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Conserved domains on  [gi|34577083|ref|NP_689937|]
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ras suppressor protein 1 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-149 7.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 122.73  E-value: 7.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSenSLPGNFFYLTT 82
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGNLTN 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577083  83 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 149
Cdd:COG4886 184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-149 7.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 122.73  E-value: 7.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSenSLPGNFFYLTT 82
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGNLTN 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577083  83 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 149
Cdd:COG4886 184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-149 4.29e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLDLTyNNLSENSLPGNFF 78
Cdd:PLN00113  85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLDLS-NNMLSGEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   79 YLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-------------------------SLPKEIGELTQLKEL 132
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHL 241

                        170
                 ....*....|....*...
gi 34577083  133 HIQGNRLT-VLPPELGNL 149
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNL 259
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-153 7.98e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 7.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   4 PNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNLS-----ENslpgnff 78
Cdd:cd21340  18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISvveglEN------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  79 yLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGNRLTVLP---- 143
Cdd:cd21340  89 -LTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEelld 162

                       170
                ....*....|....*
gi 34577083 144 -----PELGNLDLTG 153
Cdd:cd21340 163 llsswPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
11-68 8.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 8.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    11 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 68
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-149 7.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 122.73  E-value: 7.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSenSLPGNFFYLTT 82
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGNLTN 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577083  83 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 149
Cdd:COG4886 184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-152 1.13e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.96  E-value: 1.13e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEnsLPGNFFYLTT 82
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITD--LPEPLGNLTN 206

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  83 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLTVLPPELGNLDLT 152
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-142 5.04e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 5.04e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSenSLPGNFFYLT 81
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT--DLPEPLANLT 228

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34577083  82 TLRALYLSDNDFEILpPDIGKLTKLQILSLRDNDLISLPKEiGELTQLKELHIQGNRLTVL 142
Cdd:COG4886 229 NLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-149 6.43e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 6.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   3 PPNIAELKNLEVLNFFNNQieelptQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSenSLPGNFFYLTT 82
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT--DLPEPLGNLTN 160

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577083  83 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-149 1.62e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 1.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   4 PNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRlntlprGFGSLPALEVLDLTYNNLSenSLPGNFFYLTTL 83
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLT--DLPEELANLTNL 138

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 34577083  84 RALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-149 4.33e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   5 NIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNlsenslpgNFFYLTTLR 84
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLE 116

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 34577083  85 ALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-149 4.29e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLDLTyNNLSENSLPGNFF 78
Cdd:PLN00113  85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLDLS-NNMLSGEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   79 YLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-------------------------SLPKEIGELTQLKEL 132
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHL 241

                        170
                 ....*....|....*...
gi 34577083  133 HIQGNRLT-VLPPELGNL 149
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNL 259
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-147 6.02e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 6.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFY 79
Cdd:PLN00113 204 IPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLS-GPIPPSIFS 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34577083   80 LTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPPELG 147
Cdd:PLN00113 283 LQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLG 353
PLN03150 PLN03150
hypothetical protein; Provisional
 25-91 5.23e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 61.37  E-value: 5.23e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34577083   25 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDN 91
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-140 1.31e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFY 79
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT-GEIPEGLCS 378

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34577083   80 LTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT 140
Cdd:PLN00113 379 SGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-155 2.32e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 2.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSENsLPGNFFY 79
Cdd:PLN00113 372 IPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGR-INSRKWD 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   80 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPPELG------NLDL 151
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSsckklvSLDL 530


                 ....
gi 34577083  152 TGQK 155
Cdd:PLN00113 531 SHNQ 534
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
12-164 3.86e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 3.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   12 LEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRgfgSLP-ALEVLDLTYNNLSenSLPGNFfyLTTLRALYLSD 90
Cdd:PRK15370 243 IQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPE---NLPeELRYLSVYDNSIR--TLPAHL--PSGITHLNVQS 313

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34577083   91 NDFEILPPDIGklTKLQILSLRDNDLISLPKEIGelTQLKELHIQGNRLTV----LPPELGNLDLTGQKQVFKAENNP 164
Cdd:PRK15370 314 NSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVlpetLPPTITTLDVSRNALTNLPENLP 387
PLN03150 PLN03150
hypothetical protein; Provisional
 5-164 4.68e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    5 NIAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVLD-LTYNNLS 69
Cdd:PLN03150 350 THAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFIDgLGLDNQG 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   70 -ENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPPE 145
Cdd:PLN03150 430 lRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAA 509

                        170
                 ....*....|....*....
gi 34577083  146 LGNLDLTGQKqvFKAENNP 164
Cdd:PLN03150 510 LGGRLLHRAS--FNFTDNA 526
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-153 7.98e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 7.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   4 PNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNLS-----ENslpgnff 78
Cdd:cd21340  18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISvveglEN------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  79 yLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGNRLTVLP---- 143
Cdd:cd21340  89 -LTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEelld 162

                       170
                ....*....|....*
gi 34577083 144 -----PELGNLDLTG 153
Cdd:cd21340 163 llsswPSLRELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-143 6.68e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   4 PNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLpRGFGSLPALEVLDLTYNNL-SENSL---PGNFFY 79
Cdd:cd21340  40 ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLpPGEKLtfdPRSLAA 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34577083  80 L-TTLRALYLSDNDFEILPPdIGKLTKLQILSLRDNDLISLPK---EIGELTQLKELHIQGNRLTVLP 143
Cdd:cd21340 118 LsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-143 8.32e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.09  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    1 MVPPNIAELknlevlNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGF----------GSLPAL--EVLDLTYNNL 68
Cdd:PRK15387 259 VLPPGLLEL------SIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLqelsvsdnqlASLPALpsELCKLWAYNN 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   69 SENSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGEL--------------TQLKELHI 134
Cdd:PRK15387 333 QLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMV 409


                 ....*....
gi 34577083  135 QGNRLTVLP 143
Cdd:PRK15387 410 SGNRLTSLP 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-117 2.84e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    1 MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFF 78
Cdd:PLN00113 490 AVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLG 568

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 34577083   79 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 117
Cdd:PLN00113 569 NVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
2-155 5.29e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.78  E-value: 5.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPniaELKNLEVlnfFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSL--------------PALEVLDLTYNN 67
Cdd:PRK15387 240 LPP---ELRTLEV---SGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVSDNQ 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   68 LSenSLPGnffYLTTLRALYLSDNDFEILPPdigKLTKLQILSLRDNDLISLPKEIGELTQ-----------------LK 130
Cdd:PRK15387 314 LA--SLPA---LPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKlwaynnrltslpalpsgLK 385

                        170       180
                 ....*....|....*....|....*...
gi 34577083  131 ELHIQGNRLT---VLPPELGNLDLTGQK 155
Cdd:PRK15387 386 ELIVSGNRLTslpVLPSELKELMVSGNR 413
LRR_8 pfam13855
Leucine rich repeat;
11-68 8.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 8.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    11 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 68
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
33-93 8.86e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 8.86e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34577083    33 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDF 93
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 2-69 3.75e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 3.75e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    2 VPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLS 69
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-140 3.86e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  27 TQISSLQKLKHLN--LGMNRLNTLPRGFGSL-PALEVLDLTYNNLSENS---LPGNFFYLTTLRALYLSDND-----FEI 95
Cdd:cd00116 105 LRSSSLQELKLNNngLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRA 184

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 34577083  96 LPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRLT 140
Cdd:cd00116 185 LAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
56-116 8.47e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 8.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34577083    56 PALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 116
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1-129 1.11e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.55  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083     1 MVPPNIAELknlevlnFFNN--QIEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNNLS 69
Cdd:PLN03210  775 MLSPSLTRL-------FLSDipSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPDIS 845

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34577083    70 ENslpgnffylttLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 129
Cdd:PLN03210  846 TN-----------ISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
12-140 3.73e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   12 LEVLNFFNNQIEELPTQISSLQKLKHLNlgmNRLNTLPrgfgSLPA-LEVLDLTYNNLSenSLPgnfFYLTTLRALYLSD 90
Cdd:PRK15387 344 LQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLP----ALPSgLKELIVSGNRLT--SLP---VLPSELKELMVSG 411

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 34577083   91 NDFEILP--PdigklTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 140
Cdd:PRK15387 412 NRLTSLPmlP-----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 12-140 6.72e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 6.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  12 LEVLNFFNNQIEE-----LPTQISSLQKLKHLNLGMNRLN-----TLPRGFGSLPALEVLDLTYNNLSENSL----PGNF 77
Cdd:cd00116 167 LKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAaalaSALL 246

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34577083  78 FYLTTLRALYLSDNDfeilppdigkltklqilsLRDNDLISLPKEIGELTQLKELHIQGNRLT 140
Cdd:cd00116 247 SPNISLLTLSLSCND------------------ITDDGAKDLAEVLAEKESLLELDLRGNKFG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 4-157 1.32e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.47  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083     4 PNIAELKNLEVLNFFN-NQIEELPTQISSLQKLKHLNL-GMNRLNTLPRGFgSLPALEVLDL-------TYNNLSEN--- 71
Cdd:PLN03210  651 PDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMsRCENLEILPTGI-NLKSLYRLNLsgcsrlkSFPDISTNisw 729

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083    72 ---------SLPGNfFYLTTLRALYLSDNDFEILPPDIGKLTKLQI--------LSLRDN-DLISLPKEIGELTQLKELH 133
Cdd:PLN03210  730 ldldetaieEFPSN-LRLENLDELILCEMKSEKLWERVQPLTPLMTmlspsltrLFLSDIpSLVELPSSIQNLHKLEHLE 808

                         170       180       190
                  ....*....|....*....|....*....|
gi 34577083   134 IQGNR-LTVLP-----PELGNLDLTGQKQV 157
Cdd:PLN03210  809 IENCInLETLPtginlESLESLDLSGCSRL 838
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 7-142 3.80e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083   7 AELKNLEVLNFFNNQI-----EELPTQISSLQKLKHLNLGMNRLN-----TLPRGFGSLPALEVLDLTYNNLSE------ 70
Cdd:COG5238 233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDegaial 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577083  71 -NSLPGNffylTTLRALYLSDNDF-----EILPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRL 139
Cdd:COG5238 313 aEGLQGN----KTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNI 388


                ...
gi 34577083 140 TVL 142
Cdd:COG5238 389 GKQ 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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