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Conserved domains on  [gi|344031400|gb|AEM77331|]
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histone H2A, partial [Drosophila mayri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
H2A super family cl30547
Histone 2A;
16-44 4.62e-14

Histone 2A;


The actual alignment was detected with superfamily member smart00414:

Pssm-ID: 197711  Cd Length: 106  Bit Score: 59.65  E-value: 4.62e-14
                           10        20
                   ....*....|....*....|....*....
gi 344031400    16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKGTYAKRVG 29
 
Name Accession Description Interval E-value
H2A smart00414
Histone 2A;
16-44 4.62e-14

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 59.65  E-value: 4.62e-14
                           10        20
                   ....*....|....*....|....*....
gi 344031400    16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKGTYAKRVG 29
PTZ00017 PTZ00017
histone H2A; Provisional
 16-44 7.87e-13

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 57.45  E-value: 7.87e-13
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PTZ00017  19 SRSAKAGLQFPVGRVHRYLKKGRYAKRVG 47
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 16-44 1.33e-12

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 55.62  E-value: 1.33e-12
                        10        20
                ....*....|....*....|....*....
gi 344031400 16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:cd00074   2 SRSKRAGLQFPVGRIHRLLKKGTYAKRVG 30
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
16-44 3.64e-09

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 47.93  E-value: 3.64e-09
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:COG5262   18 SRSAKAGLIFPVGRVKRLLKKGNYRMRIG 46
 
Name Accession Description Interval E-value
H2A smart00414
Histone 2A;
16-44 4.62e-14

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 59.65  E-value: 4.62e-14
                           10        20
                   ....*....|....*....|....*....
gi 344031400    16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKGTYAKRVG 29
PTZ00017 PTZ00017
histone H2A; Provisional
 16-44 7.87e-13

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 57.45  E-value: 7.87e-13
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PTZ00017  19 SRSAKAGLQFPVGRVHRYLKKGRYAKRVG 47
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 16-44 1.33e-12

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 55.62  E-value: 1.33e-12
                        10        20
                ....*....|....*....|....*....
gi 344031400 16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:cd00074   2 SRSKRAGLQFPVGRIHRLLKKGTYAKRVG 30
PLN00157 PLN00157
histone H2A; Provisional
 16-44 6.33e-10

histone H2A; Provisional


Pssm-ID: 177758  Cd Length: 132  Bit Score: 49.85  E-value: 6.33e-10
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PLN00157  18 SRSAKAGLQFPVGRIARYLKAGKYATRVG 46
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
16-44 3.64e-09

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 47.93  E-value: 3.64e-09
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:COG5262   18 SRSAKAGLIFPVGRVKRLLKKGNYRMRIG 46
PLN00156 PLN00156
histone H2AX; Provisional
 16-44 3.67e-09

histone H2AX; Provisional


Pssm-ID: 215080  Cd Length: 139  Bit Score: 48.04  E-value: 3.67e-09
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PLN00156  21 SRSSKAGLQFPVGRIARFLKAGKYAERVG 49
PLN00155 PLN00155
histone H2A; Provisional
 16-44 1.68e-08

histone H2A; Provisional


Pssm-ID: 165723  Cd Length: 58  Bit Score: 44.70  E-value: 1.68e-08
                        10        20
                ....*....|....*....|....*....
gi 344031400 16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PLN00155 16 SRSAKAGLQFPVGRIARYLKKGKYAERIG 44
PLN00153 PLN00153
histone H2A; Provisional
 16-44 6.72e-08

histone H2A; Provisional


Pssm-ID: 165721 [Multi-domain]  Cd Length: 129  Bit Score: 44.71  E-value: 6.72e-08
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PLN00153  16 SRSAKAGLQFPVGRIARYLKKGKYAERIG 44
PLN00154 PLN00154
histone H2A; Provisional
 16-44 5.99e-07

histone H2A; Provisional


Pssm-ID: 177756  Cd Length: 136  Bit Score: 42.24  E-value: 5.99e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAE-RVG 44
Cdd:PLN00154  30 SRSSRAGLQFPVGRIHRQLKQRVSAHgRVG 59
PTZ00252 PTZ00252
histone H2A; Provisional
 16-44 1.93e-06

histone H2A; Provisional


Pssm-ID: 240330  Cd Length: 134  Bit Score: 40.72  E-value: 1.93e-06
                         10        20
                 ....*....|....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLLRKGNYAERVG 44
Cdd:PTZ00252  17 GRSAKAGLIFPVGRVGSLLRRGQYARRIG 45
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 16-34 5.16e-04

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


Pssm-ID: 467038  Cd Length: 105  Bit Score: 33.81  E-value: 5.16e-04
                         10
                 ....*....|....*....
gi 344031400  16 SRSNRAGLQFPVGRIHRLL 34
Cdd:cd22913   10 SKSARCGLTFSVGRFHRWM 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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