NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|345559898|gb|EGX43029|]
View 

hypothetical protein AOL_s00215g815 [Orbilia oligospora ATCC 24927]

Protein Classification

lytic polysaccharide monooxygenase auxiliary activity family 9 protein( domain architecture ID 15340318)

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9) protein may be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides

CATH:  2.70.50.70
CAZY:  AA9
Gene Ontology:  GO:0016787|GO:0046872
PubMed:  24688660|25217478

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 20-227 2.74e-80

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


:

Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 239.42  E-value: 2.74e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  20 HYRFPSLIVGGTTTGQY---QYVRQNSNM--NSPVENVQSTDFTCNAGARLGSnTGTYEVAAGSTVGFALDQQVF--HPG 92
Cdd:cd21175    1 HGTVTSLTVNGVDYGGWdpdSYVRKPPNAtdNGPVTDVTSPDIACNKGGTTPA-PKTATVAAGSTVTFEWNTWPDwsHKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  93 PYIVYLGQAPSSITNlnsWDGSGANWFKIHQRQITFGSNGPNWEML----NSLTFKLPTRIPSGLYLLRIEHIALHSASN 168
Cdd:cd21175   80 PVLTYMAKCPGDCTD---VDGTGLGWFKIDEEGLDSGGGAWATDKLiangGTWTVTIPSNLAPGNYLLRHEIIALHSAGS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898 169 YPGAQFYISCAQLKITG-GSGGSPAKVSIPGVYSGQEPGIKLNIYYPILNSYNFPGPAVY 227
Cdd:cd21175  157 VGGAQFYPSCAQIEVTGgGTGAPPPGVSFPGAYKATDPGILFNIYYPPPTSYTIPGPAVW 216
 
Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 20-227 2.74e-80

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 239.42  E-value: 2.74e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  20 HYRFPSLIVGGTTTGQY---QYVRQNSNM--NSPVENVQSTDFTCNAGARLGSnTGTYEVAAGSTVGFALDQQVF--HPG 92
Cdd:cd21175    1 HGTVTSLTVNGVDYGGWdpdSYVRKPPNAtdNGPVTDVTSPDIACNKGGTTPA-PKTATVAAGSTVTFEWNTWPDwsHKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  93 PYIVYLGQAPSSITNlnsWDGSGANWFKIHQRQITFGSNGPNWEML----NSLTFKLPTRIPSGLYLLRIEHIALHSASN 168
Cdd:cd21175   80 PVLTYMAKCPGDCTD---VDGTGLGWFKIDEEGLDSGGGAWATDKLiangGTWTVTIPSNLAPGNYLLRHEIIALHSAGS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898 169 YPGAQFYISCAQLKITG-GSGGSPAKVSIPGVYSGQEPGIKLNIYYPILNSYNFPGPAVY 227
Cdd:cd21175  157 VGGAQFYPSCAQIEVTGgGTGAPPPGVSFPGAYKATDPGILFNIYYPPPTSYTIPGPAVW 216
AA9 pfam03443
Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been ...
 21-219 7.68e-70

Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases. The substrate-binding surface of this family is a flat Ig-like fold. This family of enzymes were originally classified as glycoside hydrolases (GH61) and they have been reclassified as the Auxiliary Activity Family 9 (AA9) of CAZy.


Pssm-ID: 460918  Cd Length: 208  Bit Score: 212.44  E-value: 7.68e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898   21 YRFPSLIVGGTTTGQYQYVRQNSNM-------NSPVENVQSTDFTCNAGarlGSNTGTYEVAAGSTVGFALDQQ--VFHP 91
Cdd:pfam03443   1 GTVTSLVVNGVTYGGYDPVSDPVIRwtrpntdNGPVTDVTSPDIRCNGA---GPAATAAPVAAGSTVTFQWTQGwpESHK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898   92 GPYIVYLGQAPSsiTNLNSWDGSGANWFKIHQRQITFGSNG-PNWEML---NSLTFKLPTRIPSGLYLLRIEHIALHSAS 167
Cdd:pfam03443  78 GPVITYLAKCPG--GDCATVDGTGLVWFKIDEAGLDSGGSTwATDKLIannGTWTVTIPSDLAPGNYLLRHEIIALHSAG 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 345559898  168 NYPGAQFYISCAQLKITGGSGGSP-AKVSIPGVYSGQEPGIKLNIYYPILNSY 219
Cdd:pfam03443 156 SVGGAQFYPQCAQLEVTGSGSGTPgPGVSFPGAYKATDPGILFNIYSPGPTSY 208
 
Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 20-227 2.74e-80

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 239.42  E-value: 2.74e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  20 HYRFPSLIVGGTTTGQY---QYVRQNSNM--NSPVENVQSTDFTCNAGARLGSnTGTYEVAAGSTVGFALDQQVF--HPG 92
Cdd:cd21175    1 HGTVTSLTVNGVDYGGWdpdSYVRKPPNAtdNGPVTDVTSPDIACNKGGTTPA-PKTATVAAGSTVTFEWNTWPDwsHKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898  93 PYIVYLGQAPSSITNlnsWDGSGANWFKIHQRQITFGSNGPNWEML----NSLTFKLPTRIPSGLYLLRIEHIALHSASN 168
Cdd:cd21175   80 PVLTYMAKCPGDCTD---VDGTGLGWFKIDEEGLDSGGGAWATDKLiangGTWTVTIPSNLAPGNYLLRHEIIALHSAGS 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898 169 YPGAQFYISCAQLKITG-GSGGSPAKVSIPGVYSGQEPGIKLNIYYPILNSYNFPGPAVY 227
Cdd:cd21175  157 VGGAQFYPSCAQIEVTGgGTGAPPPGVSFPGAYKATDPGILFNIYYPPPTSYTIPGPAVW 216
AA9 pfam03443
Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been ...
 21-219 7.68e-70

Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases. The substrate-binding surface of this family is a flat Ig-like fold. This family of enzymes were originally classified as glycoside hydrolases (GH61) and they have been reclassified as the Auxiliary Activity Family 9 (AA9) of CAZy.


Pssm-ID: 460918  Cd Length: 208  Bit Score: 212.44  E-value: 7.68e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898   21 YRFPSLIVGGTTTGQYQYVRQNSNM-------NSPVENVQSTDFTCNAGarlGSNTGTYEVAAGSTVGFALDQQ--VFHP 91
Cdd:pfam03443   1 GTVTSLVVNGVTYGGYDPVSDPVIRwtrpntdNGPVTDVTSPDIRCNGA---GPAATAAPVAAGSTVTFQWTQGwpESHK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345559898   92 GPYIVYLGQAPSsiTNLNSWDGSGANWFKIHQRQITFGSNG-PNWEML---NSLTFKLPTRIPSGLYLLRIEHIALHSAS 167
Cdd:pfam03443  78 GPVITYLAKCPG--GDCATVDGTGLVWFKIDEAGLDSGGSTwATDKLIannGTWTVTIPSDLAPGNYLLRHEIIALHSAG 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 345559898  168 NYPGAQFYISCAQLKITGGSGGSP-AKVSIPGVYSGQEPGIKLNIYYPILNSY 219
Cdd:pfam03443 156 SVGGAQFYPQCAQLEVTGSGSGTPgPGVSFPGAYKATDPGILFNIYSPGPTSY 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH