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Conserved domains on  [gi|339728470|emb|CCC39623|]
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FAD synthase [Haloquadratum walsbyi C23]

Protein Classification

FAD synthase( domain architecture ID 10001817)

FAD synthase similar to Methanocaldococcus jannaschii DSM 2661 RibL which catalyzes the adenylation of FMN with ATP, and the cytidylation of FMN with CTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TagD COG0615
Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane ...
 8-141 3.21e-51

Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane/envelope biogenesis]; Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


:

Pssm-ID: 440380 [Multi-domain]  Cd Length: 131  Bit Score: 160.27  E-value: 3.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIPIERL 86
Cdd:COG0615    3 VITYGTFDLLHPGHINLLKRAKALGDELIVGVATDEFVAsKGRKPIIPEEQRKEIVEALKYVDEVILGEEWDKFEDIEEI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 339728470  87 QPDVIVLGHDQHHDIDAVRDALSGRDIACDVVRASARDPqyddeiLSTGTIVDQI 141
Cdd:COG0615   83 KPDVIVLGDDWKGDFDFLKEELEKRGIGCEVVYLPRTEG------ISSTKIKKRI 131
 
Name Accession Description Interval E-value
TagD COG0615
Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane ...
 8-141 3.21e-51

Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane/envelope biogenesis]; Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440380 [Multi-domain]  Cd Length: 131  Bit Score: 160.27  E-value: 3.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIPIERL 86
Cdd:COG0615    3 VITYGTFDLLHPGHINLLKRAKALGDELIVGVATDEFVAsKGRKPIIPEEQRKEIVEALKYVDEVILGEEWDKFEDIEEI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 339728470  87 QPDVIVLGHDQHHDIDAVRDALSGRDIACDVVRASARDPqyddeiLSTGTIVDQI 141
Cdd:COG0615   83 KPDVIVLGDDWKGDFDFLKEELEKRGIGCEVVYLPRTEG------ISSTKIKKRI 131
cytidylyltransferase cd02170
cytidylyltransferase; The cytidylyltransferase family includes cholinephosphate ...
 8-142 2.96e-38

cytidylyltransferase; The cytidylyltransferase family includes cholinephosphate cytidylyltransferase (CCT), glycerol-3-phosphate cytidylyltransferase, RafE and phosphoethanolamine cytidylyltransferase (ECT). All enzymes catalyze the transfer of a cytidylyl group from CTP to various substrates.


Pssm-ID: 173921 [Multi-domain]  Cd Length: 136  Bit Score: 127.79  E-value: 2.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIPIERL 86
Cdd:cd02170    4 VYAAGTFDIIHPGHIRFLEEAKKLGDYLIVGVARDETVAkIKRRPILPEEQRAEVVEALKYVDEVILGHPWSYFKPLEEL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 339728470  87 QPDVIVLGHDQHH--DIDAVRDALSGRDIACDVVRasardpqYDDEILSTGTIVDQIL 142
Cdd:cd02170   84 KPDVIVLGDDQKNgvDEEEVYEELKKRGKVIEVPR-------KKTEGISSSDIIKRIL 134
CTP_transf_like pfam01467
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ...
 12-134 7.22e-14

Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.


Pssm-ID: 396172 [Multi-domain]  Cd Length: 134  Bit Score: 65.03  E-value: 7.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   12 GTFDILHPGHIHYLTEAA-TFGTELHVIIARRRNVTHKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIP-IERLQPD 89
Cdd:pfam01467   4 GTFDPIHLGHLRLLEQAKeLFDEDLIVGVPSDEPPHKLKRPLFSAEERLEMLELAKWVDEVIVVAPWELTRElLKELNPD 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 339728470   90 VIVLGHDQHHDID-AVRDALSGRDIACdVVRASARDPQYDDEILST 134
Cdd:pfam01467  84 VLVIGADSLLDFWyELDEILGNVKLVV-VVRPVFFIPLKPTNGISS 128
rfaE_dom_II TIGR02199
rfaE bifunctional protein, domain II; RfaE is a protein involved in the biosynthesis of ...
 8-96 4.78e-10

rfaE bifunctional protein, domain II; RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. Domain I (TIGR02198) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (this family) adds ADP to yield ADP-D-glycero-D-manno-heptose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 131254 [Multi-domain]  Cd Length: 144  Bit Score: 55.00  E-value: 4.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470    8 VIAQGTFDILHPGHIHYLTEAATFGTELHVII---ARRRNVTHKPKPVLPDRQRRDVVDALEIVTAAHL---GHPEDIfi 81
Cdd:TIGR02199  14 VFTNGCFDILHAGHVSYLQQARALGDRLVVGVnsdASVKRLKGETRPINPEEDRAEVLAALSSVDYVVIfdeDTPEEL-- 91

                          90
                  ....*....|....*
gi 339728470   82 pIERLQPDVIVLGHD 96
Cdd:TIGR02199  92 -IGELKPDILVKGGD 105
PRK11316 PRK11316
bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose ...
 8-96 2.85e-07

bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE;


Pssm-ID: 183085 [Multi-domain]  Cd Length: 473  Bit Score: 49.06  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVII---ARRRNVTHKPKPVLPDRQRRDVVDALEIVtaahlghpeDIFIP-- 82
Cdd:PRK11316 343 VMTNGCFDILHAGHVSYLANARKLGDRLIVAVnsdASVKRLKGEGRPVNPLEQRMAVLAALEAV---------DWVVPfe 413

                         90       100
                 ....*....|....*....|.
gi 339728470  83 -------IERLQPDVIVLGHD 96
Cdd:PRK11316 414 edtpqrlIAEILPDLLVKGGD 434
 
Name Accession Description Interval E-value
TagD COG0615
Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane ...
 8-141 3.21e-51

Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family [Cell wall/membrane/envelope biogenesis]; Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440380 [Multi-domain]  Cd Length: 131  Bit Score: 160.27  E-value: 3.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIPIERL 86
Cdd:COG0615    3 VITYGTFDLLHPGHINLLKRAKALGDELIVGVATDEFVAsKGRKPIIPEEQRKEIVEALKYVDEVILGEEWDKFEDIEEI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 339728470  87 QPDVIVLGHDQHHDIDAVRDALSGRDIACDVVRASARDPqyddeiLSTGTIVDQI 141
Cdd:COG0615   83 KPDVIVLGDDWKGDFDFLKEELEKRGIGCEVVYLPRTEG------ISSTKIKKRI 131
cytidylyltransferase cd02170
cytidylyltransferase; The cytidylyltransferase family includes cholinephosphate ...
 8-142 2.96e-38

cytidylyltransferase; The cytidylyltransferase family includes cholinephosphate cytidylyltransferase (CCT), glycerol-3-phosphate cytidylyltransferase, RafE and phosphoethanolamine cytidylyltransferase (ECT). All enzymes catalyze the transfer of a cytidylyl group from CTP to various substrates.


Pssm-ID: 173921 [Multi-domain]  Cd Length: 136  Bit Score: 127.79  E-value: 2.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIPIERL 86
Cdd:cd02170    4 VYAAGTFDIIHPGHIRFLEEAKKLGDYLIVGVARDETVAkIKRRPILPEEQRAEVVEALKYVDEVILGHPWSYFKPLEEL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 339728470  87 QPDVIVLGHDQHH--DIDAVRDALSGRDIACDVVRasardpqYDDEILSTGTIVDQIL 142
Cdd:cd02170   84 KPDVIVLGDDQKNgvDEEEVYEELKKRGKVIEVPR-------KKTEGISSSDIIKRIL 134
CTP_transf_like pfam01467
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ...
 12-134 7.22e-14

Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.


Pssm-ID: 396172 [Multi-domain]  Cd Length: 134  Bit Score: 65.03  E-value: 7.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   12 GTFDILHPGHIHYLTEAA-TFGTELHVIIARRRNVTHKPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIFIP-IERLQPD 89
Cdd:pfam01467   4 GTFDPIHLGHLRLLEQAKeLFDEDLIVGVPSDEPPHKLKRPLFSAEERLEMLELAKWVDEVIVVAPWELTRElLKELNPD 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 339728470   90 VIVLGHDQHHDID-AVRDALSGRDIACdVVRASARDPQYDDEILST 134
Cdd:pfam01467  84 VLVIGADSLLDFWyELDEILGNVKLVV-VVRPVFFIPLKPTNGISS 128
RfaE_N cd02172
N-terminal domain of RfaE; RfaE is a protein involved in the biosynthesis of ...
 2-142 1.08e-12

N-terminal domain of RfaE; RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in Escherichia coli, and separate proteins in other organisms. Domain I is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (this family) adds ADP to yield ADP-D-glycero-D-manno-heptose .


Pssm-ID: 173923 [Multi-domain]  Cd Length: 144  Bit Score: 62.05  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   2 TEEAECVIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVTH-KPKPVLPDRQRRDVVDALEIVTAAHLGHPEDIF 80
Cdd:cd02172    1 QRGKTVVLCHGVFDLLHPGHVRHLQAARSLGDILVVSLTSDRYVNKgPGRPIFPEDLRAEVLAALGFVDYVVLFDNPTAL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339728470  81 IPIERLQPDVIVLGHD-QHHDIDAVRDALSGRdiacDVVRASARDPQY-DDEILSTGTIVDQIL 142
Cdd:cd02172   81 EIIDALQPNIYVKGGDyENPENDVTGKIAPEA----EAVKAYGGKIVFtGEIVFSSSALINRIF 140
rfaE_dom_II TIGR02199
rfaE bifunctional protein, domain II; RfaE is a protein involved in the biosynthesis of ...
 8-96 4.78e-10

rfaE bifunctional protein, domain II; RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. Domain I (TIGR02198) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (this family) adds ADP to yield ADP-D-glycero-D-manno-heptose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 131254 [Multi-domain]  Cd Length: 144  Bit Score: 55.00  E-value: 4.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470    8 VIAQGTFDILHPGHIHYLTEAATFGTELHVII---ARRRNVTHKPKPVLPDRQRRDVVDALEIVTAAHL---GHPEDIfi 81
Cdd:TIGR02199  14 VFTNGCFDILHAGHVSYLQQARALGDRLVVGVnsdASVKRLKGETRPINPEEDRAEVLAALSSVDYVVIfdeDTPEEL-- 91

                          90
                  ....*....|....*
gi 339728470   82 pIERLQPDVIVLGHD 96
Cdd:TIGR02199  92 -IGELKPDILVKGGD 105
cyt_tran_rel TIGR00125
cytidyltransferase-like domain; Protein families that contain at least one copy of this domain ...
 7-62 1.25e-08

cytidyltransferase-like domain; Protein families that contain at least one copy of this domain include citrate lyase ligase, pantoate-beta-alanine ligase, glycerol-3-phosphate cytidyltransferase, ADP-heptose synthase, phosphocholine cytidylyltransferase, lipopolysaccharide core biosynthesis protein KdtB, the bifunctional protein NadR, and a number whose function is unknown. Many of these proteins are known to use CTP or ATP and release pyrophosphate.


Pssm-ID: 272920 [Multi-domain]  Cd Length: 66  Bit Score: 49.23  E-value: 1.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 339728470    7 CVIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNV-THKPKPVLPDRQRRDVV 62
Cdd:TIGR00125   1 RVIFVGTFDPFHLGHLDLLERAKELFDELIVGVGSDQFVnPLKGEPVFSLEERLEML 57
PRK11316 PRK11316
bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose ...
 8-96 2.85e-07

bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE;


Pssm-ID: 183085 [Multi-domain]  Cd Length: 473  Bit Score: 49.06  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVII---ARRRNVTHKPKPVLPDRQRRDVVDALEIVtaahlghpeDIFIP-- 82
Cdd:PRK11316 343 VMTNGCFDILHAGHVSYLANARKLGDRLIVAVnsdASVKRLKGEGRPVNPLEQRMAVLAALEAV---------DWVVPfe 413

                         90       100
                 ....*....|....*....|.
gi 339728470  83 -------IERLQPDVIVLGHD 96
Cdd:PRK11316 414 edtpqrlIAEILPDLLVKGGD 434
G3P_Cytidylyltransferase cd02171
glycerol-3-phosphate cytidylyltransferase; Glycerol-3-phosphate cytidylyltransferase, ...
 8-118 5.83e-06

glycerol-3-phosphate cytidylyltransferase; Glycerol-3-phosphate cytidylyltransferase,(CDP-glycerol pyrophosphorylase). Glycerol-3-phosphate cytidyltransferase acts in pathways of teichoic acid biosynthesis. Teichoic acids are substituted polymers, linked by phosphodiester bonds, of glycerol, ribitol, etc. An example is poly(glycerol phosphate), the major teichoic acid of the Bacillus subtilis cell wall. Most, but not all, species encoding proteins in this family are Gram-positive bacteria. A closely related protein assigned a different function experimentally is a human ethanolamine-phosphate cytidylyltransferase.


Pssm-ID: 173922 [Multi-domain]  Cd Length: 129  Bit Score: 43.63  E-value: 5.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRR-NVTHKPKPVLPDRQRRDVVDALEIVtaahlghpeDIFIP---- 82
Cdd:cd02171    4 VITYGTFDLLHIGHLNLLERAKALGDKLIVAVSTDEfNAGKGKKAVIPYEQRAEILESIRYV---------DLVIPetnw 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 339728470  83 ------IERLQPDVIVLGHDQHHDIDAVRDalsgrdiACDVV 118
Cdd:cd02171   75 eqkiedIKKYNVDVFVMGDDWEGKFDFLKE-------YCEVV 109
PTZ00308 PTZ00308
ethanolamine-phosphate cytidylyltransferase; Provisional
 8-102 1.34e-03

ethanolamine-phosphate cytidylyltransferase; Provisional


Pssm-ID: 140329 [Multi-domain]  Cd Length: 353  Bit Score: 38.23  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339728470   8 VIAQGTFDILHPGHIHYLTEAATFGTELHVIIARRRNVT-HKPKPVLPDRQRRDVVDALEIVTAAHLGHP-----EDifi 81
Cdd:PTZ00308  14 VWVDGCFDMLHFGHANALRQARALGDELFVGCHSDEEIMrNKGPPVMHQEERYEALRACKWVDEVVEGYPyttrlED--- 90

                         90       100
                 ....*....|....*....|.
gi 339728470  82 pIERLQPDVIVLGHDQHHDID 102
Cdd:PTZ00308  91 -LERLECDFVVHGDDISVDLN 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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