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Conserved domains on  [gi|344031348|gb|AEM77303|]
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glycerol-3-phosphate dehydrogenase, partial [Drosophila lutescens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH super family cl29248
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-99 2.97e-42

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


The actual alignment was detected with superfamily member TIGR03376:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 140.55  E-value: 2.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348    1 PCAVLMGANLANEVAEGNFCETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLK 76
Cdd:TIGR03376 140 PCGVLSGANLANEVAKEKFSETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLG 219

                          90       100
                  ....*....|....*....|...
gi 344031348   77 LGDNTKAAVIRLGLMEMIRFVDV 99
Cdd:TIGR03376 220 WGDNAKAAVMRRGLLEMIKFARM 242
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-99 2.97e-42

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 140.55  E-value: 2.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348    1 PCAVLMGANLANEVAEGNFCETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLK 76
Cdd:TIGR03376 140 PCGVLSGANLANEVAKEKFSETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLG 219

                          90       100
                  ....*....|....*....|...
gi 344031348   77 LGDNTKAAVIRLGLMEMIRFVDV 99
Cdd:TIGR03376 220 WGDNAKAAVMRRGLLEMIKFARM 242
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-96 2.73e-34

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 120.51  E-value: 2.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PTZ00345 153 PCCALSGANVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTN 232

                         90
                 ....*....|....*.
gi 344031348  81 TKAAVIRLGLMEMIRF 96
Cdd:PTZ00345 233 TKSAIIRIGLEEMKLF 248
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 1-97 5.39e-22

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 87.01  E-value: 5.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:COG0240  128 RIAVLSGPSFAEEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDN 207

                         90
                 ....*....|....*..
gi 344031348  81 TKAAVIRLGLMEMIRFV 97
Cdd:COG0240  208 ARAALITRGLAEMTRLG 224
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 58-97 9.34e-21

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 80.13  E-value: 9.34e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 344031348   58 CGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFV 97
Cdd:pfam07479   8 GGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLG 47
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-99 2.97e-42

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 140.55  E-value: 2.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348    1 PCAVLMGANLANEVAEGNFCETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLK 76
Cdd:TIGR03376 140 PCGVLSGANLANEVAKEKFSETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLG 219

                          90       100
                  ....*....|....*....|...
gi 344031348   77 LGDNTKAAVIRLGLMEMIRFVDV 99
Cdd:TIGR03376 220 WGDNAKAAVMRRGLLEMIKFARM 242
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-96 2.73e-34

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 120.51  E-value: 2.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PTZ00345 153 PCCALSGANVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTN 232

                         90
                 ....*....|....*.
gi 344031348  81 TKAAVIRLGLMEMIRF 96
Cdd:PTZ00345 233 TKSAIIRIGLEEMKLF 248
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 1-97 5.39e-22

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 87.01  E-value: 5.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:COG0240  128 RIAVLSGPSFAEEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDN 207

                         90
                 ....*....|....*..
gi 344031348  81 TKAAVIRLGLMEMIRFV 97
Cdd:COG0240  208 ARAALITRGLAEMTRLG 224
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 58-97 9.34e-21

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 80.13  E-value: 9.34e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 344031348   58 CGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFV 97
Cdd:pfam07479   8 GGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLG 47
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-96 2.76e-20

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 82.42  E-value: 2.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PRK00094 129 PIAVLSGPSFAKEVARGLPTAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDN 208

                         90
                 ....*....|....*.
gi 344031348  81 TKAAVIRLGLMEMIRF 96
Cdd:PRK00094 209 ARAALITRGLAEITRL 224
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-96 2.66e-18

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 77.22  E-value: 2.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PRK14618 128 RVAVLSGPNHAEEIARFLPAATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDN 207

                         90
                 ....*....|....*.
gi 344031348  81 TKAAVIRLGLMEMIRF 96
Cdd:PRK14618 208 AKAALITRGLREMVRF 223
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-95 1.91e-14

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 66.73  E-value: 1.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PRK12439 134 PAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGEN 213

                         90
                 ....*....|....*
gi 344031348  81 TKAAVIRLGLMEMIR 95
Cdd:PRK12439 214 TRAMVIARALREMTK 228
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-95 1.11e-13

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 64.62  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PRK14619 105 PVVVLSGPNLSKEIQQGLPAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTN 184

                         90
                 ....*....|....*
gi 344031348  81 TKAAVIRLGLMEMIR 95
Cdd:PRK14619 185 AKAALVTRALPEMIR 199
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-93 3.94e-09

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 51.76  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344031348   1 PCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDN 80
Cdd:PRK14620 129 PIAILSGPSFAKEIAEKLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNN 208

                         90
                 ....*....|...
gi 344031348  81 TKAAVIRLGLMEM 93
Cdd:PRK14620 209 AHAAVITKGMNEI 221
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 1-31 6.74e-09

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 49.88  E-value: 6.74e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 344031348    1 PCAVLMGANLANEVAEGNFCETTIGCTDKKY 31
Cdd:pfam01210 127 PIAVLSGPSHAEEVAQGLPTATVIASKDEEA 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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