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Conserved domains on  [gi|34101286|ref|NP_057191|]
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zinc finger RNA-binding protein [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13915102)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DZF smart00572
domain in DSRM or ZnF_C2H2 domain containing proteins;
784-1038 1.17e-139

domain in DSRM or ZnF_C2H2 domain containing proteins;


:

Pssm-ID: 128842  Cd Length: 246  Bit Score: 419.86  E-value: 1.17e-139
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     784 ALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPekydikcavSEAAIILNSCVEPKMQV 863
Cdd:smart00572    1 TLKGVMRVGSFAKGTLLKGDNVAELVLLCKEKPTSELVARLARKLPEQLKAVTE---------DEALIIVTSTKEPTMEV 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     864 TITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFP 943
Cdd:smart00572   72 GILITSPLARVELLITTVPENLRKLDPEDHLDRKKCLSALASLRHAKWFQARASGLQSCVIVIRVLRDLCNRVPTWQPLS 151

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     944 SWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAF 1023
Cdd:smart00572  152 GWPLELLVEKAIGSARQPLGLGDAFRRVFECLASGILLPGSPGLTDPCEKDNTDALTALTLQQREDVTASAQTALRLLAF 231

                           250
                    ....*....|....*
gi 34101286    1024 RQIHKVLGMDPLPQM 1038
Cdd:smart00572  232 GQIHKILGMDPLPSM 246
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 581-612 6.58e-08

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 49.56  E-value: 6.58e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 34101286     581 RFHCKLCECSFNDPNAKEMHLKGRRHRLQYKK 612
Cdd:smart00451    3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 331-360 5.00e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 46.86  E-value: 5.00e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 34101286     331 HYCDVCKISCAGPQTYKEHLEGQKHKKKEA 360
Cdd:smart00451    4 FYCKLCNVTFTDEISVEAHLKGKKHKKNVK 33
PHA03255 super family cl31530
BDLF3; Provisional
 382-551 5.31e-06

BDLF3; Provisional


The actual alignment was detected with superfamily member PHA03255:

Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 49.13  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   382 LRCE--LCDVSCTGADAYAAHIRGAkhqkvvklhTKLGKPIPSTEPNVVSQATSSTAVSAskPTASPSSIAANNCTVntS 459
Cdd:PHA03255   16 LICEtsLIWTSSGSSTASAGNVTGT---------TAVTTPSPSASGPSTNQSTTLTTTSA--PITTTAILSTNTTTV--T 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   460 SVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINfvgGNKLQSTGNKAEDIKGTECVKSTPVTSAVQIPE 539
Cdd:PHA03255   83 STGTTVTPVPTTSNASTINVTTKVTAQNITATEAGTGTSTGVTS---NVTTRSSSTTSATTRITNATTLAPTLSSKGTSN 159

                         170
                  ....*....|..
gi 34101286   540 VKQDTVSEPVTP 551
Cdd:PHA03255  160 ATKTTAELPTVP 171
 
Name Accession Description Interval E-value
DZF smart00572
domain in DSRM or ZnF_C2H2 domain containing proteins;
784-1038 1.17e-139

domain in DSRM or ZnF_C2H2 domain containing proteins;


Pssm-ID: 128842  Cd Length: 246  Bit Score: 419.86  E-value: 1.17e-139
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     784 ALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPekydikcavSEAAIILNSCVEPKMQV 863
Cdd:smart00572    1 TLKGVMRVGSFAKGTLLKGDNVAELVLLCKEKPTSELVARLARKLPEQLKAVTE---------DEALIIVTSTKEPTMEV 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     864 TITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFP 943
Cdd:smart00572   72 GILITSPLARVELLITTVPENLRKLDPEDHLDRKKCLSALASLRHAKWFQARASGLQSCVIVIRVLRDLCNRVPTWQPLS 151

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     944 SWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAF 1023
Cdd:smart00572  152 GWPLELLVEKAIGSARQPLGLGDAFRRVFECLASGILLPGSPGLTDPCEKDNTDALTALTLQQREDVTASAQTALRLLAF 231

                           250
                    ....*....|....*
gi 34101286    1024 RQIHKVLGMDPLPQM 1038
Cdd:smart00572  232 GQIHKILGMDPLPSM 246
DZF pfam07528
DZF domain; The function of this domain is unknown. It is often found associated with ...
 790-1036 1.48e-74

DZF domain; The function of this domain is unknown. It is often found associated with pfam00098 or pfam00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily.


Pssm-ID: 284860  Cd Length: 248  Bit Score: 246.33  E-value: 1.48e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    790 RVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPekyDIKCAVSEAAIILNSCVEPKMQVTITLTS 869
Cdd:pfam07528    1 QVGSFKKGTLLKGSNVADVVVILKTLPTTELVDALAKKVEEDLKTSMK---TEILQSVEALIVIKNTKEPPLELGFHITS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    870 PIIRE--------ENMRegdvtsgmVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSD 941
Cdd:pfam07528   78 PVAKVrmliatlpENLR--------KLEPEDHLDRKKMQSHLASIRHTRWFEENAHHLKSIKVLIRVLKDLCRRFDTFGP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    942 FPSWAMELLVEKAISSASSPQS--PGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALR 1019
Cdd:pfam07528  150 LSGWPLDLLAHKAIMNNPSRQAlpAGEAFRRVFELLASGIFLPGSAGITDPCEKGHTRVHTHLTLQQQDDCCMTAQTLLR 229

                          250
                   ....*....|....*..
gi 34101286   1020 LLAFRQIHKVLGMDPLP 1036
Cdd:pfam07528  230 VLAHGGYKHILGMDGNT 246
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 581-612 6.58e-08

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 49.56  E-value: 6.58e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 34101286     581 RFHCKLCECSFNDPNAKEMHLKGRRHRLQYKK 612
Cdd:smart00451    3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 331-360 5.00e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 46.86  E-value: 5.00e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 34101286     331 HYCDVCKISCAGPQTYKEHLEGQKHKKKEA 360
Cdd:smart00451    4 FYCKLCNVTFTDEISVEAHLKGKKHKKNVK 33
PHA03255 PHA03255
BDLF3; Provisional
 382-551 5.31e-06

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 49.13  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   382 LRCE--LCDVSCTGADAYAAHIRGAkhqkvvklhTKLGKPIPSTEPNVVSQATSSTAVSAskPTASPSSIAANNCTVntS 459
Cdd:PHA03255   16 LICEtsLIWTSSGSSTASAGNVTGT---------TAVTTPSPSASGPSTNQSTTLTTTSA--PITTTAILSTNTTTV--T 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   460 SVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINfvgGNKLQSTGNKAEDIKGTECVKSTPVTSAVQIPE 539
Cdd:PHA03255   83 STGTTVTPVPTTSNASTINVTTKVTAQNITATEAGTGTSTGVTS---NVTTRSSSTTSATTRITNATTLAPTLSSKGTSN 159

                         170
                  ....*....|..
gi 34101286   540 VKQDTVSEPVTP 551
Cdd:PHA03255  160 ATKTTAELPTVP 171
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 384-413 5.63e-06

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 43.78  E-value: 5.63e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 34101286     384 CELCDVSCTGADAYAAHIRGAKHQKVVKLH 413
Cdd:smart00451    6 CKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 582-606 5.24e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.94  E-value: 5.24e-05
                           10        20
                   ....*....|....*....|....*
gi 34101286    582 FHCKLCECSFNDPNAKEMHLKGRRH 606
Cdd:pfam12874    1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 332-355 6.19e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.94  E-value: 6.19e-05
                           10        20
                   ....*....|....*....|....
gi 34101286    332 YCDVCKISCAGPQTYKEHLEGQKH 355
Cdd:pfam12874    2 YCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 382-406 1.97e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 39.40  E-value: 1.97e-04
                           10        20
                   ....*....|....*....|....*
gi 34101286    382 LRCELCDVSCTGADAYAAHIRGAKH 406
Cdd:pfam12874    1 FYCELCNVTFNSESQLKSHLQGKKH 25
 
Name Accession Description Interval E-value
DZF smart00572
domain in DSRM or ZnF_C2H2 domain containing proteins;
784-1038 1.17e-139

domain in DSRM or ZnF_C2H2 domain containing proteins;


Pssm-ID: 128842  Cd Length: 246  Bit Score: 419.86  E-value: 1.17e-139
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     784 ALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPekydikcavSEAAIILNSCVEPKMQV 863
Cdd:smart00572    1 TLKGVMRVGSFAKGTLLKGDNVAELVLLCKEKPTSELVARLARKLPEQLKAVTE---------DEALIIVTSTKEPTMEV 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     864 TITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFP 943
Cdd:smart00572   72 GILITSPLARVELLITTVPENLRKLDPEDHLDRKKCLSALASLRHAKWFQARASGLQSCVIVIRVLRDLCNRVPTWQPLS 151

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286     944 SWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAF 1023
Cdd:smart00572  152 GWPLELLVEKAIGSARQPLGLGDAFRRVFECLASGILLPGSPGLTDPCEKDNTDALTALTLQQREDVTASAQTALRLLAF 231

                           250
                    ....*....|....*
gi 34101286    1024 RQIHKVLGMDPLPQM 1038
Cdd:smart00572  232 GQIHKILGMDPLPSM 246
DZF pfam07528
DZF domain; The function of this domain is unknown. It is often found associated with ...
 790-1036 1.48e-74

DZF domain; The function of this domain is unknown. It is often found associated with pfam00098 or pfam00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily.


Pssm-ID: 284860  Cd Length: 248  Bit Score: 246.33  E-value: 1.48e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    790 RVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPekyDIKCAVSEAAIILNSCVEPKMQVTITLTS 869
Cdd:pfam07528    1 QVGSFKKGTLLKGSNVADVVVILKTLPTTELVDALAKKVEEDLKTSMK---TEILQSVEALIVIKNTKEPPLELGFHITS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    870 PIIRE--------ENMRegdvtsgmVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSD 941
Cdd:pfam07528   78 PVAKVrmliatlpENLR--------KLEPEDHLDRKKMQSHLASIRHTRWFEENAHHLKSIKVLIRVLKDLCRRFDTFGP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286    942 FPSWAMELLVEKAISSASSPQS--PGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALR 1019
Cdd:pfam07528  150 LSGWPLDLLAHKAIMNNPSRQAlpAGEAFRRVFELLASGIFLPGSAGITDPCEKGHTRVHTHLTLQQQDDCCMTAQTLLR 229

                          250
                   ....*....|....*..
gi 34101286   1020 LLAFRQIHKVLGMDPLP 1036
Cdd:pfam07528  230 VLAHGGYKHILGMDGNT 246
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 581-612 6.58e-08

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 49.56  E-value: 6.58e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 34101286     581 RFHCKLCECSFNDPNAKEMHLKGRRHRLQYKK 612
Cdd:smart00451    3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 331-360 5.00e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 46.86  E-value: 5.00e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 34101286     331 HYCDVCKISCAGPQTYKEHLEGQKHKKKEA 360
Cdd:smart00451    4 FYCKLCNVTFTDEISVEAHLKGKKHKKNVK 33
PHA03255 PHA03255
BDLF3; Provisional
 382-551 5.31e-06

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 49.13  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   382 LRCE--LCDVSCTGADAYAAHIRGAkhqkvvklhTKLGKPIPSTEPNVVSQATSSTAVSAskPTASPSSIAANNCTVntS 459
Cdd:PHA03255   16 LICEtsLIWTSSGSSTASAGNVTGT---------TAVTTPSPSASGPSTNQSTTLTTTSA--PITTTAILSTNTTTV--T 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34101286   460 SVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINfvgGNKLQSTGNKAEDIKGTECVKSTPVTSAVQIPE 539
Cdd:PHA03255   83 STGTTVTPVPTTSNASTINVTTKVTAQNITATEAGTGTSTGVTS---NVTTRSSSTTSATTRITNATTLAPTLSSKGTSN 159

                         170
                  ....*....|..
gi 34101286   540 VKQDTVSEPVTP 551
Cdd:PHA03255  160 ATKTTAELPTVP 171
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 384-413 5.63e-06

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 43.78  E-value: 5.63e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 34101286     384 CELCDVSCTGADAYAAHIRGAKHQKVVKLH 413
Cdd:smart00451    6 CKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 582-606 5.24e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.94  E-value: 5.24e-05
                           10        20
                   ....*....|....*....|....*
gi 34101286    582 FHCKLCECSFNDPNAKEMHLKGRRH 606
Cdd:pfam12874    1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 332-355 6.19e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.94  E-value: 6.19e-05
                           10        20
                   ....*....|....*....|....
gi 34101286    332 YCDVCKISCAGPQTYKEHLEGQKH 355
Cdd:pfam12874    2 YCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 382-406 1.97e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 39.40  E-value: 1.97e-04
                           10        20
                   ....*....|....*....|....*
gi 34101286    382 LRCELCDVSCTGADAYAAHIRGAKH 406
Cdd:pfam12874    1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 581-607 2.35e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 2.35e-03
                           10        20
                   ....*....|....*....|....*..
gi 34101286    581 RFHCKLCECSFNDPNAKEMHLKGRRHR 607
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLKSKKHK 27
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 331-356 2.64e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 2.64e-03
                           10        20
                   ....*....|....*....|....*.
gi 34101286    331 HYCDVCKISCAGPQTYKEHLEGQKHK 356
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKSKKHK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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