAMIAYCE-TQTCRRAYILRYFGENEV-EPCGN-CDNC 392
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
1-393 |
1.41e-131 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 406.20 E-value: 1.41e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQnpgCGIPAAFLTSQTALTLKRSITAELRRP 80
Cdd:PLN03137 473 MSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMNLLQ---ANIPAASLSAGMEWAEQLEILQELSSE 549
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 VPSLKLLYLTPEKIVKSAEMADLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:PLN03137 550 YSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQWGHDFRPDYQGLGILKQKFPNIPVLALTATATAS 629
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFNRQNLTFEVRDKplgsDVKAMEALYELISKTYpRDAVGIVYCMTKQDSEDVANYLFDRG 240
Cdd:PLN03137 630 VKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPK----TKKCLEDIDKFIKENH-FDECGIIYCLSRMDCEKVAERLQEFG 704
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 241 LSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:PLN03137 705 HKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYY 784
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 321 SARDISKMR----------SILFMPQKGMTKQTRAV--HMEKLRAMAEYCEDDTTCRRQQLISYFGQKFQRSDCNRTCDN 388
Cdd:PLN03137 785 SYSDYIRVKhmisqggveqSPMAMGYNRMASSGRILetNTENLLRMVSYCENEVDCRRFLQLVHFGEKFDSTNCKKTCDN 864
|
....*
gi 348679514 389 CRRTQ 393
Cdd:PLN03137 865 CSSSK 869
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
3-389 |
2.34e-118 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 356.72 E-value: 2.34e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAELRRPvp 82
Cdd:PRK11057 40 GRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLAN---GVAAACLNSTQTREQQLEVMAGCRTG-- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 83 SLKLLYLTPEKIVksaeMADLLQTLYRNKmLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPKVI 162
Cdd:PRK11057 115 QIKLLYIAPERLM----MDNFLEHLAHWN-PALLAVDEAHCISQWGHDFRPEYAALGQLRQRFPTLPFMALTATADDTTR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 163 QGVQRSLKISNGPVFSMSFNRQNLTFEVRDKplgsdVKAMEALYELISKTypRDAVGIVYCMTKQDSEDVANYLFDRGLS 242
Cdd:PRK11057 190 QDIVRLLGLNDPLIQISSFDRPNIRYTLVEK-----FKPLDQLMRYVQEQ--RGKSGIIYCNSRAKVEDTAARLQSRGIS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 243 ADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFYSA 322
Cdd:PRK11057 263 AAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDP 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348679514 323 RDISKMRSILFMPQKGMTKQtraVHMEKLRAMAEYCEDDtTCRRQQLISYFGQKFQRSdcnrtCDNC 389
Cdd:PRK11057 343 ADMAWLRRCLEEKPAGQQQD---IERHKLNAMGAFAEAQ-TCRRLVLLNYFGEGRQEP-----CGNC 400
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
1-182 |
2.05e-90 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 270.94 E-value: 2.05e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAELRRP 80
Cdd:cd17920 25 LAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQL---GIRAAALNSTLSPEEKREVLLRIKNG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 vpSLKLLYLTPEKIVkSAEMADLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:cd17920 102 --QYKLLYVTPERLL-SPDFLELLQRLPERKRLALIVVDEAHCVSQWGHDFRPDYLRLGRLRRALPGVPILALTATATPE 178
|
170 180
....*....|....*....|..
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFN 182
Cdd:cd17920 179 VREDILKRLGLRNPVIFRASFD 200
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
3-182 |
1.26e-85 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 259.37 E-value: 1.26e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQnpgCGIPAAFLTSQTALTLKRSITAELRRPVP 82
Cdd:cd18016 32 GEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTS---LDIPATYLTGDKTDAEATKIYLQLSKKDP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 83 SLKLLYLTPEKIVKSAEMADLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPKVI 162
Cdd:cd18016 109 IIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPDYKRLNMLRQKFPSVPMMALTATATPRVQ 188
|
170 180
....*....|....*....|
gi 348679514 163 QGVQRSLKISNGPVFSMSFN 182
Cdd:cd18016 189 KDILNQLKMLRPQVFTMSFN 208
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
1-182 |
5.07e-78 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 239.96 E-value: 5.07e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQnpgCGIPAAFLTSQTALTLKRSITAELRRP 80
Cdd:cd18015 31 MAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKK---LGISATMLNASSSKEHVKWVHAALTDK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 81 VPSLKLLYLTPEKIVKSAEMADLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPK 160
Cdd:cd18015 108 NSELKLLYVTPEKIAKSKRFMSKLEKAYNAGRLARIAIDEVHCCSQWGHDFRPDYKKLGILKRQFPNVPILGLTATATSK 187
|
170 180
....*....|....*....|..
gi 348679514 161 VIQGVQRSLKISNGPVFSMSFN 182
Cdd:cd18015 188 VLKDVQKILCIQKCLTFTASFN 209
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
2-171 |
9.46e-62 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 197.69 E-value: 9.46e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 2 RGEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQnpgCGIPAAFLTSQTALTLKRSITAELRRPV 81
Cdd:cd18014 28 GNKDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKT---LKIRVDSLNSKLSAQERKRIIADLESEK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 82 PSLKLLYLTPEKiVKSAEMADLLQTLYRNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPKV 161
Cdd:cd18014 105 PQTKFLYITPEM-AATSSFQPLLSSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRYGHVPWVALTATATPQV 183
|
170
....*....|
gi 348679514 162 IQGVQRSLKI 171
Cdd:cd18014 184 QEDIFAQLRL 193
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
183-320 |
1.05e-59 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 190.11 E-value: 1.05e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 183 RQNLTFEVRDKPLgsdvKAMEALYELISKTYPRDAVGIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQEAW 262
Cdd:cd18794 1 RPNLFYSVRPKDK----KDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKW 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 348679514 263 QNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:cd18794 77 LRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
1-182 |
5.05e-54 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 177.83 E-value: 5.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVL----SPGVTIVVSPLLSLIQDQVTALIQnpgcGIPAAFLTSQTALTLKRSITAE 76
Cdd:cd18018 25 LSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDALPR----AIKAAALNSSLTREERRRILEK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 77 LRRPvpSLKLLYLTPEKIVKSAEMADLLQTlyrnKMLARFVIDEAHCVSQWGHDFRPEYSQLG-MLKKTFPNVPLMALTA 155
Cdd:cd18018 101 LRAG--EVKILYVSPERLVNESFRELLRQT----PPISLLVVDEAHCISEWSHNFRPDYLRLCrVLRELLGAPPVLALTA 174
|
170 180
....*....|....*....|....*..
gi 348679514 156 TAPPKVIQGVQRSLKISNGPVFSMSFN 182
Cdd:cd18018 175 TATKRVVEDIASHLGIPESGVVRGPLY 201
|
|
| DpdF |
NF041063 |
protein DpdF; |
11-331 |
7.26e-54 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 190.89 E-value: 7.26e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 11 PTGGGKSLCYQLPAVLSP---GVTIVVSPLLSLIQDQ---VTALIQNPGCGIPAAF-LTSQTALTLKRSITAELRRPvpS 83
Cdd:NF041063 166 PTGSGKSLVAQAPALLASrqgGLTLVVVPTVALAIDQerrARELLRRAGPDLGGPLaWHGGLSAEERAAIRQRIRDG--T 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 84 LKLLYLTPEKIVKSaemadLLQTLY---RNKMLARFVIDEAHCVSQWGHDFRPEYSQLG-----MLKKTFPNVPL--MAL 153
Cdd:NF041063 244 QRILFTSPESLTGS-----LRPALFdaaEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAglrrsLLRLAPSGRPFrtLLL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 154 TATAPPKVIQ------GVQRSLKISNGpvfsmSFNRQNLTFEVRDKPlGSDVK---AMEALYELisktyPRDAvgIVYCM 224
Cdd:NF041063 319 SATLTESTLDtletlfGPPGPFIVVSA-----VQLRPEPAYWVAKCD-SEEERrerVLEALRHL-----PRPL--ILYVT 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 225 TKQDSEDVANYLFDRGLS--ADFyHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQ 302
Cdd:NF041063 386 KVEDAEAWLQRLRAAGFRrvALF-HGDTPDAERERLIEQWRENELDIVVATSAFGLGMDKSDVRTVIHACVPETLDRFYQ 464
|
330 340
....*....|....*....|....*....
gi 348679514 303 EAGRAGRDGKPSQCIIFYSARDISKMRSI 331
Cdd:NF041063 465 EVGRGGRDGKASLSLLIYTPDDLDIAKSL 493
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
3-182 |
1.34e-48 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 163.41 E-value: 1.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAVLSPGVTIVVSPLLSLIQDQVTALIQNpgcGIPAAFLTSQTALTLKRSITAElrrpvp 82
Cdd:cd18017 28 RRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMS---NIPACFLGSAQSQNVLDDIKMG------ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 83 SLKLLYLTPEKIVKSAEmadLLQTLyrNKMLARFVIDEAHCVSQWGHDFRPEYSQLGMLKKTFPNVPLMALTATAPPKVI 162
Cdd:cd18017 99 KIRVIYVTPEFVSKGLE---LLQQL--RNGITLIAIDEAHCVSQWGHDFRSSYRHLGSIRNRLPNVPIVALTATATPSVR 173
|
170 180
....*....|....*....|
gi 348679514 163 QGVQRSLKISNGPVFSMSFN 182
Cdd:cd18017 174 DDIIKNLNLRNPQITCTSFD 193
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
1-161 |
9.81e-25 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 99.24 E-value: 9.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAV------LSPGVTIVVSPLLSLIQDQVTALIQ-NPGCGIPAAFLTSQTALTLKRSi 73
Cdd:pfam00270 12 LEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKlGKGLGLKVASLLGGDSRKEQLE- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 74 taELRRPvpslKLLYLTPEKIVKSAEMADLLQTLyrnKMLarfVIDEAHCVSQWGhdFRPEYSQlgMLKKTFPNVPLMAL 153
Cdd:pfam00270 91 --KLKGP----DILVGTPGRLLDLLQERKLLKNL---KLL---VLDEAHRLLDMG--FGPDLEE--ILRRLPKKRQILLL 154
|
....*...
gi 348679514 154 TATAPPKV 161
Cdd:pfam00270 155 SATLPRNL 162
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
323-390 |
6.23e-20 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 82.72 E-value: 6.23e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348679514 323 RDISKMRSilFMPQKGMTKQTRAVHMEKLRAMAEYCEDDTTCRRQQLISYFGQKFQRSDCNrTCDNCR 390
Cdd:pfam16124 2 QDVVRLRF--LIEQSEADEERKEVELQKLQAMVAYCENTTDCRRKQLLRYFGEEFDSEPCG-NCDNCL 66
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
230-311 |
3.39e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 78.41 E-value: 3.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 230 EDVANYLFDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGR 309
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 348679514 310 DG 311
Cdd:smart00490 81 AG 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
2-191 |
1.69e-17 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 80.23 E-value: 1.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 2 RGEDCFVLMPTGGGKSLCYQLPAVL-----SPGVTIVVSPLLSLIQDQVTALIQ--NPGCGIPAAFLTSQTaltlKRSIT 74
Cdd:smart00487 23 GLRDVILAAPTGSGKTLAALLPALEalkrgKGGRVLVLVPTRELAEQWAEELKKlgPSLGLKVVGLYGGDS----KREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 75 AELRRPVPslKLLYLTPEKIVKsaemaDLLQTLYRNKMLARFVIDEAHCVSQWGhdFRPEYsqLGMLKKTFPNVPLMALT 154
Cdd:smart00487 99 RKLESGKT--DILVTTPGRLLD-----LLENDKLSLSNVDLVILDEAHRLLDGG--FGDQL--EKLLKLLPKNVQLLLLS 167
|
170 180 190
....*....|....*....|....*....|....*..
gi 348679514 155 ATAPPKVIQGVQRSLkisNGPVFSMSFNRQNLTFEVR 191
Cdd:smart00487 168 ATPPEEIENLLELFL---NDPVFIDVGFTPLEPIEQF 201
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
202-311 |
3.39e-17 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 76.48 E-value: 3.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 202 MEALYELISKTYPRDAvgIVYCMTKQDSEdvANYLFDR-GLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGI 280
Cdd:pfam00271 3 LEALLELLKKERGGKV--LIFSQTKKTLE--AELLLEKeGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 348679514 281 NKPDVRYVIHFSVAKSIEGYYQEAGRAGRDG 311
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
3-156 |
8.45e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 71.28 E-value: 8.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAVLS----PGVTIVVSPLLSLIQDQVTALIQNPGCGIPAAFLTSQTALTLKRSITAelr 78
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLllkkGKKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGGSSAEEREKNKL--- 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348679514 79 rpvPSLKLLYLTPEKIVKSAEMADLLQTlyrnKMLARFVIDEAHCVSQWGHDFRPEYSQLgmLKKTFPNVPLMALTAT 156
Cdd:cd00046 78 ---GDADIIIATPDMLLNLLLREDRLFL----KDLKLIIVDEAHALLIDSRGALILDLAV--RKAGLKNAQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
2-332 |
2.25e-13 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 71.59 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 2 RGEDCFVL-MPTGGGKSL----CYQlpAVLSPGVTIVVSPLLSLIqdqvtaliqnpgcgipaafltSQTALTLKRsitae 76
Cdd:COG1061 98 RGGGRGLVvAPTGTGKTVlalaLAA--ELLRGKRVLVLVPRRELL---------------------EQWAEELRR----- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 77 lrrpvpslkLLYLTPEKIVKSAEMADLL----QTLYRNKMLARF-------VIDEAHcvsqwgHDFRPEYSQlgmLKKTF 145
Cdd:COG1061 150 ---------FLGDPLAGGGKKDSDAPITvatyQSLARRAHLDELgdrfglvIIDEAH------HAGAPSYRR---ILEAF 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 146 PNVPLMALTATapPKVIQGVQRSLKISNGPVFSMSFNRQ-------NLTFEVRDKPLGSDVKAMEALYELISK------- 211
Cdd:COG1061 212 PAAYRLGLTAT--PFRSDGREILLFLFDGIVYEYSLKEAiedgylaPPEYYGIRVDLTDERAEYDALSERLREalaadae 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 212 -----------TYPRDAVGIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGI 280
Cdd:COG1061 290 rkdkilrellrEHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGV 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 348679514 281 NKPDVRYVIHFSVAKSIEGYYQEAGRA--GRDGKpSQCIIF-YSARDISKMRSIL 332
Cdd:COG1061 370 DVPRLDVAILLRPTGSPREFIQRLGRGlrPAPGK-EDALVYdFVGNDVPVLEELA 423
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
116-331 |
3.41e-13 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 70.56 E-value: 3.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 116 FVIDEAhcvsqwghD------FRPEYSQLgmLKKTFPNVPLMALTATAPPKVIQGVQRSLkisNGPVFsMSFNRQNLT-- 187
Cdd:COG0513 149 LVLDEA--------DrmldmgFIEDIERI--LKLLPKERQTLLFSATMPPEIRKLAKRYL---KNPVR-IEVAPENATae 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 188 ------FEV--RDKplgsdvkaMEALYELIsKTYPRDAVgIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQ 259
Cdd:COG0513 215 tieqryYLVdkRDK--------LELLRRLL-RDEDPERA-IVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERAL 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 348679514 260 EAWQNGQLSIVCAT-IAyGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFYSARDISKMRSI 331
Cdd:COG0513 285 DAFRNGKIRVLVATdVA-ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAI 356
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
220-314 |
3.07e-10 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 58.04 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 220 IVYCMTKQDSEDVANYLFDRGLSADF-------YHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFS 292
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKARLVEEGPlaskvasYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|..
gi 348679514 293 VAKSIEGYYQEAGRAGRDGKPS 314
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDS 140
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
1-324 |
4.06e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 61.78 E-value: 4.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPaVLS-----PGVT-IVVSPLLSLIQDQV---TALIQNPGCGIPAAFLTSQTALTLKR 71
Cdd:COG1205 69 RAGKNVVIATPTASGKSLAYLLP-VLEalledPGATaLYLYPTKALARDQLrrlRELAEALGLGVRVATYDGDTPPEERR 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 72 SItaeLRRPvpslKLLYLTPekivksaemaDLLQT--LYRNKMLARF-------VIDEAHcvsqwghdfrpEY-----SQ 137
Cdd:COG1205 148 WI---REHP----DIVLTNP----------DMLHYglLPHHTRWARFfrnlryvVIDEAH-----------TYrgvfgSH 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 138 LGML-------------KKTFpnvplMALTATappkviqgvqrslkISNGPVFSmsfnrQNLT---FEVRDK-------- 193
Cdd:COG1205 200 VANVlrrlrricrhygsDPQF-----ILASAT--------------IGNPAEHA-----ERLTgrpVTVVDEdgsprger 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 194 -------PLGSDVKAMEALYE---LISKTYPRDAVGIVYCMTKQDSEDVANYLFDRGLSADF------YHAGQSATDRHM 257
Cdd:COG1205 256 tfvlwnpPLVDDGIRRSALAEaarLLADLVREGLRTLVFTRSRRGAELLARYARRALREPDLadrvaaYRAGYLPEERRE 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 348679514 258 VQEAWQNGQLSIVCATIAYGMGINKPDVRYVIhfsvaksIEGY-------YQEAGRAGRDGKPSqcIIFYSARD 324
Cdd:COG1205 336 IERGLRSGELLGVVSTNALELGIDIGGLDAVV-------LAGYpgtrasfWQQAGRAGRRGQDS--LVVLVAGD 400
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
200-320 |
5.84e-10 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 56.75 E-value: 5.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 200 KAMEALYELISKTYPRDAvgIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCAT-IAyGM 278
Cdd:cd18787 13 KKLLLLLLLLEKLKPGKA--IIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVATdVA-AR 89
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 348679514 279 GINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFY 320
Cdd:cd18787 90 GLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
266-320 |
3.14e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 53.09 E-value: 3.14e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 348679514 266 QLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGK-PSQCIIFY 320
Cdd:cd18785 22 SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKdEGEVILFV 77
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
205-331 |
1.04e-08 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 56.76 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 205 LYELISKTYprdavGIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPD 284
Cdd:PTZ00424 261 LYETLTITQ-----AIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQ 335
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 348679514 285 VRYVIHFSVAKSIEGYYQEAGRAGRDGKPSQCIIFYSARDISKMRSI 331
Cdd:PTZ00424 336 VSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
2-122 |
1.98e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 53.74 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 2 RGEDCFVLMPTGGGKSLCYQLP---AVLS-PGVT-IVVSPLLSLIQDQ---VTALIQNPGCGIPAAFLTSQTALTLKRSI 73
Cdd:cd17923 14 AGRSVVVTTGTASGKSLCYQLPileALLRdPGSRaLYLYPTKALAQDQlrsLRELLEQLGLGIRVATYDGDTPREERRAI 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 348679514 74 taeLRRPvPSLkllyltpekIVKSAEMadLLQTLYRN--------KMLARFVIDEAH 122
Cdd:cd17923 94 ---IRNP-PRI---------LLTNPDM--LHYALLPHhdrwarflRNLRYVVLDEAH 135
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
10-312 |
1.99e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 56.06 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 10 MPTGGGKSLCYQLP---AVLSPGVTIVVSPLLSLIQDQVTALIQN-PGCGIPAAFLTSQTaltlkRSITAELRRPvpslK 85
Cdd:COG1204 45 APTASGKTLIAELAilkALLNGGKALYIVPLRALASEKYREFKRDfEELGIKVGVSTGDY-----DSDDEWLGRY----D 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 86 LLYLTPEKivksaemADLLqTLYRNKMLARF---VIDEAHCVsqwGHDFRpeysqlGM--------LKKTFPNVPLMALT 154
Cdd:COG1204 116 ILVATPEK-------LDSL-LRNGPSWLRDVdlvVVDEAHLI---DDESR------GPtlevllarLRRLNPEAQIVALS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 155 ATAP-PKVIqgvqrsLKISNGPVFSMSF--NRQNL------TFEVRDKPLGSDvkamEALYELISKTYPRDAVGIVYCMT 225
Cdd:COG1204 179 ATIGnAEEI------AEWLDAELVKSDWrpVPLNEgvlydgVLRFDDGSRRSK----DPTLALALDLLEEGGQVLVFVSS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 226 KQDSEDVANYL---FDRGLSAD----------------------------------FYHAGQSATDRHMVQEAWQNGQLS 268
Cdd:COG1204 249 RRDAESLAKKLadeLKRRLTPEereeleelaeellevseethtnekladclekgvaFHHAGLPSELRRLVEDAFREGLIK 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 348679514 269 IVCAT--IAYgmGINKPdVRYVI------HFSVAKSIEGYYQEAGRAGRDGK 312
Cdd:COG1204 329 VLVATptLAA--GVNLP-ARRVIirdtkrGGMVPIPVLEFKQMAGRAGRPGY 377
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
203-311 |
6.63e-08 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 51.40 E-value: 6.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 203 EALYELISKTYPRDAVGIVYCMTKQDSEDVANYLfdRGLSadFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINK 282
Cdd:cd18795 30 DIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDL--AGIA--FHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNL 105
|
90 100 110
....*....|....*....|....*....|....*..
gi 348679514 283 PDVRYVI----HFSVAK----SIEGYYQEAGRAGRDG 311
Cdd:cd18795 106 PARTVIIkgtqRYDGKGyrelSPLEYLQMIGRAGRPG 142
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
3-328 |
2.33e-07 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 52.85 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAV--------LSPG---VTIVVSPLLSLI-QDQVTAL-------IQNPGC--GIPaafl 61
Cdd:PTZ00110 167 GRDMIGIAETGSGKTLAFLLPAIvhinaqplLRYGdgpIVLVLAPTRELAeQIREQCNkfgasskIRNTVAygGVP---- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 62 tsqtaltlKRSITAELRRPVpslKLLYLTPEKIVksaemaDLLQTLYRNKMLARF-VIDEAHCVSQWGhdFRPEYSQLgm 140
Cdd:PTZ00110 243 --------KRGQIYALRRGV---EILIACPGRLI------DFLESNVTNLRRVTYlVLDEADRMLDMG--FEPQIRKI-- 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 141 LKKTFPNVPLMALTATAPpKVIQGVQRSLkISNGPV--------FSMSFN-RQNL-TFEVRDKPLgsdvkameALYELIS 210
Cdd:PTZ00110 302 VSQIRPDRQTLMWSATWP-KEVQSLARDL-CKEEPVhvnvgsldLTACHNiKQEVfVVEEHEKRG--------KLKMLLQ 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 211 KTYPRDAVGIVYCMTKQDSEDVANYLFDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIH 290
Cdd:PTZ00110 372 RIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVIN 451
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 348679514 291 FSVAKSIEGYYQEAGRAGRDGKPSQCIIFY------SARDISKM 328
Cdd:PTZ00110 452 FDFPNQIEDYVHRIGRTGRAGAKGASYTFLtpdkyrLARDLVKV 495
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
1-319 |
3.18e-07 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 52.10 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 1 MRGEDCFVLMPTGGGKSLCYQLPAVLS-------------PGVTIVVSP---LLSLIQDQVTALiqnpGCGIPAafltsQ 64
Cdd:PLN00206 156 LSGRSLLVSADTGSGKTASFLVPIISRcctirsghpseqrNPLAMVLTPtreLCVQVEDQAKVL----GKGLPF-----K 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 65 TALTLK-RSITAELRRPVPSLKLLYLTPEKIVksaemaDLL--QTLYRNKMLArFVIDEAHCVSQWGhdFRPEYSQLgml 141
Cdd:PLN00206 227 TALVVGgDAMPQQLYRIQQGVELIVGTPGRLI------DLLskHDIELDNVSV-LVLDEVDCMLERG--FRDQVMQI--- 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 142 KKTFPNVPLMALTATAPPKViQGVQRSLK-----ISNGPVFSMSFNRQNLTFEVRDKplgsdvKAMEALYE-LISKTYPR 215
Cdd:PLN00206 295 FQALSQPQVLLFSATVSPEV-EKFASSLAkdiilISIGNPNRPNKAVKQLAIWVETK------QKKQKLFDiLKSKQHFK 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 216 DAVgIVYCMTKQDSEDVANYL-FDRGLSADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVA 294
Cdd:PLN00206 368 PPA-VVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMP 446
|
330 340
....*....|....*....|....*
gi 348679514 295 KSIEGYYQEAGRAGRDGKPSQCIIF 319
Cdd:PLN00206 447 NTIKEYIHQIGRASRMGEKGTAIVF 471
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
243-311 |
2.23e-06 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 49.96 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 243 ADFYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVI----HFSVAksiEG--------YYQEAGRAGRD 310
Cdd:PRK02362 306 AAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIrdyrRYDGG---AGmqpipvleYHQMAGRAGRP 382
|
.
gi 348679514 311 G 311
Cdd:PRK02362 383 G 383
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
236-311 |
4.68e-06 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 48.78 E-value: 4.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 236 LFDRGLSAdfYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPdVRYVIHFSVAK----------SIEgYYQEAG 305
Cdd:COG4581 297 LLRRGIAV--HHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMP-ARTVVFTKLSKfdgerhrpltARE-FHQIAG 372
|
....*.
gi 348679514 306 RAGRDG 311
Cdd:COG4581 373 RAGRRG 378
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
3-122 |
7.86e-06 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 45.65 E-value: 7.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 3 GEDCFVLMPTGGGKSLCYQLPAVLS------PGVTIV-VSPLLSLIQDQ---VTALIQNPGCGIPAAFLTSQTALTLKRS 72
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVQVLyISPLKALINDQerrLEEPLDEIDLEIPVAVRHGDTSQSEKAK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 348679514 73 ItaeLRRPvPSlkLLYLTPEK---IVKSAEMADLLQTLyrnkmlaRFVI-DEAH 122
Cdd:cd17922 81 Q---LKNP-PG--ILITTPESlelLLVNKKLRELFAGL-------RYVVvDEIH 121
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
197-311 |
1.42e-05 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 47.19 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 197 SDVKAMEALYELISKTYPRDAVGIVYCMTKQDSEDVANYLFDRGLSadFYHAGQSATDRHMVQEAWQNGQLSIVCATIAY 276
Cdd:PRK01172 244 SSRKNAEDYAEMLIQHFPEFNDFKVSSENNNVYDDSLNEMLPHGVA--FHHAGLSNEQRRFIEEMFRNRYIKVIVATPTL 321
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 348679514 277 GMGINKPdVRYVIHFSVAKSIEGYY---------QEAGRAGRDG 311
Cdd:PRK01172 322 AAGVNLP-ARLVIVRDITRYGNGGIrylsnmeikQMIGRAGRPG 364
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
245-337 |
2.64e-05 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 46.35 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 245 FYHAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGY--------YQEAGRAGRD--GKPS 314
Cdd:PRK00254 300 FHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWedipvleiQQMMGRAGRPkyDEVG 379
|
90 100
....*....|....*....|....*
gi 348679514 315 QCIIFYSARDISKM--RSILFMPQK 337
Cdd:PRK00254 380 EAIIVATTEEPSKLmeRYIFGKPEK 404
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
224-331 |
7.93e-04 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 41.44 E-value: 7.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 224 MTKQDSEDVANYLFDRgLSADFYHAGQSATD-----RHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIE 298
Cdd:PRK01297 339 MVFANRKDEVRRIEER-LVKDGINAAQLSGDvpqhkRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPD 417
|
90 100 110
....*....|....*....|....*....|...
gi 348679514 299 GYYQEAGRAGRDGKPSQCIIFYSARDISKMRSI 331
Cdd:PRK01297 418 DYVHRIGRTGRAGASGVSISFAGEDDAFQLPEI 450
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
247-313 |
1.30e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 39.17 E-value: 1.30e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 348679514 247 HAGQSATDRHMVQEAWQNGQLSIVCATIAYGMGINKPDVRYVIHFSVAKSIEGYYQEAGRAGRDGKP 313
Cdd:cd18796 75 HGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGA 141
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
11-121 |
4.04e-03 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 38.38 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348679514 11 PTGGGKSLCYQLPAV--LSPGVT-----IVVSPLLSLIQdQVTALIQN--PGCGIPAAFLTSQtaltlkRSITAELRRPV 81
Cdd:cd17956 44 PTGSGKTLAYVLPIVqaLSKRVVprlraLIVVPTKELVQ-QVYKVFESlcKGTGLKVVSLSGQ------KSFKKEQKLLL 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 348679514 82 PSLKLLYLTPEKIVKSAEmADLLQTLYRNKMLA----RF-VIDEA 121
Cdd:cd17956 117 VDTSGRYLSRVDILVATP-GRLVDHLNSTPGFTlkhlRFlVIDEA 160
|
|
| |
