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Conserved domains on  [gi|341941199|sp|Q8R4F1|]
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RecName: Full=Netrin-G2; AltName: Full=Laminet-2; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 2.17e-59

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 197.42  E-value: 2.17e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199  136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341941199  215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 469-516 7.49e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 7.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 341941199  469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 516
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 7.26e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 7.26e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 341941199 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 413-461 9.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 9.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 341941199 413 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 461
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 523-547 5.19e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 5.19e-03
                         10        20
                 ....*....|....*....|....*...
gi 341941199 523 CQNGGTCQQNQ---RCACPPGYTGIRCE 547
Cdd:cd00054   11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 2.17e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 197.42  E-value: 2.17e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199  136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341941199  215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 6.64e-35

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 131.71  E-value: 6.64e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199    60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPspLEANITLSWNKSVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199   135 DdVVVTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSPSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341941199   214 -EVRdrfaifagPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATDFDN-------SPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 469-516 7.49e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 7.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 341941199  469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 516
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 469-506 1.48e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.12  E-value: 1.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 341941199 469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 506
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
469-506 3.58e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.92  E-value: 3.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 341941199   469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 506
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 7.26e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 7.26e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 341941199 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 4.07e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 4.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 341941199  287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 413-461 9.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 9.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 341941199 413 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 461
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 523-547 5.19e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 5.19e-03
                         10        20
                 ....*....|....*....|....*...
gi 341941199 523 CQNGGTCQQNQ---RCACPPGYTGIRCE 547
Cdd:cd00054   11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 413-455 6.06e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.02  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341941199  413 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRN 455
Cdd:pfam00053   1 CDCNPHGSLSDTCDPETGQ-CL-CKPGVTGRHCDRCKPGYYGL 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
287-323 6.22e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 34.98  E-value: 6.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 341941199   287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:smart00180   1 CDCDPGGSAsgtCDPDTG--QCECKPNVTGRRCDRCAPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 2.17e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 197.42  E-value: 2.17e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199  136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341941199  215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 6.64e-35

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 131.71  E-value: 6.64e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199    60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPspLEANITLSWNKSVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341941199   135 DdVVVTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSPSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341941199   214 -EVRdrfaifagPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATDFDN-------SPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 469-516 7.49e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 7.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 341941199  469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 516
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 469-506 1.48e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.12  E-value: 1.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 341941199 469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 506
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
469-506 3.58e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.92  E-value: 3.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 341941199   469 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 506
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 7.26e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 7.26e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 341941199 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 4.07e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 4.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 341941199  287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 413-461 9.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 9.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 341941199 413 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 461
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 523-547 5.19e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 5.19e-03
                         10        20
                 ....*....|....*....|....*...
gi 341941199 523 CQNGGTCQQNQ---RCACPPGYTGIRCE 547
Cdd:cd00054   11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 413-455 6.06e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.02  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341941199  413 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRN 455
Cdd:pfam00053   1 CDCNPHGSLSDTCDPETGQ-CL-CKPGVTGRHCDRCKPGYYGL 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
287-323 6.22e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 34.98  E-value: 6.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 341941199   287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:smart00180   1 CDCDPGGSAsgtCDPDTG--QCECKPNVTGRRCDRCAPGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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