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Conserved domains on  [gi|34782861|gb|AAH15163|]
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TTC37 protein, partial [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1003464)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes; similar to Saccharomyces cerevisiae ER membrane protein complex subunit 2

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NrfG super family cl34742
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-72 7.41e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG4235:

Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 7.41e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 34782861  28 LEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLA 72
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD 47
 
Name Accession Description Interval E-value
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-72 7.41e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 7.41e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 34782861  28 LEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLA 72
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD 47
TPR_8 pfam13181
Tetratricopeptide repeat;
42-74 8.05e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 33.14  E-value: 8.05e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 34782861    42 VPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQ 74
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
 
Name Accession Description Interval E-value
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-72 7.41e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 7.41e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 34782861  28 LEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLA 72
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD 47
TPR_8 pfam13181
Tetratricopeptide repeat;
42-74 8.05e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 33.14  E-value: 8.05e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 34782861    42 VPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQ 74
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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