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Conserved domains on  [gi|33620755|ref|NP_060493|]
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YEATS domain-containing protein 2 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.15e-84

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


:

Pssm-ID: 341126  Cd Length: 123  Bit Score: 271.75  E-value: 1.15e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907    1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 33620755  288 RVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907   80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 868-1118 5.67e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 5.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    868 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 947
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    948 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 1027
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755   1028 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1090
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 33620755   1091 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1118
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.15e-84

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 271.75  E-value: 1.15e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907    1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 33620755  288 RVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907   80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 231-310 1.99e-35

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 129.49  E-value: 1.99e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLD 310
Cdd:pfam03366    2 THKWTVYVRGLDNED-ISYFIKKVVFKLHPSF-ANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
201-336 2.28e-15

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 76.77  E-value: 2.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  201 TSRLFVKKTIVVGNVsKYIPPDKREENDQsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRR 280
Cdd:COG5033    7 TERLKTQRVIIPGEA-KPLGNEERFPVRH-THIWLVFVRAPGKE-DIATIVKKVIFKLHPTF-SNPTRTIESPPFEIKET 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 33620755  281 GWGEFPVRVQVHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGE 336
Cdd:COG5033   83 GWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTS 132
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 868-1118 5.67e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 5.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    868 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 947
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    948 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 1027
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755   1028 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1090
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 33620755   1091 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1118
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.15e-84

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 271.75  E-value: 1.15e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907    1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 33620755  288 RVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907   80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS cd16887
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 208-332 2.72e-42

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


Pssm-ID: 341123  Cd Length: 120  Bit Score: 150.51  E-value: 2.72e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  208 KTIVVGNVSKYIPPDKREENdqsTHKWMVYVRGSRREPsINHFVKKVWFFLHPSYKPNdLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16887    1 KPIVIGNVAEKIPKPEPDDN---THKWTVYVRSPTNED-LSSFIKKVTFKLHPSFPNP-VRVVTDPPFEVEEVGWGEFPI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 33620755  288 RVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRH 332
Cdd:cd16887   76 EIKIYFKDSNEKPVTLSHFLKLHPDGSPLKKPVVVSEKYDEIVFR 120
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 231-310 1.99e-35

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 129.49  E-value: 1.99e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLD 310
Cdd:pfam03366    2 THKWTVYVRGLDNED-ISYFIKKVVFKLHPSF-ANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
YEATS_TFIID14_like cd16910
YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; ...
 206-309 1.42e-28

YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; YEATS domain containing proteins, which include Transcription initiation factor TFIID subunits 14 and 14b of Arabidopsis, shown to be part of the TFIID general transcriptional regulator complex in a two-hybrid screen. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341129  Cd Length: 131  Bit Score: 111.90  E-value: 1.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  206 VKKTIVVGNVSKYIPPDKREENdqsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEF 285
Cdd:cd16910    1 VSVPIVYGSIAFWLGKKADETH---THKWTVYVRGANNE-DLSYFIKKVVFVLHPSF-ANPTRVVTEPPFEVTETGWGEF 75

                         90       100
                 ....*....|....*....|....
gi 33620755  286 PVRVQVHFKDSQNKRIDIIHNLKL 309
Cdd:cd16910   76 EIGITIHFKDDAEKPVELTHPLKL 99
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 208-326 2.16e-27

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 108.87  E-value: 2.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  208 KTIVVGNVSKYIPPdKREEnDQSTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16909    5 KPIVYGNIARYFGK-KREE-DGHTHQWTVYVKPYFNE-DMSTYVKKVQFKLHESY-ANPLRVVTKPPYEVTETGWGEFEI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 33620755  288 RVQVHFKDSQNKRIDIIHNLKLDRTYTGLqTLGAETVVD 326
Cdd:cd16909   81 IIKIFFIDPNERPVTLYHLLKLFQSDTNL-MLGKKTLVS 118
YEATS_Yaf9_like cd16908
YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein ...
 206-309 2.27e-23

YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein essential in the function the NuA4 histone acetyltransferase complex and the SWR1-C ATP-dependent chromatin remodeling complex. Yaf9 shares structural similarity with histone chaperone Asf1, both exhibit histone H3 and H4 binding in vitro, and evidence supports both play a role in the same histone acetylation mechanism. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: `YNK7', `ENL', `AF-9', and `TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341127  Cd Length: 145  Bit Score: 97.35  E-value: 2.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  206 VKKTIVVGNVSKYIPPDKREENDQS-THKWMVYVRGSRREpSINHFVKKVWFFLHPSYK-PNDLVEvrEPPFHLTRRGWG 283
Cdd:cd16908    2 VSRPIVYGNTARPLTPEEKPKAPPDhTHKWTVFVRGPDGE-DLSYFIKKVVFKLHESYPnPNRTIE--KPPFEVTETGWG 78

                         90       100
                 ....*....|....*....|....*..
gi 33620755  284 EFPVRVQVHFKD-SQNKRIDIIHNLKL 309
Cdd:cd16908   79 EFEIQIKIYFVPeANEKPITLYHMLKL 105
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 231-309 2.66e-17

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341125  Cd Length: 127  Bit Score: 79.54  E-value: 2.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYKPNDLVeVREPPFHLTRRGWGEFPVRVQVHFKDSQN-KRIDIIHNLKL 309
Cdd:cd16906   21 THDWTVFVRGANGSD-ISHFVEKVVFHLHESFPKPKRV-VKEPPFEVTESGYAGFTLPIEIYFKNKEEpKKVRFEYDLFL 98
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
201-336 2.28e-15

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 76.77  E-value: 2.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  201 TSRLFVKKTIVVGNVsKYIPPDKREENDQsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRR 280
Cdd:COG5033    7 TERLKTQRVIIPGEA-KPLGNEERFPVRH-THIWLVFVRAPGKE-DIATIVKKVIFKLHPTF-SNPTRTIESPPFEIKET 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 33620755  281 GWGEFPVRVQVHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGE 336
Cdd:COG5033   83 GWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTS 132
YEATS_Taf14_like cd16905
YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of ...
 206-307 1.11e-10

YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of TFIIF and TFIID transcription factor complexes, various chromatin-remodeling complexes (such as SWI/SNF, INO80, and RSC) and the NuA3 histone acetyltransferase complex. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. Specifically, Taf14 has been show to be a reader of lysine crotonylation, associated with active gene promoters and enhancers and binding acetyllysine on in histone H3. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341124  Cd Length: 118  Bit Score: 60.27  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755  206 VKKTIVVgNVSKYIPPDKREENDQSTHKW---MVYVRGSRREPSINHFvKKVWFFLHPSY-KPNdlVEVREPPFHLTRRG 281
Cdd:cd16905    1 VKRTIRI-KTQQHILPDVPPVEGFPLRKWsieLVLLDPNGEEVPADIF-DKVTYHLHPTFeNPI--RTFKKPPFRLEEKG 76

                         90       100
                 ....*....|....*....|....*.
gi 33620755  282 WGEFPVRVQVHFKDSQNKRIdIIHNL 307
Cdd:cd16905   77 WGEFDMKIVLHFLDNGGEFT-ITHDL 101
pYEATS pfam20305
prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to ...
 233-307 1.28e-10

prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to diverse effector domains, suggesting that the binding to a ligand activates an effector-based response against an invasive threat. It has been predicted to specifically recognize invader-induced modifications of macromolecules by acyl moieties (e.g. phage-encoded acylations of surface polysaccharides) to unleash the fused effectors through a conformational change.


Pssm-ID: 466455  Cd Length: 73  Bit Score: 58.45  E-value: 1.28e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33620755    233 KWMVYVRGSRREPSinhFVKKVWFFLHPSYKPNDL-VEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDiiHNL 307
Cdd:pfam20305    2 DVRLWVDGPDPVLL---LIESVEYTLHPTFPNPVRtVTDRNGNFSLSLSAWGAFTVGAEVEFKDGGEIELE--RYL 72
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 868-1118 5.67e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 5.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    868 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 947
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    948 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 1027
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755   1028 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1090
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 33620755   1091 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1118
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 889-1117 1.13e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.57  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    889 STSSAQGQQTLKVISGQKTTLFTqaahGGQASLMKISDSTLKTVPATSQLSKPGTTmlrvaGGVITTATSPAVALSANGP 968
Cdd:pfam17823   52 NKSSEQ*NFCAATAAPAPVTLTK----GTSAAHLNSTEVTAEHTPHGTDLSEPATR-----EGAADGAASRALAAAASSS 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    969 AQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTcKAATPTVVSATSLVPTPNPISGKATVSGllKIHSSQSSPQQAV 1048
Cdd:pfam17823  123 PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAP-RAAIAAASAPHAASPAPRTAASSTTAAS--STTAASSAPTTAA 199

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33620755   1049 LTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPG 1117
Cdd:pfam17823  200 SSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAG 268
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 837-1135 8.89e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.33  E-value: 8.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    837 TAGPGGISQHLTYTSYILKQTPQGTFLvgqPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHG 916
Cdd:pfam17823   71 TLTKGTSAAHLNSTEVTAEHTPHGTDL---SEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRA 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    917 GQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSStvssvtktsgqqqvc 996
Cdd:pfam17823  148 AACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGI--------------- 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620755    997 vSQATVGTckaATPTVVSATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKplSVNTSGGVQTILMPVNKV 1076
Cdd:pfam17823  213 -STAATAT---GHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAG--TINMGDPHARRLSPAKHM 286

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 33620755   1077 VQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPeTPGPSCLSQEGQTAVKTEESS 1135
Cdd:pfam17823  287 PSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTN 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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