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Conserved domains on  [gi|339781334|gb|AEK07168|]
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RusA-like resolvase [Mycobacterium phage JoeDirt]

Protein Classification

RusA family crossover junction endodeoxyribonuclease( domain architecture ID 3786)

RusA family crossover junction endodeoxyribonuclease similar to crossover junction endodeoxyribonuclease RusA that resolves Holliday junction intermediates and promotes DNA repair; may be partial

CATH:  3.30.1330.70
EC:  3.1.21.10
Gene Ontology:  GO:0006281|GO:0006310|GO:0000287|GO:0008821|GO:0000400
PubMed:  17028102|10482492

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RusA super family cl01885
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 23-110 4.92e-09

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


The actual alignment was detected with superfamily member COG4570:

Pssm-ID: 470382  Cd Length: 120  Bit Score: 50.27  E-value: 4.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339781334  23 DTVYWLARRAGIKDL--GPSVVSVTWY-TPTRRATDSDSLgpfVKGALDGLVRAGVWPDDNsryvkQ-TRMAVTDS-DTK 97
Cdd:COG4570   35 NLVALAARQQMPKKPleGPVAVEIKFYfPPDRRKPDLDNL---LKAILDALTGAGVWKDDS-----QvVDLIVEKRyDDK 106

                         90
                 ....*....|...
gi 339781334  98 HPRIEIRIWEVGD 110
Cdd:COG4570  107 GPRVEVEIEELEE 119
 
Name Accession Description Interval E-value
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 23-110 4.92e-09

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 50.27  E-value: 4.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339781334  23 DTVYWLARRAGIKDL--GPSVVSVTWY-TPTRRATDSDSLgpfVKGALDGLVRAGVWPDDNsryvkQ-TRMAVTDS-DTK 97
Cdd:COG4570   35 NLVALAARQQMPKKPleGPVAVEIKFYfPPDRRKPDLDNL---LKAILDALTGAGVWKDDS-----QvVDLIVEKRyDDK 106

                         90
                 ....*....|...
gi 339781334  98 HPRIEIRIWEVGD 110
Cdd:COG4570  107 GPRVEVEIEELEE 119
 
Name Accession Description Interval E-value
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 23-110 4.92e-09

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 50.27  E-value: 4.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339781334  23 DTVYWLARRAGIKDL--GPSVVSVTWY-TPTRRATDSDSLgpfVKGALDGLVRAGVWPDDNsryvkQ-TRMAVTDS-DTK 97
Cdd:COG4570   35 NLVALAARQQMPKKPleGPVAVEIKFYfPPDRRKPDLDNL---LKAILDALTGAGVWKDDS-----QvVDLIVEKRyDDK 106

                         90
                 ....*....|...
gi 339781334  98 HPRIEIRIWEVGD 110
Cdd:COG4570  107 GPRVEVEIEELEE 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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