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Conserved domains on  [gi|333956871|gb|EGL74500|]
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pyruvate kinase [Cronobacter sakazakii E899]

Protein Classification

pyruvate kinase( domain architecture ID 11481784)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

EC:  2.7.1.40
Gene Ontology:  GO:0006096|GO:0004743|GO:0000287|GO:0030955
PubMed:  2379684|12798932|10751408

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-433 0e+00

pyruvate kinase; Provisional


:

Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 731.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKG 80
Cdd:PRK05826  35 LNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:PRK05826 114 LPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGC-DAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:PRK05826 194 FVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKARE 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRLD 319
Cdd:PRK05826 271 AGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLD 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDNVEEAIAMSAMYAANHLKGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGV 399
Cdd:PRK05826 351 RQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTD 430

                        410       420       430
                 ....*....|....*....|....*....|....
gi 333956871 400 AAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTG 433
Cdd:PRK05826 431 DAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
 
Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-433 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 731.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKG 80
Cdd:PRK05826  35 LNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:PRK05826 114 LPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGC-DAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:PRK05826 194 FVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKARE 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRLD 319
Cdd:PRK05826 271 AGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLD 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDNVEEAIAMSAMYAANHLKGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGV 399
Cdd:PRK05826 351 RQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTD 430

                        410       420       430
                 ....*....|....*....|....*....|....
gi 333956871 400 AAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTG 433
Cdd:PRK05826 431 DAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-443 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 688.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKG 80
Cdd:COG0469   34 LNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVELKKGDTFTLTTD--DVEGDAERVSVTYPE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:COG0469  112 LPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALS 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARKL 240
Cdd:COG0469  192 FVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 241 NRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRL-D 319
Cdd:COG0469  269 GKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLrD 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDNVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGV 399
Cdd:COG0469  349 EPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTD 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 333956871 400 AAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTV 443
Cdd:COG0469  428 EMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-443 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 635.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG-KVFLNIGDKFLLDANLGKGEGDKEKVGIDYK 79
Cdd:cd00288   33 MNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGkDISLKAGDKFLVTTDPAAKKGTKEKIYVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  80 GLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLA 158
Cdd:cd00288  113 NLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 159 VSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRAR 238
Cdd:cd00288  193 ASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNN---FDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCN 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 239 KLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRL 318
Cdd:cd00288  270 LAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEM 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 319 DVEFD---NVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSA 395
Cdd:cd00288  350 RRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEP 428

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 333956871 396 -----NDGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGtTGSTNTTRVLTV 443
Cdd:cd00288  429 kpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-440 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 601.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871    1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKG 80
Cdd:TIGR01064  32 LNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVKLKKGDKVIITTDDIKGEGDEEKVYVDYKG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:TIGR01064 112 LTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAAS 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  161 FPRCGEDLNYARRLARDAG-CDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:TIGR01064 192 FVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNR 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPS-INVSKHRL 318
Cdd:TIGR01064 269 AGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKALAyLTNFNDRK 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  319 --DVEFDNVEEAIAMSAMYAANHLKgVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDS-A 395
Cdd:TIGR01064 349 nsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDEeP 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 333956871  396 NDGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRV 440
Cdd:TIGR01064 428 SDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-314 1.06e-144

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 416.38  E-value: 1.06e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871    1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK--VFLNIGDKFL--LDANLgKGEGDKEKVGI 76
Cdd:pfam00224  33 MNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKkdIELKAGDEMIvsTDAKY-KGACDDEMIYV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   77 DYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVD 155
Cdd:pfam00224 112 DYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVD 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  156 YLAVSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIR 235
Cdd:pfam00224 192 MIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  236 RARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEK-IPSINVS 314
Cdd:pfam00224 269 KCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
 
Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-433 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 731.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKG 80
Cdd:PRK05826  35 LNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:PRK05826 114 LPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGC-DAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:PRK05826 194 FVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKARE 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRLD 319
Cdd:PRK05826 271 AGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLD 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDNVEEAIAMSAMYAANHLKGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGV 399
Cdd:PRK05826 351 RQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTD 430

                        410       420       430
                 ....*....|....*....|....*....|....
gi 333956871 400 AAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTG 433
Cdd:PRK05826 431 DAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-443 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 688.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKG 80
Cdd:COG0469   34 LNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVELKKGDTFTLTTD--DVEGDAERVSVTYPE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:COG0469  112 LPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALS 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARKL 240
Cdd:COG0469  192 FVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 241 NRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRL-D 319
Cdd:COG0469  269 GKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLrD 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDNVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGV 399
Cdd:COG0469  349 EPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTD 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 333956871 400 AAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTV 443
Cdd:COG0469  428 EMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-443 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 635.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG-KVFLNIGDKFLLDANLGKGEGDKEKVGIDYK 79
Cdd:cd00288   33 MNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGkDISLKAGDKFLVTTDPAAKKGTKEKIYVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  80 GLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLA 158
Cdd:cd00288  113 NLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 159 VSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRAR 238
Cdd:cd00288  193 ASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNN---FDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCN 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 239 KLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRL 318
Cdd:cd00288  270 LAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEM 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 319 DVEFD---NVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSA 395
Cdd:cd00288  350 RRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEP 428

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 333956871 396 -----NDGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGtTGSTNTTRVLTV 443
Cdd:cd00288  429 kpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-440 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 601.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871    1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKG 80
Cdd:TIGR01064  32 LNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVKLKKGDKVIITTDDIKGEGDEEKVYVDYKG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:TIGR01064 112 LTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAAS 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  161 FPRCGEDLNYARRLARDAG-CDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:TIGR01064 192 FVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNR 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPS-INVSKHRL 318
Cdd:TIGR01064 269 AGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKALAyLTNFNDRK 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  319 --DVEFDNVEEAIAMSAMYAANHLKgVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDS-A 395
Cdd:TIGR01064 349 nsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDEeP 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 333956871  396 NDGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRV 440
Cdd:TIGR01064 428 SDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-314 1.06e-144

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 416.38  E-value: 1.06e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871    1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK--VFLNIGDKFL--LDANLgKGEGDKEKVGI 76
Cdd:pfam00224  33 MNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKkdIELKAGDEMIvsTDAKY-KGACDDEMIYV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   77 DYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVD 155
Cdd:pfam00224 112 DYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVD 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  156 YLAVSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIR 235
Cdd:pfam00224 192 MIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  236 RARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEK-IPSINVS 314
Cdd:pfam00224 269 KCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
PRK06247 PRK06247
pyruvate kinase; Provisional
 1-443 2.90e-135

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 397.37  E-value: 2.90e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDanLGKGEGDKEKVGIDYKG 80
Cdd:PRK06247  36 LNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGKVQLANGQTFRLD--VDDAPGDHDRVSLPHPE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:PRK06247 114 IAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAgcdAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARKL 240
Cdd:PRK06247 194 FVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAI---DRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRA 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 241 NRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKH--RL 318
Cdd:PRK06247 268 GKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEAVRTMARIIRQVERDPTYPPLIHaqRP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 319 DVEfDNVEEAIAMSAMYAANHLKgVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDG 398
Cdd:PRK06247 348 QPE-ATKRDAISYAARDIAERLD-LAALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDDARDT 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 333956871 399 VAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTV 443
Cdd:PRK06247 426 DDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-443 2.24e-130

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 388.51  E-value: 2.24e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKG 80
Cdd:PRK06354  39 LNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGPIELKTGDEFILTSR--EVLGTQEKFSVTYDG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMK--VFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLA 158
Cdd:PRK06354 117 LADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIA 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 159 VSFPRCGEDLNYARRL-ARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRA 237
Cdd:PRK06354 197 LSFVRNPSDVLEIRELiEEHNGKHIPIIAKIEKQEAI---DNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKA 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 238 RKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEK-IPSINVSKH 316
Cdd:PRK06354 274 NRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKdLPYRDILSK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 317 RLDvEFDNVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSAN 396
Cdd:PRK06354 354 RPE-FTTTITNAISQAVSHIALQL-DAAAIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAP 431

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 333956871 397 DGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTV 443
Cdd:PRK06354 432 STDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVV 478
PRK09206 PRK09206
pyruvate kinase PykF;
1-440 8.68e-106

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 321.62  E-value: 8.68e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK-VFLNIGDKFLL--DANLgkgEGDKEKVGID 77
Cdd:PRK09206  33 LNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGNdVSLKAGQTFTFttDKSV---VGNKERVAVT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  78 YKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYL 157
Cdd:PRK09206 110 YEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFV 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 158 AVSFPRCGEDLNYARR-LARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRR 236
Cdd:PRK09206 190 AASFIRKRSDVLEIREhLKAHGGENIQIISKIENQEGL---NNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEK 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 237 ARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVClgaEKIPSinVSKH 316
Cdd:PRK09206 267 CNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATIC---ERTDR--VMNS 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 317 RLDVEFDN----VEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVY- 391
Cdd:PRK09206 342 RLESNNDNrklrITEAVCRGAVETAEKL-DAPLIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLv 420

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 333956871 392 --FDSANDGVAAAQDAVnllRDKGYLVTGDLVIVTQGDMMgTTGSTNTTRV 440
Cdd:PRK09206 421 keIASTDDFYRLGKELA---LQSGLAQKGDVVVMVSGALV-PSGTTNTASV 467
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 1-443 3.85e-91

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 283.48  E-value: 3.85e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLG-KGEGDKEKVGIDYK 79
Cdd:PTZ00300   6 MNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfADKGTKDKFYIDYQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  80 GLPADVVPGDILLLDDGRVQLKVL---EVQGMKVFteVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDY 156
Cdd:PTZ00300  86 NLSKVVRPGGYIYIDDGILILHVQsheDEQTLKCT--VTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVDM 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 157 LAVSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRR 236
Cdd:PTZ00300 164 IFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGV---QNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 237 ARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINV--- 313
Cdd:PTZ00300 241 CNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVffn 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 314 SKHRLDVEFDNVEEAIAMSAMYAANHLKGvSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFD 393
Cdd:PTZ00300 321 SIKKLQPIPMSAEEAVCSSAVNSVYETKA-KALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFD 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 333956871 394 SANDGVAAAQD-----AVNLLRDKGYLVTGDLVIVTQGDmMGTTGSTNTTRVLTV 443
Cdd:PTZ00300 400 AERLGHDEGKEqrvamGVGFAKSKGYVQSGDLMVVVHAD-HKVKGYANQTRIILV 453
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 1-443 6.56e-91

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 284.73  E-value: 6.56e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREiAAKLGRH--VAILGDLQGPKIRVSTFKEGK-VFLNIGD--KFLLDANLgkgEGDKEKVG 75
Cdd:PTZ00066  69 FNFSHGDHESHKKTLNNVRE-AAKARPNanLGILLDTKGPEIRTGFLKNHKpITLKEGQtlKITTDYTF---LGDETCIS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  76 IDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIIT-AAKIGV 154
Cdd:PTZ00066 145 CSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDILNfAIPMGC 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 155 DYLAVSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIgDPELVGI-QKTL 233
Cdd:PTZ00066 225 DFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLIN---FDEILAESDGIMVARGDLGMEI-PPEKVFLaQKMM 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 234 IRRARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINV 313
Cdd:PTZ00066 301 ISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRV 380

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 314 SKHRLDVEFD---NVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPV 390
Cdd:PTZ00066 381 LYHAIHLAVPtpvSVQEAVARSAVETAEDI-NAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTY 459

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 333956871 391 YFDSANDGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTV 443
Cdd:PTZ00066 460 VVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVKI 512
PLN02461 PLN02461
Probable pyruvate kinase
 2-422 1.85e-86

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 273.01  E-value: 1.85e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   2 NFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK-VFLNIGDKFLL--DANLgkgEGDKEKVGIDY 78
Cdd:PLN02461  53 NFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKpVQLKQGQEITIttDYSI---KGDENMIAMSY 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  79 KGLPADVVPGDILLLDDGRVQLKVLE--VQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIIT-AAKIGVD 155
Cdd:PLN02461 130 KKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDILQwGVPNKID 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 156 YLAVSFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIR 235
Cdd:PLN02461 210 FIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDN---FDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIY 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 236 RARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEK-IPSINVS 314
Cdd:PLN02461 287 KCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEAsLDYGALF 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 315 KHRLD---VEFDNVeEAIAMSAMYAANHLKGvSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTA--------- 382
Cdd:PLN02461 367 KEIMRsapLPMSPL-ESLASSAVRTANKVKA-SLIVVLTRGGTTARLVAKYRPAVPILSVVVPEITTDSFDwscsdeapa 444

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 333956871 383 ----LYRGVTPV-YFDSANDGVAAAQD-----AVNLLRDKGYLVTGDLVI 422
Cdd:PLN02461 445 rhslIYRGLIPVlAEGSAKATDSESTEeileaAIEHAKKKGLCKPGDSVV 494
PRK06739 PRK06739
pyruvate kinase; Validated
 1-308 4.33e-75

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 238.69  E-value: 4.33e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREiaakLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKG 80
Cdd:PRK06739  32 LNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQAGDSFILHTQ--PVTGSSTEASVDYEG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  81 LPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAVS 160
Cdd:PRK06739 106 IANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 161 FPRCGEDLNYARRLARDAGCDA-KICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:PRK06739 186 FVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAI---ENFQDICKEADGIMIARGDLGVELPYQFIPLLQKMMIQECNR 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 333956871 240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKI 308
Cdd:PRK06739 263 TNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTLRLVSEFAEHV 331
PLN02623 PLN02623
pyruvate kinase
 1-425 3.02e-73

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 240.60  E-value: 3.02e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHV-AILGDLQGPKIRVSTFKEgKVFLNIGDKFLLdaNLGKGEGDKEKVGIDYK 79
Cdd:PLN02623 141 LNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ-PIMLEEGQEFTF--TIKRGVSTEDCVSVNYD 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  80 GLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIITAAKIGVDYLAV 159
Cdd:PLN02623 218 DFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAV 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 160 SFPRCGEDLNYARRLARDAGCDAKICAKVERAEAVCSneaMDDIILASDVVMVARGDLGVEIGDPELVGIQKTLIRRARK 239
Cdd:PLN02623 298 SFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPN---LHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRS 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 240 LNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEKIPSINVSKHRLD 319
Cdd:PLN02623 375 MGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLG 454

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 320 VEFDN-VEEAIAMSAMYAANHLKgvSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDG 398
Cdd:PLN02623 455 QAFKNhMSEMFAFHATMMANTLG--TSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDA 532

                        410       420
                 ....*....|....*....|....*..
gi 333956871 399 VAAAQDAVNLLRDKGYLVTGDLVIVTQ 425
Cdd:PLN02623 533 EETFARALSLLLNKGMVKEGEEVALVQ 559
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 1-423 1.78e-64

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 215.76  E-value: 1.78e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   1 MNFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTF--------KEGKVFLNIGDKFlldanlgKGEGDKE 72
Cdd:PLN02762  56 LNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLggassakaEDGEEWTFTVRKF-------DGSRPEF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  73 KVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPL---------SNNKGINKLGGGLSAeaLTEKDK 143
Cdd:PLN02762 129 TIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLlpranltfwRDGSLVRERNAMLPT--ISSKDW 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 144 ADIITAAKIGVDYLAVSFPRCGEDLNYARRL--ARDAGCDAKICAKVERAEavcSNEAMDDIILASDVVMVARGDLGVEI 221
Cdd:PLN02762 207 LDIDFGISEGVDFIAVSFVKSAEVIKHLKSYiaARSRDSDIGVIAKIESLD---SLKNLEEIIRASDGAMVARGDLGAQI 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 222 GDPELVGIQKTLIRRARKLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARV 301
Cdd:PLN02762 284 PLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSV 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 302 CL-----GAEKIPSINVSKHRLDVEF-DNVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRH- 374
Cdd:PLN02762 364 SLrmelwSREEKRHEALELPQLSSSLsDRISEEICNSAAKMANNL-GVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTt 442

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 333956871 375 --ERTLNltaLYRGVTPVYFDSANDGVAAAQDAVNLLRDKGYLVTGDLVIV 423
Cdd:PLN02762 443 svRRRLN---LQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIA 490
PLN02765 PLN02765
pyruvate kinase
 2-444 9.84e-55

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 190.27  E-value: 9.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   2 NFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKgEGDKEKVGIDYKGL 81
Cdd:PLN02765  60 DFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSK-EASSEVLPINFPGL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  82 PADVVPGDILLL--------DDGRVQLKVLEVQGMKVFTEV----TVGGPL----SNNKGInklggglSAEALTEKDKAD 145
Cdd:PLN02765 139 AKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVknsaTLAGSLftlhVSQVRI-------DLPTLSEKDKEV 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 146 IIT-AAKIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKICAKVERAEAVcsnEAMDDIILASDVVMVARGDLGVEIgD 223
Cdd:PLN02765 212 ISTwGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLsQTQIFAKIENVEGL---THFDEILQEADGIILSRGNLGIDL-P 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 224 PELVGI-QKTLIRRARKLNRAVITaTQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVC 302
Cdd:PLN02765 288 PEKVFLfQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRIC 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 303 LGAEKIpsINVSKH-RLDVEF--DNV--EEAIAMSAMYAANHLKGvSAIITMTESGRTALMTSRISSGLPIFAM------ 371
Cdd:PLN02765 367 AEAEKV--FNQDLYfKKTVKYvgEPMshLESIASSAVRAAIKVKA-SVIIVFTSSGRAARLIAKYRPTMPVLSVviprlk 443

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 372 ---SRHERTLNLTA----LYRGVTPVYFDS--ANDGVAAAQD-----AVNLLRDKGYLVTGDLVIVTQgdmmgTTGSTNT 437
Cdd:PLN02765 444 tnqLKWSFTGAFQArqclIVRGLFPMLADPrhSAESTSATNEsvlkvALDHGKAAGVIKSHDRVVVCQ-----KVGDSSV 518


                 ....*..
gi 333956871 438 TRVLTVD 444
Cdd:PLN02765 519 VKIIELD 525
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 327-441 1.71e-42

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 145.70  E-value: 1.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  327 EAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSANDGVAAAQDAV 406
Cdd:pfam02887   1 EAIAHAAVEAAEEL-GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 333956871  407 NLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVL 441
Cdd:pfam02887  80 KVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
244-444 2.60e-41

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 149.28  E-value: 2.60e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 244 VITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPAETVSAMARVCLGAEK-------IPSINVSKH 316
Cdd:COG3848    9 VITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEdleyreqRVPRAKESS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 317 RldvefdNVEEAIAMSAMYAANHLkGVSAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSAN 396
Cdd:COG3848   89 T------TITDAISHAVATTAADL-GAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 333956871 397 DGVAAAQDAVNLLRDKGYLVTGDLVIVTQGDMMGTTGSTNTTRVLTVD 444
Cdd:COG3848  162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVG 209
PRK08187 PRK08187
pyruvate kinase; Validated
 2-301 6.62e-29

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 118.58  E-value: 6.62e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871   2 NFSHGTPEDHQLRADKVREIAAKLGRHVAILGDLQGPKIRVSTF--KEGKVFLNIGDKFLLDANLGKGEGDKE--KVGID 77
Cdd:PRK08187 166 NCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVagPLGKTRLYTGDRLALVAQGPPRRIDEEhfQVTCT 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  78 YKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGP----LSNNKGINKLGGGLSAEALTEKDKADIITAAKiG 153
Cdd:PRK08187 246 LPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPkglkLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-H 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 154 VDYLAVSFPRCGEDLN-----YARRLARDAGcDAKICAKVERAEAVcsnEAMDDIILASD-----VVMVARGDLGVEIGD 223
Cdd:PRK08187 325 ADLVGYSFVQSPGDVEalqaaLAARRPDDWR-KLGLVLKIETPRAV---ANLPELIVQAAgrqpfGVMIARGDLAVEIGF 400

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333956871 224 PELVGIQKTLIRRARKLNRAVITATQMMESMITNPMPTRAEVMDVANAvlDGTDAVMLSaetaAGQYPAETVSAMARV 301
Cdd:PRK08187 401 ERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 45-281 5.67e-24

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 104.65  E-value: 5.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871  45 FKEGKVFLNIGDKFLL--DANLG---KGEGDKEKVGIdykGLPA---DVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTV 116
Cdd:PRK14725 328 PVEQKLRLKVGDRLVLtrDDAPGdpaQGDAPPARISC---TLPEafrAARVGERVWFDDGKIGAVVVKVEADEVELRITH 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 117 GGP----LSNNKGINKLGGGLSAEALTEKDKADIITAAKIGvDYLAVSFPRCGEDLNY-----ARRLARDAGcdakICAK 187
Cdd:PRK14725 405 ARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLlldalEKLGADDLG----VVLK 479

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956871 188 VERAEAVcsnEAMDDIILAS----DV-VMVARGDLGVEIGDPELVGIQKTLIRRARKLNRAVITATQMMESMITNPMPTR 262
Cdd:PRK14725 480 IETRRAF---ENLPRILLEAmrhpRFgVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSR 556

                        250
                 ....*....|....*....
gi 333956871 263 AEVMDVANAVLdgTDAVML 281
Cdd:PRK14725 557 AEITDAAMALR--AECVML 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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