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Conserved domains on  [gi|33598950|ref|NP_005388|]
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podocalyxin isoform 2 precursor [Homo sapiens]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 13557104)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 326-526 2.58e-76

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 239.26  E-value: 2.58e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   326 VLNLTGNTLCAG--GASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDEL 403
Cdd:pfam06365   1 ILNLNETSDCEDfkKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   404 KEAGVSDMKLGDQGPPEE--AEDRFSMPLIITIVC--MASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNP 479
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDvqSHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33598950   480 TLEVME-TSSEMQEK----KVVSLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 526
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-293 8.45e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 8.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    33 NATQTTTDSSNKTAPTpassvTIMATDTAQQSTVPT-----SKANEilASVKATTLGVSSDSPGTTTLAQQVSGPVNTTV 107
Cdd:pfam05109 386 NRTFDITVSGLGTAPK-----TLIITRTATNATTTThkvifSKAPE--STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNL 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   108 ARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPL 187
Cdd:pfam05109 459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPT 538

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   188 -------------SPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLPSSVISQRTQQTSSQMPAS 254
Cdd:pfam05109 539 lgktsptsavttpTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 33598950   255 STAPSSQETVQPT---------SPATALRTPTLPETMSSSPTAASTTH 293
Cdd:pfam05109 619 TSPPKNATSAVTTgqhnitsssTSSMSLRPSSISETLSPSTSDNSTSH 666
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 326-526 2.58e-76

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 239.26  E-value: 2.58e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   326 VLNLTGNTLCAG--GASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDEL 403
Cdd:pfam06365   1 ILNLNETSDCEDfkKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   404 KEAGVSDMKLGDQGPPEE--AEDRFSMPLIITIVC--MASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNP 479
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDvqSHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33598950   480 TLEVME-TSSEMQEK----KVVSLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 526
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-293 8.45e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 8.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    33 NATQTTTDSSNKTAPTpassvTIMATDTAQQSTVPT-----SKANEilASVKATTLGVSSDSPGTTTLAQQVSGPVNTTV 107
Cdd:pfam05109 386 NRTFDITVSGLGTAPK-----TLIITRTATNATTTThkvifSKAPE--STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNL 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   108 ARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPL 187
Cdd:pfam05109 459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPT 538

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   188 -------------SPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLPSSVISQRTQQTSSQMPAS 254
Cdd:pfam05109 539 lgktsptsavttpTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 33598950   255 STAPSSQETVQPT---------SPATALRTPTLPETMSSSPTAASTTH 293
Cdd:pfam05109 619 TSPPKNATSAVTTgqhnitsssTSSMSLRPSSISETLSPSTSDNSTSH 666
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
76-286 1.22e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.83  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  76 ASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDT 155
Cdd:COG3469   4 VSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATAT 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950 156 TNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQP----TSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGM 231
Cdd:COG3469  84 AAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGsvtsTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGT 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33598950 232 TTTLPSSvisqrTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSP 286
Cdd:COG3469 164 TTTSTTT-----TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
PHA03247 PHA03247
large tegument protein UL36; Provisional
 183-302 2.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   183 PTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLP--SSVISQRTQQTSSQMPASSTAPSS 260
Cdd:PHA03247 2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavASLSESRESLPSPWDPADPPAAVL 2812

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 33598950   261 QETvqPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPT 302
Cdd:PHA03247 2813 APA--AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 326-526 2.58e-76

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 239.26  E-value: 2.58e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   326 VLNLTGNTLCAG--GASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDEL 403
Cdd:pfam06365   1 ILNLNETSDCEDfkKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   404 KEAGVSDMKLGDQGPPEE--AEDRFSMPLIITIVC--MASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNP 479
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDvqSHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33598950   480 TLEVME-TSSEMQEK----KVVSLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 526
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 33-293 8.45e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 8.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    33 NATQTTTDSSNKTAPTpassvTIMATDTAQQSTVPT-----SKANEilASVKATTLGVSSDSPGTTTLAQQVSGPVNTTV 107
Cdd:pfam05109 386 NRTFDITVSGLGTAPK-----TLIITRTATNATTTThkvifSKAPE--STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNL 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   108 ARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPL 187
Cdd:pfam05109 459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPT 538

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   188 -------------SPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLPSSVISQRTQQTSSQMPAS 254
Cdd:pfam05109 539 lgktsptsavttpTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 33598950   255 STAPSSQETVQPT---------SPATALRTPTLPETMSSSPTAASTTH 293
Cdd:pfam05109 619 TSPPKNATSAVTTgqhnitsssTSSMSLRPSSISETLSPSTSDNSTSH 666
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
76-286 1.22e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.83  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  76 ASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDT 155
Cdd:COG3469   4 VSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATAT 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950 156 TNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQP----TSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGM 231
Cdd:COG3469  84 AAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGsvtsTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGT 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33598950 232 TTTLPSSvisqrTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSP 286
Cdd:COG3469 164 TTTSTTT-----TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 35-272 1.31e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    35 TQTTTDSSNKTAPTPA-SSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGS 113
Cdd:pfam05109 511 SAVTTPTPNATSPTPAvTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNA 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   114 GNPTTTIESPKSTK--------SADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTs 185
Cdd:pfam05109 591 TSPTVGETSPQANTtnhtlggtSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPL- 669

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   186 pLSPRQPTSTHPVA--TPTSSGHDHLmkisSSSSTVAIPGYT--FTSPGMTTTLPSSVISQRTQQTSSQMPASSTAPSSQ 261
Cdd:pfam05109 670 -LTSAHPTGGENITqvTPASTSTHHV----STSSPAPRPGTTsqASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQ 744

                         250
                  ....*....|.
gi 33598950   262 ETVQPTSPATA 272
Cdd:pfam05109 745 KTAVPTVTSTG 755
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 89-307 9.86e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 9.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    89 SPGTTTLAQQVSGPVNTT----VARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTS----SQNGAEDTTNSGG 160
Cdd:pfam05109 369 TSGTPSGCENISGAFASNrtfdITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSptlnTTGFAAPNTTTGL 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   161 KSSHSVTTDLTS--TKAEHLTTPHPTSPlSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLPSS 238
Cdd:pfam05109 449 PSSTHVPTNLTApaSTGPTVSTADVTSP-TPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAV 527

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33598950   239 VISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTP----TLPETMSSSPTAASTTHRyPKTPSPTVAHES 307
Cdd:pfam05109 528 TTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPtpnaTIPTLGKTSPTSAVTTPT-PNATSPTVGETS 599
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 37-291 2.05e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    37 TTTDSSNKTAPTPA-SSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGN 115
Cdd:pfam05109 499 TESKAPDMTSPTSAvTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTS 578

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   116 PTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTdltstkAEHLTTPHPTSPLSPRQPTST 195
Cdd:pfam05109 579 PTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTT------GQHNITSSSTSSMSLRPSSIS 652

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   196 HPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTT------LPSSVISQRTQQTSSQMPASSTAPSSQETVQPTSP 269
Cdd:pfam05109 653 ETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSThhvstsSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPP 732

                         250       260
                  ....*....|....*....|..
gi 33598950   270 ATALRTPTLPETMSSSPTAAST 291
Cdd:pfam05109 733 KNATSPQAPSGQKTAVPTVTST 754
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 37-301 4.82e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    37 TTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNP 116
Cdd:pfam05109 451 STHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTP 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   117 TTTIESPKSTKSADTTTVATSTatakPNTTSsqngaedttnsggkSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTH 196
Cdd:pfam05109 531 TPNATSPTLGKTSPTSAVTTPT----PNATS--------------PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATS 592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   197 PV---ATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLPSSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATAL 273
Cdd:pfam05109 593 PTvgeTSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTS 672

                         250       260
                  ....*....|....*....|....*....
gi 33598950   274 RTPTLPETMSS-SPTAASTTHRYPKTPSP 301
Cdd:pfam05109 673 AHPTGGENITQvTPASTSTHHVSTSSPAP 701
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 142-307 9.26e-04

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 42.19  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  142 KPNTTSSQNGA-EDTTNSGGKSSHSVTTDLTSTKAEHLTTPH-----PTSPLSPRQPTSTHPVATPTSSGHDHL----MK 211
Cdd:COG5422   40 KLNPISIRNGAdNDIINSESKESFGKYALGHQIFSSFSSSPKlfqrrNSAGPITHSPSATSSTSSLNSNDGDQFspasDS 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  212 ISSSSSTVAI---PGYTFTSPGMTTT---LPSSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSS 285
Cdd:COG5422  120 LSFNPSSTQSrkdSGPGDGSPVQKRKnplLPSSSTHGTHPPIVFTDNNGSHAGAPNARSRKEIPSLGSQSMQLPSPHFRQ 199

                        170       180       190
                 ....*....|....*....|....*....|....
gi 33598950  286 PTAASTT------------HRYPKTPSPTVAHES 307
Cdd:COG5422  200 KFSSSDTsngfsypsirknSRHSSNSMPSFPHSS 233
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
33-239 2.40e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.51  E-value: 2.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  33 NATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSkaneilaSVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGG 112
Cdd:COG3469  12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGS-------VVVAASGSAGSGTGTTAASSTAATSSTTSTTATATA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950 113 SGNPTTTieSPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQP 192
Cdd:COG3469  85 AAAAATS--TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGG 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33598950 193 TSTHPVATPTSsghdhlmkiSSSSSTVAIPGYTFTSPGMTTTLPSSV 239
Cdd:COG3469 163 TTTTSTTTTTT---------SASTTPSATTTATATTASGATTPSATT 200
PHA03247 PHA03247
large tegument protein UL36; Provisional
 183-302 2.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   183 PTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLP--SSVISQRTQQTSSQMPASSTAPSS 260
Cdd:PHA03247 2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavASLSESRESLPSPWDPADPPAAVL 2812

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 33598950   261 QETvqPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPT 302
Cdd:PHA03247 2813 APA--AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 178-301 2.96e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 40.64  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    178 LTTPHPTSPLSPRQPTSTH-PVATPTSSGHDHLMKISSSSStvaipgytftspgmtttlpssvisQRTQQTSSQMPASST 256
Cdd:pfam15324  988 VPTPQPTPPCSPPSPLKEPsPVKTPDSSPCVSEHDFFPVKE------------------------IPPEKGADTGPAVSL 1043

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 33598950    257 APSSQETVQPTSPATALRTPTLPETMSSSPTAAStthryPKTPSP 301
Cdd:pfam15324 1044 VITPTVTPIATPPPAATPTPPLSENSIDKLKSPS-----PELPKP 1083
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 37-302 3.01e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950    37 TTTDSSNKTAPTPASSvtimatdtaqQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNP 116
Cdd:PHA03307  106 PTPPGPSSPDPPPPTP----------PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   117 -------TTTIESPKSTKSADTTTVATSTATAKPNTTSSQnGAEDTTNSGGK------------SSHSVTTDLTSTKAEH 177
Cdd:PHA03307  176 lsspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISA-SASSPAPAPGRsaaddagasssdSSSSESSGCGWGPENE 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   178 LTTPHPTSPLSPRQPTSTHPvATPTSSGHDHlmkiSSSSSTVAIPGYTFT-----SPGMTTTLPSSVISQRTQQTSSQMP 252
Cdd:PHA03307  255 CPLPRPAPITLPTRIWEASG-WNGPSSRPGP----ASSSSSPRERSPSPSpsspgSGPAPSSPRASSSSSSSRESSSSST 329

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 33598950   253 ASSTAPSSQETVQPTSPATALRTPTLPE--TMSSSPTAASTTHRYPKTPSPT 302
Cdd:PHA03307  330 SSSSESSRGAAVSPGPSPSRSPSPSRPPppADPSSPRKRPRPSRAPSSPAAS 381
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
179-379 3.45e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.03  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   179 TTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSST--VAIPGYTFTSPGMTTTLPSSviSQRTQQTSSQMPASST 256
Cdd:pfam05539 177 TTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTepVGTQGTTTSSNPEPQTEPPP--SQRGPSGSPQHPPSTT 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   257 APSSQETVQPTSPATALRTPTLPE---TMSSSPTAASTTHR---YPKTPSPTVAHESNWAKCEDLETQTQSekqlvlNLT 330
Cdd:pfam05539 255 SQDQSTTGDGQEHTQRRKTPPATSnrrSPHSTATPPPTTKRqetGRPTPRPTATTQSGSSPPHSSPPGVQA------NPT 328

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 33598950   331 GNTLCAGGASDEKLISLICRAVkATFNPAQDK-CGIRLASVPGSQTVVVK 379
Cdd:pfam05539 329 TQNLVDCKELDPPKPNSICYGV-GIYNEALPRgCDIVVPLCSTYTIMCMD 377
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 162-297 7.03e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950   162 SSHSVTTDLTSTKAEHLTTPHPTSPLSPrqPTSTHPVATPTSSghdhlmkiSSSSSTVAIPGYTFTSPGMttTLPSSVis 241
Cdd:pfam03154 445 ASHPPTSGLHQVPSQSPFPQHPFVPGGP--PPITPPSGPPTST--------SSAMPGIQPPSSASVSSSG--PVPAAV-- 510

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 33598950   242 qrtqqTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPK 297
Cdd:pfam03154 511 -----SCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQSARFYK 561
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
32-203 8.71e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 38.58  E-value: 8.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950  32 QNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANeiLASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGG 111
Cdd:COG3469  33 TLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATS--STTSTTATATAAAAAATSTSATLVATSTASGANTGTS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33598950 112 GSGNPTTTIESPKSTKSADTTTVATSTATAkPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQ 191
Cdd:COG3469 111 TVTTTSTGAGSVTSTTSSTAGSTTTSGASA-TSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATT 189

                       170
                ....*....|..
gi 33598950 192 PTSTHPVATPTS 203
Cdd:COG3469 190 ASGATTPSATTT 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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