NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|341892718|gb|EGT48653|]
View 

CBN-RIC-8 protein [Caenorhabditis brenneri]

Protein Classification

synembryn( domain architecture ID 10562755)

synembryn is a guanine nucleotide exchange factor (GEF) which promotes exchange of bound GDP for free GTP, similar to human synembryn-A (also known as Ric-8A) and synembryn-B (also known as Ric-8B)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-521 1.69e-130

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


:

Pssm-ID: 462973  Cd Length: 412  Bit Score: 386.94  E-value: 1.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718   66 LLETIRLLSRDRNGLEGLLNVDLCNKVLAFAglqTGEGVPKNPHALMEAQKCLINTMYHSQRMRDVFyateensenLLFY 145
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLG---LAFDSAGSSEVSREALRCLANALLLSPEARQIF---------VDRL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  146 LLEFSPQnrktsehQWIREMHEVQAAEVWFFYHRIGFISTAMSRDFQKKWANEPKMIDNLLPAVEYIIEKKD-------- 217
Cdd:pfam10165  69 LGYADKA-------CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAkrypdssa 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  218 --FISQDRERANEALKTFFNIFCHFHGEVQaiDQKHAIKATRILRDIICSDRSD----DELIMSAVHAVSVPPLpivlsv 291
Cdd:pfam10165 142 ssLSPMEDMALTETLKLLFNLTLFYPDLVP--DSAFSPALPPILRLLLLLPIPSpdplEPPLSHLINALLNLPL------ 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  292 wcqDPEKDakataeddevvdlfREYDDMKMTEALLSSLDKQLtvavkmlnntphdkvstEANT-LCDLIGPYFQALARLC 370
Cdd:pfam10165 214 ---TDSKK--------------YEGNNMDVVERLLDLLDKRL-----------------DAYDeLDELLTPLLTLLTRLY 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  371 VESKHARRYCRIRVIPPLVadEVKKRPEEHDSLRGRIVRIMMLPSA--TKDVAAEFLFIICKRSVNRMIKYFGFGHSAGH 448
Cdd:pfam10165 260 EAAREVRKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLTprLKDAAAELLFVLCKEDASRFVKYVGYGNAAGF 337

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341892718  449 LANMGLLGQINQQKHASDSEDSETEEYNQVRDNVNPVTGAIYPEDHGSALAGMSDEQKEYEAMKLVDAMNKMM 521
Cdd:pfam10165 338 LANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPENPMEEMTEEEKEREAERLFVLFDRLK 410
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-521 1.69e-130

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 386.94  E-value: 1.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718   66 LLETIRLLSRDRNGLEGLLNVDLCNKVLAFAglqTGEGVPKNPHALMEAQKCLINTMYHSQRMRDVFyateensenLLFY 145
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLG---LAFDSAGSSEVSREALRCLANALLLSPEARQIF---------VDRL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  146 LLEFSPQnrktsehQWIREMHEVQAAEVWFFYHRIGFISTAMSRDFQKKWANEPKMIDNLLPAVEYIIEKKD-------- 217
Cdd:pfam10165  69 LGYADKA-------CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAkrypdssa 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  218 --FISQDRERANEALKTFFNIFCHFHGEVQaiDQKHAIKATRILRDIICSDRSD----DELIMSAVHAVSVPPLpivlsv 291
Cdd:pfam10165 142 ssLSPMEDMALTETLKLLFNLTLFYPDLVP--DSAFSPALPPILRLLLLLPIPSpdplEPPLSHLINALLNLPL------ 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  292 wcqDPEKDakataeddevvdlfREYDDMKMTEALLSSLDKQLtvavkmlnntphdkvstEANT-LCDLIGPYFQALARLC 370
Cdd:pfam10165 214 ---TDSKK--------------YEGNNMDVVERLLDLLDKRL-----------------DAYDeLDELLTPLLTLLTRLY 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  371 VESKHARRYCRIRVIPPLVadEVKKRPEEHDSLRGRIVRIMMLPSA--TKDVAAEFLFIICKRSVNRMIKYFGFGHSAGH 448
Cdd:pfam10165 260 EAAREVRKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLTprLKDAAAELLFVLCKEDASRFVKYVGYGNAAGF 337

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341892718  449 LANMGLLGQINQQKHASDSEDSETEEYNQVRDNVNPVTGAIYPEDHGSALAGMSDEQKEYEAMKLVDAMNKMM 521
Cdd:pfam10165 338 LANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPENPMEEMTEEEKEREAERLFVLFDRLK 410
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 66-521 1.69e-130

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 386.94  E-value: 1.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718   66 LLETIRLLSRDRNGLEGLLNVDLCNKVLAFAglqTGEGVPKNPHALMEAQKCLINTMYHSQRMRDVFyateensenLLFY 145
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLG---LAFDSAGSSEVSREALRCLANALLLSPEARQIF---------VDRL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  146 LLEFSPQnrktsehQWIREMHEVQAAEVWFFYHRIGFISTAMSRDFQKKWANEPKMIDNLLPAVEYIIEKKD-------- 217
Cdd:pfam10165  69 LGYADKA-------CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAkrypdssa 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  218 --FISQDRERANEALKTFFNIFCHFHGEVQaiDQKHAIKATRILRDIICSDRSD----DELIMSAVHAVSVPPLpivlsv 291
Cdd:pfam10165 142 ssLSPMEDMALTETLKLLFNLTLFYPDLVP--DSAFSPALPPILRLLLLLPIPSpdplEPPLSHLINALLNLPL------ 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  292 wcqDPEKDakataeddevvdlfREYDDMKMTEALLSSLDKQLtvavkmlnntphdkvstEANT-LCDLIGPYFQALARLC 370
Cdd:pfam10165 214 ---TDSKK--------------YEGNNMDVVERLLDLLDKRL-----------------DAYDeLDELLTPLLTLLTRLY 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341892718  371 VESKHARRYCRIRVIPPLVadEVKKRPEEHDSLRGRIVRIMMLPSA--TKDVAAEFLFIICKRSVNRMIKYFGFGHSAGH 448
Cdd:pfam10165 260 EAAREVRKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLTprLKDAAAELLFVLCKEDASRFVKYVGYGNAAGF 337

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 341892718  449 LANMGLLGQINQQKHASDSEDSETEEYNQVRDNVNPVTGAIYPEDHGSALAGMSDEQKEYEAMKLVDAMNKMM 521
Cdd:pfam10165 338 LANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPENPMEEMTEEEKEREAERLFVLFDRLK 410
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH