|
Name |
Accession |
Description |
Interval |
E-value |
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
948-1264 |
2.90e-157 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
:
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 477.56 E-value: 2.90e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 948 VTVLGDILGSAMQ----NTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDG 1023
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1024 SYSTFGDKPGrshaNTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSA 1103
Cdd:pfam07678 81 SYSAFGHSPG----STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1104 YITIALLEM-----SLPVTHPVVRNALFCLDTAwksarRGASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKED 1178
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1179 NSVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVAL 1258
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 341940160 1259 HALSKY 1264
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
738-828 |
2.15e-40 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 144.27 E-value: 2.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 738 TWIWDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 341940160 818 LQTCIRVGVQL 828
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
356-451 |
6.38e-33 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
:
Pssm-ID: 465507 Cd Length: 95 Bit Score: 123.13 E-value: 6.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 356 LSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEANQNINTTTDKNGLARFSINTDDiMGTSLTVRAKYKDSN 435
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 341940160 436 VCYGFRWLTEENVEAW 451
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1374-1464 |
2.40e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 121.14 E-value: 2.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1374 SDSNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTE-VSNNHVLIYLDKVSNQMLTLFFMVQQDIPVRDLKPAIVKVYDY 1452
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 341940160 1453 YEKDEFAVAKYS 1464
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
135-1330 |
4.01e-31 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 133.67 E-value: 4.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 135 VFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELiPL-LYIQDSKKNRIAQwQNFRL-EGGLKQLSFPLSSEPTQGSYKVV 212
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 213 IRTESGRTV-EHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPG-HVTVNICRK------------- 277
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 278 YSNPSSCFGEESLAFcekFSQQLDGRGCFSQLVKTKsfQLKRQEYEMQLDVNAKIQEEGtgveetgkGLTkITRTITKL- 356
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG--------GRP-VTRSATVPv 594
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 357 ----SFVNV-----DTHFRQG-IPFvgQVLLVDGRGTPIP--------------------------YEMIFIGADEANQN 400
Cdd:COG2373 595 hpadFYVGIrlplfDGDPEGApATF--EVVAVDPDGKPVAgkglkvelyreewryvwyksddggwrYESQEKEEPVAEGT 672
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 401 IntTTDKNGLARFSINTDDimGTSLTVRAKYKDSNVcygfrwLTEENVEAWHTA-NAVFSPSRSFVHLESLPYKLRCEQT 479
Cdd:COG2373 673 L--TTGADGPASLSLTPVE--WGRYRLEVKDPDGGL------ATSVRFYAGGNAsWGAERPDRLELSLDKESYKPGETAK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 480 LAVQAHYilNDEAVL--ERKELVFYYLMMAKGGivraGTHV-LPVTQGHKKGHFsILISM-----ETDLAPVARLVLY-- 549
Cdd:COG2373 743 LLIQSPF--AGRALVtvERDGVLETQWVDVKGG----GTTVeIPVTEDWAPNAY-VSATLvrpgdSTANDMPARAYGVap 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 550 ------------------TILPNGEVvgdTVKYEIEkclankvdlvfhpniGLPATRAFLSVMAspqslcglraVDQSVL 611
Cdd:COG2373 816 lpvdpparrlkveltapeKLRPGETL---TVTVKVK---------------GAAGKAAEVTLAA----------VDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 612 ltkpeaelsaslvydllpvkDLTGFP-----KGVNQQEEdtngclkqndtyiNGILYSpvqntneeDMYGFLKDmglkvf 686
Cdd:COG2373 868 --------------------NLTGYKtpdplDFFYGKRA-------------LGVETR--------DLYGRLIG------ 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 687 tnlnirkpkvcerlGVNKIPAAyhlvSQGHMDAFLeSSESPTETTRSYFPETWIWD-LVIVDSTGVAEMEVTVPDTITEW 765
Cdd:COG2373 901 --------------AFGGAAGA----LRSGGDGAL-GRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTL 961
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 766 K--AGAFclsNDTGLGlSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFlaTPEEKEQ 843
Cdd:COG2373 962 RvmAVAW---SDDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEAT 1035
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 844 KSHCICMNERHTMSWAVIPKSLGNVNFTVSAEAL---DSKELcrnEVPVVPeRGKKDTIIKSLLVEPEGlenevtfnsll 920
Cdd:COG2373 1036 QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGgesDAREV---ELPVRP-ANPLVTRATSGVLAPGE----------- 1100
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 921 cptgaevSEQISLKLPSDVVEESARASVTV----LGDILGSAMQntqdLLKMPYGCGEQNMVLFAPNIYVLDyLNETEQL 996
Cdd:COG2373 1101 -------SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGL 1168
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 997 TQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFgdkPGRSHANTWLTAFVLKSFAQARRY-IFIDESHITQALTWLSQQQK 1075
Cdd:COG2373 1169 KGDKDAELRARIQAAIARLLSMQNSDGGFGLW---PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLR 1245
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1076 DNGcfrssgsllnnAMKGGVEDEVTLSAYITIALLEMSLPVTHPVvrNALFCLDTAWKS----ARRGASgnhvytkalla 1151
Cdd:COG2373 1246 NPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSplakAQLAAA----------- 1301
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1152 yaFALAGNQDTKKEILKSLdEEAVKEDNSVHWTRAqkprvpadlWYqpqapSAEVEMTAYVLLAYLTtelvpTREDLTAA 1231
Cdd:COG2373 1302 --LALLGDKARAEELLAAA-LARLRETGARDYWYG---------DY-----GSPLRDQALALALLAE-----LGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1232 MLIVKWLTKQQNShGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSsgafyTKFQVNNDNqlLLQRVTLP---TV 1308
Cdd:COG2373 1360 PKLARWLAKALKS-GRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRG--PLARVTLPaaeLL 1431
|
1290 1300
....*....|....*....|..
gi 341940160 1309 PGDYTAKVAGEGCVYLQTSLKY 1330
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSG 1453
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
948-1264 |
2.90e-157 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 477.56 E-value: 2.90e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 948 VTVLGDILGSAMQ----NTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDG 1023
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1024 SYSTFGDKPGrshaNTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSA 1103
Cdd:pfam07678 81 SYSAFGHSPG----STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1104 YITIALLEM-----SLPVTHPVVRNALFCLDTAwksarRGASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKED 1178
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1179 NSVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVAL 1258
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 341940160 1259 HALSKY 1264
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
958-1264 |
4.03e-153 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 465.90 E-value: 4.03e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 958 AMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGRSha 1037
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1038 NTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVT 1117
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1118 HPVVRNALFCLDTAWKSArrgasgNHVYTKALLAYAFALAGnQDTKKEILKSLDEEAVKEDNSVHWTRaqKPRVPADLWY 1197
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSR--PPPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940160 1198 QPQAPSAEVEMTAYVLLAYLTTElvptREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY 1264
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
738-828 |
2.15e-40 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 144.27 E-value: 2.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 738 TWIWDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 341940160 818 LQTCIRVGVQL 828
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
356-451 |
6.38e-33 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 123.13 E-value: 6.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 356 LSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEANQNINTTTDKNGLARFSINTDDiMGTSLTVRAKYKDSN 435
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 341940160 436 VCYGFRWLTEENVEAW 451
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1374-1464 |
2.40e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 121.14 E-value: 2.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1374 SDSNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTE-VSNNHVLIYLDKVSNQMLTLFFMVQQDIPVRDLKPAIVKVYDY 1452
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 341940160 1453 YEKDEFAVAKYS 1464
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
135-1330 |
4.01e-31 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 133.67 E-value: 4.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 135 VFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELiPL-LYIQDSKKNRIAQwQNFRL-EGGLKQLSFPLSSEPTQGSYKVV 212
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 213 IRTESGRTV-EHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPG-HVTVNICRK------------- 277
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 278 YSNPSSCFGEESLAFcekFSQQLDGRGCFSQLVKTKsfQLKRQEYEMQLDVNAKIQEEGtgveetgkGLTkITRTITKL- 356
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG--------GRP-VTRSATVPv 594
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 357 ----SFVNV-----DTHFRQG-IPFvgQVLLVDGRGTPIP--------------------------YEMIFIGADEANQN 400
Cdd:COG2373 595 hpadFYVGIrlplfDGDPEGApATF--EVVAVDPDGKPVAgkglkvelyreewryvwyksddggwrYESQEKEEPVAEGT 672
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 401 IntTTDKNGLARFSINTDDimGTSLTVRAKYKDSNVcygfrwLTEENVEAWHTA-NAVFSPSRSFVHLESLPYKLRCEQT 479
Cdd:COG2373 673 L--TTGADGPASLSLTPVE--WGRYRLEVKDPDGGL------ATSVRFYAGGNAsWGAERPDRLELSLDKESYKPGETAK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 480 LAVQAHYilNDEAVL--ERKELVFYYLMMAKGGivraGTHV-LPVTQGHKKGHFsILISM-----ETDLAPVARLVLY-- 549
Cdd:COG2373 743 LLIQSPF--AGRALVtvERDGVLETQWVDVKGG----GTTVeIPVTEDWAPNAY-VSATLvrpgdSTANDMPARAYGVap 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 550 ------------------TILPNGEVvgdTVKYEIEkclankvdlvfhpniGLPATRAFLSVMAspqslcglraVDQSVL 611
Cdd:COG2373 816 lpvdpparrlkveltapeKLRPGETL---TVTVKVK---------------GAAGKAAEVTLAA----------VDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 612 ltkpeaelsaslvydllpvkDLTGFP-----KGVNQQEEdtngclkqndtyiNGILYSpvqntneeDMYGFLKDmglkvf 686
Cdd:COG2373 868 --------------------NLTGYKtpdplDFFYGKRA-------------LGVETR--------DLYGRLIG------ 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 687 tnlnirkpkvcerlGVNKIPAAyhlvSQGHMDAFLeSSESPTETTRSYFPETWIWD-LVIVDSTGVAEMEVTVPDTITEW 765
Cdd:COG2373 901 --------------AFGGAAGA----LRSGGDGAL-GRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTL 961
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 766 K--AGAFclsNDTGLGlSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFlaTPEEKEQ 843
Cdd:COG2373 962 RvmAVAW---SDDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEAT 1035
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 844 KSHCICMNERHTMSWAVIPKSLGNVNFTVSAEAL---DSKELcrnEVPVVPeRGKKDTIIKSLLVEPEGlenevtfnsll 920
Cdd:COG2373 1036 QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGgesDAREV---ELPVRP-ANPLVTRATSGVLAPGE----------- 1100
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 921 cptgaevSEQISLKLPSDVVEESARASVTV----LGDILGSAMQntqdLLKMPYGCGEQNMVLFAPNIYVLDyLNETEQL 996
Cdd:COG2373 1101 -------SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGL 1168
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 997 TQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFgdkPGRSHANTWLTAFVLKSFAQARRY-IFIDESHITQALTWLSQQQK 1075
Cdd:COG2373 1169 KGDKDAELRARIQAAIARLLSMQNSDGGFGLW---PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLR 1245
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1076 DNGcfrssgsllnnAMKGGVEDEVTLSAYITIALLEMSLPVTHPVvrNALFCLDTAWKS----ARRGASgnhvytkalla 1151
Cdd:COG2373 1246 NPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSplakAQLAAA----------- 1301
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1152 yaFALAGNQDTKKEILKSLdEEAVKEDNSVHWTRAqkprvpadlWYqpqapSAEVEMTAYVLLAYLTtelvpTREDLTAA 1231
Cdd:COG2373 1302 --LALLGDKARAEELLAAA-LARLRETGARDYWYG---------DY-----GSPLRDQALALALLAE-----LGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1232 MLIVKWLTKQQNShGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSsgafyTKFQVNNDNqlLLQRVTLP---TV 1308
Cdd:COG2373 1360 PKLARWLAKALKS-GRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRG--PLARVTLPaaeLL 1431
|
1290 1300
....*....|....*....|..
gi 341940160 1309 PGDYTAKVAGEGCVYLQTSLKY 1330
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSG 1453
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
229-319 |
6.03e-29 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 111.21 E-value: 6.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 229 EFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPGHVTVNICRKYSNPSSCFgeeslafcEKFSQQLDGRGCFSQ 308
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCF--------ESFSKELDKDGCGSA 72
|
90
....*....|.
gi 341940160 309 LVKTKSFQLKR 319
Cdd:pfam17791 73 SLSTEEFQLTF 83
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
948-1264 |
2.90e-157 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 477.56 E-value: 2.90e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 948 VTVLGDILGSAMQ----NTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDG 1023
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1024 SYSTFGDKPGrshaNTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSA 1103
Cdd:pfam07678 81 SYSAFGHSPG----STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1104 YITIALLEM-----SLPVTHPVVRNALFCLDTAwksarRGASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKED 1178
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1179 NSVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVAL 1258
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 341940160 1259 HALSKY 1264
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
958-1264 |
4.03e-153 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 465.90 E-value: 4.03e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 958 AMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGRSha 1037
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1038 NTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVT 1117
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1118 HPVVRNALFCLDTAWKSArrgasgNHVYTKALLAYAFALAGnQDTKKEILKSLDEEAVKEDNSVHWTRaqKPRVPADLWY 1197
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSR--PPPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940160 1198 QPQAPSAEVEMTAYVLLAYLTTElvptREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY 1264
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
958-1264 |
8.70e-107 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 340.52 E-value: 8.70e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 958 AMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGdkpGRSHA 1037
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1038 NTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVt 1117
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1118 HPVVRNALFCLDTAWKSArrgasgNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWtraqkprvpADLWY 1197
Cdd:cd02891 157 DASIEKALAYLETQLDGL------LDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW---------SLSWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940160 1198 QPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY 1264
Cdd:cd02891 222 GDYGSSLRVEATAYALLALL------KLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
961-1264 |
1.32e-77 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 259.13 E-value: 1.32e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 961 NTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQ---EIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGrsha 1037
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKlgpERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPS---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1038 NTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGV---EDEVTLSAYITIALLEmSL 1114
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQE-AR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1115 PVTHPVVRNalfcldtaWKSARRGASG---------NHVYTKALLAYAFALAgNQDTKKEILKSLDEEAVKEDNSVHWtr 1185
Cdd:cd02896 159 SICPPEVQN--------LDQSIRKAISylenqlpnlQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYW-- 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 341940160 1186 aqkPRVPADLWYQPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY 1264
Cdd:cd02896 228 ---WTIDSPYWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
958-1264 |
1.61e-61 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 212.80 E-value: 1.61e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 958 AMQNTQDLLKMPYG--------CGEQNMVLFAPNIYVLDYLNETEqltqeIKTKAITYLNTGYQRQLNYKHRDGSYSTFg 1029
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGW- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1030 dkPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMkgGVEDEVTLSAYITIAL 1109
Cdd:cd00688 75 --GGNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1110 LEMSLPVTHPVVRNALFCLDTAWKSARRGASG--NHVYTKALLAYAFALAG--NQDTKKEILKSLDEEAVKEDNSVHWTR 1185
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCQNYDGGFGPGgeSHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1186 aqkprvpadlWYQPQAPSAEVEMTAYVLLAYLttelvpTREDLTAAMLIVKWLTKQQNSHGGFSS-------TQDTVVAL 1258
Cdd:cd00688 231 ----------RTNKLSDSCYTEWAAYALLALG------KLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFAL 294
|
....*.
gi 341940160 1259 HALSKY 1264
Cdd:cd00688 295 LALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
738-828 |
2.15e-40 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 144.27 E-value: 2.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 738 TWIWDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 341940160 818 LQTCIRVGVQL 828
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
356-451 |
6.38e-33 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 123.13 E-value: 6.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 356 LSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEANQNINTTTDKNGLARFSINTDDiMGTSLTVRAKYKDSN 435
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 341940160 436 VCYGFRWLTEENVEAW 451
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1374-1464 |
2.40e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 121.14 E-value: 2.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1374 SDSNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTE-VSNNHVLIYLDKVSNQMLTLFFMVQQDIPVRDLKPAIVKVYDY 1452
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 341940160 1453 YEKDEFAVAKYS 1464
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
135-1330 |
4.01e-31 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 133.67 E-value: 4.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 135 VFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELiPL-LYIQDSKKNRIAQwQNFRL-EGGLKQLSFPLSSEPTQGSYKVV 212
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 213 IRTESGRTV-EHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPG-HVTVNICRK------------- 277
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 278 YSNPSSCFGEESLAFcekFSQQLDGRGCFSQLVKTKsfQLKRQEYEMQLDVNAKIQEEGtgveetgkGLTkITRTITKL- 356
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG--------GRP-VTRSATVPv 594
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 357 ----SFVNV-----DTHFRQG-IPFvgQVLLVDGRGTPIP--------------------------YEMIFIGADEANQN 400
Cdd:COG2373 595 hpadFYVGIrlplfDGDPEGApATF--EVVAVDPDGKPVAgkglkvelyreewryvwyksddggwrYESQEKEEPVAEGT 672
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 401 IntTTDKNGLARFSINTDDimGTSLTVRAKYKDSNVcygfrwLTEENVEAWHTA-NAVFSPSRSFVHLESLPYKLRCEQT 479
Cdd:COG2373 673 L--TTGADGPASLSLTPVE--WGRYRLEVKDPDGGL------ATSVRFYAGGNAsWGAERPDRLELSLDKESYKPGETAK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 480 LAVQAHYilNDEAVL--ERKELVFYYLMMAKGGivraGTHV-LPVTQGHKKGHFsILISM-----ETDLAPVARLVLY-- 549
Cdd:COG2373 743 LLIQSPF--AGRALVtvERDGVLETQWVDVKGG----GTTVeIPVTEDWAPNAY-VSATLvrpgdSTANDMPARAYGVap 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 550 ------------------TILPNGEVvgdTVKYEIEkclankvdlvfhpniGLPATRAFLSVMAspqslcglraVDQSVL 611
Cdd:COG2373 816 lpvdpparrlkveltapeKLRPGETL---TVTVKVK---------------GAAGKAAEVTLAA----------VDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 612 ltkpeaelsaslvydllpvkDLTGFP-----KGVNQQEEdtngclkqndtyiNGILYSpvqntneeDMYGFLKDmglkvf 686
Cdd:COG2373 868 --------------------NLTGYKtpdplDFFYGKRA-------------LGVETR--------DLYGRLIG------ 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 687 tnlnirkpkvcerlGVNKIPAAyhlvSQGHMDAFLeSSESPTETTRSYFPETWIWD-LVIVDSTGVAEMEVTVPDTITEW 765
Cdd:COG2373 901 --------------AFGGAAGA----LRSGGDGAL-GRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTL 961
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 766 K--AGAFclsNDTGLGlSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFlaTPEEKEQ 843
Cdd:COG2373 962 RvmAVAW---SDDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEAT 1035
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 844 KSHCICMNERHTMSWAVIPKSLGNVNFTVSAEAL---DSKELcrnEVPVVPeRGKKDTIIKSLLVEPEGlenevtfnsll 920
Cdd:COG2373 1036 QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGgesDAREV---ELPVRP-ANPLVTRATSGVLAPGE----------- 1100
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 921 cptgaevSEQISLKLPSDVVEESARASVTV----LGDILGSAMQntqdLLKMPYGCGEQNMVLFAPNIYVLDyLNETEQL 996
Cdd:COG2373 1101 -------SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGL 1168
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 997 TQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFgdkPGRSHANTWLTAFVLKSFAQARRY-IFIDESHITQALTWLSQQQK 1075
Cdd:COG2373 1169 KGDKDAELRARIQAAIARLLSMQNSDGGFGLW---PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLR 1245
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1076 DNGcfrssgsllnnAMKGGVEDEVTLSAYITIALLEMSLPVTHPVvrNALFCLDTAWKS----ARRGASgnhvytkalla 1151
Cdd:COG2373 1246 NPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSplakAQLAAA----------- 1301
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1152 yaFALAGNQDTKKEILKSLdEEAVKEDNSVHWTRAqkprvpadlWYqpqapSAEVEMTAYVLLAYLTtelvpTREDLTAA 1231
Cdd:COG2373 1302 --LALLGDKARAEELLAAA-LARLRETGARDYWYG---------DY-----GSPLRDQALALALLAE-----LGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 1232 MLIVKWLTKQQNShGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSsgafyTKFQVNNDNqlLLQRVTLP---TV 1308
Cdd:COG2373 1360 PKLARWLAKALKS-GRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRG--PLARVTLPaaeLL 1431
|
1290 1300
....*....|....*....|..
gi 341940160 1309 PGDYTAKVAGEGCVYLQTSLKY 1330
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSG 1453
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
229-319 |
6.03e-29 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 111.21 E-value: 6.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 229 EFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPGHVTVNICRKYSNPSSCFgeeslafcEKFSQQLDGRGCFSQ 308
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCF--------ESFSKELDKDGCGSA 72
|
90
....*....|.
gi 341940160 309 LVKTKSFQLKR 319
Cdd:pfam17791 73 SLSTEEFQLTF 83
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
465-612 |
8.63e-24 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 98.58 E-value: 8.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 465 VHLESLPYKLRCEQTLAVQAHYILNDEAVLERkelvFYYLMMAKGGIVRAGThvlpvtqghKKGHFSILISMETDLAPVA 544
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDG----FTYLVLSKGQIVVVGR---------GGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 341940160 545 RLVLYTI---LPNGEVVGDTVKYEIEKCLANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLL 612
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLL 138
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
135-227 |
5.41e-21 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 88.91 E-value: 5.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940160 135 VFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELIPLLYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSEPTQGSYKVVIR 214
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 341940160 215 TE-SGRTVEHPFSV 227
Cdd:pfam01835 82 DGaGGSLGSGSFRV 95
|
|
| |
