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Conserved domains on  [gi|338745209|emb|CCB95575|]
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peptide chain release factor 1 (RF-1) [Streptococcus salivarius JIM8777]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-358 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 660.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   2 NIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMAK 81
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  82 EELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGI 161
Cdd:COG0216   80 EELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 162 KEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKV 241
Cdd:COG0216  160 KEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 242 ATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDH 321
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 338745209 322 RIGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEELN 358
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-358 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 660.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   2 NIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMAK 81
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  82 EELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGI 161
Cdd:COG0216   80 EELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 162 KEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKV 241
Cdd:COG0216  160 KEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 242 ATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDH 321
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 338745209 322 RIGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEELN 358
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-358 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 649.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   1 MNIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMA 80
Cdd:PRK00591   2 PSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEES-DPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  81 KEELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 161 IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNK 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 241 VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTD 320
Cdd:PRK00591 241 TDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTD 320

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 338745209 321 HRIGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEELN 358
Cdd:PRK00591 321 HRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-357 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 517.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209    3 IYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEasGDPDLEEMAKE 82
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE--SDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   83 ELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIK 162
Cdd:TIGR00019  83 ELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  163 EVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKVA 242
Cdd:TIGR00019 163 EVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  243 TAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHR 322
Cdd:TIGR00019 243 SAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHR 322

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 338745209  323 IGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEEL 357
Cdd:TIGR00019 323 INLTLYKLDEVLEGDLDELIEALIAEDQAQQLAAL 357
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 10-205 4.32e-106

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 308.93  E-value: 4.32e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   10 VEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKeasgDPDLEEMAKEELKESKA 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE----DPELAELAEEELEELEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   90 AKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVS 169
Cdd:pfam03462  77 RLEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEIS 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 338745209  170 GQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATV 205
Cdd:pfam03462 157 GEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
65-180 6.54e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 168.03  E-value: 6.54e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209    65 EMIKEASgDPDLEEMAKEELKESKAA-KEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAET 143
Cdd:smart00937   1 ELLEEEE-DDEMRELAEEELEELEAElEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAER 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 338745209   144 QGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYE 180
Cdd:smart00937  80 KGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-358 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 660.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   2 NIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMAK 81
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  82 EELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGI 161
Cdd:COG0216   80 EELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 162 KEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKV 241
Cdd:COG0216  160 KEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 242 ATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDH 321
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 338745209 322 RIGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEELN 358
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-358 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 649.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   1 MNIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMA 80
Cdd:PRK00591   2 PSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEES-DPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  81 KEELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 161 IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNK 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 241 VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTD 320
Cdd:PRK00591 241 TDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTD 320

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 338745209 321 HRIGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEELN 358
Cdd:PRK00591 321 HRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-357 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 517.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209    3 IYDQLQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEasGDPDLEEMAKE 82
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE--SDPEMREMAKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   83 ELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIK 162
Cdd:TIGR00019  83 ELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  163 EVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKVA 242
Cdd:TIGR00019 163 EVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  243 TAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHR 322
Cdd:TIGR00019 243 SAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHR 322

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 338745209  323 IGLTLQKLDTILAGKMDEVIDALVLYDQTQKLEEL 357
Cdd:TIGR00019 323 INLTLYKLDEVLEGDLDELIEALIAEDQAQQLAAL 357
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 10-205 4.32e-106

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 308.93  E-value: 4.32e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   10 VEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKeasgDPDLEEMAKEELKESKA 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE----DPELAELAEEELEELEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   90 AKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVS 169
Cdd:pfam03462  77 RLEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEIS 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 338745209  170 GQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATV 205
Cdd:pfam03462 157 GEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 7-344 1.94e-75

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 236.98  E-value: 1.94e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209    7 LQAVEDRYEELGELLSDPEVVSDTKRFMELSREEANTRETVtayREYKQVIQSISDAEEMIKEASGDPDlEEMAKEELKE 86
Cdd:TIGR00020  25 PEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVL---DTLEELKNSLEDLSELLELAVEEDD-EETFNELDAE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209   87 SKAAKEEYEERLKILLLpKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVA 166
Cdd:TIGR00020 101 LKALEKKLAELELRTML-SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  167 MVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEV-EEVEYEIDPKDLRVDIYHASGAGGQNVNKVATAV 245
Cdd:TIGR00020 180 LIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAV 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  246 RMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDA--ERKSTVGTGDrseRIRTYNF-PQNRVTDHR 322
Cdd:TIGR00020 260 RITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAkeGEKSEIGWGS---QIRSYVLhPYSMVKDLR 336

                         330       340
                  ....*....|....*....|..
gi 338745209  323 IGLTLQKLDTILAGKMDEVIDA 344
Cdd:TIGR00020 337 TGYETGNVQAVLDGDIDQFIEA 358
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 56-344 8.86e-62

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 200.27  E-value: 8.86e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  56 VIQSISDAEEMIKEASGDPDlEEMAKEELKESKAAKEEYEeRLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLA 135
Cdd:PRK08787  12 VLSGLADAGELLDLAESEQD-EDTALAVIADLDKYQAHVE-KLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 136 MYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEE-V 214
Cdd:PRK08787  90 MYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDnI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 215 EYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDA- 293
Cdd:PRK08787 170 EIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDAl 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 338745209 294 -ERKSTVGTGdrsERIRTYNFPQNRVTDHRIGLTLQKLDTILAGKMDEVIDA 344
Cdd:PRK08787 250 eATKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 212-322 9.53e-55

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 175.30  E-value: 9.53e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  212 EEVEYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADhfAQIAQDEQ 291
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 338745209  292 DAER-KSTVGTGDRSERIRTYNF-PQNRVTDHR 322
Cdd:pfam00472  79 KKRRiKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 21-344 9.77e-55

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 182.31  E-value: 9.77e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  21 LSDPEVVSDTKRFMELSREEANTRETVTAYREYKQVIQSISDAEEMIKEasgdpDLEEMAKEELKESKAAKEEYEeRLKI 100
Cdd:PRK05589   1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSE-----EDDEMKKEIISEVKNIKEEID-RFKI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 101 LLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYE 180
Cdd:PRK05589  75 ETLLSGEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 181 SGAHRVQRVPVTESQGRVHTSTATVLVMPEV-EEVEYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQ 259
Cdd:PRK05589 155 KGIHRLVRISPFNANGKRQTSFASVEVLPELtDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQ 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 260 EERTQQKNRDKAMKIIRARVadhfaqIAQDEQDAERKSTVGTGDRSE-----RIRTYNF-PQNRVTDHRIGLTLQKLDTI 333
Cdd:PRK05589 235 NERSQHSNKETAMKMLKSKL------VELKERAHKEKIEDLTGELKDmgwgsQIRSYVFhPYNLVKDHRTGVETSNVDSV 308

                        330
                 ....*....|.
gi 338745209 334 LAGKMDEVIDA 344
Cdd:PRK05589 309 MDGDIDNFITQ 319
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 23-344 9.05e-54

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 180.46  E-value: 9.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  23 DPEVVSDTKRFMELSREEANTRETVTAYREYKQviqSISDAEEMIK--EASGDPDLEEMAKEELKESKAakEEYEERLKI 100
Cdd:PRK07342   5 DPSLWNDAQEAQKLMRERQQLDDSINGINHLEQ---TLNDNIELIAmgEEEGDKSIVEDAEKTIRDLKD--EIDRRQIDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 101 LLLPK-DPNDdknIILEIRGAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKY 179
Cdd:PRK07342  80 LLSGEaDAND---TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 180 ESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEE-VEYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEM 258
Cdd:PRK07342 157 ESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQC 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 259 QEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAER--KSTVGTGdrsERIRTYNF-PQNRVTDHRIGLTLQKLDTILA 335
Cdd:PRK07342 237 QQERSQHKNRAKAWSMLRARLYEEELKKREEATNAAAasKTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLD 313


                 ....*....
gi 338745209 336 GKMDEVIDA 344
Cdd:PRK07342 314 GDLNEFMEA 322
PCRF smart00937
This domain is found in peptide chain release factors;
65-180 6.54e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 168.03  E-value: 6.54e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209    65 EMIKEASgDPDLEEMAKEELKESKAA-KEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKYAET 143
Cdd:smart00937   1 ELLEEEE-DDEMRELAEEELEELEAElEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAER 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 338745209   144 QGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYE 180
Cdd:smart00937  80 KGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-344 1.05e-50

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 172.23  E-value: 1.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209  40 EANT-RETVTAYREYKQVIQSISDAEEMIKEASgDPDLEEMAKEELKESKAAKEEYEerlkILLLPKDPNDDKNIILEIR 118
Cdd:PRK06746  19 EANAlKDMVGKFRQLDETFENLEITHELLKEEY-DEDLHEELESEVKGLIQEMNEYE----LQLLLSDPYDKNNAILELH 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 119 GAAGGDEAALFAGDLLAMYQKYAETQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRV 198
Cdd:PRK06746  94 PGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 199 HTSTATVLVMPEV-EEVEYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRA 277
Cdd:PRK06746 174 HTSFVSCEVVPEFnDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKA 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 338745209 278 RVADHFAQIAQDEQDAERKSTVGTGDRSErIRTYNF-PQNRVTDHRIGLTLQKLDTILAGKMDEVIDA 344
Cdd:PRK06746 254 KLYQKKLEEQQAELDEIRGEQKEIGWGSQ-IRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 215-322 3.72e-25

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 99.05  E-value: 3.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 215 EYEIDPKDLRVDIYHASGAGGQNVNKVATAVRMVH------------IPTGIKVEMQEERTQQKNRDKAMKIIRARVADh 282
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYE- 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 338745209 283 fAQIAQDEQDAERKSTVGTGDRSE--RIRtynfpqNRVTDHR 322
Cdd:COG1186   99 -AELEPKERRATKPTRGSKKRRLWgkQIR------SMVKDLR 133
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
216-281 7.72e-07

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 47.84  E-value: 7.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338745209 216 YEIDPKDLRVDIYHASGAGGQNVNKVATAVRMV------HIPTGIK------------------VEMQEERTQQKNRDKA 271
Cdd:PRK09256   8 LVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPEFYKerllalaghritkdgvivIKAQEFRSQERNREDA 87

                         90
                 ....*....|
gi 338745209 272 mkiiRARVAD 281
Cdd:PRK09256  88 ----LERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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