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Conserved domains on  [gi|339732821|emb|CAZ96162|]
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TonB-dependent Receptor [Zobellia galactanivorans]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 11499350)

SusC/RagA family TonB-linked outer membrane protein might act as a TonB-dependent receptor similar to Bacteroides thetaiotaomicron starch-utilization system protein C (SusC), which mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation

CATH:  1.25.40.390
Gene Ontology:  GO:0009279|GO:0016020
PubMed:  15111112|28077872|11717282|17965357

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 35-1013 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 959.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    35 VSGTVSDSNG-PLPGANVIVKGTNNGAQADFDGNYALdNVADDASLVFSYVGFKTKEVALNGQTVINVTLEEDAESLEEV 113
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSL-KVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   114 VVVGYGTQKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSGKLPGVITRQETGKPGADgGEFLIRGKSTF-GNNSALILVDG 192
Cdd:TIGR04056   82 VVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGD-AEIWIRGISSFgGNNSPLYVIDG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   193 VERS--IDRLDPNAIESITILKDAASAAIYGARAANGVVLVTTKRGALGAPSISYNSSFGFQSAVQVPEMLNAGEFAEYF 270
Cdd:TIGR04056  161 VPRDngLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELY 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   271 NEASLNSGDNP--AFTGEQVQQYQNGTL----PSTDWWGEVIRKSAPIQQQGITVSGGGERVRYFTSLGMLDQKGLYETS 344
Cdd:TIGR04056  241 NEALLNRGSSPpdIYTDEEIEAYRNGLDpdlyPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   345 SFKRYNVRANVDIDLTDRFTLGIDLAGRKEKI---SDSSNSPFNSLLNSQPTSPAYVPDSVEPG-GLGYNGVN---INPI 417
Cdd:TIGR04056  321 DYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYnnpGGSTSNIWGALMLFPRGTPYSTPPVYSDGyYPAYNSGNtslQNPY 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   418 GeAIYSGYKRTNWNVFQGNFKLKYDIpIEGLTTTFKYNYDHSFKNEKefkepyTFYVSDPvnnIYTPFNSISNITLTEGY 497
Cdd:TIGR04056  401 A-LLNRGYNENERNRLNGNASLEQKI-TKGLKLKGTFSYDYSNYKNK------KYYKNPY---YYNATGGANNGYYSESN 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   498 DEIVQETTQFFVNYDRAFGKHNLGALFVYEKVDNERKNieagrQGFVSPSIDQLFAGGATGQISdGTASESARQGYIGRV 577
Cdd:TIGR04056  470 SRSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSS-----YGGLLDDLPSLDAGTSDASVS-GSDSEYRLQSLFGRA 543

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   578 TYSYADKYLFQANVRHDGSYNFPKDKRWGTFPAFSVGWKISEEGFLSGV-DAIETLKLRASWGKFGNDRVGP-FQFLSGY 655
Cdd:TIGR04056  544 TYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDrYPYLSLY 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   656 TFNSGSVI--GTSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILIARnaSIPKSFGAS 733
Cdd:TIGR04056  624 NLGDGGYNfgTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSR--SLPSVTGYS 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   734 LPKENLGIVDNKGFELALTYKGRIGENFKFELSPNMTKATSEVIFIDEPED---VEDRIRKTGRPFDQLYGYTSEGLFKS 810
Cdd:TIGR04056  702 SPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYlpvKYPYISKEGGPIGQIYGYIADGLFKD 781

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   811 QEEIDgwadqdgQGNASLKTGDIKYKDINNDDVIDGFDVQQIGKSVIPEIVYGLNLSMSYKNLDLNASFQGA--TDYNSY 888
Cdd:TIGR04056  782 DDSPK-------QTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGYSNTPDLTYGFGNSFSYKGFDLSALFQGSggGDVFND 854

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   889 --AYIGAFSLGSNAIRERVLDSY-REGNENATFPRAYFNTPPN--NERTSTFWMIDGSYLKLRNVEVGYNLPDAVMDKLG 963
Cdd:TIGR04056  855 grGFYPFNGGDWGNVLKIVADNRwTPENPNADYPRLSYGDSNNsnNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIG 934

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|
gi 339732821   964 IDSIRFFVSGNNLLTFSKYDFYDPERPleeSGNSLYYPQLRRVNLGFSVN 1013
Cdd:TIGR04056  935 ISNLRVYFSGQNLFTFSKYKGWDPELQ---GNDGGAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 35-1013 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 959.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    35 VSGTVSDSNG-PLPGANVIVKGTNNGAQADFDGNYALdNVADDASLVFSYVGFKTKEVALNGQTVINVTLEEDAESLEEV 113
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSL-KVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   114 VVVGYGTQKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSGKLPGVITRQETGKPGADgGEFLIRGKSTF-GNNSALILVDG 192
Cdd:TIGR04056   82 VVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGD-AEIWIRGISSFgGNNSPLYVIDG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   193 VERS--IDRLDPNAIESITILKDAASAAIYGARAANGVVLVTTKRGALGAPSISYNSSFGFQSAVQVPEMLNAGEFAEYF 270
Cdd:TIGR04056  161 VPRDngLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELY 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   271 NEASLNSGDNP--AFTGEQVQQYQNGTL----PSTDWWGEVIRKSAPIQQQGITVSGGGERVRYFTSLGMLDQKGLYETS 344
Cdd:TIGR04056  241 NEALLNRGSSPpdIYTDEEIEAYRNGLDpdlyPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   345 SFKRYNVRANVDIDLTDRFTLGIDLAGRKEKI---SDSSNSPFNSLLNSQPTSPAYVPDSVEPG-GLGYNGVN---INPI 417
Cdd:TIGR04056  321 DYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYnnpGGSTSNIWGALMLFPRGTPYSTPPVYSDGyYPAYNSGNtslQNPY 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   418 GeAIYSGYKRTNWNVFQGNFKLKYDIpIEGLTTTFKYNYDHSFKNEKefkepyTFYVSDPvnnIYTPFNSISNITLTEGY 497
Cdd:TIGR04056  401 A-LLNRGYNENERNRLNGNASLEQKI-TKGLKLKGTFSYDYSNYKNK------KYYKNPY---YYNATGGANNGYYSESN 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   498 DEIVQETTQFFVNYDRAFGKHNLGALFVYEKVDNERKNieagrQGFVSPSIDQLFAGGATGQISdGTASESARQGYIGRV 577
Cdd:TIGR04056  470 SRSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSS-----YGGLLDDLPSLDAGTSDASVS-GSDSEYRLQSLFGRA 543

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   578 TYSYADKYLFQANVRHDGSYNFPKDKRWGTFPAFSVGWKISEEGFLSGV-DAIETLKLRASWGKFGNDRVGP-FQFLSGY 655
Cdd:TIGR04056  544 TYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDrYPYLSLY 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   656 TFNSGSVI--GTSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILIARnaSIPKSFGAS 733
Cdd:TIGR04056  624 NLGDGGYNfgTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSR--SLPSVTGYS 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   734 LPKENLGIVDNKGFELALTYKGRIGENFKFELSPNMTKATSEVIFIDEPED---VEDRIRKTGRPFDQLYGYTSEGLFKS 810
Cdd:TIGR04056  702 SPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYlpvKYPYISKEGGPIGQIYGYIADGLFKD 781

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   811 QEEIDgwadqdgQGNASLKTGDIKYKDINNDDVIDGFDVQQIGKSVIPEIVYGLNLSMSYKNLDLNASFQGA--TDYNSY 888
Cdd:TIGR04056  782 DDSPK-------QTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGYSNTPDLTYGFGNSFSYKGFDLSALFQGSggGDVFND 854

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   889 --AYIGAFSLGSNAIRERVLDSY-REGNENATFPRAYFNTPPN--NERTSTFWMIDGSYLKLRNVEVGYNLPDAVMDKLG 963
Cdd:TIGR04056  855 grGFYPFNGGDWGNVLKIVADNRwTPENPNADYPRLSYGDSNNsnNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIG 934

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|
gi 339732821   964 IDSIRFFVSGNNLLTFSKYDFYDPERPleeSGNSLYYPQLRRVNLGFSVN 1013
Cdd:TIGR04056  935 ISNLRVYFSGQNLFTFSKYKGWDPELQ---GNDGGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
110-900 2.91e-47

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 180.02  E-value: 2.91e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  110 LEEVVVVGYGT-QKKSDLTGAVAVVKGEKVNIAPTPSLTQNLsGKLPGVITRQETGkpgaDGGEFLIRGKSTFGNNsALI 188
Cdd:COG1629     1 LEEVVVTATRTdESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSVTSAGG----GAGQISIRGFGGGGNR-VLV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  189 LVDGVE--------RSIDRLDPNAIESITILKDAaSAAIYGARAANGVVLVTTKRGALGaPSISYNSSFGfqsavqvpem 260
Cdd:COG1629    75 LVDGVPlndpsggdGGLSYIDPEDIERVEVLRGP-SSALYGSGALGGVINIVTKKPKDG-KGGEVSASYG---------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  261 lnagefaeyfneaslnsgdnpaftgeqvqqyQNGTlpstdwwgevirksapiQQQGITVSGGGERVRYFTSLGMLDQKGL 340
Cdd:COG1629   143 -------------------------------SYGT-----------------YRASLSLSGGNGKLAYRLSASYRDSDGY 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  341 YETSSFKRYNVRANVDIDLTDRFTLGIDLAGRKEKISDSSNSPFNSLlnsqptspayvpdsvEPGGLGYNGVNInpigea 420
Cdd:COG1629   175 RDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAAL---------------RPRGAMDDGTNP------ 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  421 iYSGYKRTNWNvFQGNFKLKYDIPIEGLTTTFKYNYDHSFKNekefkepytfyvsdpVNNIYTPFNSISNiTLTEGYDEI 500
Cdd:COG1629   234 -YSNDTDDNTR-DRYSLSLEYEHLGDGLKLSASAYYRYDDTD---------------LDSDFTPTPADGG-TLEQTDFDN 295

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  501 VQETTQFFVNYDRAFG-KHNLGALFVYEKVDNERKNIEAGRQGFVSPSIDQLFAggatgqisdgTASESARQGYIGRVTY 579
Cdd:COG1629   296 RTYGLELRLTYDLGFGgKHTLLVGLDYQRQDLDGSGYPLDLGSGSLPTLTSGAD----------DDGTTTSLALYAQDTY 365

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  580 SYADKYLFQANVRHDGSYNFPKDKRWGT------------FPAFSVGWKISEegflsgvdaieTLKLRASWGKfgndrvg 647
Cdd:COG1629   366 KLTDKLTLTAGLRYDYVSYDVDDTVTGTdsasgsrsysafSPSLGLTYQLSP-----------NLSLYASYSR------- 427

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  648 pfqflsgyTFNSGSVigtSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILIarNASIP 727
Cdd:COG1629   428 --------GFRAPTF---GELYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEIL--SVPLP 494

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  728 KSFGASLPKENLGIVDNKGFELALTYkgRIGENFKFELSPNMTKAtsEVIFIDEPEDVEDRIRKTGRPFDQLYGYTsegl 807
Cdd:COG1629   495 NDSGFSTYYTNAGKARSYGVELELSY--QLTPGLSLNASYSYTDA--KFDDDTDGSADLDGNRLPGVPPLTANLGL---- 566

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  808 fkSQEEIDGWadqDGQGNASLkTGDIKYKDINNDDVIDGFDVqqigksvipeivygLNLSMSYK---NLDLNASFQGATD 884
Cdd:COG1629   567 --TYEFPGGW---SLGLGVRY-VGDRYLDDANTQGAPGGYTL--------------VDLGAGYRfgdNLTLSLGVDNLFD 626

                         810
                  ....*....|....*.
gi 339732821  885 YNsYAYIGAFSLGSNA 900
Cdd:COG1629   627 KK-YATSLSVRASNVR 641
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 35-115 1.14e-22

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 93.04  E-value: 1.14e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    35 VSGTVSDSNG--PLPGANVIVKGTNNGAQADFDGNYALDNV-ADDASLVFSYVGFKTKEVAL---NGQTV-INVTLEEDA 107
Cdd:pfam13715    1 ISGTVVDENTgePLPGATVYVKGTTKGTVTDADGNFELKNLpAGTYTLVVSFVGYKTQEKKVtvsNDNTLdVNFLLKEDA 80


                   ....*...
gi 339732821   108 ESLEEVVV 115
Cdd:pfam13715   81 LLLDEVVV 88
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 154-558 2.50e-10

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 64.39  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  154 LPGVITrqeTGKPGADGGEFLIRGkstFGNNSALILVDGVE---------RSIDRLDPNAIESITILKDAASaAIYGARA 224
Cdd:cd01347    25 IPGVSV---TRGGGGGGSTISIRG---FGPDRTLVLVDGLPlassnygrgVDLNTIPPELIERVEVLKGPSS-ALYGSGA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  225 ANGVVLVTTKRGA---LGAPSISYNSS---FGFQSAVQVPEMLNAGEFAEYFNEASLNSGD---NPAFTGEQVQQYQNGT 295
Cdd:cd01347    98 IGGVVNIITKRPTdefGGSVTAGYGSDnsgSSGGGGFDVSGALADDGAFGARLYGAYRDGDgtiDGDGQADDSDEERYNV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  296 LPSTDWWGE---VIRKSAPIQQQGITVSGGGERVRYFTSLGMLDQKGLYETSSFKRYNVRanvdidLTDRFTLGIDLAGR 372
Cdd:cd01347   178 AGKLDWRPDddtRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDR------YRKRASLGLEHDLN 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  373 KEKISDSSNSPFNSLLNSQPTSPAYVPDSVEPGGLGYNGVninpigeaiYSGYKRTNWnVFQGNFKLKYDIPIEGLTTTF 452
Cdd:cd01347   252 DTGWTLRANLSYSYTDNDGDPLILNGGNNAAGGDLGRSGY---------SSERDTTQL-GFDAGLNAPFGTGPVAHTLTL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  453 KYNYDHSFKNEKEfkepYTFYVSDpvnniytPFNSISNITLTEG--YDEIVQETTQFFVNYDRA--FGKHNLGALFVYEK 528
Cdd:cd01347   322 GVEYRREELDEKQ----TALYAQD-------TIELTDDLTLTLGlrYDHYDQDSKDTIAGGTTAkkSYSHWSPSLGLVYK 390

                         410       420       430
                  ....*....|....*....|....*....|...
gi 339732821  529 VDNE---RKNIEagrQGFVSPSIDQLFAGGATG 558
Cdd:cd01347   391 LTDGlslYASYS---QGFRAPSLGELYGGGSHG 420
PRK13486 PRK13486
TonB-dependent receptor;
77-387 1.15e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 49.25  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   77 ASLVFSYVGFktkevalngqTVINVTLEEDAesleeVVVVGYGTQKK-SDLTGAVAVVKGEKVNIAPTPSLTQNLSGkLP 155
Cdd:PRK13486    7 ASVVIPCLGF----------SASSIAAAEDV-----MIVSASGYEKKlTNAAASVSVISQEELQSSQYHDLAEALRS-VE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  156 GVITRQETGKPGadGGEFLIRGKSTfgnNSALILVDGVERS-IDRLDPN--------------AIESITILKDAASAaIY 220
Cdd:PRK13486   71 GVDVESGTGKTG--GLEISIRGMPA---SYTLILIDGVRQGgSSDVTPNgfsamntgfmpplaAIERIEVIRGPMST-LY 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  221 GARAANGVVLVTTKRgalgapsisynssfgfqsavqvpemlNAGEFaeyfnEASLNSGDNpaftgeqvQQYQN--GTLPS 298
Cdd:PRK13486  145 GSDAMGGVVNIITRK--------------------------NADKW-----LSSVNAGLN--------LQESNkwGNSSQ 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  299 TDWW--GEVIRKSAPIQQQGITVSGGGERVryfTSLGMLDQKGL-YETSSfKRYNVRANVDIDLTDRFTLGIDLAGRKEK 375
Cdd:PRK13486  186 FNFWssGPLVDDSVSLQVRGSTQQRQGSSV---TSLSDTAATRIpYPTES-QNYNLGARLDWKASEQDVLWFDMDTTRQR 261

                         330
                  ....*....|..
gi 339732821  376 IsDSSNSPFNSL 387
Cdd:PRK13486  262 Y-DNRDGQLGSL 272
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 35-1013 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 959.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    35 VSGTVSDSNG-PLPGANVIVKGTNNGAQADFDGNYALdNVADDASLVFSYVGFKTKEVALNGQTVINVTLEEDAESLEEV 113
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSL-KVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   114 VVVGYGTQKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSGKLPGVITRQETGKPGADgGEFLIRGKSTF-GNNSALILVDG 192
Cdd:TIGR04056   82 VVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGD-AEIWIRGISSFgGNNSPLYVIDG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   193 VERS--IDRLDPNAIESITILKDAASAAIYGARAANGVVLVTTKRGALGAPSISYNSSFGFQSAVQVPEMLNAGEFAEYF 270
Cdd:TIGR04056  161 VPRDngLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELY 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   271 NEASLNSGDNP--AFTGEQVQQYQNGTL----PSTDWWGEVIRKSAPIQQQGITVSGGGERVRYFTSLGMLDQKGLYETS 344
Cdd:TIGR04056  241 NEALLNRGSSPpdIYTDEEIEAYRNGLDpdlyPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   345 SFKRYNVRANVDIDLTDRFTLGIDLAGRKEKI---SDSSNSPFNSLLNSQPTSPAYVPDSVEPG-GLGYNGVN---INPI 417
Cdd:TIGR04056  321 DYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYnnpGGSTSNIWGALMLFPRGTPYSTPPVYSDGyYPAYNSGNtslQNPY 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   418 GeAIYSGYKRTNWNVFQGNFKLKYDIpIEGLTTTFKYNYDHSFKNEKefkepyTFYVSDPvnnIYTPFNSISNITLTEGY 497
Cdd:TIGR04056  401 A-LLNRGYNENERNRLNGNASLEQKI-TKGLKLKGTFSYDYSNYKNK------KYYKNPY---YYNATGGANNGYYSESN 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   498 DEIVQETTQFFVNYDRAFGKHNLGALFVYEKVDNERKNieagrQGFVSPSIDQLFAGGATGQISdGTASESARQGYIGRV 577
Cdd:TIGR04056  470 SRSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSS-----YGGLLDDLPSLDAGTSDASVS-GSDSEYRLQSLFGRA 543

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   578 TYSYADKYLFQANVRHDGSYNFPKDKRWGTFPAFSVGWKISEEGFLSGV-DAIETLKLRASWGKFGNDRVGP-FQFLSGY 655
Cdd:TIGR04056  544 TYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDrYPYLSLY 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   656 TFNSGSVI--GTSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILIARnaSIPKSFGAS 733
Cdd:TIGR04056  624 NLGDGGYNfgTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSR--SLPSVTGYS 701

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   734 LPKENLGIVDNKGFELALTYKGRIGENFKFELSPNMTKATSEVIFIDEPED---VEDRIRKTGRPFDQLYGYTSEGLFKS 810
Cdd:TIGR04056  702 SPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYlpvKYPYISKEGGPIGQIYGYIADGLFKD 781

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   811 QEEIDgwadqdgQGNASLKTGDIKYKDINNDDVIDGFDVQQIGKSVIPEIVYGLNLSMSYKNLDLNASFQGA--TDYNSY 888
Cdd:TIGR04056  782 DDSPK-------QTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGYSNTPDLTYGFGNSFSYKGFDLSALFQGSggGDVFND 854

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   889 --AYIGAFSLGSNAIRERVLDSY-REGNENATFPRAYFNTPPN--NERTSTFWMIDGSYLKLRNVEVGYNLPDAVMDKLG 963
Cdd:TIGR04056  855 grGFYPFNGGDWGNVLKIVADNRwTPENPNADYPRLSYGDSNNsnNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIG 934

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|
gi 339732821   964 IDSIRFFVSGNNLLTFSKYDFYDPERPleeSGNSLYYPQLRRVNLGFSVN 1013
Cdd:TIGR04056  935 ISNLRVYFSGQNLFTFSKYKGWDPELQ---GNDGGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
110-900 2.91e-47

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 180.02  E-value: 2.91e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  110 LEEVVVVGYGT-QKKSDLTGAVAVVKGEKVNIAPTPSLTQNLsGKLPGVITRQETGkpgaDGGEFLIRGKSTFGNNsALI 188
Cdd:COG1629     1 LEEVVVTATRTdESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSVTSAGG----GAGQISIRGFGGGGNR-VLV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  189 LVDGVE--------RSIDRLDPNAIESITILKDAaSAAIYGARAANGVVLVTTKRGALGaPSISYNSSFGfqsavqvpem 260
Cdd:COG1629    75 LVDGVPlndpsggdGGLSYIDPEDIERVEVLRGP-SSALYGSGALGGVINIVTKKPKDG-KGGEVSASYG---------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  261 lnagefaeyfneaslnsgdnpaftgeqvqqyQNGTlpstdwwgevirksapiQQQGITVSGGGERVRYFTSLGMLDQKGL 340
Cdd:COG1629   143 -------------------------------SYGT-----------------YRASLSLSGGNGKLAYRLSASYRDSDGY 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  341 YETSSFKRYNVRANVDIDLTDRFTLGIDLAGRKEKISDSSNSPFNSLlnsqptspayvpdsvEPGGLGYNGVNInpigea 420
Cdd:COG1629   175 RDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAAL---------------RPRGAMDDGTNP------ 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  421 iYSGYKRTNWNvFQGNFKLKYDIPIEGLTTTFKYNYDHSFKNekefkepytfyvsdpVNNIYTPFNSISNiTLTEGYDEI 500
Cdd:COG1629   234 -YSNDTDDNTR-DRYSLSLEYEHLGDGLKLSASAYYRYDDTD---------------LDSDFTPTPADGG-TLEQTDFDN 295

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  501 VQETTQFFVNYDRAFG-KHNLGALFVYEKVDNERKNIEAGRQGFVSPSIDQLFAggatgqisdgTASESARQGYIGRVTY 579
Cdd:COG1629   296 RTYGLELRLTYDLGFGgKHTLLVGLDYQRQDLDGSGYPLDLGSGSLPTLTSGAD----------DDGTTTSLALYAQDTY 365

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  580 SYADKYLFQANVRHDGSYNFPKDKRWGT------------FPAFSVGWKISEegflsgvdaieTLKLRASWGKfgndrvg 647
Cdd:COG1629   366 KLTDKLTLTAGLRYDYVSYDVDDTVTGTdsasgsrsysafSPSLGLTYQLSP-----------NLSLYASYSR------- 427

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  648 pfqflsgyTFNSGSVigtSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILIarNASIP 727
Cdd:COG1629   428 --------GFRAPTF---GELYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEIL--SVPLP 494

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  728 KSFGASLPKENLGIVDNKGFELALTYkgRIGENFKFELSPNMTKAtsEVIFIDEPEDVEDRIRKTGRPFDQLYGYTsegl 807
Cdd:COG1629   495 NDSGFSTYYTNAGKARSYGVELELSY--QLTPGLSLNASYSYTDA--KFDDDTDGSADLDGNRLPGVPPLTANLGL---- 566

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  808 fkSQEEIDGWadqDGQGNASLkTGDIKYKDINNDDVIDGFDVqqigksvipeivygLNLSMSYK---NLDLNASFQGATD 884
Cdd:COG1629   567 --TYEFPGGW---SLGLGVRY-VGDRYLDDANTQGAPGGYTL--------------VDLGAGYRfgdNLTLSLGVDNLFD 626

                         810
                  ....*....|....*.
gi 339732821  885 YNsYAYIGAFSLGSNA 900
Cdd:COG1629   627 KK-YATSLSVRASNVR 641
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 102-766 2.34e-35

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 143.46  E-value: 2.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  102 TLEEDAESLEEVVVVGYGT-QKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSgKLPGVITRQETGKPGadGGEFLIRGkst 180
Cdd:COG4771    19 ALAEDATELEEVVVTATRTeQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGG--SSGISIRG--- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  181 FGNNSALILVDGVERS---------IDRLDPNAIESITILKDAASAaIYGARAANGVVLVTTKRGAlgapsisynssfgf 251
Cdd:COG4771    93 LGGDRVLVLIDGVPVNnpalggggdLSYIPPDDIERIEVIRGPASA-LYGSDAIGGVINIITKKPT-------------- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  252 qsavqvpemlnagefAEYFNEASLNSGDNPAFTgeqvqqyqngtlpstdwwgevirksapiQQQGITVSGGGERVRYFTS 331
Cdd:COG4771   158 ---------------DELEGSVSLGYGSNGNGT----------------------------YSGSLSLGGPGDKLSFLLS 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  332 LGMLDQKGLYET--------SSFKRYNVRANVDIDLTDRFTLGIDLAGRKEKisdssnspfnsllnsqptspayvpdsve 403
Cdd:COG4771   195 GSYRDRDGYLDYrnggfvgnSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQD---------------------------- 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  404 pgglGYNGVNINPIGEAIYSGYKRTNWNVFQGNFKLKYDIPIeGLTTTFKYNYDHSFKNEkefkepytfyvsdpvnniyt 483
Cdd:COG4771   247 ----RDGGPPTLGDTEISSDNAGDRDTTTDRGNYSLRYNGDL-GDNLDLSLYYSRTDRDS-------------------- 301

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  484 pfNSISNITLTEGYDEIVQETTQFFVNYDRAFG-KHNL--GALFVYEKVDNERknieagrqgfvspsidqlfaggatgqI 560
Cdd:COG4771   302 --TNGSLGGSTGSFSDSDDTTYGLELDLTYPLGgNHTLtlGAEYRYDDLDSSS--------------------------F 353

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  561 SDGTASESARQGYIGRVTYSYADKYLFQANVRHDGSYNFPKDKRWGTFPAFSVGWKISEEgflsgvdaietLKLRASWGK 640
Cdd:COG4771   354 LGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDN-----------LTLRASYGR 422

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  641 fgndrvgpfqflsgyTFNSGSVIGTSGAYKPGIQDTGIPNPNITWETATAKNLGLDFSLWKGRLSGEFDIFSKRTKDILI 720
Cdd:COG4771   423 ---------------GFRAPSLAELYGSGTGTPGRYVLGNPDLKPETSDNYELGLEYRLGNGGLSLSLTGFYTDIKDLIV 487

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 339732821  721 ARNasIPKSFGASLPKENLGIVDNKGFELALTYkgRIGENFKFELS 766
Cdd:COG4771   488 LVP--VGPGPGDVLQYENVGKARTYGLELELKY--RLGKGLTLTAS 529
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
113-391 4.36e-29

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 117.67  E-value: 4.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  113 VVVVGYG-TQKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSgKLPGVITRQeTGKPGAdGGEFLIRGkstFGNNSALILVD 191
Cdd:COG4206     1 VVVTATRlEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSS-SGGPGS-AASISIRG---LGSNQTLVLID 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  192 GVERS--------IDRLDPNAIESITILKDAASAaIYGARAANGVVLVTTKRGALGA-PSISYN-SSFGFQSAvQVPEML 261
Cdd:COG4206    75 GVPLNdpslggvdLSLIPPDDIERIEVLKGAASA-LYGSDAIGGVINITTKKGKKGFkGSVSASyGSFGTRRL-SASLSG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  262 NAGEFAEYFNEASLNSGDnpaftgeqvQQYQNGTLPSTDWWgevirksapiQQQGITVSGG---GERVRYFTSLGMLDQK 338
Cdd:COG4206   153 GAGKFSYSLSASYRRSDG---------YRYNDPDLRNNDGY----------ENTSLNARLGyklGDNGSLSLSGGYSDSE 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 339732821  339 GLYETSSFKRYNVRANVDIDLTDRFTLGIDLAGRKEKISDSSNSPFNSLLNSQ 391
Cdd:COG4206   214 RGYPGAVGSDRNLRLSLSLEYKLSDGWSLLLLAYYYYDRDYEDGGGDSAGTSN 266
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 35-115 1.14e-22

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 93.04  E-value: 1.14e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    35 VSGTVSDSNG--PLPGANVIVKGTNNGAQADFDGNYALDNV-ADDASLVFSYVGFKTKEVAL---NGQTV-INVTLEEDA 107
Cdd:pfam13715    1 ISGTVVDENTgePLPGATVYVKGTTKGTVTDADGNFELKNLpAGTYTLVVSFVGYKTQEKKVtvsNDNTLdVNFLLKEDA 80


                   ....*...
gi 339732821   108 ESLEEVVV 115
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 122-228 1.15e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 73.84  E-value: 1.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   122 KKSDLTGAVAVVKGEKVNIAPTPSLTQNLSGkLPGVITrqeTGKPGADGGEFLIRGkstFGNNSALILVDGV-------- 193
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSV---SSGGGGGGSSISIRG---FGSNRVLVLVDGVplnsgggg 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 339732821   194 ERSIDRLDPNAIESITILKDAASaAIYGARAANGV 228
Cdd:pfam07715   74 SVDLNSIDPEDIERVEVLKGPAS-ALYGSGAIGGV 107
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 205-234 6.98e-13

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 63.37  E-value: 6.98e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 339732821   205 IESITILKDAASAAIYGARAANGVVLVTTK 234
Cdd:TIGR04057    2 IESISVLKDASAAAIYGSRGANGVILITTK 31
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
34-103 1.10e-11

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 61.53  E-value: 1.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821    34 SVSGTVSDSNG-PLPGANVIVK----GTNNGAQADFDGNYALDNV-ADDASLVFSYVGFKTKE-----VALNGQTVINVT 102
Cdd:pfam13620    1 TISGTVTDPSGaPVPGATVTVTntdtGTVRTTTTDADGRYRFPGLpPGTYTVTVSAPGFKTATrtgvtVTAGQTTTLDVT 80


                   .
gi 339732821   103 L 103
Cdd:pfam13620   81 L 81
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 389-753 1.07e-10

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 65.18  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   389 NSQPTSPAYVPDSVEPGGLGYNGVNIN-PIGEAIYSGYKRTNWNVFQGNFKLKYDIPIEGLTTTFKYNYDHSFKNEKEFK 467
Cdd:pfam00593    1 GWQLSLDLLGDDTLLTLGYDYSRYTDGlDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSLGYDYDLGDGLSWLST 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   468 EPYTFYVSDPVNNIYTPFNSISNITLTEGYDEIVQETT-------QFFVNYDRAFGKHNLGALFVYEKVDNERKNIeagr 540
Cdd:pfam00593   81 LRLGLRYSSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGldgdlelSLDLSHDLLLGVELRTAGLDYRRLDDDAYDP---- 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   541 qgfvspsidqlfAGGATGQISDGTASESARQGYIGRVTYSYADKYLFQANVRHD----------GSYNFPKDKRWGTFPA 610
Cdd:pfam00593  157 ------------YDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDhystdgddgnGGGDNFSRSYSAFSPR 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   611 FSVGWKISEEgflsgvdaietLKLRASWGK-FgndRVGPFQFLSGYTFNSGSVIGTSGaykpgiqdtgipNPNITWETAT 689
Cdd:pfam00593  225 LGLVYKPTDN-----------LSLYASYSRgF---RAPSLGELYGSGSGGGGGAVAGG------------NPDLKPETSD 278

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339732821   690 AKNLGLDFSlwKGRLSGEFDIFSKRTKDiLIARNASIPKSFGASLPKENLGIVDNKGFELALTY 753
Cdd:pfam00593  279 NYELGLKYD--DGRLSLSLALFYIDIKN-LITSDPDGPGLGGTVYTYTNVGKARIRGVELELSG 339
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 154-558 2.50e-10

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 64.39  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  154 LPGVITrqeTGKPGADGGEFLIRGkstFGNNSALILVDGVE---------RSIDRLDPNAIESITILKDAASaAIYGARA 224
Cdd:cd01347    25 IPGVSV---TRGGGGGGSTISIRG---FGPDRTLVLVDGLPlassnygrgVDLNTIPPELIERVEVLKGPSS-ALYGSGA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  225 ANGVVLVTTKRGA---LGAPSISYNSS---FGFQSAVQVPEMLNAGEFAEYFNEASLNSGD---NPAFTGEQVQQYQNGT 295
Cdd:cd01347    98 IGGVVNIITKRPTdefGGSVTAGYGSDnsgSSGGGGFDVSGALADDGAFGARLYGAYRDGDgtiDGDGQADDSDEERYNV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  296 LPSTDWWGE---VIRKSAPIQQQGITVSGGGERVRYFTSLGMLDQKGLYETSSFKRYNVRanvdidLTDRFTLGIDLAGR 372
Cdd:cd01347   178 AGKLDWRPDddtRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDR------YRKRASLGLEHDLN 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  373 KEKISDSSNSPFNSLLNSQPTSPAYVPDSVEPGGLGYNGVninpigeaiYSGYKRTNWnVFQGNFKLKYDIPIEGLTTTF 452
Cdd:cd01347   252 DTGWTLRANLSYSYTDNDGDPLILNGGNNAAGGDLGRSGY---------SSERDTTQL-GFDAGLNAPFGTGPVAHTLTL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  453 KYNYDHSFKNEKEfkepYTFYVSDpvnniytPFNSISNITLTEG--YDEIVQETTQFFVNYDRA--FGKHNLGALFVYEK 528
Cdd:cd01347   322 GVEYRREELDEKQ----TALYAQD-------TIELTDDLTLTLGlrYDHYDQDSKDTIAGGTTAkkSYSHWSPSLGLVYK 390

                         410       420       430
                  ....*....|....*....|....*....|...
gi 339732821  529 VDNE---RKNIEagrQGFVSPSIDQLFAGGATG 558
Cdd:cd01347   391 LTDGlslYASYS---QGFRAPSLGELYGGGSHG 420
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
104-236 3.17e-06

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 51.08  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  104 EEDAESLEEVVVVGYGTQKKS--DLTGAVAVVKGEKVNIAPTPSLTQNLSgKLPGVITRQETGkpgadGGEFL---IRGK 178
Cdd:COG4772    17 AEAATTLETVVVTGSRAAEARlkDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDG-----FGLRPnigIRGL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 339732821  179 STFGNNSALILVDGV----------ERSIDrLDPNAIESITILKDAASAAiYGARAANGVVLVTTKRG 236
Cdd:COG4772    91 GPRRSRGITLLEDGIpiapapygdpAAYYF-PDLERMERIEVLRGAAALR-YGPQTVGGAINFVTRTI 156
PRK13486 PRK13486
TonB-dependent receptor;
77-387 1.15e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 49.25  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   77 ASLVFSYVGFktkevalngqTVINVTLEEDAesleeVVVVGYGTQKK-SDLTGAVAVVKGEKVNIAPTPSLTQNLSGkLP 155
Cdd:PRK13486    7 ASVVIPCLGF----------SASSIAAAEDV-----MIVSASGYEKKlTNAAASVSVISQEELQSSQYHDLAEALRS-VE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  156 GVITRQETGKPGadGGEFLIRGKSTfgnNSALILVDGVERS-IDRLDPN--------------AIESITILKDAASAaIY 220
Cdd:PRK13486   71 GVDVESGTGKTG--GLEISIRGMPA---SYTLILIDGVRQGgSSDVTPNgfsamntgfmpplaAIERIEVIRGPMST-LY 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  221 GARAANGVVLVTTKRgalgapsisynssfgfqsavqvpemlNAGEFaeyfnEASLNSGDNpaftgeqvQQYQN--GTLPS 298
Cdd:PRK13486  145 GSDAMGGVVNIITRK--------------------------NADKW-----LSSVNAGLN--------LQESNkwGNSSQ 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  299 TDWW--GEVIRKSAPIQQQGITVSGGGERVryfTSLGMLDQKGL-YETSSfKRYNVRANVDIDLTDRFTLGIDLAGRKEK 375
Cdd:PRK13486  186 FNFWssGPLVDDSVSLQVRGSTQQRQGSSV---TSLSDTAATRIpYPTES-QNYNLGARLDWKASEQDVLWFDMDTTRQR 261

                         330
                  ....*....|..
gi 339732821  376 IsDSSNSPFNSL 387
Cdd:PRK13486  262 Y-DNRDGQLGSL 272
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 91-235 9.24e-05

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 46.43  E-value: 9.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   91 VALNGQTVINVTLEEDAESLEEVVVVGYGTQKKSDLTGAVAVvkGEKVNIAP--TPsltQNLSgklpgVITRQE------ 162
Cdd:COG4773    13 AAAGALAQAAAAAAAEATTLPEVTVTGTAEGTGGYTAKSSST--ATKLDTPLreTP---QSVS-----VVTRQLiedqga 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  163 ---------------TGKPGADGGEFLIRGkstFGNNSalILVDGV---ERSIDRLDPNAIESITILKDAASAaIYGARA 224
Cdd:COG4773    83 ttlddalrnvpgvtvSSYDGGGRDSFSIRG---FSIDN--YLRDGLplgGFGGGQPDTANLERVEVLKGPAGL-LYGAGS 156

                         170
                  ....*....|.
gi 339732821  225 ANGVVLVTTKR 235
Cdd:COG4773   157 PGGLVNLVTKR 167
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
155-235 3.88e-04

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 44.48  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  155 PGVitRQETGkPGADGGEFLIRGKSTFGNnsalILVDGV-ERSIDRLDPNAIESITILKDAASAaIYGARAANGVVLVTT 233
Cdd:COG4774    37 PGV--TFGAG-EGGNGDSFSIRGFSASGD----IYVDGLrDPGQYRRDTFNLERVEVLKGPASV-LYGRGSPGGVINLVT 108


                  ..
gi 339732821  234 KR 235
Cdd:COG4774   109 KR 110
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 110-234 5.00e-04

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 43.92  E-value: 5.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   110 LEEVVVVGYGTQKKSDLTGA-VAVVKGEKVNIAPTPSLTQNLSgKLPGViTRQETGKPGadGGEFLIRGkstFGNNSALI 188
Cdd:TIGR01785    1 LDTVTVTATRTRQVLSEAPAsVSVISGEQIESKQANNLADALN-TVPGV-DVTGGGRPP--GQSINIRG---LQDNRVLV 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 339732821   189 LVDGVERSIDR---------LDPNAIESITILKdAASAAIYGARAANGVVLVTTK 234
Cdd:TIGR01785   74 VVDGARQNYQRggahngslfVDPELLKRIEIVK-GPSSSLYGSGALGGVVAFRTK 127
PRK13483 PRK13483
ligand-gated channel protein;
104-235 9.36e-04

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 43.23  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  104 EEDAESLEEVVVVGYG-TQKKSDLTGAVAVVKGEKVNIAPTPSLTQNLSgKLPGVITrqeTGkpGADGGEFLIRGkstFG 182
Cdd:PRK13483   27 AAPDKTMETVVVTASGyEQQIRDAPASISVITREDLENRFYRDLTDALL-DVPGVVV---TG--GGDRTDISLRG---MG 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 339732821  183 NNSALILVDGVERSIDRLDPN---------------AIESITILKDAASaAIYGARAANGVVLVTTKR 235
Cdd:PRK13483   98 SQYTLILVDGKRQSSRETRPNsdgpgveqawtpplaAIERIEVIRGPMS-SLYGSDAIGGVINIITRK 164
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 81-235 4.93e-03

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 40.90  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821   81 FSYVGFKTKEVALNGQTVINVTLEEDAESLEEVVVVGYGTQKKSDLTGaVAVVKGEkvNIAPTPSlTQNLSG---KLPGV 157
Cdd:PRK13528    5 VNKILWLLTVLLVGLNSPVSAAESSDDDNGETMVVEATAEQELKQQPG-VSIITAE--DIKKRPP-VNDLSDiirKMPGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339732821  158 itrQETGKP--GADGG--EFLIRGkstFGNNSALILVDGV--------------ERSIdRLDPN-----AIESITILKDA 214
Cdd:PRK13528   81 ---NLTGNSasGTRGNnrQIDIRG---MGPENTLILIDGVpvtsrnsvryswrgERDT-RGDTNwvppeMVERIEVIRGP 153

                         170       180
                  ....*....|....*....|.
gi 339732821  215 AsAAIYGARAANGVVLVTTKR 235
Cdd:PRK13528  154 A-AARYGSGAAGGVVNIITKR 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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