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Conserved domains on  [gi|33667034|ref|NP_612501|]
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PRELI domain-containing protein 2 isoform c [Homo sapiens]

Protein Classification

PRELI/slowmo family protein( domain architecture ID 488)

PRELI/slowmo family protein may regulate lipid accumulation in mitochondria by shuttling phospholipids in a lipid-specific manner across the intermembrane space

Gene Ontology:  GO:0015914|GO:1990050

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRELI super family cl04693
PRELI-like family; This family includes a conserved region found in the PRELI protein and ...
 1-144 9.05e-45

PRELI-like family; This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.


The actual alignment was detected with superfamily member pfam04707:

Pssm-ID: 398400  Cd Length: 156  Bit Score: 143.98  E-value: 9.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667034     1 MDKNVISVKIMEEKRDEsTGVIYRKRIAICQNVVPEILRKVsILKVPNIQLEEESWLNPRERNMAIRSHCLTWTQYASMK 80
Cdd:pfam04707  15 YSPHVISVDVLERELDD-DGKLHTERLLTKQGRLPRWLKKL-IGVAHTVYVVEVSVVDPKKRTLTLETRNLTFSNRLSVD 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33667034    81 EESVFRESMENPNWTEFIQRGRISITG-VGFLNCVLETFASTFLRQgAQKGIRIMEMLLKEQCGA 144
Cdd:pfam04707  93 ERCRYTPHPENPNWTIFDQEASISISGfFGFSSKVEKWSLKRFSQN-AKKGREGMEYVLQKLEEE 156
 
Name Accession Description Interval E-value
PRELI pfam04707
PRELI-like family; This family includes a conserved region found in the PRELI protein and ...
 1-144 9.05e-45

PRELI-like family; This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.


Pssm-ID: 398400  Cd Length: 156  Bit Score: 143.98  E-value: 9.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667034     1 MDKNVISVKIMEEKRDEsTGVIYRKRIAICQNVVPEILRKVsILKVPNIQLEEESWLNPRERNMAIRSHCLTWTQYASMK 80
Cdd:pfam04707  15 YSPHVISVDVLERELDD-DGKLHTERLLTKQGRLPRWLKKL-IGVAHTVYVVEVSVVDPKKRTLTLETRNLTFSNRLSVD 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33667034    81 EESVFRESMENPNWTEFIQRGRISITG-VGFLNCVLETFASTFLRQgAQKGIRIMEMLLKEQCGA 144
Cdd:pfam04707  93 ERCRYTPHPENPNWTIFDQEASISISGfFGFSSKVEKWSLKRFSQN-AKKGREGMEYVLQKLEEE 156
 
Name Accession Description Interval E-value
PRELI pfam04707
PRELI-like family; This family includes a conserved region found in the PRELI protein and ...
 1-144 9.05e-45

PRELI-like family; This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.


Pssm-ID: 398400  Cd Length: 156  Bit Score: 143.98  E-value: 9.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667034     1 MDKNVISVKIMEEKRDEsTGVIYRKRIAICQNVVPEILRKVsILKVPNIQLEEESWLNPRERNMAIRSHCLTWTQYASMK 80
Cdd:pfam04707  15 YSPHVISVDVLERELDD-DGKLHTERLLTKQGRLPRWLKKL-IGVAHTVYVVEVSVVDPKKRTLTLETRNLTFSNRLSVD 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33667034    81 EESVFRESMENPNWTEFIQRGRISITG-VGFLNCVLETFASTFLRQgAQKGIRIMEMLLKEQCGA 144
Cdd:pfam04707  93 ERCRYTPHPENPNWTIFDQEASISISGfFGFSSKVEKWSLKRFSQN-AKKGREGMEYVLQKLEEE 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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