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Conserved domains on  [gi|347983506|gb|AEP39848|]
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gyrase B, partial [Burkholderia sp. SD2053]

Protein Classification

DNA gyrase subunit B family protein( domain architecture ID 999984)

DNA gyrase subunit B (GyrB) is the ATPase subunit of DNA gyrase, which is a type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state; may be partial

CATH:  3.30.230.10
EC:  5.6.2.2
Gene Ontology:  GO:0006265|GO:0005524|GO:0003677|GO:0003918
PubMed:  11395412|7980433|12596227
SCOP:  4000168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gyrB super family cl36442
DNA gyrase subunit B; Provisional
 1-220 5.03e-142

DNA gyrase subunit B; Provisional


The actual alignment was detected with superfamily member PRK14939:

Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 414.49  E-value: 5.03e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTGLKRDDKhdpkRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALS 80
Cdd:PRK14939  54 LAGHCDDITVTIHADGSVSVSDNGRGIPTDIHPEEG----VSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  81 EWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMRELSF 160
Cdd:PRK14939 130 EWLELTIRRDGKIHEQEFEHGVPV------------APLKVVGETDKTGTEVRFWPSPEIFENTEFDYDILAKRLRELAF 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506 161 LNNGVRIRLTDQRTGKEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:PRK14939 198 LNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
 
Name Accession Description Interval E-value
gyrB PRK14939
DNA gyrase subunit B; Provisional
 1-220 5.03e-142

DNA gyrase subunit B; Provisional


Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 414.49  E-value: 5.03e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTGLKRDDKhdpkRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALS 80
Cdd:PRK14939  54 LAGHCDDITVTIHADGSVSVSDNGRGIPTDIHPEEG----VSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  81 EWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMRELSF 160
Cdd:PRK14939 130 EWLELTIRRDGKIHEQEFEHGVPV------------APLKVVGETDKTGTEVRFWPSPEIFENTEFDYDILAKRLRELAF 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506 161 LNNGVRIRLTDQRTGKEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:PRK14939 198 LNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
1-220 5.25e-111

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 331.22  E-value: 5.25e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKHdPK--RSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNA 78
Cdd:COG0187   52 LAGYCDRIEVTLHADGSVTVEDNGRGIPV-----DIH-PKegKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  79 LSEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMREL 158
Cdd:COG0187  126 LSERLEVEVKRDGKIYRQRFERGKPV------------GPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLAERLREL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347983506 159 SFLNNGVRIRLTDQRTG--KEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:COG0187  194 AFLNKGLTITLTDEREEepKEETFHYEGGIKDFVEYLNEDKEPLHPEVIYFEGEKDGIEVEVAL 257
HATPase_GyrB-like cd16928
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ...
 1-180 3.54e-87

Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.


Pssm-ID: 340405 [Multi-domain]  Cd Length: 180  Bit Score: 255.15  E-value: 3.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKH-DPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNAL 79
Cdd:cd16928   17 LAGYATEIEVTLHEDNSITVEDNGRGIPV-----DIHpKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGLHGVGVSVVNAL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  80 SEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMRELS 159
Cdd:cd16928   92 SERLEVEVKRDGKIYRQEFSRGGPL------------TPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDTLKRRLRELA 159

                        170       180
                 ....*....|....*....|.
gi 347983506 160 FLNNGVRIRLTDQRTGKEDDF 180
Cdd:cd16928  160 FLNKGLKIVLEDERTGKEEVF 180
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 1-220 4.29e-81

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 252.86  E-value: 4.29e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506     1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKH-DPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNAL 79
Cdd:smart00433  18 LAGYMDTIKVTIDKDNSISVEDNGRGIPV-----EIHpKEKKYAPEVIFTVLHAGGKFDDDAYKVSGGLHGVGASVVNAL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    80 SEWLRLTVRRDGKKHFMEFARGvvqnreiveedGVQYSPMPVVGDTENRGTEVHFMADVTIFGN-VEFHYDILAKRMREL 158
Cdd:smart00433  93 STEFEVEVARDGKEYKQSFSNN-----------GKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMtTDDDFELLKRRLREL 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347983506   159 SFLNNGVRIRLTDQRTGKEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:smart00433 162 AFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAF 223
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 2-90 5.11e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 43.90  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    2 AGYCDDIHVVIHADN--SISVTDNGRGVPtglkrDDKHDpkrsaaeivmtelHAGGKFDQnSYKVSGGLHGVGVSCVNAL 79
Cdd:pfam02518  21 AAKAGEITVTLSEGGelTLTVEDNGIGIP-----PEDLP-------------RIFEPFST-ADKRGGGGTGLGLSIVRKL 81

                          90
                  ....*....|.
gi 347983506   80 SEWLRLTVRRD 90
Cdd:pfam02518  82 VELLGGTITVE 92
 
Name Accession Description Interval E-value
gyrB PRK14939
DNA gyrase subunit B; Provisional
 1-220 5.03e-142

DNA gyrase subunit B; Provisional


Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 414.49  E-value: 5.03e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTGLKRDDKhdpkRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALS 80
Cdd:PRK14939  54 LAGHCDDITVTIHADGSVSVSDNGRGIPTDIHPEEG----VSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  81 EWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMRELSF 160
Cdd:PRK14939 130 EWLELTIRRDGKIHEQEFEHGVPV------------APLKVVGETDKTGTEVRFWPSPEIFENTEFDYDILAKRLRELAF 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506 161 LNNGVRIRLTDQRTGKEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:PRK14939 198 LNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
1-220 5.25e-111

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 331.22  E-value: 5.25e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKHdPK--RSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNA 78
Cdd:COG0187   52 LAGYCDRIEVTLHADGSVTVEDNGRGIPV-----DIH-PKegKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  79 LSEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMREL 158
Cdd:COG0187  126 LSERLEVEVKRDGKIYRQRFERGKPV------------GPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLAERLREL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347983506 159 SFLNNGVRIRLTDQRTG--KEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:COG0187  194 AFLNKGLTITLTDEREEepKEETFHYEGGIKDFVEYLNEDKEPLHPEVIYFEGEKDGIEVEVAL 257
gyrB PRK05644
DNA gyrase subunit B; Validated
 1-220 3.15e-108

DNA gyrase subunit B; Validated


Pssm-ID: 235542 [Multi-domain]  Cd Length: 638  Bit Score: 323.97  E-value: 3.15e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKHdPK--RSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNA 78
Cdd:PRK05644  54 LAGYCDHIEVTINEDGSITVTDNGRGIPV-----DIH-PKtgKPAVEVVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  79 LSEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMREL 158
Cdd:PRK05644 128 LSTWLEVEVKRDGKIYYQEYERGVPV------------TPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLATRLREL 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347983506 159 SFLNNGVRIRLTDQRTG--KEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:PRK05644 196 AFLNKGLKITLTDEREGeeKEETFHYEGGIKEYVEYLNRNKEPLHEEPIYFEGEKDGIEVEVAM 259
HATPase_GyrB-like cd16928
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ...
 1-180 3.54e-87

Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.


Pssm-ID: 340405 [Multi-domain]  Cd Length: 180  Bit Score: 255.15  E-value: 3.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKH-DPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNAL 79
Cdd:cd16928   17 LAGYATEIEVTLHEDNSITVEDNGRGIPV-----DIHpKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGLHGVGVSVVNAL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  80 SEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDTENRGTEVHFMADVTIFGNVEFHYDILAKRMRELS 159
Cdd:cd16928   92 SERLEVEVKRDGKIYRQEFSRGGPL------------TPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDTLKRRLRELA 159

                        170       180
                 ....*....|....*....|.
gi 347983506 160 FLNNGVRIRLTDQRTGKEDDF 180
Cdd:cd16928  160 FLNKGLKIVLEDERTGKEEVF 180
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 1-220 4.29e-81

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 252.86  E-value: 4.29e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506     1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKH-DPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNAL 79
Cdd:smart00433  18 LAGYMDTIKVTIDKDNSISVEDNGRGIPV-----EIHpKEKKYAPEVIFTVLHAGGKFDDDAYKVSGGLHGVGASVVNAL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    80 SEWLRLTVRRDGKKHFMEFARGvvqnreiveedGVQYSPMPVVGDTENRGTEVHFMADVTIFGN-VEFHYDILAKRMREL 158
Cdd:smart00433  93 STEFEVEVARDGKEYKQSFSNN-----------GKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMtTDDDFELLKRRLREL 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347983506   159 SFLNNGVRIRLTDQRTGKEDDFAFAGGVKGFVEYINKAKTVLHPNVFHAVGERENVTVEVAM 220
Cdd:smart00433 162 AFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAF 223
PRK05559 PRK05559
DNA topoisomerase IV subunit B; Reviewed
 1-220 2.29e-79

DNA topoisomerase IV subunit B; Reviewed


Pssm-ID: 235501 [Multi-domain]  Cd Length: 631  Bit Score: 249.25  E-value: 2.29e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrdDKH-DPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNAL 79
Cdd:PRK05559  54 LAGHGKRIEVTLHADGSVSVRDNGRGIPV-----GIHpEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNAL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  80 SEWLRLTVRRDGKKHFMEFARGVVQnreiveedgvqySPMPVVGDT--ENRGTEVHFMADVTIFGNVEFHYDILAKRMRE 157
Cdd:PRK05559 129 SSRLEVEVKRDGKVYRQRFEGGDPV------------GPLEVVGTAgkRKTGTRVRFWPDPKIFDSPKFSPERLKERLRS 196

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347983506 158 LSFLNNGVRIRLTDQRtgKEDDFAFAGGVKGFVEYINKAKTVLHPN-VFHAVGERENVTVEVAM 220
Cdd:PRK05559 197 KAFLLPGLTITLNDER--ERQTFHYENGLKDYLAELNEGKETLPEEfVGSFEGEAEGEAVEWAL 258
PTZ00109 PTZ00109
DNA gyrase subunit b; Provisional
 1-220 1.05e-37

DNA gyrase subunit b; Provisional


Pssm-ID: 240272 [Multi-domain]  Cd Length: 903  Bit Score: 138.86  E-value: 1.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   1 LAGYCDDIHVVIHADNSISVTDNGRGVPTglkrDDKHDPKRSAAEIVMTELHAGGKF--------------DQNS----- 61
Cdd:PTZ00109 146 LAGECNKITVVLHKDGSVEISDNGRGIPC----DVSEKTGKSGLETVLTVLHSGGKFqdtfpknsrsdkseDKNDtkssk 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  62 ---------------------YKVSGGLHGVGVSCVNALSEWLRLTVRRDGKKHFMEFARGvvqnrEIVEEDGVQYSPMp 120
Cdd:PTZ00109 222 kgksshvkgpkeakekessqmYEYSSGLHGVGLSVVNALSSFLKVDVFKGGKIYSIELSKG-----KVTKPLSVFSCPL- 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506 121 vvgdtENRGTEVHFMADV-TIFGN--------------VEFHYDILAKRMRELSFLNNGVRIRLTDQRTGKEDDFAF--- 182
Cdd:PTZ00109 296 -----KKRGTTIHFLPDYkHIFKThhqhteteeeegckNGFNLDLIKNRIHELSYLNPGLTFYLVDERIANENNFYPyet 370

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 347983506 183 ---AGGVKGFVEYINKAKTVLHP--NVFHAVGERENVTVEVAM 220
Cdd:PTZ00109 371 ikhEGGTREFLEELIKDKTPLYKdiNIISIRGVIKNVNVEVSL 413
39 PHA02569
DNA topoisomerase II large subunit; Provisional
 8-194 5.12e-10

DNA topoisomerase II large subunit; Provisional


Pssm-ID: 177398 [Multi-domain]  Cd Length: 602  Bit Score: 58.61  E-value: 5.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   8 IHVVIHaDNSISVTDNGRGVPTGLKRDD--KHDPKRSAAeivMTELHAGGKFDqNSYKVSGGLHGVGVSCVNALSEWLrL 85
Cdd:PHA02569  72 IDVTIK-NNQVTVSDNGRGIPQAMVTTPegEEIPGPVAA---WTRTKAGSNFD-DTNRVTGGMNGVGSSLTNFFSVLF-I 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506  86 TVRRDGKKHFmefargVVQNREIVEEDGVQYSPmpvvgdTENRGTEVHFMADVTIFGNVEF---HYDILAKRMRELS--- 159
Cdd:PHA02569 146 GETCDGKNEV------TVNCSNGAENISWSTKP------GKGKGTSVTFIPDFSHFEVNGLdqqYLDIILDRLQTLAvvf 213

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 347983506 160 ----FLNNGVRIRLTDQRTGK---------EDD---FAFAGGVKGF--VEYIN 194
Cdd:PHA02569 214 pdikFTFNGKKVSGKFKKYAKqfgddtivqENDnvsIALAPSPDGFrqLSFVN 266
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 5-216 9.78e-10

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 57.80  E-value: 9.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    5 CDDIHVVIHAD-NSISVTDNGRGVPTG-LKRDDKHDPkrsaaEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSEw 82
Cdd:PLN03128   74 MDSLKVDIDVEqNTISVYNNGKGIPVEiHKEEGVYVP-----ELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFST- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   83 lRLTVR-RDGK--KHFmefaRGVVQNREIVEEDgvqyspmPVVGDTENRG--TEVHFMADVTIFGNVEFHYDI---LAKR 154
Cdd:PLN03128  148 -EFTVEtADGNrgKKY----KQVFTNNMSVKSE-------PKITSCKASEnwTKITFKPDLAKFNMTRLDEDVvalMSKR 215

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347983506  155 MRELS-FLNNGVRIRLTDQRTgkeddfafagGVKGFVEYIN-----KAKTVLHPNVFHAVGERENVTV 216
Cdd:PLN03128  216 VYDIAgCLGKKLKVELNGKKL----------PVKSFQDYVGlylgpNSREDPLPRIYEKVNDRWEVCV 273
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 8-194 9.20e-09

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 55.05  E-value: 9.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    8 IHVVI-HADNSISVTDNGRGVPtgLKRDDKHD---PkrsaaEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSEwl 83
Cdd:PTZ00108   85 IKVTIdEENGEISVYNDGEGIP--VQIHKEHKiyvP-----EMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFST-- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   84 RLTV----RRDGKKHFMEFARGVVQNREiveedgvqyspmPVVGDTENRG--TEVHFMADVTIFGNVEF---HYDILAKR 154
Cdd:PTZ00108  156 KFTVecvdSKSGKKFKMTWTDNMSKKSE------------PRITSYDGKKdyTKVTFYPDYAKFGMTEFdddMLRLLKKR 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 347983506  155 MRELSFLNNGVRIRLTDQRTgkeddfafagGVKGFVEYIN 194
Cdd:PTZ00108  224 VYDLAGCFGKLKVYLNGERI----------AIKSFKDYVD 253
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 5-93 3.55e-07

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 47.26  E-value: 3.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506     5 CDDIHVVIHADN---SISVTDNGRGVPtglkrddkhdpkrsaAEIVMTELHAGGKFDQNSYKVSGglHGVGVSCVNALSE 81
Cdd:smart00387  24 GGRITVTLERDGdhvEITVEDNGPGIP---------------PEDLEKIFEPFFRTDKRSRKIGG--TGLGLSIVKKLVE 86

                           90
                   ....*....|..
gi 347983506    82 WLRLTVRRDGKK 93
Cdd:smart00387  87 LHGGEISVESEP 98
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 2-90 5.11e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 43.90  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    2 AGYCDDIHVVIHADN--SISVTDNGRGVPtglkrDDKHDpkrsaaeivmtelHAGGKFDQnSYKVSGGLHGVGVSCVNAL 79
Cdd:pfam02518  21 AAKAGEITVTLSEGGelTLTVEDNGIGIP-----PEDLP-------------RIFEPFST-ADKRGGGGTGLGLSIVRKL 81

                          90
                  ....*....|.
gi 347983506   80 SEWLRLTVRRD 90
Cdd:pfam02518  82 VELLGGTITVE 92
HATPase_TopII-like cd16930
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ...
 8-99 4.69e-05

Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.


Pssm-ID: 340407 [Multi-domain]  Cd Length: 147  Bit Score: 41.94  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   8 IHVVIHAD-NSISVTDNGRGVPtgLKRDDKHdpKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSewLRLT 86
Cdd:cd16930   29 IKVTIDPEnNEISVWNNGKGIP--VVIHKEE--KIYVPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFS--TEFT 102

                         90
                 ....*....|....*..
gi 347983506  87 V----RRDGKKHFMEFA 99
Cdd:cd16930  103 VetadSESKKKFKQTWT 119
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 6-216 8.14e-05

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 42.93  E-value: 8.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506    6 DDIHVVIHAD-NSISVTDNGRGVPTGLKRDDK-HDPkrsaaEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALS-EW 82
Cdd:PLN03237  100 DSLRVVIDVEqNLISVYNNGDGVPVEIHQEEGvYVP-----EMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFStEF 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347983506   83 LRLTVrrDGKKHfmefargvVQNREIVEEDGVQYSPmPVV---GDTENrGTEVHFMADVTIFGNVEFHYDILA---KRMR 156
Cdd:PLN03237  175 VIETA--DGKRQ--------KKYKQVFSNNMGKKSE-PVItkcKKSEN-WTKVTFKPDLAKFNMTHLEDDVVAlmkKRVV 242

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347983506  157 ELS-FLNNGVRIRLTDQRTgkeddfafagGVKGFVEYIN-------KAKTVLHPNVFHAVGERENVTV 216
Cdd:PLN03237  243 DIAgCLGKTVKVELNGKRI----------PVKSFSDYVDlylesanKSRPENLPRIYEKVNDRWEVCV 300
DNA_gyraseB pfam00204
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ...
 185-220 2.17e-04

DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.


Pssm-ID: 425522 [Multi-domain]  Cd Length: 173  Bit Score: 40.29  E-value: 2.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 347983506  185 GVKGFVEYINKAKTVLHPNVFHAVGEREN--VTVEVAM 220
Cdd:pfam00204   1 GLKDFVEELNKDKKPLHKEIIYFEGESPDnrIEVEVAL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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