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Conserved domains on  [gi|341931143|gb|AEL04673|]
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activity-dependent neuroprotector, partial [Phymaturus palluma]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADNP_N super family cl45031
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
 8-153 1.50e-62

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


The actual alignment was detected with superfamily member pfam19627:

Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 204.31  E-value: 1.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341931143    8 GVNMMSNVHLQQNNYGVKSVPPSYVSHTGGRLSLTGNSPVSLSQPSPSMKQYPPSGNGRHYPLGGEPRSQATARYSLQSA 87
Cdd:pfam19627 310 KANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSG 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 341931143   88 NSPSLSSGSLKSTSLAQSQAASRVLAQSTPKPL--GAGVNTSSTQKWKICTICNELFPENVYSVHFEK 153
Cdd:pfam19627 390 NSASSSSSQLKSPPLSSSVAATRALGQGPSKSSasAAGLNTSYTQKWKICTICNELFPENVYSAHFEK 457
 
Name Accession Description Interval E-value
ADNP_N pfam19627
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
 8-153 1.50e-62

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 204.31  E-value: 1.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341931143    8 GVNMMSNVHLQQNNYGVKSVPPSYVSHTGGRLSLTGNSPVSLSQPSPSMKQYPPSGNGRHYPLGGEPRSQATARYSLQSA 87
Cdd:pfam19627 310 KANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSG 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 341931143   88 NSPSLSSGSLKSTSLAQSQAASRVLAQSTPKPL--GAGVNTSSTQKWKICTICNELFPENVYSVHFEK 153
Cdd:pfam19627 390 NSASSSSSQLKSPPLSSSVAATRALGQGPSKSSasAAGLNTSYTQKWKICTICNELFPENVYSAHFEK 457
 
Name Accession Description Interval E-value
ADNP_N pfam19627
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
 8-153 1.50e-62

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 204.31  E-value: 1.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341931143    8 GVNMMSNVHLQQNNYGVKSVPPSYVSHTGGRLSLTGNSPVSLSQPSPSMKQYPPSGNGRHYPLGGEPRSQATARYSLQSA 87
Cdd:pfam19627 310 KANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSG 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 341931143   88 NSPSLSSGSLKSTSLAQSQAASRVLAQSTPKPL--GAGVNTSSTQKWKICTICNELFPENVYSVHFEK 153
Cdd:pfam19627 390 NSASSSSSQLKSPPLSSSVAATRALGQGPSKSSasAAGLNTSYTQKWKICTICNELFPENVYSAHFEK 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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