NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|346652042]
View 

Chain C, Iron-regulated surface determinant protein H

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IsdH_HarA super family cl31363
haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr ...
 21-164 1.79e-92

haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr Transporter, pfam05031) protein which has been shown to bind to the haptoglobin-hemoglobin complex in order to extract heme from it. HarA has also been reported to bind hemoglobin directly. HarA (also known as IsdH) contains three NEAT domains as well as a sortase A C-terminal signal for localization to the cell wall. The heme bound at the third of these NEAT domains has been shown to be transferred to the IsdA protein also localized at the cell wall, presumably through an additional specific protein-protein interaction. Haptoglobin is a hemoglobin carrier protein involved in scavenging hemoglobin in the blood following red blood cell lysis and targetting it to the liver.


The actual alignment was detected with superfamily member TIGR03658:

Pssm-ID: 132697 [Multi-domain]  Cd Length: 895  Bit Score: 286.76  E-value: 1.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   21 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 100
Cdd:TIGR03658  86 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 346652042  101 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 164
Cdd:TIGR03658 166 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 229
 
Name Accession Description Interval E-value
IsdH_HarA TIGR03658
haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr ...
 21-164 1.79e-92

haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr Transporter, pfam05031) protein which has been shown to bind to the haptoglobin-hemoglobin complex in order to extract heme from it. HarA has also been reported to bind hemoglobin directly. HarA (also known as IsdH) contains three NEAT domains as well as a sortase A C-terminal signal for localization to the cell wall. The heme bound at the third of these NEAT domains has been shown to be transferred to the IsdA protein also localized at the cell wall, presumably through an additional specific protein-protein interaction. Haptoglobin is a hemoglobin carrier protein involved in scavenging hemoglobin in the blood following red blood cell lysis and targetting it to the liver.


Pssm-ID: 132697 [Multi-domain]  Cd Length: 895  Bit Score: 286.76  E-value: 1.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   21 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 100
Cdd:TIGR03658  86 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 346652042  101 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 164
Cdd:TIGR03658 166 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 229
NEAT smart00725
NEAr Transporter domain;
42-164 2.68e-29

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 103.97  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042    42 GPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVpEDHAYIR 121
Cdd:smart00725   2 DGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKD-NDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 346652042   122 FPVSDGTQELKIVSSTQIDDGEetNYDYTKLVFAKPIYNDPSL 164
Cdd:smart00725  81 FPVPNLDADLDAKVHVVVPEIG--VENYDHDYTVQLIFDEAST 121
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 46-154 8.96e-12

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 58.43  E-value: 8.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   46 QVNFQLL-DKNNET----QYyhffsIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVpEDHAYI 120
Cdd:pfam05031   8 TIDFKVLkDGTDEAsmanGY-----LDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTG-KDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 346652042  121 RFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVF 154
Cdd:pfam05031  82 RFEVPDLDKKLNAKVHVYVPMGNYDHKYDVQLQF 115
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
47-154 6.32e-03

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 36.03  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042  47 VNFQLL-DKNNET----QYyhffsIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYsPVPEDHAYIR 121
Cdd:COG5386   43 INFKVLkDGTDEAsmmnQY-----FEKPAKLTVKNGKYYVTMTLNDSSWVTSFKVEVNGSFVDATVVSE-DKAANTRVVE 116

                         90       100       110
                 ....*....|....*....|....*....|...
gi 346652042 122 FPVSDGTQELKIVSSTQIDDGEETNYDYTKLVF 154
Cdd:COG5386  117 FEVPDLSKPLNAKVHVVIPAINYDHKYDVRLVF 149
 
Name Accession Description Interval E-value
IsdH_HarA TIGR03658
haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr ...
 21-164 1.79e-92

haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr Transporter, pfam05031) protein which has been shown to bind to the haptoglobin-hemoglobin complex in order to extract heme from it. HarA has also been reported to bind hemoglobin directly. HarA (also known as IsdH) contains three NEAT domains as well as a sortase A C-terminal signal for localization to the cell wall. The heme bound at the third of these NEAT domains has been shown to be transferred to the IsdA protein also localized at the cell wall, presumably through an additional specific protein-protein interaction. Haptoglobin is a hemoglobin carrier protein involved in scavenging hemoglobin in the blood following red blood cell lysis and targetting it to the liver.


Pssm-ID: 132697 [Multi-domain]  Cd Length: 895  Bit Score: 286.76  E-value: 1.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   21 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 100
Cdd:TIGR03658  86 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 346652042  101 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 164
Cdd:TIGR03658 166 QKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL 229
IsdH_HarA TIGR03658
haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr ...
 21-162 5.15e-41

haptoglobin-binding heme uptake protein HarA; HarA is a heme-binding NEAT-domain (NEAr Transporter, pfam05031) protein which has been shown to bind to the haptoglobin-hemoglobin complex in order to extract heme from it. HarA has also been reported to bind hemoglobin directly. HarA (also known as IsdH) contains three NEAT domains as well as a sortase A C-terminal signal for localization to the cell wall. The heme bound at the third of these NEAT domains has been shown to be transferred to the IsdA protein also localized at the cell wall, presumably through an additional specific protein-protein interaction. Haptoglobin is a hemoglobin carrier protein involved in scavenging hemoglobin in the blood following red blood cell lysis and targetting it to the liver.


Pssm-ID: 132697 [Multi-domain]  Cd Length: 895  Bit Score: 146.16  E-value: 5.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   21 ADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENN 100
Cdd:TIGR03658 326 ADESLQDAIKNPAIIDKEHTADNWRPIDFQMKNDKGERQFYHYASTVEPATVIFTKTGPIIELGLKTASTWKKFEVYEGD 405

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 346652042  101 QKLPVRLVSYSPvPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDP 162
Cdd:TIGR03658 406 KKLPVELVSYDS-DKDYAYIRFPVSNGTREVKIVSSIEYGENIHEDYDYTLMVFAQPITNNP 466
NEAT smart00725
NEAr Transporter domain;
42-164 2.68e-29

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 103.97  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042    42 GPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVpEDHAYIR 121
Cdd:smart00725   2 DGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKD-NDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 346652042   122 FPVSDGTQELKIVSSTQIDDGEetNYDYTKLVFAKPIYNDPSL 164
Cdd:smart00725  81 FPVPNLDADLDAKVHVVVPEIG--VENYDHDYTVQLIFDEAST 121
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 46-154 8.96e-12

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 58.43  E-value: 8.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042   46 QVNFQLL-DKNNET----QYyhffsIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVpEDHAYI 120
Cdd:pfam05031   8 TIDFKVLkDGTDEAsmanGY-----LDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTG-KDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 346652042  121 RFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVF 154
Cdd:pfam05031  82 RFEVPDLDKKLNAKVHVYVPMGNYDHKYDVQLQF 115
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
47-154 6.32e-03

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 36.03  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346652042  47 VNFQLL-DKNNET----QYyhffsIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYsPVPEDHAYIR 121
Cdd:COG5386   43 INFKVLkDGTDEAsmmnQY-----FEKPAKLTVKNGKYYVTMTLNDSSWVTSFKVEVNGSFVDATVVSE-DKAANTRVVE 116

                         90       100       110
                 ....*....|....*....|....*....|...
gi 346652042 122 FPVSDGTQELKIVSSTQIDDGEETNYDYTKLVF 154
Cdd:COG5386  117 FEVPDLSKPLNAKVHVVIPAINYDHKYDVRLVF 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH