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Conserved domains on  [gi|333956870|gb|EGL74499|]
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lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [Cronobacter sakazakii E899]

Protein Classification

lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase( domain architecture ID 10793125)

lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A; can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold-adapted Kdo(2)-lipid A

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08943 PRK08943
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated
 1-321 0e+00

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated


:

Pssm-ID: 236355  Cd Length: 314  Bit Score: 615.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   1 MDTKKTKSEYIPEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEA 80
Cdd:PRK08943   1 MEMKKDNKEYIPRFQKSFLHPRYWGTWLGIGALAGLALMPPRLRDPLAAKLGRLVGKLAKKARRRARINLSLCFPEKSEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  81 QREAIIDNMFATAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAM 160
Cdd:PRK08943  81 EREAIIDEMFATAPQAMLMMAELALRSPKHLQRRVEWHGLEILEEARANGENVIFLVPHGWAIDIPAMLLASQGQPMAAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 161 FHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVC 240
Cdd:PRK08943 161 FHNQRNPLFDWLWNRVRRRFGGRLHAREDGIKPFISSVRQGYWGYYLPDEDHGPEHSVFVDFFATYKATLPGIGRLAKVC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 241 NARVIPLFPVYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGEtepyrrkDLY 320
Cdd:PRK08943 241 RARVVPLFPVYNGKTHRLDIEIRPPMDDLLSADDETIARRMNEEVEQFVGPHPEQYMWILKLLKTRKPGE-------DLY 313


                 .
gi 333956870 321 P 321
Cdd:PRK08943 314 P 314
 
Name Accession Description Interval E-value
PRK08943 PRK08943
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated
 1-321 0e+00

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated


Pssm-ID: 236355  Cd Length: 314  Bit Score: 615.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   1 MDTKKTKSEYIPEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEA 80
Cdd:PRK08943   1 MEMKKDNKEYIPRFQKSFLHPRYWGTWLGIGALAGLALMPPRLRDPLAAKLGRLVGKLAKKARRRARINLSLCFPEKSEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  81 QREAIIDNMFATAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAM 160
Cdd:PRK08943  81 EREAIIDEMFATAPQAMLMMAELALRSPKHLQRRVEWHGLEILEEARANGENVIFLVPHGWAIDIPAMLLASQGQPMAAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 161 FHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVC 240
Cdd:PRK08943 161 FHNQRNPLFDWLWNRVRRRFGGRLHAREDGIKPFISSVRQGYWGYYLPDEDHGPEHSVFVDFFATYKATLPGIGRLAKVC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 241 NARVIPLFPVYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGEtepyrrkDLY 320
Cdd:PRK08943 241 RARVVPLFPVYNGKTHRLDIEIRPPMDDLLSADDETIARRMNEEVEQFVGPHPEQYMWILKLLKTRKPGE-------DLY 313


                 .
gi 333956870 321 P 321
Cdd:PRK08943 314 P 314
lipid_A_msbB TIGR02208
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; This family consists of MsbB ...
 10-314 6.84e-171

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; This family consists of MsbB in E. coli and closely related proteins in other species. MsbB is homologous to HtrB (TIGR02207) and acts immediately after it in the biosynthesis of KDO-2 lipid A (also called Re LPS and Re endotoxin). These two enzymes act after creation of KDO-2 lipid IV-A by addition of the KDO sugars. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274032  Cd Length: 305  Bit Score: 476.22  E-value: 6.84e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   10 YIPEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNM 89
Cdd:TIGR02208   1 YDRRFQKSFLHPKYWGTWLGVFALVLLAFMPAKLRDPIAKVLAKFVGPIAKKPRGRARINLSACFPEKSEAERETIIDNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   90 FATAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLL 169
Cdd:TIGR02208  81 FATFVQVMLSQAELAIRSKAHLRRRVNLMGLEHIEAAQAAGKPVIFLVPHGWAIDYAGLRLASQGLPMVTMFNNHKNPLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  170 DYVWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFP 249
Cdd:TIGR02208 161 DWLWNRVRSRFGGHVYAREAGIKALLASLKRGESGYYLPDEDHGPEQSVFVPFFATYKATLPVVGRLAKAGNAQVVPVFP 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 333956870  250 VYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:TIGR02208 241 GYNQVTGKFELTVRPAMATELSVDPEQEARAMNKEVEQFILPYPEQYMWILRLLKTRPDGEASIY 305
Lip_A_acyltrans pfam03279
Bacterial lipid A biosynthesis acyltransferase;
12-305 2.42e-122

Bacterial lipid A biosynthesis acyltransferase;


Pssm-ID: 281296 [Multi-domain]  Cd Length: 294  Bit Score: 352.80  E-value: 2.42e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   12 PEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFA 91
Cdd:pfam03279   1 PKFSPELLHPRYWLDWLGIAVLRLLALLPYSALRRIGKGLGRLAGRFLKRRRKIARRNLALCFPEMSEAEREQIIDKSFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   92 TAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDY 171
Cdd:pfam03279  81 SVGRAIVETGRVWFWPDSRIAKRFEVIGLEHIKEALAQGRGAILVGPHFGNWDLGGRVLGQQYPGMAVYRPNLKNPLLDW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  172 VWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVY 251
Cdd:pfam03279 161 LQTSGRERFGGRMLPRQNGIKGLIKALRKGEVVWYLPDQDLGRKDSVFVPFFGVPAATTTGPAKLALKTKAAVIPVFPIR 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 333956870  252 NAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKT 305
Cdd:pfam03279 241 NGDGSGYTVIVHPALDLTITDDVEQIAQAMNQIVEKFIMPAPEQYFWLHRRWKT 294
LpxP COG1560
Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and ...
 34-301 2.88e-88

Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and metabolism]; Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 441168 [Multi-domain]  Cd Length: 271  Bit Score: 265.13  E-value: 2.88e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  34 AALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMVFMAELALRGPEKVLN 113
Cdd:COG1560    3 RLLRLLPLRLLYRLGDLLGRLLYRLAGRRRRVARRNLALAFPELSEAEREALARASFRNLGRTLLETLRLWRLSPERLRK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 114 RVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKP 193
Cdd:COG1560   83 RVEVEGLEHLEAALAEGRGVILLTPHFGNWELAGAALALRGYPVTAVYRPLKNPLLDRLIRRGRERFGGELIPRKDGVRA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 194 FIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNAKTHRLDVLIRPPMDDLAnAD 273
Cdd:COG1560  163 LLRALRKGGIVGLLPDQDPGRKSGVFVPFFGVPAATPTGPARLARRTGAPVVPVFARRLPDGRGYRLEIEPPLEDFS-ED 241

                        250       260
                 ....*....|....*....|....*...
gi 333956870 274 DVTLARRMNEEVEHFVGPHPEQYTWILK 301
Cdd:COG1560  242 VEADTQRLNRALEAWIREHPEQWLWLHR 269
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 112-304 1.54e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 158.15  E-value: 1.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 112 LNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQDGI 191
Cdd:cd07984    1 LKRVEREGLEHLEAALAKGKGVILLTAHFGNWELAGLALALLGYPVTVVYRPLKNPLLDRLITRGRERFGARLIPRGGGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 192 KPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNaKTHRLDVLIRPPMDDLAN 271
Cdd:cd07984   81 RELIRALKKGEIVGILPDQDPGRKGGVFVPFFGRPAATPTGPARLALKTGAPVVPAFAYRL-PGGGYRIEFEPPLENPPS 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 333956870 272 ADDVTLARRMNEEVEHFVGPHPEQYTWILKLLK 304
Cdd:cd07984  160 EDVEEDTQRLNDALEAAIREHPEQWLWFHRRWK 192
 
Name Accession Description Interval E-value
PRK08943 PRK08943
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated
 1-321 0e+00

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated


Pssm-ID: 236355  Cd Length: 314  Bit Score: 615.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   1 MDTKKTKSEYIPEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEA 80
Cdd:PRK08943   1 MEMKKDNKEYIPRFQKSFLHPRYWGTWLGIGALAGLALMPPRLRDPLAAKLGRLVGKLAKKARRRARINLSLCFPEKSEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  81 QREAIIDNMFATAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAM 160
Cdd:PRK08943  81 EREAIIDEMFATAPQAMLMMAELALRSPKHLQRRVEWHGLEILEEARANGENVIFLVPHGWAIDIPAMLLASQGQPMAAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 161 FHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVC 240
Cdd:PRK08943 161 FHNQRNPLFDWLWNRVRRRFGGRLHAREDGIKPFISSVRQGYWGYYLPDEDHGPEHSVFVDFFATYKATLPGIGRLAKVC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 241 NARVIPLFPVYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGEtepyrrkDLY 320
Cdd:PRK08943 241 RARVVPLFPVYNGKTHRLDIEIRPPMDDLLSADDETIARRMNEEVEQFVGPHPEQYMWILKLLKTRKPGE-------DLY 313


                 .
gi 333956870 321 P 321
Cdd:PRK08943 314 P 314
lipid_A_msbB TIGR02208
lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; This family consists of MsbB ...
 10-314 6.84e-171

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; This family consists of MsbB in E. coli and closely related proteins in other species. MsbB is homologous to HtrB (TIGR02207) and acts immediately after it in the biosynthesis of KDO-2 lipid A (also called Re LPS and Re endotoxin). These two enzymes act after creation of KDO-2 lipid IV-A by addition of the KDO sugars. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274032  Cd Length: 305  Bit Score: 476.22  E-value: 6.84e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   10 YIPEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNM 89
Cdd:TIGR02208   1 YDRRFQKSFLHPKYWGTWLGVFALVLLAFMPAKLRDPIAKVLAKFVGPIAKKPRGRARINLSACFPEKSEAERETIIDNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   90 FATAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLL 169
Cdd:TIGR02208  81 FATFVQVMLSQAELAIRSKAHLRRRVNLMGLEHIEAAQAAGKPVIFLVPHGWAIDYAGLRLASQGLPMVTMFNNHKNPLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  170 DYVWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFP 249
Cdd:TIGR02208 161 DWLWNRVRSRFGGHVYAREAGIKALLASLKRGESGYYLPDEDHGPEQSVFVPFFATYKATLPVVGRLAKAGNAQVVPVFP 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 333956870  250 VYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:TIGR02208 241 GYNQVTGKFELTVRPAMATELSVDPEQEARAMNKEVEQFILPYPEQYMWILRLLKTRPDGEASIY 305
Lip_A_acyltrans pfam03279
Bacterial lipid A biosynthesis acyltransferase;
12-305 2.42e-122

Bacterial lipid A biosynthesis acyltransferase;


Pssm-ID: 281296 [Multi-domain]  Cd Length: 294  Bit Score: 352.80  E-value: 2.42e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   12 PEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFA 91
Cdd:pfam03279   1 PKFSPELLHPRYWLDWLGIAVLRLLALLPYSALRRIGKGLGRLAGRFLKRRRKIARRNLALCFPEMSEAEREQIIDKSFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   92 TAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDY 171
Cdd:pfam03279  81 SVGRAIVETGRVWFWPDSRIAKRFEVIGLEHIKEALAQGRGAILVGPHFGNWDLGGRVLGQQYPGMAVYRPNLKNPLLDW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  172 VWNTVRRRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVY 251
Cdd:pfam03279 161 LQTSGRERFGGRMLPRQNGIKGLIKALRKGEVVWYLPDQDLGRKDSVFVPFFGVPAATTTGPAKLALKTKAAVIPVFPIR 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 333956870  252 NAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKT 305
Cdd:pfam03279 241 NGDGSGYTVIVHPALDLTITDDVEQIAQAMNQIVEKFIMPAPEQYFWLHRRWKT 294
LpxP COG1560
Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and ...
 34-301 2.88e-88

Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and metabolism]; Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 441168 [Multi-domain]  Cd Length: 271  Bit Score: 265.13  E-value: 2.88e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  34 AALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMVFMAELALRGPEKVLN 113
Cdd:COG1560    3 RLLRLLPLRLLYRLGDLLGRLLYRLAGRRRRVARRNLALAFPELSEAEREALARASFRNLGRTLLETLRLWRLSPERLRK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 114 RVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKP 193
Cdd:COG1560   83 RVEVEGLEHLEAALAEGRGVILLTPHFGNWELAGAALALRGYPVTAVYRPLKNPLLDRLIRRGRERFGGELIPRKDGVRA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 194 FIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNAKTHRLDVLIRPPMDDLAnAD 273
Cdd:COG1560  163 LLRALRKGGIVGLLPDQDPGRKSGVFVPFFGVPAATPTGPARLARRTGAPVVPVFARRLPDGRGYRLEIEPPLEDFS-ED 241

                        250       260
                 ....*....|....*....|....*...
gi 333956870 274 DVTLARRMNEEVEHFVGPHPEQYTWILK 301
Cdd:COG1560  242 VEADTQRLNRALEAWIREHPEQWLWLHR 269
lipid_A_htrB TIGR02207
lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; This model represents a narrow ...
 12-306 2.78e-49

lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; This model represents a narrow clade of acyltransferases, nearly all of which transfer a lauroyl group to KDO2-lipid IV-A, a lipid A precursor; these proteins are termed lipid A biosynthesis lauroyl acyltransferase, HtrB. An exception is a closely related paralog of E. coli HtrB, LpxP, which acts in cold shock conditions by transferring a palmitoleoyl rather than lauroyl group to the lipid A precursor. Members of this family are homologous to the family of acyltransferases responsible for the next step in lipid A biosynthesis. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274031 [Multi-domain]  Cd Length: 303  Bit Score: 166.36  E-value: 2.78e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   12 PEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFA 91
Cdd:TIGR02207   1 PEFSASLLHPRYWPTWLGLGVLWLIVQLPYPVLLALGRGIGRLAMRLMKRRVHIARRNLELCFPHMSDAERERLLRENFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870   92 TAPQAMVFMAeLALRGPEKVLNR-VDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVrMAAMFHHQGNRLLD 170
Cdd:TIGR02207  81 STGMALFETG-MAWFWSDARIKKwMQIEGLEHLQRAQKQGRGVLLVGVHFLTLELGARIFGQQQP-GIGVYRPHNNPLFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  171 YVWNTVRRRFGGRLHPRQDgIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKA-TLPAVGRLMKVCNARVIPLFP 249
Cdd:TIGR02207 159 WIQTRGRLRSNKAMIDRKD-LRGMIKALKNGERIWYAPDHDYGRKSSVFVPFFAVPDAaTTTGTSILARLSKCAVVPFTP 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 333956870  250 VYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTR 306
Cdd:TIGR02207 238 RRNEDGSGYRLKIDPPLDDFPGDDEIAAAARMNKIVEKMIMRAPEQYMWLHRRFKTR 294
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 112-304 1.54e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 158.15  E-value: 1.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 112 LNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQDGI 191
Cdd:cd07984    1 LKRVEREGLEHLEAALAKGKGVILLTAHFGNWELAGLALALLGYPVTVVYRPLKNPLLDRLITRGRERFGARLIPRGGGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 192 KPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNaKTHRLDVLIRPPMDDLAN 271
Cdd:cd07984   81 RELIRALKKGEIVGILPDQDPGRKGGVFVPFFGRPAATPTGPARLALKTGAPVVPAFAYRL-PGGGYRIEFEPPLENPPS 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 333956870 272 ADDVTLARRMNEEVEHFVGPHPEQYTWILKLLK 304
Cdd:cd07984  160 EDVEEDTQRLNDALEAAIREHPEQWLWFHRRWK 192
PRK05646 PRK05646
lipid A biosynthesis lauroyl acyltransferase; Provisional
 12-317 1.02e-46

lipid A biosynthesis lauroyl acyltransferase; Provisional


Pssm-ID: 235543 [Multi-domain]  Cd Length: 310  Bit Score: 159.98  E-value: 1.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  12 PEFERAFLHPRYWGAWLGIGACAALALTPPsfrdPLLGKLGRLAG----KFGKSARRRARINLFYCFPELSEAQREAIID 87
Cdd:PRK05646   4 PRFRAAFLHPRFWPLWLGLGLLWLVVQLPY----RVLLWLGRALGalmyRLAGSRRRIAARNLELCFPEKSAAERERLLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  88 NMFATAPQAMVFMAeLALRGPEKVLNRV-DWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRgVRMAAMFHHQGN 166
Cdd:PRK05646  80 ENFASTGIAFFEMA-MSWWWPKARLARLaHIEGLEHLQQAQQEGQGVILMALHFTTLEIGAALLGQQ-HTIDGMYREHKN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 167 RLLDYVWNTVRRRFG-GRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVI 245
Cdd:PRK05646 158 PVFDFIQRRGRERHNlDSTAIEREDVRGMLKLLRAGRAIWYAPDQDYGAKQSIFVPLFGIPAATVTATTKFARLGRARVI 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 333956870 246 PLFPVYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPYRRK 317
Cdd:PRK05646 238 PFTQKRLADGSGYRLVIHPPLEDFPGESEEADCLRINQWVERVVRECPEQYLWAHRRFKSRPEGEPKLYPKR 309
PRK06860 PRK06860
lipid A biosynthesis lauroyl acyltransferase; Provisional
 11-315 2.01e-43

lipid A biosynthesis lauroyl acyltransferase; Provisional


Pssm-ID: 235880 [Multi-domain]  Cd Length: 309  Bit Score: 151.22  E-value: 2.01e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  11 IPEFERAFLHPRYWGAWLGIGACAALALTP-PSFRdpLLGK-LGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDN 88
Cdd:PRK06860   6 LPKFSRALLHPRYWLTWLGIGLLWLIVLLPyPVLY--KLGRgLGKLALRFMKRRAKIARRNLELCFPEMSEQEREAIVVK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  89 MFATAPQAMVFMAeLALRGPEKVLNR-VDWHGEAFLNELLANKENVILLVPHGWGVDIpamllasrGVRMAAMfHHQG-- 165
Cdd:PRK06860  84 NFESVGMALIETG-MAWFWPDWRIKRwTEVEGLEHIREVQAQGRGVLLVGVHFLTLEL--------GARIFGM-HNPGig 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 166 ------NRLLDYVWNTVRRRFGGRLHPRQDgIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKA-TLPAVGRLMK 238
Cdd:PRK06860 154 vyrpndNPLYDWLQTWGRLRSNKSMLDRKD-LKGMIKALKKGERIWYAPDHDYGPRSSVFVPFFAVEQAaTTTGTWMLAR 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 333956870 239 VCNARVIPLFPVYNAKTHRLDVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPYR 315
Cdd:PRK06860 233 MSKAAVIPFVPRRKPDGKGYELIILPPEDSPPLDDAEATAAWMNKVVEKCILMAPEQYMWLHRRFKTRPEGVPSRYD 309
PRK08706 PRK08706
lipid A biosynthesis lauroyl acyltransferase; Provisional
 36-314 9.70e-42

lipid A biosynthesis lauroyl acyltransferase; Provisional


Pssm-ID: 169557 [Multi-domain]  Cd Length: 289  Bit Score: 146.55  E-value: 9.70e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  36 LALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMVFMAELALRGPEKVLNRV 115
Cdd:PRK08706  11 LQFLPFALLHKLADLTGLLAYLLVKPRRRIGEINLAKCFPEWDEEKRKTVLKQHFKHMAKLMLEYGLYWYAPAGRLKSLV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 116 DWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLaSRGVRMAAMFHHQGNRLLDYVWNTVRRRFGG-RLHPRQDGIKPF 194
Cdd:PRK08706  91 RYRNKHYLDDALAAGEKVIILYPHFTAFEMAVYAL-NQDVPLISMYSHQKNKILDEQILKGRNRYHNvFLIGRTEGLRAL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 195 IKSVREGYWGY-YLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNAKThRLDVLIRPPMDDLANAD 273
Cdd:PRK08706 170 VKQFRKSSAPFlYLPDQDFGRNDSVFVDFFGIQTATITGLSRIAALANAKVIPAIPVREADN-TVTLHFYPAWDSFPSED 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 333956870 274 DVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:PRK08706 249 AQADAQRMNRFIEERVREHPEQYFWLHKRFKTRPEGSPDFY 289
PRK06946 PRK06946
lipid A biosynthesis lauroyl acyltransferase; Provisional
 25-314 3.82e-39

lipid A biosynthesis lauroyl acyltransferase; Provisional


Pssm-ID: 180770 [Multi-domain]  Cd Length: 293  Bit Score: 139.82  E-value: 3.82e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  25 GAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMV------ 98
Cdd:PRK06946   5 GTALAIGLLKLLAFLPYGLTARFGDGLGWLLYRIPSRRRRIVHTNLKLCFPDWSDARREELARRHFRHVIRSYVersvqw 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  99 FMAELALRGPEKVLNRVDwhgeafLNELlaNKENVILLVPHGWGVDIPAMLLA-SRGVRMAAMFHHQGNRLLDYVWNTVR 177
Cdd:PRK06946  85 FGSEKKLEKLVQVDSAID------LTDP--DGPPTIFLGLHFVGIEAGSIWLNySLRRRVGSLYTPMSNPLLDAIAKAAR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 178 RRFGGRLHPRQDGIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLF----PVYna 253
Cdd:PRK06946 157 GRFGAEMVSRADSARQVLRWLRDGKPVMLGADMDFGLRDSTFVPFFGVPACTLTAVSRLARTGGAQVVPFItevlPDY-- 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 333956870 254 KTHRLDVLirPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:PRK06946 235 KGYRLRVF--KPWENYPTGDDDLDARRMNAFLEEQIRLMPEQYYWVHKRFKTRPPGEPSVY 293
PRK08025 PRK08025
kdo(2)-lipid IV(A) palmitoleoyltransferase;
12-314 1.44e-30

kdo(2)-lipid IV(A) palmitoleoyltransferase;


Pssm-ID: 181200  Cd Length: 305  Bit Score: 117.15  E-value: 1.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  12 PEFERAFLHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFA 91
Cdd:PRK08025   5 QKFSREFLHPRYWLTWFGLGVLWLLVQLPYPVLCFLGTRIGRMSRPFLKRRESIARKNLELCFPQMSAEEREKMIAENFR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  92 TAPQAMVFMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLvphgwGVDIPAMLLASRGV----RMAAMFHHQGNR 167
Cdd:PRK08025  85 SLGMALLETGMAWFWPDSRVRKWFDVEGLDNLKRAQMQNRGVMVV-----GVHFMSLELGGRVMglcqPMMATYRPHNNK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 168 LLDYVWNTVRRRFGGRLHPRQDgIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYK-ATLPAVGRLMKVCNARVIP 246
Cdd:PRK08025 160 LMEWVQTRGRMRSNKAMIGRNN-LRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENvATTNGTYVLSRLSGAAMLT 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333956870 247 LFPVYNAKTHRLDVLIRPPMDDLAnADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:PRK08025 239 VTMVRKADYSGYRLFITPEMEGYP-TDENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPVGESSLY 305
PRK08733 PRK08733
LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferase;
19-315 2.74e-26

LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferase;


Pssm-ID: 181542 [Multi-domain]  Cd Length: 306  Bit Score: 105.76  E-value: 2.74e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  19 LHPRYWGAWLGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMV 98
Cdd:PRK08733  14 RNPKHWPMYLGLAVMVLAARLPWTLQRALGRGVGWVAMRLAGTRRRAAEVNLKLCFPEQDDAWRARLLRDSFDALGVGLF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  99 FMAELALRGPEKVLNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRgVRMAAMFHHQGNRLLDYVWNTVRR 178
Cdd:PRK08733  94 EFARAWWGSIDVIRPGVQIEGLEHLQQLQQQGRGVLLVSGHFMTLEMCGRLLCDH-VPLAGMYRRHRNPVFEWAVKRGRL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 179 RFGGRLHPRQDgIKPFIKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFpvYNAKTHRL 258
Cdd:PRK08733 173 RYATHMFANED-LRATIKHLKRGGFLWYAPDQDMRGKDTVFVPFFGHPASTITATHQLARLTGCAVVPYF--HRREGGRY 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 333956870 259 DVLIRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPYR 315
Cdd:PRK08733 250 VLKIAPPLADFPSDDVIADTTRVNAAIEDMVREAPDQYLWIHRRFKRQPGGRSDFYR 306
PRK08905 PRK08905
lysophospholipid acyltransferase family protein;
33-313 1.59e-17

lysophospholipid acyltransferase family protein;


Pssm-ID: 236348 [Multi-domain]  Cd Length: 289  Bit Score: 81.19  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  33 CAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIidnmFATAPQAMVFMAELALRGPEKVL 112
Cdd:PRK08905   6 FRLLSRLPLSWLHALGGWLGRLAYRLPGRYRRRLRANLRQAGGDPDPAMVKAA----AAETGRMILELPYVWFRKPEEIE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 113 NRV-DWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGvRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQ-DG 190
Cdd:PRK08905  82 TMVkDDHGWEHVEAALAEGRGILFLTPHLGCFEVTARYIAQRF-PLTAMFRPPRKAALRPLMEAGRARGNMRTAPATpQG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 191 IKPFIKSVREGYWGYYLPdeDHGPEQSE--FVDFFATYKATLPAVGRLMKVCNARVIPLFpvynakTHRL------DVLI 262
Cdd:PRK08905 161 VRMLVKALRRGEAVGILP--DQVPSGGEgvWAPFFGRPAYTMTLVARLAEVTGVPVIFVA------GERLprgrgyRLHL 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 333956870 263 RPPMDDLaNADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEP 313
Cdd:PRK08905 233 RPVQEPL-PGDKAADAAVINAEIERLIRRFPTQYLWGYNRYKRPRGAPAPP 282
PRK08419 PRK08419
lipid A biosynthesis lauroyl acyltransferase; Reviewed
 36-304 2.31e-15

lipid A biosynthesis lauroyl acyltransferase; Reviewed


Pssm-ID: 181420 [Multi-domain]  Cd Length: 298  Bit Score: 75.06  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  36 LALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPE-LSEAQREAIIDNMFATAPQAMVFMAELALRGPEKVLNR 114
Cdd:PRK08419  17 LAKMPHCIFLRLAKALAFIMRYLDKKRRKIAKANLDFCFGEsKSQEEKKRIIKKCYENFAFFGLDFIRNQNTTKEEILNK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 115 VDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHPRQDGIKPF 194
Cdd:PRK08419  97 VTFINEENLLDALKKKRPIIVTTAHYGYWELFSLALAAYYGAVSIVGRLLKSAPINEMISKRREQFGIELIDKKGAMKEL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 195 IKSVREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFpVYNAKTHRLDVLIRPPMD----DLA 270
Cdd:PRK08419 177 LKALKQGRALGILVDQNVVPKEGVEVKFFNKRVTHTTIASILARRYNALIIPVF-IFNDDYSHFTITFFPPIRskitDDA 255

                        250       260       270
                 ....*....|....*....|....*....|....
gi 333956870 271 NADDVTLARRMNEEVEHFVGPHPEQYTWILKLLK 304
Cdd:PRK08419 256 EADILEATQAQASACEEMIRKKPDEYFWFHRRFK 289
PRK05645 PRK05645
lysophospholipid acyltransferase;
28-314 1.22e-13

lysophospholipid acyltransferase;


Pssm-ID: 135493 [Multi-domain]  Cd Length: 295  Bit Score: 69.93  E-value: 1.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  28 LGIGACAALALTPPSFRDPLLGKLGRLAGKFGKSARRRARINLFYCFPELSEAQREAIIDNMFATAPQAMVFMAELALRG 107
Cdd:PRK05645   8 LMVGALRLFALLPWRAVQGVGAGIGWLMWKLPNRSREVVRINLSKCFPELSPAELEKLVGQSLMDIGKTLTESACAWIWP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 108 PEKVLNRV-DWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRgVRMAAMFHHQGNRLLDYVWNTVRRRFGGRLHP 186
Cdd:PRK05645  88 PQKSLELVrEVEGLEVLEQALASGKGVVGITSHLGNWEVLNHFYCSQ-CKPIIFYRPPKLKAVDELLRKQRVQLGNRVAP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 187 R-QDGIKPFIKSVREGywGYYLPDEDHGPEQSE--FVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNAKTHRLDVLIR 263
Cdd:PRK05645 167 StKEGILSVIKEVRKG--GQVGIPADPEPAESAgiFVPFLGTQALTSKFVPNMLAGGKAVGVFLHALRLPDGSGYKVILE 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 333956870 264 PPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEPY 314
Cdd:PRK05645 245 AAPEDMYSTDVEVSAAAMSKVVERYVRAYPSQYMWSMKRFKKRPAGEARWY 295
PRK08734 PRK08734
lauroyl acyltransferase;
46-313 1.45e-10

lauroyl acyltransferase;


Pssm-ID: 181543 [Multi-domain]  Cd Length: 305  Bit Score: 61.05  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  46 PLLGKLGRLAG----KFGKSARRRARINLFYCFPELSEAQREAI-IDNMFATAPQAMVfMAELALRGPEKVLNRV-DWHG 119
Cdd:PRK08734  23 PLLKRLADLLAwswrKLNARESRVTRRNLELAYPELSPQQRAQLhAQILRSTARQALE-VLRTWTHPPAENLARLrQRHG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 120 EAFLNELLANKENVILLVPHGWGVDIPAMLLASRGvRMAAMFHHQGNRLLDYVWNTVRRRFGGRlHPRQDG--IKPFIKS 197
Cdd:PRK08734 102 QELYDAALASGRGVIVAAPHFGNWELLNQWLSERG-PIAIVYRPPESEAVDGFLQLVRGGDNVR-QVRAEGpaVRQLFKV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 198 VREGYWGYYLPDEDHGPEQSEFVDFFATYKATLPAVGRLMKVCNARVIPLFPVYNAKTHRLDVLIRPPMDDLANADDVTL 277
Cdd:PRK08734 180 LKDGGAVGILPDQQPKMGDGVFAPFFGIPALTMTLVNRLAERTGATVLYGWCERIGPDLEFALHVQPADPAVADPDPLRA 259

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 333956870 278 ARRMNEEVEHFVGPHPEQYTWILKLLKTRKAGETEP 313
Cdd:PRK08734 260 ATALNAGIERIARRDPAQYQWTYKRYTLRPPGSGEH 295
PRK06553 PRK06553
lipid A biosynthesis lauroyl acyltransferase; Provisional
 26-298 1.96e-04

lipid A biosynthesis lauroyl acyltransferase; Provisional


Pssm-ID: 235827 [Multi-domain]  Cd Length: 308  Bit Score: 42.65  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870  26 AWLGIGACAALALTPPsfrDPLLGKLGRLAGKFGK--SARRRARINLFYCFPELSEAQREAII----DNMFATAPQaMVF 99
Cdd:PRK06553  25 AQLVFGLLGLLRLFPA---DKAINFFGRLARLIGPllPRHRVALDNLRAAFPEKSEAEIEAIAlgmwDNLGRLGAE-YAF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 100 MAELALRGPEKV-LNRVDWHGEAFLNELLANKENVILLVPHGWGVDIPAMLLASRGVRMAAMFHHQGNRLLDYVWNTVRR 178
Cdd:PRK06553 101 LDAIFDYDPEAPePGRVEVRGIEIFERLRDDGKPALIFTAHLGNWELLAIAAAAFGLDVTVLFRPPNNPYAARKVLEARR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333956870 179 RFGGRLHPRQDGiKPF--IKSVREGYWGYYLPDE--DHGPEqsefVDFFATYKATLPAVGRLMK-----VCNARVIPLfp 249
Cdd:PRK06553 181 TTMGGLVPSGAG-AAFalAGVLERGGHVGMLVDQkfTRGVE----VTFFGRPVKTNPLLAKLARqydcpVHGARCIRL-- 253

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 333956870 250 vyNAKTHRLDVL--IRPPMDDLANADDVTLARRMNEEVEHFVGPHPEQYTW 298
Cdd:PRK06553 254 --PGGRFRLELTerVELPRDADGQIDVQATMQALTDVVEGWVREYPGQWLW 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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